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Effects of changes in the content of growth factors on the body size of Eothenomys miletus in different regions of Hengduan Mountain

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Effects of changes in the content of growth factors on the b...

第十六届全国野生动物生态与资源保护学术研讨会

作者： Liao Yuqiu Jia ting zhu wanglong School of Life Sciences of Yunnan Normal University

Growth factors can regulate the proliferation and differentiation ability of cells, keep the internal environment stable and affect the body size. In order to explore the influence of the change of the expression of growth factors on the body size of the Eothenomys miletus in different regions of Hengduan Mountain, the E. miletus in Dali(DL), Jianchuan(JC), Lijiang(LJ), Xianggelila(XGLL) and Deqin(DQ) were collected, and their seven morphological indicators and nine growth factors, including insulin-like growth factor1(IGF1), basic fibroblast growth factor(b FGF), epidermal growth factor(EGF), growth hormone release inhibitory factor(GRIF), platelet-derived growth factor(PDGF), transcription elongation factor1(TCEA1), a disintegrin and metalloprotease17(ADAM7), branched-chain amino acid transaminase1(BCAT1), high mobility group protein1(HMG1)were statistically analyzed. It was found that the body size of E. miletus in five regions of Hengduan Mountain differentiated, the body mass, body length, tail length, forelimb length, hind limb length, IGF, bFGF, EGF, PDGF, TCEA1 content of the E. miletus in DL, JC and LJ are greater than those in XGLL and DQ, and the contents of GRIF, ADAM7, BCAT1 and HMG1 are also different, decrease with the increase of regional latitude. The regional differences in the body size of E. miletus in different regions may be related to the changes in body mass, body length, tail length, forelimb length, hind limb length and the content of growth factors. The increase in the content of growth factors leads to the increase in the body size of E. miletus. It is speculated that growth factors may affect the body size of E. miletus by affecting the bone, epidermis, muscle and proliferation and differentiation of cells.

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Influence of rare earths on eutectic carbides in AISI M2 high speed steel

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Journal of Rare Earths 2012年第10期30卷 1075-1078页

作者：周雪峰殷晓燕方峰蒋建清朱旺龙 Jiangsu Key Laboratory of Advanced Metallic Materials Southeast University Jiangsu Engineering Research Center of Tool and Die Steel

The effect of rare earths on the morphology and microstructure of eutectic carbides in M2 high speed steel was studied. The results showed that rare earths promoted the forrmation of fishbone-like M6C eutectic carbides, compared to plate-like M2C carbides in ingots without modification. The formation of M6C was expected to be caused by rare earth inclusions which acted effectively as the substratc for nucleation of M6C carbides during solidification. M2C and M6C eutectic carbides exhibited different stability during heating. M2C eutectic carbides were much less stable than M6C carbides, and decomposed at high temperatures, favoring the spheroidization and refmement of carbides inhigh speed steels.

关键词： rare earths eutectic carbide morphology microstructure high speed steel

Differentially expressed genes analysis of brown adipose tissue during cold acclimation in tree shrews(Tupaia belangeri) based on RNA-Seq

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Differentially expressed genes analysis of brown adipose tis...

第十六届全国野生动物生态与资源保护学术研讨会

作者： Wang huijuan Jia ting zhu wanglong Wang zhengkun School of Life Sciences of Yunnan Normal University

The thermogenic function of brown adipose tissue(BAT) was known to be markedly elevated when animals were exposed to the cold, and intensive studies have been carried out tounderst and the molecular basis enabling effective thermogenesis in cold-exposed animals. In the present study, transcriptome sequencing of BAT in Tupaia belangeri between control and cold acclimation group were carried out by Illumina novaseq 6000 platform, respectively. Then the pathways and key genes related to lipid metabolism and energy metabolism were screened out by bioinformatics analysis, the regulation mechanism of cold adaptation in small mammals was explored at RNA level. The results showed that there were significant differences in the expression of 2879 genes in cold acclimation group compared with that of control group, 1181 were up-regulated and 1698 were down-regulated in cold acclimation group. Pathway analyses showed that the differentially expressed genes were significantly enriched in oxidative phosphorylation, steroid biosynthesis, glycerophospholipid and fatty acid metabolism pathways related to energy metabolism and lipid metabolism. The differentially expressed genes ND3, ND4, ND5, ND6, ND4L, CYTB, ATP8 and ATP6 in the oxidative phosphorylation pathway were significantly up-regulated. Key genes related to lipid metabolism were identified as ELOVL6, ACACA, HSD17B12, SQLE, LSS, DHCR7, DHCR24, CYP51A1, HMGCS1, LPL, and ACACA, etc, which were down-regulated in the lipid metabolism pathway. All of the above results indicated that the T. belangeri could adapt to the cold environment by regulating genes expression in oxidative phosphorylation, steroid biosynthesis, glycerophospholipid and fatty acid metabolism pathways in BAT. Among them, the expression of genes in the oxidative phosphorylation pathway were up-regulated, and most of the genes related to the lipid metabolism pathway were down-regulated, which promoted energy expenditure and heat production, and also provided ener

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Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3β/β-Catenin Signaling

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Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovar...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Ye Zhao Lan Yin Yuhan Yang wanglong zhu Yu Xian Zhengyu Han Houyi Huang Liaotian Peng Kun Zhang Chengdu Medical College

Ovarian cancer is the most lethal gynaecologic tumor, with which multi-drug resistance as the major therapeutic hindrance. Heat shock protein 90(Hsp90) has been involved in cancer malignant ***, its role and mechanism in multi-drug resistance of ovarian cancer remains poorly understood. Our results demonstrated that Hsp90 was overexpressed in multi-drug resistant ovarian cancer cells. Hsp90 downregulation by shHsp90 or inhibitor BⅡB021 increased the sensitivity of multi-drug resistant ovarian cancer cells to paclitaxel and cisplatin, and augmented the drugs-induced apoptosis. Hsp90 positively regulated the expressions of multi-drug resistance protein 1(P-gp/MDR1),breast cancer resistance protein(BCRP), Survivin and Bcl-2 expressions closely associated with multidrug resistance. Moreover, overexpression of Hsp90 promoted β-catenin accumulation, while Hsp90 downregulation decreased the accumulation, nuclear translocation and transcriptional activity of β-catenin. We also identifified that β-catenin was responsible for Hsp90-mediated expressions of P-gp,BCRP, Survivin, and Bcl-2. Furthermore, Hsp90 enhanced the AKT/GSK3β signaling, and AKT signaling played a critical role in Hsp90-induced accumulation and transcriptional activity of β-catenin,as well as multi-drug resistance to paclitaxel and cisplatin. In conclusion, Hsp90 enhanced the AKT/GSK3β/β-catenin signaling to induce multi-drug resistance of ovarian cancer. Suppressing Hsp90 chemosensitized multi-drug resistant ovarian cancer cells via impairing the AKT/GSK3β/β-catenin signaling, providing a promising therapeutic strategy for a successful treatment of ovarian cancer.

关键词： multi-drug resistance heat shock protein 90 ovarian cancer β-catenin chemotherapy

不同截面尺寸Cr8Mo2SiV和Cr12Mo1V1钢的组织与性能

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金属热处理 2014年第3期39卷 102-107页

作者：曾芬迟宏宵马党参马幼平徐辉霞朱旺龙西安建筑科技大学冶金工程学院陕西西安710055 钢铁研究总院特殊钢所北京100081 江苏天工工具有限公司江苏丹阳212312

对不同截面尺寸Cr8Mo2SiV和Cr12Mo1V1冷作模具钢的组织,共晶碳化物尺寸及不均匀度,冲击性能进行了研究。结果表明,Cr8Mo2SiV钢和Cr12Mo1V1钢退火组织均为球状珠光体上分布着碳化物;随热轧截面尺寸的增大,碳化物尺寸变大,分布均匀性变差... 详细信息

对不同截面尺寸Cr8Mo2SiV和Cr12Mo1V1冷作模具钢的组织,共晶碳化物尺寸及不均匀度,冲击性能进行了研究。结果表明,Cr8Mo2SiV钢和Cr12Mo1V1钢退火组织均为球状珠光体上分布着碳化物;随热轧截面尺寸的增大,碳化物尺寸变大,分布均匀性变差。适当减小试验钢的截面尺寸,能够显著减小共晶碳化物的尺寸并改善其分布不均度,提高材料的冲击性能。

关键词： Cr8Mo2SiV钢 Cr12Mo1V1钢截面尺寸组织性能

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Al对M2高速钢凝固组织的影响

金属学报 2014年第7期50卷 769-776页

作者：周雪峰方峰涂益友蒋建清徐辉霞朱旺龙东南大学江苏省先进金属材料高技术研究重点实验室南京211189 江苏省(天工)工模具钢工程技术研究中心丹阳212312

采用OM,TEM,SEM,EBSD,XRD等手段,分析了不同Al加入量(0%,0.6%,1.2%)的M2高速钢的铸态组织,研究了Al对高速钢凝固组织转变特别是共晶碳化物形貌和微观结构的影响规律.结果表明,M2高速钢铸态组织主要由位错型马氏体和M2C共晶莱氏体组成.过... 详细信息

采用OM,TEM,SEM,EBSD,XRD等手段,分析了不同Al加入量(0%,0.6%,1.2%)的M2高速钢的铸态组织,研究了Al对高速钢凝固组织转变特别是共晶碳化物形貌和微观结构的影响规律.结果表明,M2高速钢铸态组织主要由位错型马氏体和M2C共晶莱氏体组成.过量Al(1.2%)促进大量铁素体和针状碳化物形成.Al提高了共晶碳化物的分布均匀性,促进M2C形貌由纤维状转变为片状,并使碳化物微观结构发生明显改变.片状碳化物表面平行于(0002)晶面,内部存在微孪晶、层错等缺陷,片层之间具有不同的晶体取向,而纤维状碳化物内部缺陷极少,呈单晶取向.与纤维状碳化物相比,加Al后形成的片状碳化物高温加热时不易团球化,对碳化物尺寸细化不利.添加过量Al(1.2%)形成的铁素体无法通过常规热处理消除,使高速钢淬火硬度显著降低.

关键词： M2高速钢 Al 凝固组织 M2C共晶碳化物微观结构

Carbide refinement in M42 high speed steel by rare earth metals and spheroidizing treatment

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Journal of Southeast University(English Edition) 2014年第4期30卷 445-448页

作者：周雪峰方峰涂益友蒋建清朱旺龙尹松艳东南大学江苏省先进金属材料高技术研究重点实验室南京211189 江苏省工模具钢工程技术研究中心丹阳212312 盛利维尔(中国)新材料技术有限公司常州213200

The influence of rare earth metals and heat treatment on the microstructure and performance of M42 steel has been investigated by means of an optical microscope OM scanning electron microscope SEM energy dispersive spectroscopy EDS transmission electron microscope TEM electron back-scatter diffraction EBSD and X-ray diffraction XRD . The results show that M2 C is the prevailing type of eutectic carbides in M42 steel. After modification with rare earth metals M2 C eutectic carbides change from the ordered lamellar structure into a circular *** different morphologies the two carbides present the same characteristics of microstructure and growth *** with lamellar carbides M2 C carbides with the circular structure are much easier to decompose and spheroidize after heating which remarkably refines the carbide *** refined carbides improve the supersaturation of alloying elements in martensite and increase the hardness of M42 steel by 1.5 HRC.

关键词： high speed steel rare earth metals carbide dimension spheroidization

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绶草化学成分和药理作用研究进展

辽宁中医药大学学报 2022年第11期24卷 215-220页

作者：张丹李嘉欣朱旺龙黑龙江中医药大学黑龙江哈尔滨150040

绶草属兰科草本植物,为我国珍稀药材,已列入国家二级保护植物,具有滋阴益气、补肾益阳、清热凉血、止咳润肺、消炎、解毒、强筋骨、祛风除湿的功能,外用则治疗毒蛇咬伤、烫伤、疮痈等功效,经多年研究发现了多种化合物,包括二氢菲类、黄... 详细信息

绶草属兰科草本植物,为我国珍稀药材,已列入国家二级保护植物,具有滋阴益气、补肾益阳、清热凉血、止咳润肺、消炎、解毒、强筋骨、祛风除湿的功能,外用则治疗毒蛇咬伤、烫伤、疮痈等功效,经多年研究发现了多种化合物,包括二氢菲类、黄酮类和苯丙素类、甾醇类等化合物。其主要化学成分在抗炎、抗肿瘤、抗氧化、抗血糖和血脂及抗菌等方面疗效显著。由于近年来国内外研究人员对绶草的研究与综述较少,故对国内外近30年来的研究成果进行了分类和评述。为绶草进一步的研究和合理应用提供参考。

关键词：绶草化学成分药理作用抗肿瘤作用抗血糖降血脂

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昭通绒鼠体温调节季节性变化和热中性区漂移

生物学杂志 2021年第6期38卷 41-44页

作者：杨押佐贾婷张浩王政昆朱万龙云南省高校西南山地生态系统动植物生态适应进化及保护重点实验室云南师范大学生命科学学院生物能源持续开发利用教育部工程研究中心云南省生物质能与环境生物技术重点实验室昆明650500 云南经济管理学院昆明650106

为探究我国云南省昭通地区的昭通绒鼠(Eothenomys olitor)生理适应特征,分别于夏季和冬季测定其在5℃~30℃范围内的体温、代谢率和热传导。结果表明:昭通绒鼠的体温、静止代谢率和热传导存在季节性差异;夏季体温高于冬季,分别为36.17℃... 详细信息

为探究我国云南省昭通地区的昭通绒鼠(Eothenomys olitor)生理适应特征,分别于夏季和冬季测定其在5℃~30℃范围内的体温、代谢率和热传导。结果表明:昭通绒鼠的体温、静止代谢率和热传导存在季节性差异;夏季体温高于冬季,分别为36.17℃±0.52℃和35.55℃±0.46℃;热中性区表现出季节性差异,夏季和冬季的热中性区分别为20℃~27.5℃和15℃~25℃,即呈现出冬季的下限临界点较夏季低;在热中性区内,夏季静止代谢率(2.76±0.19)mL O_(2)/(g·h)低于冬季(4.78±0.22)mL O_(2)/(g·h);夏季和冬季的热传导在热中性区内都基本维持稳定,分别为(0.18±0.02)和(0.31±0.04)mL O_(2)/(g·h·℃)。结果表明昭通绒鼠通过调节体温、代谢率和热传导来适应昭通地区冬夏两季温差较大、年极端气温较低的气候特征。

关键词：昭通绒鼠热中性区体温调节静止代谢率热传导