检索结果-南通市图书馆

Nutri-microbiome epidemiology,an emerging field to disentangle the interplay between nutrition and microbiome for human health

引用

Protein & Cell 2023年第11期14卷 787-806页

作者： wanglong gou Zelei Miao Kui Deng Ju-Sheng Zheng Westlake Intelligent Biomarker Discovery Lab Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Research Center for Industries of the Future Key Laboratory of Growth Regulation and Translational Research of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310030China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Diet and nutrition have a substantial impact on the human microbiome,and interact with the microbiome,especially gut microbiome,to modulate various diseases and health *** research has also guided the nutrition field to a more integrative direction,becoming an essential component of the rising area of precision *** this review,we provide a broad insight into the interplay among diet,nutrition,microbiome,and microbial metabolites for their roles in the human *** the microbiome epidemiological studies regarding the associations of diet and nutrition with microbiome and its derived metabolites,we summarize those most reliable findings and highlight evidence for the relationships between diet and disease-associated microbiome and its functional ***,the latest advances of the microbiome-based precision nutrition research and multidisciplinary integration are ***,we discuss several outstanding challenges and opportunities in the field of nutri-microbiome epidemiology.

关键词： microbiome nutrition human health epidemiology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gut microbiome,cognitive function and brain structure:a multi-omics integration analysis

引用

Translational Neurodegeneration 2022年第1期11卷 178-191页

作者： Xinxiu Liang Yuanqing Fu Wen-ting Cao Zhihong Wang Ke Zhang Zengliang Jiang Xiaofang Jia Chun-ying Liu Hong-rou Lin Haili Zhong Zelei Miao wanglong gou Menglei Shuai Yujing Huang Shengdi Chen Bing Zhang Yu-ming Chen Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China School of Life Sciences Westlake University18 Shilongshan RdCloud TownHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of Medical Statistics and EpidemiologySchool of Public HealthSun Yat-Sen UniversityGuangzhou 510080China Chinese Center for Disease Control and Prevention National Institute for Nutrition and HealthBeijing 100050China School of Public Health Hainan Medical UniversityHaikou 571199China Westlake Intelligent Biomarker Discovery Lab Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Trace Element Nutrition National Health CommissionBeijing 100050China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China.

Background:Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes,but evidence from large human cohorts is *** study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent ***:We included 1430 participants from the Guangzhou Nutrition and Health Study(GNHS)with both gut microbiome and cognitive assessment data available as a discovery cohort,of whom 272 individuals provided fecal samples twice before cognitive *** selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up *** 16S rRNA and shotgun metagenomic sequencing,tar-geted serum metabolomics,and cytokine measurements were performed in the *** validation analyses were conducted in an Alzheimer’s disease case-control study(replication study 1,n=90)and another community-based cohort(replication study 2,n=1300)with cross-sectional ***:We found protective associations of specific gut microbial genera(Odoribacter,Butyricimonas,and Bac-teroides)with cognitive impairment in both the discovery cohort and the replication study *** of Bacteroides was further validated in the replication study *** was positively associated with hippocampal volume(β,0.16;95%CI 0.06-0.26,P=0.002),which might be mediated by acetic *** intra-individual alterations in gut microbial composition were found in participants with cognitive *** also identified several serum metabolites and inflammation-associated metagenomic species and pathways linked to impaired ***:Our findings reveal that specific gut microbial features are closely associated with cognitive impair-ment and decreased hippocampal volume,which may play an important role in dementia development.

关键词： Gut microbiome Cognitive impairment Brain structure Metagenomics Microbiome-gut-brain axis Cohort

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gut microbiota,inflammation,and molecular signatures of host response to infection

引用

Journal of Genetics and Genomics 2021年第9期48卷 792-802页

作者： wanglong gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai Menglei Shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang Zelei Miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao Wenhua Ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of EpidemiologySchool of Public HealthSun Yat-sen UniversityGuangzhou 510275China Taizhou Hospital Wenzhou Medical UniversityLinhai 325035China CAS Key Laboratory for Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Gut microbial dysbiosis has been linked to many noncommunicable ***,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to ***,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the *** demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,*** further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 *** metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and ***,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy *** results may provide novel insights into the cross-talk between gut microbiota and host immune system.

关键词： Gut microbiota Proinflammatory cytokines Proteomic biomarkers COVID-19 Host infection response

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：