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结直肠癌的早期诊断策略和治疗进展

广州医药 2024年第1期55卷 1-8,53页

作者：黄庆索彩霞何凤罗青青李旺林曹杰华南理工大学附属第二医院(广州市第一人民医院) 广州消化疾病中心广东广州510180

通过筛查和早期发现,可以降低结直肠癌(CRC)的发病率,有效切除肿瘤病变可以降低CRC的病死率。虽然对CRC的危险因素、发病机制和前体病变的了解已经取得进展,但最近年轻人群CRC发病率升高,原因尚不清楚。在过去十年中,出现了多种侵入性... 详细信息

通过筛查和早期发现,可以降低结直肠癌(CRC)的发病率,有效切除肿瘤病变可以降低CRC的病死率。虽然对CRC的危险因素、发病机制和前体病变的了解已经取得进展,但最近年轻人群CRC发病率升高,原因尚不清楚。在过去十年中,出现了多种侵入性、半侵入性和非侵入性筛查方式。目前对结肠镜检查质量的重视提高了筛查的有效性,人工智能等影像新技术在肿瘤检测中的作用正在迅速显现。而且,CRC有效干预措施,如保肛治疗新术式、靶向治疗及免疫治疗领域的新进展,被证明可以提高CRC患者的生存率。该文旨在总结目前国内外CRC筛查方式和指南的证据,并综述CRC治疗领域的进展。

关键词：结直肠癌筛查早期诊断手术治疗靶向治疗

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Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

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Frontiers of Medicine 2007年第2期1卷 147-156页

作者： CAO Jie CHEN Xiaoping li wanglin XIA Jie DU Hong TANG Weibiao CHEN Shanming WANG Hui CHEN Xiwen XIAO Huanqing li Yuyuan Department of Gastrointestinal Surgery Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Center of Hepatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Scientific Research and Education Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Gastroenterology Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China

The fragile histidine triad(FHIT)gene,a candidate tumor suppressor gene located at 3p14.2,has been shown to be involved in the carcinogenesis of many human tissues,including digestive tract ***,the expression and the role of the FHIT in the initiation and the development of the colorectal cancer(CRC)are poorly *** have shown that the FHIT gene exhibits significantly decreased expression in human CRC compared to colorectal adenoma and normal colorectal tissue by tissue microarray(TMA).The positive rate of FHIT gene expression in normal colorectal tissue,adenoma and adenocarcinoma were 93.75%,68.75%and 46.25%,*** show this decreased expression to be significantly correlated with the progression of colorectal carcinoma(Pling)assay by comparing FHIT-positive CRC ***-negative *** the second experiment,the protein expression of the FHIT and other apoptosis related proteins(Bax,Bcl-2 and Survivin)were measured in human CRC by *** combined results demonstrate the mutation in the FHIT gene significantly reduced FHIT expression in human *** TUNEL and TMA experiments demonstrated significantly inhibited apoptosis by down-regulation of Bax and the up-regulation of Survivin and ***,these studies identify the mechanism by which an important tumor suppressor gene,FHIT is inactivated specifically in human CRC contribut

关键词： fragile histidine triad expression apoptosis colorectal cancer

Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

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The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 44-51页

作者： Jie Cao Xiaoping Chen wanglin li Jie Xia Hong Du Weibiao Tang Hui Wang Xiwen Chen Huanqing Xiao Yuyuan li Center of Hepatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Gastrointestinal Surgery Affiliated Guangzhou First People＇s Hospital Guangzhou Medical College Guangzhou 510180 China Department of Pathology Affiliated Guangzhou First People＇s Hospital Guangzhou Medical College Guangzhou 510180 China Department of Gastroenterology Affiliated Guangzhou First People＇s Hospital Guangzhou Medical College Guang- zhou 510180 China

Objective： To investigate the expression of fragile histidine triad （FHIT） protein in normal colorectal tissue, colorectal adenoma and colorectal cancer （CRC）, and to study the relationships between the expression of FHIT protein and the clinical pathology, the apoptosis-associated protein （Bcl-2, Bax, Survivin）, apoptosis in colorectal cancer. Methods： Tissue microarray （TMA） and immunohistochemistry SP were used to detect the expression of FHIT gene, Bcl-2, Bax and Survivin in 16 cases of the normal colorectal tissue, 16 cases of colorectal adenoma and 80 cases of the colorectal cancer. TUNEL was used to detect the apoptosis index （Al） in 80 cases of the colorectal cancer. Results：（1） The positive rates of FHIT gene expression in normal colorectal tissue, colorectal adenoma and adenocancer were 93.75%, 68.75% and 46.25% respectively. There were no significant differences in the relationships between the FHIT gene expression and histological types, the gender as well as the age （P〉0.05）. There were significant relationships between FHIT gene expression and lymph node metastasis, histological grades, Duke＇s system as well as the 5-year survival rate after operation. （2） The positive rates of Bax, Bcl-2 and Survivin in colorectal adenocancer were 72.50%, 51.25%, 77.50% respectively. The expression of FHIT gene was positively correlated with that of Bcl-2, Bax and Survivin. （3） The mean AI in FHIT negative tumors was significantly lower than that in FHIT positive tumors （P〈0.01）. Conclusion： FHIT gene may play a role in the oncogenesis and progression of colorectal cancer. The abnormal regulation of apoptosis may play an important role in the pathogenesis of colorectal cancer.

关键词： fragile histidine triad (FHIT) expression apoptosis colorectal cancer

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基层法律援助的困境及其理念重塑

思想战线 2017年第3期43卷 141-146页

作者：李婉琳昆明理工大学法学院

我国法律援助的供需矛盾在基层体现得最为突出,因为一方面基层要直接面向社会提供法律援助服务,另一方面基层法律援助资源供给的不足又影响着法律援助的活动。基层法律援助关系中不同主体对法律援助的不同考量,导致了"行动中的法律援助... 详细信息

我国法律援助的供需矛盾在基层体现得最为突出,因为一方面基层要直接面向社会提供法律援助服务,另一方面基层法律援助资源供给的不足又影响着法律援助的活动。基层法律援助关系中不同主体对法律援助的不同考量,导致了"行动中的法律援助"形成了多元规则,并建构了基层法律援助的多维"半自治社会领域"空间,从而使基层法律援助的结构形成了错位的格局。从"半自治社会领域"中行为、规则、结构的关系来看,法律援助中的各方主体应重塑以受援人合法利益为本位、理性回应援助需求、以援助品质为核心的三重援助理念,使基层法律援助活动突破当前的瓶颈。

关键词：基层法律援助 “半自治社会领域” 错位多元规则援助理念

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土工布环向约束球形鼓胀变形及破坏特性分析

工程科学与技术 2023年第2期55卷 267-274页

作者：韩瑞晨薛霞李辰李旺林济南大学水利与环境学院山东济南250022 山东省水利工程试验中心山东济南250013

复合土工膜由土工膜和土工布组成,在平原水库防渗中,土工布起保护加强作用,并对复合土工膜鼓胀变形有重要影响。本文将土工布气胀现象简化为环向约束球形鼓胀变形模型,借助土工布布下铺设的不透气薄膜,通过鼓胀变形专门试验设备,进行鼓... 详细信息

复合土工膜由土工膜和土工布组成,在平原水库防渗中,土工布起保护加强作用,并对复合土工膜鼓胀变形有重要影响。本文将土工布气胀现象简化为环向约束球形鼓胀变形模型,借助土工布布下铺设的不透气薄膜,通过鼓胀变形专门试验设备,进行鼓胀变形试验,研究土工布鼓胀的变形特征和力学特性,并借助显微镜着重分析土工布变形过程中纤维结构变化过程和胀破机理。结果表明:(1)土工膜胀破压力约为土工布胀破压力的50%~60%,可见膜上土工布除起保护作用外,还会对土工膜变形产生约束作用,并增加其抵抗变形的能力。(2)土工布在鼓胀变形中,张应力–应变曲线表现为塑性变形特征,可分为线弹性、屈服、强化和胀破拉断共4个阶段。(3)土工布鼓胀变形形状为半球状,撕裂点一般出现在冠顶处,且进一步扩展为纺锤形撕裂破坏;微观结构分析表明,针刺短纤维形成的缠结点具有一定的缠结力,缠结点之间的纤维具有一定的拉伸强度,缠结点缠结力逐渐失效和纤维断裂是土工布鼓胀变形破坏的主要原因。(4)土工布单位面积质量越大,纤维和缠结点越密,可承受的鼓胀压力越大,即抵抗鼓胀变形的能力越强。研究成果对于分析膜上土工布对土工膜鼓胀变形强度的贡献具有一定实际意义。

关键词：土工布鼓胀变形胀破分析力学特性纤维缠结点

基于优化自适应阈值的非线性机电系统传感器故障检测和主动容错控制

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仪器仪表学报 2022年第4期43卷 26-37页

作者：郁明李旺林蓝盾合肥工业大学电气与自动化工程学院合肥230009

针对具有参数不确定性和传感器故障的非线性机电系统,提出一种基于优化自适应阈值和故障重构策略的主动容错控制方法。首先,利用线性分式变换理论对存在参数不确定性的非线性机电系统进行建模,并提出基于粒子群优化算法的优化自适应阈... 详细信息

针对具有参数不确定性和传感器故障的非线性机电系统,提出一种基于优化自适应阈值和故障重构策略的主动容错控制方法。首先,利用线性分式变换理论对存在参数不确定性的非线性机电系统进行建模,并提出基于粒子群优化算法的优化自适应阈值以提高参数不确定条件下的故障检测性能。其次,通过解析冗余关系推导出系统的动力学方程,并提出一种基于递归终端滑模的跟踪控制策略,以实现系统健康状态下的负载位置跟踪。当系统发生故障时,构建自适应滑模观测器进行传感器故障重构,根据重构结果设计自适应主动容错控制律,并利用故障检测结果进行控制律的实时切换。实验结果表明,所提出的故障检测和主动容错控制方法能在0.06 s内准确的实现传感器故障检测和容错控制,验证了该方法的可行性。

关键词：非线性机电系统优化自适应阈值自适应递归终端滑模传感器故障重构主动容错控制

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反滤回灌井的改进技术

水利水电技术 2013年第2期44卷 48-50,54页

作者：李旺林李英特济南大学山东济南250002 山东省地下水数值模拟与污染控制工程技术研究中心山东济南250022

反滤回灌井是我国山东半岛地下水回灌中广泛采用的一种有效的回灌设施,它由回灌井和回灌池组成。文中分析了反滤回灌井的利用现状及存在的主要问题,提出了综合改进措施,研发了土工织物反滤回灌井技术,并导出土工织物反滤回灌井单井回灌... 详细信息

反滤回灌井是我国山东半岛地下水回灌中广泛采用的一种有效的回灌设施,它由回灌井和回灌池组成。文中分析了反滤回灌井的利用现状及存在的主要问题,提出了综合改进措施,研发了土工织物反滤回灌井技术,并导出土工织物反滤回灌井单井回灌量的理论计算公式。

关键词：地下水库反滤回灌井回灌池土工织物单井回灌量

Additives strategies to improving cycling stability of li metal batteries by modifying electrode electrolyte interphases

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Progress in Natural Science:Materials International 2024年第2期34卷 338-344页

作者： Yuan li Pengfei Huang Chunyu Cui Xiaoyuan Ma li Chen Zekun li linhai li Yuhong Tian School of Biological and Chemical Engineering Guangxi University of Science and Technology School of College of Chemistry and Chemical Engineering Hunan University Isky Future Energy Institute

li metal batteries（LMBs） have attracted much attention due to the ultra-high theoretical capacity of the li metal anode（LMA）.However,the uncontrollable dendrites growth and low coulombic efficiency hinder their practical ***,we explore 3,5-difluoropyridine（2F-BD） as a novel electrolyte additive to enable highperformance *** 2F-BD additive participates in and modifies the solvation structure of li ions by reducing the coordinated number of PF6-at the electrode surface,leading to the formation of a liF and li3N-rich solid electrolyte interphase（SEI）.The liF component increases the robustness of SEI and suppresses the formation of li dendrites,while the li3N component facilitates the transportation and reaction kinetics of li *** a result,the li‖li symmetric cell presents a stable cycling performance of up to 500 h at a current density of 1 mA *** coupling with liFePO4cathode,the obtained full cell achieves high specific capacities of 106.06 mA h g-1and 84.98 mA h g-1at 2.55 mA cm-2and 5.10 mA cm-2,respectively,and maintains a high capacity retention of84.0% after 1000 cycles at 0.13 mA cm-2,with an average cycling CE of 99.58%.

关键词： Electrolyte additive li dendrites li metal batteries liF and li3N-Rich electrode-electrolyte interphase liFePO4 cathode

Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode *** this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery *** mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this *** leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/***,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami *** interaction of Al and F is advantageous to realize the defluoridation to some *** is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics