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结肠镜诊断回肠末段疾病临床意义

中国内镜杂志 2005年第10期11卷 1045-1046,1055页

作者：丁西平王巧民郑邦海贾勇吴正祥安徽省立医院消化内科安徽合肥230001

目的探讨结肠镜检查回肠末段临床意义。方法单人操作结肠镜到达回肠末段1015例,发现回肠末段疾病118例,分析回肠末段疾病病因。结果回肠末段病变检出率11.6%,回肠末段炎最多,其次是回肠末段淋巴滤泡增生症、回肠克罗恩病、结核、淋巴瘤... 详细信息

目的探讨结肠镜检查回肠末段临床意义。方法单人操作结肠镜到达回肠末段1015例,发现回肠末段疾病118例,分析回肠末段疾病病因。结果回肠末段病变检出率11.6%,回肠末段炎最多,其次是回肠末段淋巴滤泡增生症、回肠克罗恩病、结核、淋巴瘤等;回肠末段病变同时合并结肠病变45例(占38.1%);结肠镜检查结肠未发现病变时,进入回肠末段有时发现病变;结合内镜表现、组织病理及临床表现作出回肠末段疾病的病因诊断,为治疗疾病提供依据。结论结肠镜到达回肠末段不仅是必要的,而且对正确地诊断和治疗回肠末段疾病有重要临床意义。

关键词：结肠镜回肠末段疾病诊断

Fault Diagnosis for Service Composition by Spiking Neural P Systems with Colored Spikes

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Chinese Journal of Electronics 2019年第5期28卷 1033-1040页

作者： PANG Shanchen wang min qiao Sibo wang Xun CHEN Hongqi College of Computer and Communication Engineering China University of Petroleum

A variety of web services have emerged with the rapid development of the Internet. These services are often of a single function. The value-added services can be achieved by combing with multiple *** processing speed and stability of existing methods in service composition were not very well and seldom consider the fault diagnosis and handling methods for the service, which results in a greater probability of the service composition failure at run time. We use spiking neural P systems with colored spikes to model the fault of available service, component, and connector in the service composition. The proposed model can be used to locate a fault and handle it correctly when the service combination fails, the advantage of efficiency and stability of proposed method has been proved by comparing with the method of Petri net.

关键词： Spiking neural P system with colored spikes Service composition Fault handling

内镜黏膜下挖除术治疗消化道黏膜下肿瘤108例分析

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中华消化杂志 2013年第11期33卷 756-760页

作者：张明黎王业涛宋继中丁西平王巧民盛明伶卫梅枝安徽省立医院消化内科合肥230001

目的探讨内镜黏膜下挖除术治疗消化道黏膜下肿瘤的疗效和安全性。方法选择2010年至2013年经内镜、超声内镜及增强CT检查发现。以向腔内生长为主的消化道黏膜下肿瘤108例进行内镜黏膜下挖除术。完整挖除病变后送病理检查，术后1、3、6、1... 详细信息

目的探讨内镜黏膜下挖除术治疗消化道黏膜下肿瘤的疗效和安全性。方法选择2010年至2013年经内镜、超声内镜及增强CT检查发现。以向腔内生长为主的消化道黏膜下肿瘤108例进行内镜黏膜下挖除术。完整挖除病变后送病理检查，术后1、3、6、12、24个月内镜随访。结果108例病变中位于食管27例，责门8例，胃部59例，十二指肠2例，直肠12例。最大径为0．5～5．5cm，平均为2．1cm，操作时间为18～240rain，平均为105min。3例胃部黏膜下肿瘤分别因肿瘤向腔外生长、与肌层紧密粘连无法分离、穿孔大无法修补而转腹腔镜手术；3例胃底黏膜下肿瘤操作失败而放弃，其余102例病变（94．44％）一次性完整切除。术中穿孔19例（17．59％），其中1例行转腹腔镜手术，18例在内镜下有效缝合。术中出血0～50mL不等，无术后出血。术后发生颈部皮下气肿8例，气腹9例，左侧腮腺肿胀1例。9例失访，其余99例随访1～24个月，无一例复发。结论内镜黏膜下挖除术能一次性完整挖除较大的，以向腔内生长为主的黏膜下肿瘤，可提供完整的病理诊断资料且安全、有效。

关键词：内窥镜检查消化系统黏膜消化系统肿瘤

Efficacy of Sailuotong(塞络通)on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease

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Journal of Traditional Chinese Medicine 2024年第2期44卷 289-302页

作者： SUN Linjuan LI Chengfu LIU Jiangang LI Nannan HAN Fuhua qiao Dandan TAO Zhuang ZHAN min CHEN Wenjie ZHANG Xiaohui TONG Chenguang CHEN Dong Qi Jiangxia LIU Yang LIANG Xiao ZHENG Xiaoying ZHANG Yunling Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China China Population and Development Research Center Beijing 100081China Department of Institute of Population Research Peking UniversityBeijing 100087China Graduate School of China Academy of Chinese Medical Sciences Beijing 100700China Graduate School of Beijing University of Chinese Medicine Beijing 100029China

OBJECTIVE:To discuss the influence of Sailuotong(塞络通,SLT)on the Neurovascular Unit(NVUs)of amyloid precursor protein(APP)/presenilin-1(PS1)mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's disease(AD).METHODS:The mice were allocated into the following nine groups:(a)the C57 Black(C57BL)sham-operated group(control group),(b)ischaemic treatment in C57BL mice(the C57 ischaemic group),(c)the APP/PS1 sham surgery group(APP/PS1 model group),(d)ischaemic treatment in APP/PS1 mice(APP/PS1 ischaemic group),(e)C57BL mice treated with aspirin following ischaemic treatment(C57BL ischaemic+aspirin group),(f)C57BL mice treated with SLT following ischaemic treatment(C57BL ischaemic+SLT group),(g)APP/PS1 mice treated with SLT(APP/PS1+SLT group),(h)APP/PS1 mice treated with donepezil hydrochloride following ischaemic treatment(APP/PS1 ischaemic+donepezil hydrochloride group)and(i)APP/PS1 mice treated with SLT following ischaemic treatment(APP/PS1 ischaemic+SLT group).The ischaemic model was established by operating on the bilateral common carotid arteries and creating a *** Morris water maze and step-down tests were used to detect the spatial behaviour and memory ability of *** hippocampus of each mouse was observed by haematoxylin and eosin(HE)and Congo red *** ultrastructure of NVUs in each group was observed by electron microscopy,and various biochemical indicators were detected by enzymelinked immunosorbent assay(ELISA).The protein expression level was detected by Western *** mRNA expression was detected by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS:The results of the Morris water maze and step-down tests showed that ischemia reduced learning and memory in the mice,which were restored by *** results of HE staining showed that SLT restored the pathological changes of the *** Congo red staining results revealed that SLT also improved the scattered

关键词： Alzheimer disease amyloid beta-protein precursor presenilin-1 mice transgenic replenishing Qi and activating blood neurovascular unit Sailuotong

Design of low-energy transfer from lunar orbit to asteroid in the Sun-Earth-Moon system

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Acta Mechanica Sinica 2014年第6期30卷 966-972页

作者： Ya-min wang Dong qiao Ping-Yuan Cui School of Aerospace Engineering Beijing Institute of Technology Key Laboratory of Dynamics and Control of Flight Vehicle Ministry of Education

Asteroid exploration trajectories which start from a lunar orbit are investigated in this *** is assumed that the probe departs from lunar orbit and returns to the vicinity of Earth,then escapes from the Earth by performing a perigee maneuver.A low-energy transfer in Sun-EarthMoon system is ***,the feasible region of lowenergy transfer from lunar orbit to perigee within 5 000 km height above the Earth surface in Sun-Earth-Moon system is calculated and *** transfer types are found,i.e.,large maneuver and fast transfers,small maneuver and fast transfers,and disordered and slow *** of feasibility trajectories belong to the first two ***,the lowenergy trajectory leg from lunar orbit to perigee and a heliocentric trajectory leg from perigee to asteroid are patched by a perigee *** optimal full-transfer trajectory is obtained by exploiting the differential evolution ***,taking 4179 Toutatis asteroid as the target,some low-energy transfer trajectories are obtained and analyzed.

关键词： Lunar orbit Asteroid exploration Low-energy transfer Sun-Earth-Moon system

新麦草异戊烯基转移酶PjIPT基因的功能验证

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生物技术通报 2024年第7期40卷 207-215页

作者：任晓敏云岚艾芊赵乔内蒙古农业大学草原与资源环境学院呼和浩特010018 草地资源教育部重点实验室呼和浩特010011 中国科学院深圳先进技术研究院深圳518055

【目的】异戊烯基转移酶(isopentenyl transferases,IPT)参与反式玉米素(trans-zeatin,tZ)的生物合成。tZ是调节植物生长发育和抵抗逆境胁迫的一种细胞分裂素类型,在促进芽生长和调控植物侧枝发育方面具有重要作用。探索IPT的功能,为后... 详细信息

【目的】异戊烯基转移酶(isopentenyl transferases,IPT)参与反式玉米素(trans-zeatin,tZ)的生物合成。tZ是调节植物生长发育和抵抗逆境胁迫的一种细胞分裂素类型,在促进芽生长和调控植物侧枝发育方面具有重要作用。探索IPT的功能,为后续新麦草产量性状改良提供了理论依据。【方法】通过对新麦草IPT进行系统发育和多序列比对,探究其编码氨基酸序列的特征和同源性。通过花粉管通道法获得过表达PjIPT拟南芥(Arabidopsis thaliana)植株,并运用逆转录PCR(RT-PCR)和蛋白质印迹(Western blot,WB)对转基因植株进行验证,利用实时荧光定量逆转录PCR(RT-qPCR)对其组织表达模式进行分析,使用液质联用系统测定反式玉米素。【结果】IPT在新麦草(Psathyrostachys juncea)和二粒小麦(Triticum dicoccoides)等麦类作物中具有高度同源性,且AtIPT9是PjIPT的同源蛋白。通过花粉管通道法获得过表达PjIPT拟南芥(Arabidopsis thaliana)植株,证明PjIPT上调植株分枝数。RT-PCR和蛋白质印迹分析显示,PjIPT在转录水平和蛋白水平均能够正常表达。利用不同部位组织RT-qPCR分析PjIPT的空间特异性表达,结果显示,PjIPT在拟南芥的分蘖节和叶中特异性表达。此外,反式玉米素的定量分析表明PjIPT通过参与tZ的生物合成去调控拟南芥植株分枝数。【结论】PjIPT是上调植株分枝数的关键基因。

关键词：新麦草异戊烯基转移酶反式玉米素分蘖功能验证

Health risk assessment of heavy metals in soils and vegetables from wastewater irrigated area,Beijing-Tianjin city cluster,China

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Journal of Environmental Sciences 2012年第4期24卷 690-698页

作者： Yanchun wang min qiao Yunxia Liu Yongguan Zhu State Key Laboratory of Reginal and Urban Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Beijing Institute of Landscape Architecture Beijing 100102China Key Laboratory of Urban Environment Health Institute of Urban EnvironmentChinese Academy of ScienceXiamen 361021China

The possible health risks of heavy metals contamination to local population through food chain were evaluated in Beijing and Tianjin city cluster, China, where have a long history of sewage irrigation. The transfer factors （TF） for heavy metals from soil to vegetables for six elements including Cu, Zn, Pb, Cr, As and Cd were calculated and the pollution load indexes （PLI） were also assessed. Results indicate that only Cd exceeded the maximum acceptable limit in these sites. So far, the heavy metal concentrations in soils and vegetables were all below the permissible limits set by the ministry of Environmental Protection of China and World Health Organization. The transfer factors of six heavy metals showed the trend as Cd 〉 Zn 〉 Cu 〉 Pb 〉 As 〉 Cr, which were dependent on the vegetable species. The estimated dietary intakes of Cu, Zn, Pb, Cr, As and Cd were far below the tolerable limits and the target hazard quotient （THQ） values were less than 1, which suggested that the health risks of heavy metals exposure through consuming vegetables were generally assumed to be safe.

关键词： heavy metals soil transfer factor human health risk wastewater irrigation

Attention-GRU神经网络辅助的SINS/DVL组合导航算法

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中国惯性技术学报 2024年第6期32卷 565-571页

作者：王立辉刘恩东吴璠胡桥郝程鹏吴敏东南大学仪器科学与工程学院微惯性仪表与先进导航技术教育部重点实验室南京210096 西安交通大学机械工程学院西安710049 中国科学院声学研究所北京100190

针对多普勒测速仪(DVL)短时失效导致定位精度下降的问题,提出了一种注意力机制门控循环单元(Attention-GRU)辅助的捷联惯导(SINS)/DVL组合导航算法。当DVL测速有效时,使用SINS/DVL组合导航信息对Attention-GRU神经网络进行训练。当DVL... 详细信息

针对多普勒测速仪(DVL)短时失效导致定位精度下降的问题,提出了一种注意力机制门控循环单元(Attention-GRU)辅助的捷联惯导(SINS)/DVL组合导航算法。当DVL测速有效时,使用SINS/DVL组合导航信息对Attention-GRU神经网络进行训练。当DVL故障时,使用训练完毕的Attention-GRU神经网络预测DVL速度辅助校正SINS。仿真结果表明:当DVL故障时,Attention-GRU相对纯惯性导航系统和GRU在匀速运动状态的平均速度误差分别减小了71.35%和3.48%,平均位置误差分别减小了34.76%和1.74%;在运动状态变化时平均速度误差分别减小了58.45%和14.67%,平均位置误差分别减小了9.82%和2.27%。

关键词：组合导航自适应卡尔曼滤波 DVL故障门控循环单元注意力机制

Nonlinear Vibration of A Loosely Supported Curved Pipe Conveying Pulsating Fluid under Principal Parametric Resonance

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Acta Mechanica Solida Sinica 2016年第5期29卷 468-478页

作者： Yangyang Luo min Tang qiao Ni Yikun wang Lin wang Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074 China Wuhan Second Ship Design and Research Institute Wuhan 430205 China

In this paper,the nonlinear dynamics of a curved pipe is investigated in the case of principal parametric resonance due to pulsating flow and impact with loose *** coupled in-plane and out-of-plane governing equations with the consideration of von Karman geometric nonUnearity are presented and discretized via the differential quadrature method（DQM）.The nonlinear dynamic responses are calculated numerically to demonstrate the influence of pulsating ***,the impact is taken into *** influence of clearance on frettingwear damage,such as normal work rate,contact ratio and impact force level,is demonstrated.

关键词： curved governing quadrature clearance Karman numerically loose conveying parametric dynamical