检索结果-南通市图书馆

Digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

International Journal of Ophthalmology(English edition) 2024年第2期17卷 239-246页

作者： Yue Di Zhong-Bao Qiao Hai-Yun Ye Xin-Yue Li Wen-Ting Luo wang-yi fang Tong Qiao Department of Ophthalmology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China

AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python technology.METHODS:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes respectively.The corresponding photo pixels-actual length ratio was acquired by a proportional scale.The edge coordinates were identified artificially by ginput function.Circle and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal view.The curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric principles.Next,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in vitro.The results were compared between in vivo and in vitro.RESULTS:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the keratometer.The horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°respectively.For the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical planes.CONCLUSION:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in Matlab.There are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of binoculus.This study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.

关键词： ocular morphological parameters guinea pig digital measurement Python

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical treatment of Pitt-Hopkins syndrome associated with strabismus and early-onset myopia:Two case reports

引用

World Journal of Clinical Cases 2022年第34期10卷 12734-12741页

作者： ying Huang Yue Di Xiao-Xiao Zhang Xin-Yue Li wang-yi fang Tong Qiao Department of Ophthalmology Shanghai Children's HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200062China

BACKGROUND Pitt-Hopkins syndrome(PTHS;MIM#610954)is a rare genetic neurological disorder.Myopia and strabismus have been reported in approximately 50%of PTHS patients.No studies have reported details about the required surgery for PTHS with strabismus and early-onset myopia.Here,we retrospectively reviewed the surgical management of two patients with PTHS combined with strabismus and/or early-onset myopia.CASE SUMMARY A 5-year-old girl presented with congenital esotropia and left eye myopia,and the second girl was a 5-year-old girl who presented with intermittent exotropia.Genetic testing performed on both patients showed a mutation in transcription factor 4,which is a diagnostic marker of PTHS.The first girl underwent bilateral medial rectus recession combined with posterior scleral reinforcement(PSR)in the left eye and the second patient underwent bilateral lateral rectus recession strabismus surgery.We made key innovations in surgical timing and strategy,and the results were satisfactory.The combination of strabismus and PSR surgery is an innovative strategy for patients with both strabismus and early-onset myopia.CONCLUSION Early treatment of strabismus and myopia positively influence motor development and should be included in rehabilitation programs for patients with PTHS.

关键词： Pitt-Hopkins syndrome Transcription factor 4 Strabismus Myopia Surgery Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress of Sintering Technology in Handan Iron and Steel Company

引用

Journal of Iron and Steel Research(International) 2004年第5期11卷 1-7页

作者： LIU Zheng-ping wang yi-fang WU Jin-bo Handan Iron and Steel Group Co Ltd

As one of the biggest iron and steel companies in China, Handan Iron and Steel Co has made a substantial progress in the sintering process. The mini-pellet sintering technology has been successfully applied based on lab investigation and industrial trials. Equipment enlargement was realized through replacing small sintering strands with the construction of huge sintering machine with a grate area of 400 m 2. The productivity, iron content and the metallurgical properties of sintering process have been improved.

关键词： sintering process mini-pellet sintering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

絮凝-电化学氧化协同工艺处理兰炭废水

引用

中国环境科学 2024年第4期44卷 2063-2072页

作者：王亚宋永辉李金城尹宁董萍王一帆龙江李弯弯西安建筑科技大学陕西省黄金与资源重点实验室陕西西安710055 长安大学水利与环境学院陕西西安710054 陕西新能星炭能源有限公司陕西西安710199

采用絮凝-电化学氧化协同工艺处理兰炭废水,探究了反应过程中絮凝剂投加量、反应时间、初始pH值、外加电压以及NaCl添加量对化学需氧量(COD)和氨氮(NH_(3)-N)去除的影响及絮凝-电化学氧化协同作用机制.结果表明,随着絮凝剂聚合氯化铝铁(... 详细信息

采用絮凝-电化学氧化协同工艺处理兰炭废水,探究了反应过程中絮凝剂投加量、反应时间、初始pH值、外加电压以及NaCl添加量对化学需氧量(COD)和氨氮(NH_(3)-N)去除的影响及絮凝-电化学氧化协同作用机制.结果表明,随着絮凝剂聚合氯化铝铁(PAFC)投加量和外加电压的增加,兰炭废水中COD和NH_(3)-N的去除率逐渐升高.当PAFC投加量为50g/L、电压6V、反应时间4h,初始pH=9,NaCl添加量30g/L时,COD和NH_(3)-N去除率分别为82.37%和100%,更换极板进行二次电解COD去除率可达100%.兰炭废水中有机污染物主要是苯酚类､醇类和酰胺类物质,处理后酚类物质含量大幅减少,酮类、醇类和酸类物质相对占比有所增加.絮凝-电化学氧化过程中,PAFC既是絮凝剂又是Cl^(-)的提供者,其水解产生的Cl^(-)与NaCl引入的Cl^(-)在电场作用下向阳极定向迁移.阳极表面发生氧化反应产生的有效氯(Cl_(2)/ClO^(-))将兰炭废水中有机污染物氧化成中间产物氯酚,与絮凝剂中Al^(3+)的水解产物Al(OH)^(2+)、Al(OH)^(+)_(2)及Al(OH)_(3)通过静电和吸附作用结合形成絮凝体被去除.废水中剩余少量的氯酚及酰胺、环己二醇等有机污染物及NH_(3)-N则在ClO^(-)的间接氧化作用下转化为N_(2)、CO_(2)和H_(2)O得以去除.

关键词：兰炭废水絮凝电解电化学氧化协同作用聚合氯化铝铁(PAFC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment of multisystem inflammatory syndrome in children

引用

World Journal of Pediatrics 2024年第4期20卷 325-339页

作者： Tong Tong yi-Hua Jin Min wang fang-Qi Gong Department of Cardiology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNo.3333 Binsheng RoadHangzhou 310052China

Background Multisystem inflammatory syndrome in children(MIS-C),a relatively uncommon but severe pediatric complication,is associated with coronavirus disease 2019(COVID-19).A variety of treatment approaches,including intravenous immunoglobulins(IVIGs),glucocorticoids(GCs)and biologic agents,such as anakinra and infliximab,have been described for the management of COVID-19-related MIS-C.Anticoagulant therapy is also important.However,a well-developed treatment system has not been established,and many issues remain controversial.Several recently published articles related to the treatment of MIS-C have been released.Hence,in this review,we identified relevant articles published recently and summarized the treatment of MIS-C more comprehensively and systematically.Data sources We reviewed the literature on the treatment of MIS-C through 20 September 2023.The PubMed/Medline,Web of Science,EMBASE,and Cochrane Library databases were searched with the combination of the terms"multisystem inflammatory syndrome","MIS-C","PIMS-TS","therapy","treatment","drug","IVIG","GCs","intravenous immunoglobulin","corticosteroids","biological agent",and"aspirin".Results The severity of MIS-C varies,and different treatment schemes should be used according to the specific condition.Ongoing research and data collection are vital to better understand the pathophysiology and optimal management of MIS-C.Conclusions MIS-Cis a disease involving multiple systems and has great heterogeneity.With the accumulation of additional experience,we have garnered fresh insights into its treatment strategies.However,there remains a critical need for greater standardization in treatment protocols,alongside the pressing necessity for more robust and meticulously conducted studies to deepen our understanding of these protocols.

关键词： Coronavirus disease 2019-Corticosteroids Intravenous immunoglobulin Multisystem inflammatory syndrome in children-Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance of iron-air battery with iron nanoparticle-encapsulated C-N composite electrode

引用

Frontiers in Energy 2024年第1期18卷 42-53页

作者： Can fang Xiangmei TANG Jiaoyan wang Qingfeng yi School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Xiangtan 411201China

Highly efficient and stable iron electrodes are of great significant to the development of iron-air battery(IAB).In this paper,iron nanoparticle-encapsulated C–N composite(NanoFe@CN)was synthesized by pyrolysis using polyaniline as the C–N source.Electrochemical performance of the NanoFe@CN in different electrolytes(alkaline,neutral,and quasi-neutral)was investigated via cyclic voltammetry(CV).The IAB was assembled with NanoFe@CN as the anode and IrO_(2)+Pt/C as the cathode.The effects of different discharging/charging current densities and electrolytes on the battery performance were also studied.Neutral K_(2)SO_(4)electrolyte can effectively suppress the passivation of iron electrode,and the battery showed a good cycling stability during 180 charging/discharging cycles.Compared to the pure nano-iron(NanoFe)battery,the NanoFe@CN battery has a more stable cycling stability either in KOH or NH_(4)Cl+KCl electrolyte.

关键词： energy storage and conversion metallic composites nanocomposites iron-air battery iron anode

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flexible, efficient, and accurate tests for epidemics

引用

Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie fang Bing-yi Jing Shen Ling Qiyue wang Qing Yang Data Science and Analytics Thrust The Hong Kong University of Science and Technology Department of Statistics and Data Science Southern University of Science and Technology Department of Mathematics and Statistics Dalhousie University Department of Mathematics The Hong Kong University of Science and Technology

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of tests. It has been widely used for industrial testing, information technology, and biology, especially epidemic screening. Tests, in reality, are noisy for the presence of false outcomes. Some tests are accurate but time-consuming, while others are cheaper but less accurate. Exactly which test to use is constrained by various considerations, such as availability, cost, accuracy, and efficiency.In this paper, we propose flexible, efficient, and accurate tests(FEATs). FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated tests. FEATs could dramatically improve the efficiency or accuracy of existing tests. For example, for accurate but slow tests, the FEAT can improve efficiency multiple times without compromising accuracy. On the other hand,for fast but inaccurate tests, the FEAT can sharply reduce the false-negative rate(FNR) and significantly increase efficiency. Theoretical justifications are provided. We point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

引用

Frontiers of Medicine 2024年第1期18卷 180-191页

作者： fang wang Yuxing Liu yi Dong Meifang Zhao Hao Huang Jieyuan Jin Liangliang Fan Rong Xiang Department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid metabolism.However,little is known about the function of Lipin3 in triglyceride(TG)metabolism.Here,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger sequencing.Functional studies revealed that the novel variant altered the half-life and stability of the Lipin3 protein.Hence,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG metabolism.We found that Lipin3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver disorder.Mechanistic study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and nucleoplasm.The increased expression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG catabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

引用

Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong SHAO Ming-yi FU Yu ZHAO Rui-xia wang Jing-wen fang Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical decision-making.MethodsRandomized controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation results.ResultsA total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, respectively.ConclusionBased on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

引用

Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi yi-Ming Ou Hua-Jie Jiang yi-Jun fang Qi-Ming wang Quan Gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic scaffolds.Structurally diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：