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Tillering and small grain 1 dominates the tryptophan aminotransferase family required for local auxin biosynthesis in rice

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Journal of Integrative Plant Biology 2020年第5期62卷 581-600页

作者： Tao Guo Ke Chen Nai-Qian Dong wang-wei ye Jun-Xiang Shan Hong-Xuan Lin National Key Laboratory of Plant Molecular Genetics CAS Centre for Excellence in Molecular Plant Sciences and Collaborative Innovation Center of Genetics&DevelopmentShanghai Institute of Plant Physiology&EcologyShanghai Institute for Biological SciencesChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Auxin is a crucial phytohormone,controlling multiple aspects of plant growth and responses to the changing ***,the role of local auxin biosynthesis in specific developmental programs remains unknown in *** study characterized the rice tillering and small grain 1(tsg1)mutant,which has more tillers but a smaller panicle and grain size resulting from a reduction in endogenous ***1 encodes a tryptophan aminotransferase that is allelic to the FISH BONE(FIB)*** tsg1 mutant showed hypersensitivity to indole-3-acetic acid and the competitive inhibitor of aminotransferase,***1 knockout resulted in an increased tiller number but reduction in grain number and size,and decrease in ***,deletion of the TSG1 homologs OsTAR1,Os TARL1,and OsTARL2 caused no obvious changes,although the phenotype of the TSG1/Os TAR1 double mutant was intensified and infertile,suggesting gene redundancy in the rice tryptophan aminotransferase ***,TSG1 and Os TAR1,but not Os TARL1 and OsTARL2,displayed marked aminotransferase ***,subcellular localization was identified as the endoplasmic reticulum,while phylogenetic analysis revealed functional divergence of TSG1 and OsTAR1 from OsTARL1 and *** findings suggest that TSG1 dominates the tryptophan aminotransferase family,playing a prominent role in local auxin biosynthesis in rice.

关键词： grain local auxin

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Effect of Vasocation Intestinal Peptide on Immune Privilege of the Rat Testis

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Journal of Reproduction and Contraception 2008年第1期19卷 1-8页

作者： wei wang ye-bin XI Guang-jie CHEN Jing HAO Bao-guo wang Tian-wei SHEN Li-hua JIANG wei-yi LI Shanghai Institute of lmmunology Shanghai Jiaotong University School of Medicine Shanghai 200025 China

Objective To study the effect of vasocation intestinal peptide （VIP） on immune privilege of the rat testis. Methods The UU infected SD rats and Leydig cells were intervened by VIP, the secretion of TGF-β and the expression of FasL in rat Leydig cells were compared between VIP-intervened group and control group to test the effect of VIP on immune privilege of the rat testis in vitro and in vivo. Results In vitro, the secretion of TGF-β in Leydig cells could be increased by low dosage of VIP while inhibitited by high dosage of VIP; expression of FasL mRNA in Leydig cells could be decreased by VIP In vivo, increased expression of TGF-β mRNA and decreased FasL mRNA were observed in VIP group in 2-3 weeks after infected by UU. In addition, the apoptosis of Jurkat cells mediated by Leydig cells could be prevented by VIP Conclusion When Leydig cells or testis infected by UU, VIP could regulate the immune function of rat Leydig cells and participate in the regulation of immune privilege of testis through the regulation of TGF-β secretion and FasL expression pattern of Leydig cells.

关键词： vasocation intestinal peptide (VIP) Leydig cell FasL TFG-β immune privilege

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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A QTL GN1.1, encoding FT-L1, regulates grain number and yield by modulating polar auxin transport in rice

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Journal of Integrative Plant Biology 2024年第10期66卷 2158-2174页

作者： Huai-Yu Zhao Jun-Xiang Shan wang-wei ye Nai-Qian Dong Yi Kan Yi-Bing Yang Hong-Xiao Yu Zi-Qi Lu Shuang-Qin Guo Jie-Jie Lei Ben Liao Hong-Xuan Lin National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Rice grain number is a crucial agronomic trait impacting yield. In this study, we characterized a quantitative trait locus(QTL), GRAIN NUMBER 1.1(GN1.1), which encodes a Flowering Locus T-like1(FT-L1) protein and acts as a negative regulator of grain number in rice. The elite allele GN1.1^(B),derived from the Oryza indica variety, BF3-104,exhibits a 14.6% increase in grain yield compared with the O. japonica variety, Nipponbare, based on plot yield tests. We demonstrated that GN1.1 interacted with and enhanced the stability of ADP-ribosylation factor(Arf)-GTPase-activating protein(Gap), OsZAC. Loss of function of OsZAC results in increased grain number. Based on our data, we propose that GN1.1^(B)facilitates the elevation of auxin content in young rice panicles by affecting polar auxin transport(PAT) through interaction with OsZAC. Our study unveils the pivotal role of the GN1.1 locus in rice panicle development and presents a novel, promising allele for enhancing rice grain yield through genetic improvement.

关键词： auxin GN1.1 grain number OsZAC QTL mapping

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Simulations of electron zebra stripes in the inner radiation belt using a composite empirical electric field model

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Science China Earth Sciences 2025年第1期68卷 27-38页

作者： Ziyang wang Ying LIU Qiugang ZONG Hong ZOU Yuguang ye Xuzhi ZHOU Chao YUE Shan wang Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology

The phenomenon termed “zebra stripes” manifests as regular patterns in the energy-space(L shell) spectrum of energetic electrons(ranging from tens to hundreds ke V) within the inner radiation belt. These structures exhibit drift-periodic behavior and commonly arise from large-scale electric field perturbations near the substorm onsets. In this study, we introduce a composite electric field model and replicate the formation, structure, and evolution of zebra stripes using a bounce-averaged test particle code under this electric field model. High-resolution measurements of energetic electrons obtained from the Van Allen Probes and the recently launched Macao Science Satellites-1 are used as initial conditions and served to validate our test particle simulations. Comparative analyses between observed data and simulations demonstrate our test particle method's efficacy in capturing zebra stripes' general behavior. Moreover, the composite model proves capable of reproducing realistic variations in the electric field within the inner radiation belt to a certain extent. Nevertheless, subtle differences emerge in the flux strength and the positions of stripes. These disparities primarily stem from limitations inherent in the electric field model and the initial conditions of the simulation. Acknowledging that the model represents an average case, it is conceivable that real-world scenarios may deviate from the average, thereby introducing variations in the observed phenomena.

关键词： Zebra stripes Inner radiation belt Large-scale electric fields Van Allen Probes Macao Science Satellite

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A TT1–SCE1 module integrates ubiquitination and SUMOylation to regulate heat tolerance in rice

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Molecular Plant 2024年第12期17卷 1899-1918页

作者： Hong-Xiao Yu Ying-Jie Cao Yi-Bing Yang Jun-Xiang Shan wang-wei ye Nai-Qian Dong Yi Kan Huai-Yu Zhao Zi-Qi Lu Shuang-Qin Guo Jie-Jie Lei Ben Liao Hong-Xuan Lin National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China These authors contributed equally to this article

Heat stress poses a significant threat to grain *** anα2 subunit of the 26S proteasome,TT1 has been shown to act as a critical regulator of rice heat ***,the heat tolerance mechanisms mediated by TT1 remain *** this study,we unveiled that small ubiquitin-like modifier(SUMO)-conjugating enzyme 1(SCE1),which interacts with TT1 and acts as a downstream component of TT1,is engaged in TT1-mediated 26S proteasome *** showed that SCE1 functions as a negative regulator of heat tolerance in rice,which is associated with its ubiquitination ***,we observed that small heat-shock proteins(sHSPs)such as Hsp24.1 and Hsp40 can undergo SUMOylation mediated by SCE1,leading to increased accumulation of sHSPs in the absence of *** protein levels of SCE1 significantly enhanced grain yield under high-temperature stress by improving seed-setting rate and rice grain filling *** together,these results uncover the critical role of SCE1 in the TT1-mediated heat tolerance pathway by regulating the abundance of sHSPs and SUMOylation,and ultimately modulating rice heat *** findings underscore the great potential of the TT1–SCE1 module in improving the heat tolerance of crops.

关键词： rice heat tolerance ubiquitination SUMOylation heat-shock protein

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5-羟色胺2C受体作为精神分裂症治疗靶点的研究进展

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上海交通大学学报（医学版） 2018年第7期38卷 801-804页

作者：汪也微张晨上海交通大学医学院附属精神卫生中心生化研究室上海200030

随着第2代抗精神病药物引起体质量增加和心血管不良反应的报道越来越多,研究者近年来开始将关注点投向治疗精神分裂的新靶点——5-羟色胺2C受体(5-HT2C受体)。一方面,有研究表明激动5-HT2C受体具有降低黑质纹状体多巴胺的作用,推测其潜... 详细信息

随着第2代抗精神病药物引起体质量增加和心血管不良反应的报道越来越多,研究者近年来开始将关注点投向治疗精神分裂的新靶点——5-羟色胺2C受体(5-HT2C受体)。一方面,有研究表明激动5-HT2C受体具有降低黑质纹状体多巴胺的作用,推测其潜在的抗精神病作用;另一方面,第2代抗精神病药物对5-HT2C受体的拮抗作用是其引起患者体质量增加的重要因素,反之激动5-HT2C受体则可能具有降低体质量的效应。该文以文献综述的形式就5-HT2C受体的抗精神病效应和与之相关的体质量增加不良反应进行阐述。

关键词： 5-羟色胺2C受体精神分裂症抗精神病药所致的体质量增加基因多态性戊卡色林

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Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong Zhu Hualong wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

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Boosting high-performance in Zr-rich side protonic solid oxide electrolysis cells by optimizing functional interlayer

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Green Energy & Environment 2025年第1期10卷 150-160页

作者： Chunmei Tang Ning wang Sho Kitano Hiroki Habazaki Yoshitaka Aoki Siyu ye Huangpu Hydrogen Energy Innovation Center School of Chemistry and Chemical EngineeringGuangzhou UniversityNo.230 Wai Huan Xi RoadGuangzhou510006China Graduate School of Chemical Sciences and Engineering Hokkaido UniversityN13W8Kita-kuSapporo060-8628Japan Faculty of Engineering Hokkaido UniversityN13W8Kita-kuSapporo060-8628Japan

Protonic solid oxide electrolysis cells(P-SOECs)are a promising technology for water electrolysis to produce green ***,there are still challenges related key materials and anode/electrolyte interface.P-SOECs with Zr-rich electrolyte,called Zr-rich side P-SOECs,possess high thermodynamically stability under high steam concentrations but the large reaction resistances and the current leakage,thus the inferior *** this study,an efficient functional interlayer Ba_(0.95)La_(0.05)Fe_(0.8)Zn_(0.2)O_(3-δ)(BLFZ)in-between the anode and the electrolyte is *** electrochemical performances of P-SOECs are greatly enhanced because the BLFZ can greatly increase the interface contact,boost anode reaction kinetics,and increase proton injection into *** a result,the P-SOEC yields high current density of 0.83 A cm^(-2) at 600℃ in 1.3 Vamong all the reported Zr-rich side *** work not only offers an efficient functional interlayer for P-SOECs but also holds the potential to achieve P-SOECs with high performances and long-term stability.

关键词： Functional interlayer Zr-rich side electrolyte Protonic solid oxide electrolysis cells Current density Faradaic efficiency

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2017年8月8日九寨沟M_s7.0地震震源谱及震中区域品质因子

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地球物理学报 2017年第10期60卷 4117-4123页

作者：王宏伟任叶飞温瑞智中国地震局工程力学研究所中国地震局地震工程与工程振动重点实验室哈尔滨150080

2017年8月8日四川省九寨沟县发生M_s7.0地震,国家强震动台网中心正式发布了此次地震中收集的66组强震动记录,采用其中震源距不超过150 km且台站场地反应已确定的8组记录,基于S波傅氏谱反演方法确定了此次地震的震源谱及震中区域的地壳... 详细信息

2017年8月8日四川省九寨沟县发生M_s7.0地震,国家强震动台网中心正式发布了此次地震中收集的66组强震动记录,采用其中震源距不超过150 km且台站场地反应已确定的8组记录,基于S波傅氏谱反演方法确定了此次地震的震源谱及震中区域的地壳介质品质因子.结果为:品质因子Q(f)=84.9f^(0.71),说明该区域的S波非弹性衰减较为强烈;根据ω^(-2)震源谱模型,确定该地震的地震矩为9.42X10^(18)Nm,其对数标准差为0.12,相应的矩震级M_w=6.616±0.079,拐角频率为0.131±0.O11 Hz,应力降为3.854 MPa,该值明显低于全球板内地震的应力降平均水平(4.89 MPa),但高于2013年芦山M_w6.6地震的应力降.

关键词：九寨沟地震谱反演震源谱品质因子

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