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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong fang Zhao-hui QIU Xiao-tang wang Mei LI Qing-bo LI Shan-shan wang Shi-dong DAI fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

复方倍他米松注射液耳后注射治疗突发性耳聋患者的临床研究

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中国临床药理学杂志 2024年第7期40卷 977-980页

作者：周书芳钟志生李滇汪旭海安市人民医院耳鼻咽喉头颈外科江苏南通226600

目的观察复方倍他米松注射液治疗突发性耳聋患者的临床疗效及对经颅多普勒(TCD)参数、纤溶-凝血指标的影响。方法将突发性耳聋患者按队列法分为对照组和试验组。对照组在常规治疗的基础上,给予地塞米松磷酸钠静脉注射,连用10d;试验组在... 详细信息

目的观察复方倍他米松注射液治疗突发性耳聋患者的临床疗效及对经颅多普勒(TCD)参数、纤溶-凝血指标的影响。方法将突发性耳聋患者按队列法分为对照组和试验组。对照组在常规治疗的基础上,给予地塞米松磷酸钠静脉注射,连用10d;试验组在常规治疗的基础上,给予复方倍他米松耳后注射,每次0.8mg,隔日1次,共5次。比较2组患者的临床疗效、听力水平、血流动力学指标及实验室指标[同型半胱氨酸(Hcy)、血小板(PLT)计数],统计药物不良反应发生情况。结果试验组入组50例,对照组入组50例。治疗后,试验组和对照组的总有效率分别为94.00%(47例/50例)和80.00%(40例/50例),在统计学上差异有统计学意义(P<0.05)。治疗后,试验组和对照组的听阈值在0.5kHz下分别为(42.48±5.65)和(50.64±6.92)dB,在1kHz下分别为(45.35±6.44)和(57.66±7.41)dB,在2kHz下分别为(48.67±5.58)和(60.24±8.31)dB,在4kHz下分别为(50.25±6.06)和(63.15±8.25)dB,在统计学上差异均有统计学意义(均P<0.05)。治疗后,试验组和对照组的全血高切黏度分别为(4.18±0.58)和(4.99±0.76)mpa·s,全血低切黏度分别为(9.18±1.15)和(10.31±1.28)mpa·s,血浆黏度分别为(1.44±0.32)和(1.76±0.25)mpa·s,Hcy分别为(15.57±4.25)和(21.75±4.93)μmol·L^(-1),PLT分别为(198.72±21.41)×10^(9)·L^(-l)和(212.67±18.46)×10^(9)·L^(-1),在统计学上差异均有统计学意义(均P<0.05)。试验组和对照组均未见明显药物不良反应发生。结论复方倍他米松注射液耳后注射用于突发性耳聋患者的治疗,可改善患者的听力水平、提高临床疗效,还有助于改善血流动力学、降低血清Hcy水平,且安全性较好。

关键词：复方倍他米松耳后注射突发性耳聋经颅多普勒超声血流动力学

HNTs@CeO_(2)-Au@Co_(3)O_(4)催化还原对硝基苯酚和染料污染物

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中国环境科学 2024年第1期44卷 193-201页

作者：方嘉声陈铭刁琪琪赵硕黄振庭卫昆卓琼芳东莞理工学院生态环境与建筑工程学院广东东莞523808 东莞市新污染物重点实验室广东东莞523808 山东理工大学化学化工学院山东淄博255049

制备了HNTs@CeO_(2)-Au@Co_(3)O_(4)核壳中空管状复合催化剂,用于还原降解水体中对硝基苯酚(4-NP)和染料(MB,MO)污染物.采用TEM,SEM,EDS,XRD,N_(2)吸脱附,XPS等方法对催化剂微观结构和物化特征进行表征.结果表明,CeO_(2)和Co_(3)O_(4)作为内外活性层较好地分散固载Au纳米颗粒,通过界面反应构筑于埃洛石纳米管中,形成CeO_(2)/Co_(3)O_(4)叠层结构封装埃洛石载金核壳复合催化剂(HNTs@CeO_(2)-Au@Co_(3)O_(4)).该催化剂分别在3.5,8和3min内可还原去除96%以上的4-NP,MB和MO污染物,其相应的一级反应动力学速率常数(0.856,0.370,1.337min^(-1))和转换频率(10.99,1.90,2.80min^(-1))均明显优于HNTs-Au@Co_(3)O_(4),HNTs@CeO_(2)-Au和HNTs@CeO_(2)@Co_(3)O_(4)对照材料.HNTs@CeO_(2)-Au@Co_(3)O_(4)催化剂连续进行6次使用后,仍保持较高的4-NP,MB和MO污染物还原转化率(91.2%,87.3%,89.5%)和结构稳定性.独特的CeO_(2)/Co_(3)O_(4)叠层结构特征和复合组分协同增强效应有效促进了高性能催化体系的构建,极大提升了Au颗粒的催化活性和稳定性,使HNTs@CeO_(2)-Au@Co_(3)O_(4)催化剂呈现较为优异的催化效能和循环使用性能.

关键词：纳米金催化剂埃洛石核壳结构对硝基苯酚染料污染物催化还原

服务贸易开放下的制造业服务化与全要素生产率

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技术经济与管理研究 2024年第2期 137-143页

作者：王宏森方栓喜张东生东北大学工商管理学院辽宁沈阳110167 中国(海南)改革发展研究院海南海口570311 烟台大学经济管理学院山东烟台264005

服务贸易开放可以促进服务要素跨境流通,进而推动制造业与服务要素的融合。使用WIOD面板数据和SFA模型,研究服务贸易开放和制造业服务化对制造业全要素生产率(TFP)的影响。结果显示,制造业的服务化转型和服务贸易开放都对TFP有正向影响... 详细信息

服务贸易开放可以促进服务要素跨境流通,进而推动制造业与服务要素的融合。使用WIOD面板数据和SFA模型,研究服务贸易开放和制造业服务化对制造业全要素生产率(TFP)的影响。结果显示,制造业的服务化转型和服务贸易开放都对TFP有正向影响,并且二者的相互作用可以进一步提高TFP水平。异质性分析表明,这种影响对低技术制造业TFP的促进作用最大;制造业投入生产性服务及其与服务贸易开放的交互效应对TFP的正向影响大于投入生活性服务和公共服务。应积极推动制造业的服务化转型和服务贸易开放,以促进制造业的高质量发展。

关键词：服务贸易开放制造业服务化全要素生产率高质量发展

基于产权视角的政府投资农村水利设施可持续供给研究

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中国农村水利水电 2024年第2期 64-73页

作者：杨高升方玥河海大学商学院江苏南京211100

随着乡村振兴的不断推进,农村水利设施的重要性愈发凸显。为探究如何提高设施的可持续供给水平、实现政府投资农村水利设施持续性高质量供给,基于案例分析,梳理总结出产权明晰度、运行秩序合理性和农民管护积极性是政府投资农村水利设... 详细信息

随着乡村振兴的不断推进,农村水利设施的重要性愈发凸显。为探究如何提高设施的可持续供给水平、实现政府投资农村水利设施持续性高质量供给,基于案例分析,梳理总结出产权明晰度、运行秩序合理性和农民管护积极性是政府投资农村水利设施供给可持续性的主要影响因素,并结合产权理论、交易费用理论、集体行动理论、制度分析与发展框架等理论,构建了产权明晰度、运行秩序合理性、农民管护积极性对政府投资农村水利设施供给可持续性影响机理的理论模型。基于对华东地区多个省份农民的问卷调查,运用SPSS 26.0和Amos 24.0软件进行分析,结果表明:(1)产权明晰度、运行秩序合理性、农民管护积极性分别与政府投资农村水利设施供给可持续性正相关;(2)运行秩序合理性、农民管护积极性在产权明晰度与政府投资农村水利设施供给可持续性之间存在中介作用,农民管护积极性在运行秩序合理性与供给可持续性之间存在中介作用。

关键词：农村水利设施可持续供给产权运行秩序管护积极性

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU fang-Chao LIU Shu-Feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU Department of Epidemiology&Key Laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina Department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina Department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina Department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

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基于递归神经网络的非结构化数据加密存储

信息技术 2023年第4期47卷 167-172页

作者：杨莲崔永春王圣芳山东省肿瘤防治研究院济南250117

为实现非结构化大数据的安全存储并提高其抗攻击能力,提出了基于递归神经网络的非结构化数据加密存储方法。通过分块处理医院非结构化大数据,获得输入、输出张量,构建基于LSTM的递归神经网络,生成医院大数据序列;通过向前反馈和向后反... 详细信息

为实现非结构化大数据的安全存储并提高其抗攻击能力,提出了基于递归神经网络的非结构化数据加密存储方法。通过分块处理医院非结构化大数据,获得输入、输出张量,构建基于LSTM的递归神经网络,生成医院大数据序列;通过向前反馈和向后反馈获得加密数据,将加密后数据包用加密后源数据包的线性组合代替;再设计基于列不满秩概率存储算法,通过加密存储子节点控制器分配加密存储任务。实验结果表明:该方法具有较强的抗攻击能力,存储效率优势更显著。

关键词：递归神经网络非结构化加密存储抗攻击权值矩阵

家蝇幼虫血淋巴MAC-1对LPS诱导小鼠腹腔巨噬细胞分泌炎性因子的影响

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中国病原生物学杂志 2018年第12期13卷 1375-1379,1408页

作者：王芳胜庞芸迟茜文张霞朱家洪魏洪贵州医科大学微生物学教研室贵州省高校病原生物学特色重点实验室贵州贵阳550025 贵州医科大学感染与免疫学实验室

目的探讨家蝇幼虫血淋巴多肽MAC-1对脂多糖(LPS)诱导小鼠腹腔巨噬细胞分泌肿瘤坏死因子α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)水平的影响及其基于NF-κB转录因子可能的作用机制。方法用5%淀粉经小鼠腹腔注射诱导巨噬细胞产生... 详细信息

目的探讨家蝇幼虫血淋巴多肽MAC-1对脂多糖(LPS)诱导小鼠腹腔巨噬细胞分泌肿瘤坏死因子α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)水平的影响及其基于NF-κB转录因子可能的作用机制。方法用5%淀粉经小鼠腹腔注射诱导巨噬细胞产生,采用差速贴壁法分离纯化。96孔板中细胞随机分成6组:5mg/L LPS分别与50、200、500、1 000μg/ml浓度MAC-1共同作用组,阴性对照组(10%MEM),阳性对照组(5mg/L LPS);12孔板细胞随机分6组:MEM阴性对照组,50μg/ml MAC-1组,5mg/L LPS组,50μg/ml MAC-1+5mg/L LPS组,5mg/L LPS+10μmol/L PDTC组,5mg/L LPS+10μmol/L PDTC+50μg/ml MAC-1。两种分组均给药培养12h,收集细胞上清液并提取细胞mRNA,采用酶联免疫吸附试验(ELISA)和逆转录实时荧光定量PCR(RT-qPCR)法检测细胞炎性因子及其基因表达和Toll样受体(TLR4)、NF-κBp50基因相对表达量。结果阴性对照组和LPS组巨噬细胞IL-1β和IL-6分别为220.9±20.3pg/ml和269.06±13.54pg/ml以及212.21±13.54pg/ml和269.43±21.12pg/ml,差异有统计学意义(F=11.02,15.60,P0.05)。50μg/ml组与其他MAC-1浓度组相比IL-1β、IL-6、TNF-α均显著降低(F=10.46,68.13,16.45,P0.05)。结论 MAC-1能抑制LPS诱导小鼠腹腔巨噬细胞分泌相关炎性因子,其机制可能与NF-κB转录因子有关,尚待进一步研究。

关键词：家蝇幼虫血淋巴MAC-1 脂多糖巨噬细胞细胞因子信号分子

太阳光——二氧化钛催化降解水中有机污染物研究

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天水师范学院学报 2001年第2期21卷 42-45页

作者：左国防杨声王小芳天水师范学院化学系!甘肃　天水 741001

太阳光──化钛体系光催化降解水体有机污染物是一项非常有前途的水处理技术。本文从二氧化钛的改性角度对其有效利用自然光源降解有机污染物进行了探讨。

关键词：二氧化钛自然光改性催化降解有机污染物