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Copper homeostasis and neurodegenerative diseases

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan wang Daidi Li Kaifei Xu guoqing wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu guoqing wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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A systematic literature review of human-centered design approach in single pilot operations

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Chinese Journal of Aeronautics 2023年第11期36卷 1-23页

作者： guoqing wang Min LI Miao wang Dongjin DING School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200241China China Eastern Airlines Corporation Limited Shanghai 201100China

Single Pilot Operations(SPO),as a NextGen concept of operation,can save both crew costs and human resources for airlines,and has attracted the attention of aviation *** explore in advance the problems that the introduction of SPO into the aviation system would bring,the Human-Centered Design(HCD)approach has been widely used in the development of SPO.A systematic review of the progress of HCD approach in SPO research can promote further development of *** this paper,the literature resources of SPO were firstly retrieved from scientific research databases by subject search and were used as the input of scientometric analysis to obtain the highly cited literature,the number of annual publications,and the co-authorship network,which enables readers to understand the research trends and research groups of current ***,the development,application,and research process of the HCD approach were introduced in detail,and the progress of the HCD approach in SPO research was reviewed systematically from three aspects:concept design,function allocation,and system ***,limitations of current SPO research and future research directions for applying the HCD approach to SPO were also discussed.

关键词： Concept design Function allocation Human-Centered Design(HCD) Scientometric analysis Single Pilot Operations(SPO) System evaluation

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Adaptive robust cubature Kalman filtering for satellite attitude estimation

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Chinese Journal of Aeronautics 2018年第4期31卷 806-819页

作者： Zhenbing QIU Huaming QIAN guoqing wang College of Automation Harbin Engineering University

This paper is concerned with the adaptive robust cubature Kalman filtering problem for the case that the dynamics model error and the measurement model error exist simultaneously in the satellite attitude estimation system. By using Hubel-based robust filtering methodology to correct the measurement covariance formulation of cubature Kalman filter, the proposed filtering algorithm could effectively suppress the measurement model error. To further enhance this effect and reduce the impact of the dynamics model error, two different adaptively robust filtering algorithms,one with the optimal adaptive factor based on the estimated covariance matrix of the predicted residuals and the other with multiple fading factors based on strong tracking algorithm, are developed and applied for the satellite attitude estimation. The quaternion is employed to represent the global attitude parameter, and three-dimensional generalized Rodrigues parameters are introduced to define the local attitude error. A multiplicative quaternion error is derived from the local attitude error to maintain quaternion normalization constraint in the filter. Simulation results indicate that the proposed novel algorithm could exhibit higher accuracy and faster convergence compared with the multiplicative extended Kalman filter, the unscented quaternion estimator, and the adaptive robust unscented Kalman filter.

关键词： Attitude estimation Cubature Kalman filter Multiple fading factors Optimal adaptive factor Robust filtering

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The Boundary Contour Method for Half-Plane Piezoelectric Media

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上海交通大学学报 2004年第z2期38卷 176-181页

作者： wang guoqing wang Qing LIU Zhengxing DING Haojiang Department of Engineering Mechanics Shanghai Jiaotong Univ. Shanghai200030 China Department of Engineering Mechanics Shanghai Jiaotong Univ. Shanghai200030 China Department of Engineering Mechanics Shanghai Jiaotong Univ. Shanghai200030 China Department of Civil Engineering Zhejiang Univ. Hangzhou310027 China

This paper presents a further development of the Boundary Contour Method (BCM) for half-plane piezoelectric media. Firstly, the divergence free property of the integrand of the half-plane piezoelectric boundary element is proven. Secondly, the boundary contour method formulation is derived and potential functions are obtained by introducing linear shape functions and Green's functions[1] for half-plane piezoelectric media. Finally, numerical solutions for illustrative example are compared with exact ones and that of conventional boundary element method (BEM) ones. The numerical results of BCM coincide very well with exact solution, and the feasibility and efficiency of the method are verified.

关键词： boundary contour method piezoelectricity half-plane shape function

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DYNAMICS ANALYSIS OF SPECIAL STRUCTURE OF MILLING-HEAD MACHINE TOOL

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 103-107页

作者： YANG Qingdong LIU guoqing wang Keshe College of Machinery and Electricity Engineering Beijing Information Science and Technology University Beijing 100192 China

The milling-head machine tool is a sophisticated and high-quality machine tool of which the spindle system is made up of special multi-element structure. Two special mechanical configurations make the cutting performance of the machine tool decline. One is the milling head spindle supported on two sets of complex bearings. The mechanical dynamic rigidity of milling head structure is researched on designed digital prototype with finite element analysis（FEA） and modal synthesis analysis （ MSA ） for identifying the weak structures. The other is the ram structure hanging on milling head. The structure is researched to get dynamic performance on cutting at different ram extending positions. The analysis results on spindle and ram are used to improve the mechanical configurations and structure in design. The machine tool is built up with modified structure and gets better dynamic rigidity than it was before.

关键词： Milling-head machine tool Dynamic characteristics Finite element analysis Modal synthesis analysis

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Optimization and verification of single pilot operations model for commercial aircraft based on biclustering method

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Chinese Journal of Aeronautics 2023年第5期36卷 286-305页

作者： Miao wang Yue LUO Kai HUANG Zhao PEI guoqing wang School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Computer Science Shaanxi Normal UniversityShaanxi 710062China

Commercial aircraft crews have experienced a trend from five-person crew to dual-pilot *** from both technological and market demands,Single Pilot Operations(SPO)is considered an important development direction in modern aviation *** this paper,starting from Dual-Pilot Operations(DPO),the piloting process,decision-making process and decisionmaking mode of DPO for commercial aircraft are studied to obtain the operational requirements of ***,based on above analysis,the operational mechanism of SPO is studied and the core technology of SPO mode is ***,a new closed frequent bicluster mining algorithm named FsCluster is proposed for the optimization of the SPO model,and the other efficient bicluster mining algorithm named TsCluster is proposed for the analysis and verification of the SPO ***,a typical flight phase scenario is modelled by Magic System of System,and combined with the proposed algorithms for analysis and verification to determine whether the SPO mode can meet the DPO requirements.

关键词： Commercial aircraft Differential bicluster Dual-pilot operations Single pilot operations System modelling

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Friction stir welding of high-strength aerospace aluminum alloy and application in rocket tank manufacturing

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Journal of Materials Science & Technology 2018年第1期34卷 73-91页

作者： guoqing wang Yanhua Zhao Yunfei Hao China Academy of Launch Vehicle Technology Beijing 100076 China Capital Aerospace Machinery Company Beijing 100076 China

Friction stir welding （FSW） has been widely adopted in aerospace industry for fabricating high-strength aluminum alloy structures, such as large volume fuel tanks, due to its exceptional advantages includ- ing low distortion, less defects and high mechanical properties of the joint. This article systematically reviews the key technical issues in producing large capacity aluminum alloy fuel tanks by using FSW, including tool design. FSW process optimization, nondestructive testing （NDT） techniques and defect repairing techniques, etc. To fulfill the requirements of Chinese aerospace industry, constant-force FSW, retractable tool FSW, lock joint FSW, on-line NDT and solid-state equal-strength FSW techniques, as well as a complete set of aerospace aluminum FSW equipment, have been successfully developed. All these techniques have been engineered and validated in rocket tanks, which enormously improved the fabrication ability of Chinese aerospace industry.

关键词： Fuel tank High-strength aluminum alloy Friction stir welding Application

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Preparation and Properties of Carbon Fiber Chiral Materials

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Journal of Wuhan University of Technology(Materials Science) 2008年第4期23卷 510-512页

作者： ZHANG Ping HUANG Zhixin wang guoqing Department of Physics Yunyang Teachers College Danjiangkou 442700 China Department of Physics Huazhong Normal University Wuhan 430079 China

The chiral materials were prepared by using the carbon fiber helices as chiral inclusions, and the composite of Fe3O4 and polyaniline as matrix. The electromagnetic properties, including the rotation angles, the axial ratios and the complex chirality parameters, were measured by using a circular waveguide method in the 8.5-11.0 GHz frequency range. The dependence of these electromagnetic properties on the frequency and the concentration of the Fe3O4 in the composite matrix were analyzed. The results show that an appropriate concentration of Fe3O4 in the matrix is useful in improving the electromagnetic properties of the chiral material.

关键词： carbon fiber composite matrix circular waveguide method rotation angle axial ratio chirality parameter

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DFCluster:An efficient algorithm to mine maximal differential biclusters for single pilot operations task synthesis safety analysis

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Chinese Journal of Aeronautics 2022年第5期35卷 400-418页

作者： Yong CHEN Yue LUO Miao wang Kelin ZHONG Gang XIAO guoqing wang School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China Commercial Aircraft Corporation of China Ltd.Shanghai 200436China China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

With the continuous advancement of the avionics system,crew members are correspondingly reduced,and Single Pilot Operations(SPO)has attracted widespread attention from *** meet the flight requirements in SPO mode,it is necessary to further strengthen air-ground coordination system integration,but at the same time,there will be some safety issues caused by resource integration,function fusion,and task *** at the safety problems caused by task synthesis,an efficient differential bicluster mining algorithm--DFCluster algorithm is proposed in this paper to discover potential hazardous elements or propagation mechanisms through mining the resource-function *** mine efficiently,several pruning techniques are designed for generating maximal biclusters without candidate *** experimental results show that the DFCluster algorithm is more efficient than the existing differential biclustering algorithms under different scales of artificial datasets and public ***,a typical flight scenario is designed based on SPO air-ground collaborative system architecture,and combined with our proposed DFCluster algorithm for task synthesis safety *** on the mining results,the SPO airground collaborative system architecture is modified,which ultimately improves the safety of the SPO system.

关键词： Differential bicluster Flight scenario design Safety analysis Single pilot operations Task synthesis

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