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Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion

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World Journal of Gastroenterology 2008年第31期14卷 4943-4948页

作者： Yong-Lian wu Sheng Zhang Guo-rong wang Yu-Peng Chen The Medical College of Putian University Putian 351100 Fujian Province China Department of Pathology the First Affiliated Hospital of Fujian Medical University Fuzhou 350005 Fujian Province China Hanjiang Hospital Putian 351100 Fujian Province China

AIM: To investigate the relation of expression transfor-mation of claudin-1 with invasiveness and metastasis of gastric carcinoma. METHODS: By using immunohistochemistry, expres-sion of claudin-1 in mucosa and invasive front of 136 gastric adenocarcinoma cases and proliferative index (Ki-67) were detected and analyzed. RESULTS: In mucosa, the claudin-1 over-expression rate of mucinous adenocarcinomas (including signet-ring cell carcinomas) was the highest. It was nega-tively related with the differentiation but positively related with the invasiveness and metastasis of gastric cancer. In invasive front, the claudin-1 over-expression rate was positively related with the differentiation, in-vasiveness and metastasis of gastric carcinoma. The expression transformation of claudin-1 was found in gastric carcinoma. The expression of claudin-1 in inva-sive front was transformed in 28/136 gastric carcinoma cases. The transformation rate in highly differentiated tubular adenocarcinomas was the highest (51.5%, 17/33). The deeper was the invasiveness, the higher was the transformation rate. The claudin-1 expression transformation rate in serosa and omenta was signifi -cantly higher (92.9%) than in tunica muscularis of in-vasive gastric cancer cases, as well as in patients withlymph node metastasis than in those without lymph node metastasis. CONCLUSION: Up-regulation of claudin-1 expres-sion and its transformation in invasive and metastatic gastric carcinoma suggest that claudin-1 participates in the transformation of biological behaviors in neo-plasms. Further study is needed to elucidate the pre-cise mechanism and the relation of claudin-1 expres-sion with the neoplasm progress.

关键词： Gastric carcinoma Claudin-1 Expression transformation Invasiveness Metastasis Immunohistochemistry

In-situ stitching interferometric test system for large piano optics

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Advances in Manufacturing 2018年第2期6卷 195-203页

作者： Xin wu Ying-Jie yu Ke-Bing Mou Wei-rong wang College of Mechanical Engineering Shanghai University of Engineering Science Shanghai 201620 People's Republic of China Department of Precision Mechanical Engineering Shanghai University Shanghai 200072 People's Republic of China Shanghai Machine Tool Works Ltd. Shanghai 200093 People's Republic of China

In-situ testing is an ideal technology for improv- ing the precision and efficiency of fabrication. We developed an in-situ subaperture stitching interferometric test system for large piano optics in the workshop environment with high precision and satisfactory repeatability. In this paper, we provide a brief account of this system and the principle ofin- situ subaperture stitching measurement. Several validation tests are presented, which demonstrate that the developed system is capable of realizing in-situ testing. The size of optical flats can be measured is up to 420 mm×780 mm, and repeatability is smaller than 0.03λ. The paper also dis- cusses the necessary requirements for a suitable workshop environment for ensuring that the tests are stable and reliable.

关键词： In-situ measurement Subaperture stitching Dynamic interferometry Large plano optics

Effect of Solution Treatment on the Microstructure and Mechanical Properties of Sand-Cast Mg–9Gd–4Y–0.5Zr Alloy

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Acta Metallurgica Sinica(English Letters) 2018年第2期31卷 189-198页

作者： Jing-Li Li Na Zhang Xiao-Xuan wang Di wu rong-Shi Chen The Group of Magnesium Alloys and Their Applications Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China School of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China AVIC Shenyang Liming Aero--Engine Group Corporation Shenyang 110043 China

Sand-cast Mg–9Gd–4Y–0.5 Zr（wt%） alloy was solution-treated at 500–565 ℃ in the time range of 0.5–30 h in air or vacuum to investigate its microstructure evolution and mechanical properties. The results showed that solution treatment temperature had a significant influence on the dissolving rate of eutectic phase and grain growth. Taken both of them into consideration, 510–520 ℃ was considered to be the optimum solution treatment temperature range for this *** should be noted that the trace（0.4–0.9 vol%） and insoluble cuboid-shaped phase precipitated during solution treatment was identified to be YH2, of which the hydrogen was thought to come from both the melting and solution heating *** addition, the 3D morphology and dissolving process of Mg24（Gd,Y）5 eutectic phases in the as-cast alloy were also discussed via in-situ observation under X-ray tomography.

关键词： Mg-Gd-Y-Zr alloy Solution treatment Microstructure Rare-earth hydride

Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage

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Neuroscience Bulletin 2014年第1期30卷 90-98页

作者： rong-Yi Liu Jun-Jun wang Xia Qiu Ji-Min wu Department of Neurology Second Affiliated Hospital College of Medicine Zhejiang University Department of Neurology Zhejiang Hospital

Recent evidence suggests that admission hypergly- cemia has deleterious effects on the survival and functional outcome of patients with intracerebral hemorrhage （ICH）. In this study, we first induced acute hyperglycemia in male adult Sprague-Dawley rats by intraperitoneal injection of 50% glucose （6 mL/kg）, and created the ICH model thereafter by delivering autologous whole blood or homologous normal- glucose blood into the right basal ganglia. Twenty- four hours later, we assessed the neurological injury, evaluated the hematoma and brain water content, and investigated autophagy. We found elevations of neurological deficit scores, brain water content, and microtubule-associated protein light chain-3 （LC3） and beclin-1 protein levels, and decreased SQSTM1/ p62 levels after ICH with normal-glucose blood （without hyperglycemia）. Acute hyperglycemia with ICH of high-glucose blood hematoma was associated with significantly increased forelimb-use asymmetry test scores, brain water content and SQSTM1/p62 protein levels, and evident decreases in the ratio of LC3-11/LC3-1 and beclin-1 protein levels. On the other hand, acute hyperglycemia and ICH with normal- glucose blood hematoma only slightly increased the neurological deficit scores and brain water content （P 〉0.05）. In conclusion, the autophagy pathway was activated after ICH, and acute hyperglycemia with hematoma of high-glucose blood exacerbates the neurological injury, and reduces autophagy around the hematoma.

关键词： intracerebral hemorrhage hyperglycemia autophagy

Numerical study on catalytic combustion of methane with ozone using Pd-exchanged zeolite X

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Science China Chemistry 2015年第5期58卷 899-904页

作者： Rui wu rong Chen Hong wang Zhibin wang Xun Zhu Qiang Liao Kwansan Hui Kwunnam Hui Key Laboratory of Low-Grade Energy Utilization Technologies and Systems Chongqing University Institute of Engineering Thermophysics Chongqing University School of Energy and Power Engineering University of Shanghai for Science and Technology Department of Mechanical Convergence Engineering Hanyang University School of Materials Science and Engineering Pusan National University

A steady-state ID macro-homogeneous model is developed to illustrate the combustion process of methane with ozone in the reactor composed of Pd-exchanged zeolite X. The model is validated by comparing the predicted results with the measured data. The methane conversion increases with decreasing the inlet methane concentration and gas space velocity and increasing the inlet ozone concentration and temperature. As the reactor length reduces, the methane conversion varies little if the reactor is too long but decreases when the reactor is too short. Therefore, the reactor should he properly designed to balance costs and the methane-conversion efficiency.

关键词： catalytic combustion methane conversion porous medium ozone

Extensive Inter-plant Protein Transfer between Cuscuta Parasites and Their Host Plants

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Molecular Plant 2020年第4期13卷 573-585页

作者： Nian Liu guojing Shen Yuxing Xu Hui Liu Jingxiong Zhang Shalan Li Jing Li Cuiping Zhang Jinfeng Qi Lei wang Jianqiang wu Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of the Chinese Academy of Sciences Beijing 100049China

Cuscuta species(dodders)are holoparasites that totally rely on host plants to *** various mobile proteins have been identified to travel within a plant,whether and to what extent protein transfer between Cuscuta and host plants remain *** found that hundreds to more than 1500 proteins were transferred between Cuscuta and the host plants Arabidopsis and soybean,and hundreds of interplant mobile proteins were even detected in the seeds of Cuscuta and the host *** hosts bridge-connected by dodder were also found to exchange hundreds of ***,the mobile proteins represent a few to more than 10%of the proteomes of foreign *** Arabidopsis plants expressing different reporter proteins,we further showed that these reporter proteins could travel between plants and,importantly,retained their activity in the foreign *** analysis between the interplant mobile proteins and mRNAs indicated that the majority of mobile proteins were not de novo synthesized from the translocated mRNAs,but bona fide mobile *** propose that large-scale inter-plant protein translocation may play an important role in the interactions between host plants and dodder and even among the dodder bridge-connected hosts.

关键词： dodder Cuscuta host plants protein transfer plant-plant interaction

Evaluation of N-acetylcysteine and glutathione as quenching agents for the analysis of halogenated disinfection by-products

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Journal of Environmental Sciences 2022年第7期34卷 71-79页

作者： Shunke Ding Menglin wu rong Xiao Chao Fang Qi wang Bin Xu Wenhai Chu State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Key Laboratory of Yangtze River Water Environment Ministry of EducationTongji UniversityShanghai 200092China School of Life and Environmental Science Wenzhou UniversityZhejiang 325035China

Disinfection by-products(DBPs), formed from the reactions of disinfectants with natural organic matter and halides in drinking water, were considered to be cytotoxic and genotoxic, and might trigger various cancers. The relatively low concentration of DBPs in finished water(low μg/L or even ng/L levels) and the interference from water matrix inhibited in situ determination of DBPs. Moreover, the further formation and degradation of DBPs by disinfectants during the holding time(several hours to several days) from sample collection to analysis could adversely affect the determination of DBPs. To obtain accurate, precise and reliable data of DBP occurrence and formation, robust and reliable sample preservation is indispensable. However, the commonly used quenching agents(e.g., sodium sulfite, sodium thiosulfate, and ascorbic acid) for sample preservation can decompose reactive DBPs by reductive dehalogenation. This study evaluated the performance of N-acetylcysteine(NAC) and glutathione(GSH) as quenching agents for the analysis of halogenated DBPs by investigating the stoichiometry of the disinfectant-quenching agent reaction, the formation of DBPs during chlor(am)ination of NAC or GSH, and the effects of NAC or GSH on the stability of 18 individual DBPs and total organic halogen(TOX). Based on the results of this study, NAC and GSH were considered to be ideal quenching agents for the analysis of most DBPs and TOX, except halonitromethanes.

关键词： Disinfection by-products Total organic halogen Quenching agents N-acetylcysteine Glutathione

Effect of irradiation on temperature performance of dispersioncompensation no-core cascade optical-fiber sensor coated with polydimethylsiloxane film

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Nuclear Science and Techniques 2022年第9期33卷 10-20页

作者： Fang wang Qiu-Feng wu Yu-rong Jiang Chan Jin Xiao-Hui wang Ben-Shang Zhang Chun-wang Ma College of Electronic and Electrical Engineering Henan Normal UniversityXinxiang 453007China Key Laboratory of Optoelectronic Sensing Integrated Application of Henan Province Xinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Engineering Laboratory of Intelligent Additive Manufacturing of Henan Province Xinxiang 453007China Key Laboratory of Interfacial Physics Technology Project Chinese Academy of SciencesShanghai 201800China Institute of Isotope Research Henan Academy of SciencesZhengzhou 450000China

A temperature measurement device can produce data deviations and can even be damaged in a high-dose radiation *** reduce the radiation damage to such a device and improve the temperature measurement accuracy in a radiation environment,a temperature sensor based on optical-fiber sensing technology is *** sensor has a cascade structure composed of a single-mode fiber(SMF),a dispersion-compensation fiber(DCF),a nocore fiber(NCF),and another SMF(SDNS).The DCF and NCF are coated with a polydimethylsiloxane(PDMS)film,which is a heat-sensitive material with high thermal optical and thermal expansion *** experiments,PDMS was found to produce an irradiation crosslinking effect after irradiation,which improved the temperature sensitivity of the SDNS *** experimental results showed that within a range of 30–100℃,the maximum temperature sensitivity after irradiation was 62.86 pm/℃,and the maximum transmission sensitivity after irradiation was 3.353×10^(-2)dB/℃,which were 1.22 times and 2.267 times the values before irradiation,*** addition,repeated temperature experiments verified that the SDNS sensor coated with the PDMS film had excellent temperature ***,it was found that with an increase in the irradiation intensity,the irradiation crosslinking degree of PDMS increased,and the temperature sensitivity of the sensor was *** proposed sensor could potentially be applied to temperature measurement in a nuclear-radiation environment.

关键词： ^(60)Co-γirradiation Optical-fiber sensor Temperature performance PDMS Radiation crosslinking

Untethered quadrupedal hopping and bounding on a trampoline

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Frontiers of Mechanical Engineering 2020年第2期15卷 181-192页

作者： Boxing wang Chunlin ZHOU Ziheng DUAN Qichao ZHU Jun wu rong XIONG State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang UniversityHangzhou 310027China Binhai Industrial Technology Research Institute of Zhejiang University Tianjin 300301China

For quadruped robots with springy legs,a successful jump usually requires both suitable elastic parts and well-designed control ***,these two problems are mutually restricted and hard to solve at the same *** this study,we attempt to solve the problem of controller design with the help of a robot without any elastic mounted parts,in which the untethered robot is made to jump on a *** differences between jumping on hard surfaces with springy legs and jumping on springy surfaces with rigid legs are briefly *** intuitive control law is proposed to balance foot contact forces;in this manner,excessive pitch oscillation during hopping or bounding can be *** height is controlled by tuning the time delay of the leg *** with other motion generators based on kinematic law,the robot can perform translational and rotational movements while hopping or bounding on the *** are conducted to validate the effectiveness of the proposed control framework.

关键词： hopping and bounding gait compliant mechanism compliant contact balance control strategy legged locomotion control quadruped robot