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Investigation on Breakdown Characteristics of Various Surface Terminal Structures for GaN-Based Vertical P-i-N Diodes

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Journal of Applied Mathematics and Physics 2024年第2期12卷 554-568页

作者： Song Shi guanyu wang Yingcong Xiang Chuan Guo Xing wang Yinlin Pu Huilan Li Zhixian Li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Chongqing China

GaN-based vertical P-i-N diode with mesa edge terminal structure due to electric field crowding effect, the breakdown voltage of the device is significantly reduced. This work investigates three terminal structures, including deeply etched, bevel, and stepped-mesas terminal structures, to suppress electric field crowding effects at the device and junction edges. Deeply-etched mesa terminal yields a breakdown voltage of 1205 V, i.e., 89% of the ideal voltage. The bevel-mesa terminal achieves about 89% of the ideal breakdown voltage, while the step-mesa terminal is less effective in mitigating electric field crowding, at about 32% of the ideal voltage. This work can provide an important reference for the design of high-power, high-voltage GaN-based P-i-N power devices, finding a terminal protection structure suitable for GaNPiN diodes to further enhance the breakdown performance of the device and to unleash the full potential of GaN semiconductor materials.

关键词： GaN P-i-N Mesa Edge Terminal Electric Field Crowding

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新时代网络空间文化安全的治理之道

理论视野 2024年第3期289卷 58-63页

作者：王冠宇史献芝南京大学社会学院南京邮电大学马克思主义学院

网络空间文化安全治理是维护网络安全和文化安全的核心议题。网络空间文化安全治理置身于实在性和虚拟性并存的空间样态,力图以防御性和适应性兼具的制度安排构建开放性和秩序性相统一的安全形态。作为一种复合型的安全治理问题,网络空... 详细信息

网络空间文化安全治理是维护网络安全和文化安全的核心议题。网络空间文化安全治理置身于实在性和虚拟性并存的空间样态,力图以防御性和适应性兼具的制度安排构建开放性和秩序性相统一的安全形态。作为一种复合型的安全治理问题,网络空间文化安全治理面临着多重挑战和难题。要有力破解西方文化扩张战略、全新媒介传播语境和技术力量相对薄弱等现实挑战,应当进一步提升网络空间文化安全治理的科学化水平,坚持以立为本和立破并举相结合、党的领导和社会参与相配合、顶层设计和实践执行相铆接、技术创新和技术规制相统合,以源头治理、协同效应、法治保障和技术支撑等有效守护网络空间文化安全阵地,从而为文化强国建设奠定坚实基础。

关键词：网络空间文化安全网络安全治理

衰老清除药物对规模化长期培养中牙髓干细胞增殖和分化功能的影响

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中华口腔医学杂志 2024年第5期59卷 444-452页

作者：王冠玉廖立田卫东四川大学华西口腔医院创伤整形外科、口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、教育部口腔转化医学工程研究中心成都610041

目的探讨间断清除衰老细胞对规模化长期培养中牙髓干细胞(dental pulp stem cell,DPSC)增殖和分化功能的影响,探索维持体外培养DPSC年轻状态的方法。方法从四川大学华西口腔医院口腔颌面外科提供的因正畸或阻生拔除的健康恒牙中提取人DP... 详细信息

目的探讨间断清除衰老细胞对规模化长期培养中牙髓干细胞(dental pulp stem cell,DPSC)增殖和分化功能的影响,探索维持体外培养DPSC年轻状态的方法。方法从四川大学华西口腔医院口腔颌面外科提供的因正畸或阻生拔除的健康恒牙中提取人DPSC,模拟DPSC体外规模化长期培养过程,并对年轻DPSC(第5代,P5)、衰老DPSC(第25代,P25)进行细胞衰老β-半乳糖苷酶染色、集落形成实验、成骨分化诱导茜素染色实验。利用细胞衰老β-半乳糖苷酶染色比较5种衰老清除药物[那维克拉(ABT-263)、姜黄素、达沙替尼、非瑟酮、槲皮素]的清除效率,选择清除效率最高的药物进行后续实验。选取衰老细胞占比开始显著增多的代数,给予间隔3代、累计3次的衰老清除药物处理,对对照组和药物处理组细胞进行荧光细胞衰老β-半乳糖苷酶染色、实时荧光定量PCR(qPCR)、集落形成实验、细胞划痕实验、成骨诱导茜素红染色实验。体内验证使用裸鼠皮下异位成骨实验,对移植物进行HE染色、碱性磷酸酶(ALP)免疫组织化学染色。结果衰老细胞占比随培养周期延长而增加,相比年轻DPSC,衰老DPSC的增殖和成骨分化能力减退(P<0.05)。与年轻DPSC相比,衰老DPSC衰老相关蛋白p21、p16^(INK4a)、白细胞介素(IL-6)mRNA及增殖相关蛋白Ki67 mRNA表达量均发生显著改变(P<0.001)。5种衰老清除药物中,ABT-263有较高的清除效率(P<0.05)。培养过程中间断使用ABT-263后,药物处理组衰老细胞占比[(6.72±2.34)%]显著小于对照组[(31.82±0.57)%](P<0.001);qPCR证实,药物处理组p21、p16^(INK4a)、IL-6 mRNA表达量均显著小于对照组(P<0.05),Ki67 mRNA表达量显著大于对照组(P<0.01)。药物处理组的细胞愈合能力、成骨分化能力均显著大于对照组(P<0.05)。体内实验结果显示,药物处理组DPSC移植体内后相对新生骨质面积[(2.36±0.48)%]显著大于对照组[(1.00±0.46)%](P<0.05)。结论ABT-263可有效清除规模化长期培养DPSC衰老细胞,培养过程中不断给予的ABT-263处理可维持规模化长期培养DPSC的体内及体外增殖、分化功能。

关键词：牙髓干细胞细胞衰老细胞培养技术衰老清除药物

西达本胺联合传统药物治疗复发/难治性皮肤T细胞淋巴瘤2例

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中国皮肤性病学杂志 2024年第9期38卷 1000-1006页

作者：王冠钰王艺萌张春雷北京大学第三医院皮肤科北京100191

目的观察西达本胺联合传统药物治疗复发/难治性皮肤T细胞淋巴瘤的效果。方法采用西达本胺治疗原有系统治疗失败、出现疾病复发或治疗抵抗的皮肤T细胞淋巴瘤,观察其疗效和不良反应。结果纳入的2例患者分别诊断为晚期蕈样肉芽肿(T3N1M0B0,... 详细信息

目的观察西达本胺联合传统药物治疗复发/难治性皮肤T细胞淋巴瘤的效果。方法采用西达本胺治疗原有系统治疗失败、出现疾病复发或治疗抵抗的皮肤T细胞淋巴瘤,观察其疗效和不良反应。结果纳入的2例患者分别诊断为晚期蕈样肉芽肿(T3N1M0B0,ⅡB期)及原发性皮肤外周T细胞淋巴瘤,非特指型(T3bN0M0)。在采用西达本胺联合传统药物的治疗方案后,诊断为蕈样肉芽肿的患者临床获得完全缓解,并保持疾病稳定至少1年,不良反应为中性粒细胞降低及血小板降低;诊断为原发性皮肤外周T细胞淋巴瘤的患者获得部分缓解,未见明显不良反应。结论西达本胺对复发/难治性皮肤T细胞淋巴瘤患者具有良好疗效,不良反应以血液学不良反应为主。

关键词：皮肤T细胞淋巴瘤复发/难治性西达本胺蕈样肉芽肿原发性皮肤外周T细胞淋巴瘤,非特指型

The Environment Significance of Aerinite——First Discovered in the UBC Cliffs

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Acta Geologica Sinica(English Edition) 2020年第1期94卷 103-113页

作者： wang guanyu wang Hejing School of Earth and Space Sciences Peking University Beijing 100871 China

To analyze the composition and structure of the pale blue outcrop from the UBC Cliffs and research the environmental significance of aerinite recorded in the sediments, mineral composition, bulk chemical composition and structural analyses were carried out by means of X-ray diffraction(XRD), field emission scanning electron microscope(FESEM), transmission electron microscope(TEM), electron microprobe analysis(EMPA) and X-ray fluorescence spectra(XRF). Quartz, feldspar, mica, chlorite and aerinite as well as a small amount of amphibole, calcite, clinopyroxene, rutile, perovskite and apatite are recorded in the sediments. It is reported for the first time that the aerinite occurs in a high latitude area and in sediments paragenetic with mica and chlorite. The large span in grain size shows a typical characteristic of fluvioglacial sediments. Geochemistry characteristics(CIA, CIW, PIA, WIP and ICV) verify that there is virtually no chemical weathering. Mineralogy and geochemistry features of the UBC Cliffs sediments indicate that aerinite is accommodate to the high latitude and cold, dry climate. As the sediments show high similarity to those of their provenance, they have great significance in the identification of the forming condition and origin of the aerinite.

关键词： UBC Cliffs sediments aerinite muscovite chlorite environment significance

Entanglement purification for memory nodes in a quantum network

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 47-54页

作者： guanyu wang GuiLu Long State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Tsinghua National Laboratory of Information Science and Technology Beijing 100084China Collaborative Innovation Center of Quantum Matter Beijing 100084China

The entanglement between quantum memory nodes is a prerequisite in a quantum network, and the diamond nitrogen-vacancy(NV) center is a promising candidate serving as a quantum memory node. Here, we investigate the possibility of achieving an entanglement purification protocol(EPP) for entangled NV centers in distant diamonds. To construct the EPP, we design a nondestructive parity-check detector(PCD) utilizing an auxiliary polarization-entangled photon pair, which makes our EPP less time consuming and insensitive to the phase fluctuation of the optical path length. The satisfied fidelity of an NV center pair after purification and efficiency of obtaining a purified NV center pair with our EPP can be obtained with current experimental techniques in the realistic condition. This EPP is useful for a quantum network in which NV centers are used as quantum memory nodes.

关键词： entanglement purification memory nodes quantum network nitrogen-vacancy center system parity-check detectors

Testing the leanocentric locking-point theory by in silico partial lipectomy

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Quantitative Biology 2021年第1期9卷 73-83页

作者： guanyu wang Department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Computational Science and Material Design Shenzhen 518055China

Background:The lipostatic set-point theory,ascribing fat mass homeostasis to leptin mediated central feedback regulation targeting the body9s fat storage,has caused a variety of *** recently proposed a leanocentric locking-point theory and the corresponding mathematical model,which not only resolve these conundrums but also provide valuable insights into weight control and health *** paper aims to further test the leanocentric ***:Partial lipectomy is a touchstone to test both the leanocentric and lipostatic *** we perform in silico lipectomy by using a mathematical model embodying the leanocentric theory to simulate the long-term body fat change after removing some fat cells in the ***:The mathematical modeling uncovers a phenomenon called post-surgical fat loss,which was well-documented in real partial lipectomy surgeries;thus,the phenomenon can serve as an empirical support to the leanocentric *** the other hand,the leanocentric theory,but not the lipostatic theory,can well explain the post-surgical fat ***:The leanocentric locking-point theory is a promising theory and deserves further *** lipectomy surgeries are beneficial to obese patients for quite a long period.

关键词： leanocentric locking-point theory lipostatic set-point theory weight stability fat mass homeostasis partial lipectomy

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西汉“三囷共厨”铜鼎及相关问题

文博 2024年第1期 43-47页

作者：权弼成王雪薇张伏麟王冠宇西北大学文化遗产学院陕西西安710127 西安市隋唐长安城遗址保护中心陕西西安710054 陕西省考古研究院陕西西安710109 西安碑林博物馆陕西西安710001

陕西考古博物馆收藏一件兴平北吴墓地M64出土的西汉铭文铜鼎,其器盖和器身皆刻有铭文“三囷共厨”。根据铜鼎的形制和铭文内容判断该器应为西汉中期铜器。文献中鲜见有关“三囷”的记载,笔者结合秦汉时期地理命名的原则,并通过与其他“... 详细信息

陕西考古博物馆收藏一件兴平北吴墓地M64出土的西汉铭文铜鼎,其器盖和器身皆刻有铭文“三囷共厨”。根据铜鼎的形制和铭文内容判断该器应为西汉中期铜器。文献中鲜见有关“三囷”的记载,笔者结合秦汉时期地理命名的原则,并通过与其他“共厨”类铭文进行对比研究,推测“三囷”可能是西汉时期的一处皇家宫苑。“三囷共厨”铭文反映出西汉时期“共厨”类铜器的分布范围十分广泛,该类铭文铜器受到不同层级机构的使用。“共厨”铭文正是相关职官管理器物时所留下的錾刻记录。

关键词：西汉三囷共厨性质

Global quantitative biology can illuminate ontological connections between diseases

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Frontiers of Electrical and Electronic Engineering in China 2017年第2期5卷 191-198页

作者： guanyu wang Department of Biology Southern University of Science and Technology Shenzhen 518055 China

Owing to its interdisciplinary nature, quantitative biology is playing ever-increasing roles in biological researches. To make quantitative biology even more powerful, it is important to develop a holistic perspective by integrating information from multiple biological levels and by considering related biocomplexity simultaneously. Using complex diseases as an example, I show in this paper how their ontological connections can be revealed by considering the diseases on a common ground. The obtained insights may be useful to the prediction and treatment of the diseases. Although the example involves only with cancer and diabetes, the approaches are applicable to the study of other diseases, or even to other biological problems.

关键词： quantitative biology disease modeling systems biology nonlinear dynamics