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Clinical efficacy and identification of factors confer resistance to afatinib(tyrosine kinase inhibitor)in EGFR-overexpressing esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3130-3140页

作者： Yanni wang Chang Liu Huan Chen Xi Jiao Yujiao wang Yanshuo Cao Jian Li Xiaotian Zhang Yu Sun Na Zhuo Fengxiao Dong Mengting Gao fengyuan wang Liyuan Dong Jifang Gong Tianqi Sun Wei Zhu Henghui Zhang Lin Shen Zhihao Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Genecast Biotechnology Co. LtdWuxiPR China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijingChina Precision Scientific(Beijing)Co. Ltd.BeijingChina Generulor Company Bio-X Lab ZhuhaiGuangdongChina Biomedical Innovation Center Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory for Therapeutic Cancer Vaccines Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival *** preclinical data showed the promising antitumor activity of afatinib in EGFR-overexpressing *** proof-of-concept,phase II trial assessed the efficacy and safety of afatinib in pretreated metastatic ESCC patients(n=41)with EGFR overexpression(NCT03940976).The study met its primary endpoint,with a confirmed objective response rate(ORR)of 39%in 38 efficacy-evaluable patients and a median overall survival of 7.8 months,with a manageable toxicity *** analysis of pretreatment tumors revealed that neurotrophic receptor tyrosine kinase 2(NTRK2)was negatively associated with afatinib sensitivity and might serve as a predictive biomarker,irrespective of EGFR ***,knocking down or inhibiting NTRK2 sensitized ESCC cells to afatinib *** study provides novel findings on the molecular factors underlying afatinib resistance and indicates that afatinib has the potential to become an important treatment for metastatic ESCC patients.

关键词： esophageal squamous expressing

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Living Bacterial Microneedles for Fungal Infection Treatment

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Research 2020年第1期2020卷 446-454页

作者： fengyuan wang Xiaoxuan Zhang Guopu Chen Yuanjin Zhao Department of Burns&Plastic Surgery Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Dermatology Zhongda HospitalSoutheast UniversityNanjing 210009China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Fungal infections are everlasting health challenges all over the world,bringing about great financial and medical ***,inspired by the natural competition law of beneficial bacteria against other microbes,we present novel living microneedles(LMNs)with functionalized bacteria encapsulation for efficient fungal infection *** chosen beneficial bacterial components,Bacillus subtilis(***),which are naturally found on the human skin and widely used for food processing,can get nutrients from the skin and escape from the immune system with the help of ***,the encapsulated *** can continuously produce and secrete various potential antifungal agents which can directly bind to fungal cell surfaceassociated proteins and destruct the cell membranes,thus avoiding drug *** immobilization in the LMNs,the bacteria can stay within the LMNs without invasion and the encapsulated bacteria together with microneedles can be removed after ***,the side effects,especially the risk for subsequent bacterial infections,are controlled to a minimum to ensure *** addition,strong penetrability of the microneedles enhances penetration of antifungal agents,and their heights can be adjusted according to the infected depth to acquire better therapeutic *** features make the LMNs potentially valuable for clinical applications.

关键词： invasion bringing removed

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Advances in core–shell engineering of carbon-based composites for electromagnetic wave absorption

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Nano Research 2022年第10期15卷 9410-9439页

作者： Lixue Gai Honghong Zhao fengyuan wang Pan wang Yonglei Liu Xijiang Han Yunchen Du MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

Electromagnetic(EM)absorption is paving the way to overcome the challenges related to conventional shielding strategy against EM pollution through sustainable energy *** characteristic functional media that can interact with electric or magnetic field branch,EM wave absorption materials(EWAMs)have received extensive attention and realized considerable development in the past two decades,where carbon-based composites are always considered as promising candidates for high-performance EMAWs due to their synergetic loss mechanism as well as diversified composition and microstructure *** progress indicates that there is more and more interest in the fabrication of carbon-based composites with unique core–shell *** one hand,core–shell configuration usually ensures good chemical homogeneity of final products and provides some positive protections for the components with susceptibility to corrosion,on the other hand,it creates enough heterogeneous interfaces between different EM components,which may bring enhanced polarization effect and intensify the consumption of EM *** this review,we firstly introduce EM wave absorption theory,and then highlight the advances of core–shell engineering in carbonbased composites in terms of built-in carbon cores and built-out carbon ***,we also show some special core–shell carbon-based composites,including carbon/carbon composites,assembled composites,and decorated *** analyzing EM absorption performance of some representative composites,we further propose some challenges and perspectives on the development of core–shell carbon-based composites.

关键词： carbon-based composites core-shell configuration synergetic effect interfacial polarization electromagnetic(EM)absorption performance

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Immune tolerance induced by immune-homeostatic particles

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Engineered Regeneration 2021年第1期2卷 133-136页

作者： Guopu Chen Hui Zhang Huan wang fengyuan wang Institute of Translational Medicine The Affiliated Drum Tower Hospital of NanjingUniversity Medical SchoolNanjing210008China Department of Dermatology Zhongda HospitalSoutheast UniversityNanjing210009China The Eighth Affiliated Hospital of Sun Yat-sen University Shenzhen518033China

Autoimmune diseases,induced by dysfunction of the adaptive immune system,are the common disease categories ***,regulatory T cells(Tregs)enhancing therapies have been demonstrated to treat autoimmune diseases,which could induce immune tolerance to protect cells and tissues from self-attacking of the immune ***,their widespread application is limited by complex manufacturing process,long production period and high ***,we give a perspective of immune-homeostatic particles as immune regulators to induce antigen-specific Tregs for treating autoimmune ***-specific autoantigen is loaded into the particle to induce Tregs differentiation after *** addition,the surface of the particles is decorated by specific ligands that could bind and trigger apoptosis of activated T cells,thereby impressing the overreacted immune ***,liver sinusoidal endothelial cells(LSEC)-targeting particles are developed to stimulate CD4^(+)T cells differentiation into *** believe that the immune-homeostatic particles have great potential in autoimmune diseases treatment and are valuable in various immune-related disease treatments.

关键词： Autoimmune disease Immune tolerance Immune-homeostatic particle Regulatory T cell Immunomodulator

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Composition Optimization and Microstructure Design in MOFs-Derived Magnetic Carbon-Based Microwave Absorbers:A Review

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Nano-Micro Letters 2021年第12期13卷 383-415页

作者： Honghong Zhao fengyuan wang Liru Cui Xianzhu Xu Xijiang Han Yunchen Du MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China

Magnetic carbon-based composites are the most attractive candidates for electromagnetic(EM)absorption because they can terminate the propagation of surplus EM waves in space by interacting with both electric and magnetic ***-organic frameworks(MOFs)have demonstrated their great potential as sacrificing precursors of magnetic metals/carbon composites,because they provide a good platform to achieve high dispersion of magnetic nanoparticles in carbon ***,the chemical composition and microstructure of these composites are always highly dependent on their precursors and cannot promise an optimal EM state favorable for EM absorption,which more or less discount the superiority of MOFs-derived *** is hence of great importance to develop some accompanied methods that can regulate EM properties of MOFs-derived magnetic carbon-based composites e *** review comprehensively introduces recent advancements on EM absorption enhancement in MOFs-derived magnetic carbon-based composites and some available strategies *** addition,some challenges and prospects are also proposed to indicate the pending issues on performance breakthrough and mechanism exploration in the related field.

关键词： Magnetic carbon-based composites Metal–organic frameworks Composition optimization Microstructure design EM absorption enhancement

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Dynamic Characteristics Analysis on Truck Drive Axle Assembly

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仪器仪表学报 2013年第S1期34卷 153-158页

作者： wang fengyuan Han Longhai Zhang Mengmeng School of Automobile and Transportation Qingdao Technological University

A kind of single impulse welding drive axle used in a truck was selected as research *** dynamic characteristic simulation of the drive axle was analyzed through building the vehicle dynamics simulation model in virtu... 详细信息

关键词： drive axle assembly dynamic characteristics model

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Bio-inspired clamping microneedle arrays from flexible ferrofluid-configured moldings

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Science Bulletin 2019年第15期64卷 1110-1117页

作者： Xiaoxuan Zhang fengyuan wang Yunru Yu Guopu Chen Luoran Shang Lingyu Sun Yuanjin Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Department of Dermatology Zhongda HospitalSoutheast UniversityNanjing210009China Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjing210002China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA

Microneedle(MN)arrays have demonstrated value for cosmetics,diagnosis,transdermal drug delivery,and other biomedical *** effort has been devoted to developing simple stratagem for creating versatile moldings and generating functional MN ***,inspired by the serrated microstructure of mantises’forelegs,we present a novel serration-like clamping MN array based on ferrofluidconfigured *** from the flexibility and versatility of ferrofluids,negative microhole array moldings with various sizes and angles toward the midline could be created *** corresponding biocompatible polymer MN arrays with both isotropic and anisotropic structures could then be produced feasibly and cost-effectively by simply replicating these *** was found that the resultant serrated clamping MN arrays had the ability to adhere to skin firmly,enabling them to be used over a relatively long time and while the recipient was *** proposed technology performed well in minimally invasive drug administration and sustained glucocorticoids release during treatment for imiquimod-induced psoriasis in *** features indicated that such MN arrays could play important roles in wearable transdermal drug delivery systems and in other applications.

关键词： Bioinspired Ferrofluids Microneedle arrays Drug release Biomaterials

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Polymer-bubbling for one-step synthesis of three-dimensional cobalt/carbon foams against electromagnetic pollution

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Journal of Materials Science & Technology 2021年第34期93卷 7-16页

作者： fengyuan wang Ping Xu Ning Shi Liru Cui Yahui wang Dawei Liu Honghong Zhao Xijiang Han Yunchen Du MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

Constructing three-dimensional(3D)foam-like structure in magnetic metal/carbon composites is regarded as a promising pathway to reinforce their electromagnetic(EM)***,a nitrateassisted polymer-bubbling strategy is reported for the synthesis of Co/carbon foams,which is simply accomplished by direct pyrolyzing the mixture of polyvinylpyrrolidone(PVP)and cobalt nitrate hexahydrate(Co(NO_(3))_(2)·6 H_(2) O).Co(NO_(3))_(2)·6H_(2)O not only plays as the source of Co nanoparticles,but also accounts for the formation of 3D microstructure through releasing *** manipulating the weight ratio of Co(NO_(3))_(2)·6H_(2)O to PVP,the chemical composition,microstructure,and EM properties of these composites can be easily *** the weight ratio reaches 1.5,the resultant composite displays good microwave absorption performance,whose reflection loss intensity and effective absorption bandwidth are superior to those of many common Co/C *** analysis reveals that such architecture is greatly helpful to establish cross-linked conductive networks in the wax matrix,resulting in powerful dielectric loss under low absorber ***,3D microstructure is also beneficial for multiple reflections that equal to extend the transmission path of incident EM *** synthesis strategy and desirable properties of these magnetic carbon foams may render them as the low-cost substitute of 3D graphene for the application against EM pollution.

关键词： Polymer-bubbling Three-dimensional foams Co/C composites Electromagnetic pollution Microwave absorption

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农机农艺融合促进农业机械化高质高效发展

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农业工程 2024年第8期14卷 5-9页

作者：王博马小非王凤元陈卓然林波山东省农业机械技术推广站山东济南250100 德州市齐河县农业农村局山东德州251100

农机农艺融合是农业机械化工作的主要目标之一。深入研究农机农艺融合与农业机械化的内在逻辑、分析农机农艺融合中存在的问题、研究国内外农机农艺融合典型模式,指出推进农机农艺融合既应充分吸收国外发展经验,更要紧密结合人多地少与... 详细信息

农机农艺融合是农业机械化工作的主要目标之一。深入研究农机农艺融合与农业机械化的内在逻辑、分析农机农艺融合中存在的问题、研究国内外农机农艺融合典型模式,指出推进农机农艺融合既应充分吸收国外发展经验,更要紧密结合人多地少与适度规模经营快速发展的基本国情,走出一条坚持产量、效率、效益并重的路径,提出推进农机农艺融合、促进农业机械化高质高效发展的政策建议。

关键词：农机农艺融合农业机械化农业机械高质高效发展

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Ratio of photosynthetically active radiation to global solar radiation above forest canopy in complex terrain: measurements and analyses based on Qingyuan Ker Towers

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Ecological Processes 2024年第2期13卷 204-217页

作者： Shuangtian Li Qiaoling Yan Tian Gao Xingchang wang Qingwei wang fengyuan Yu Deliang Lu Huaqi Liu Jinxin Zhang Jiaojun Zhu CAS Key Laboratory of Forest Ecology and Silviculture Institute of Applied Ecology Chinese Academy of Sciences Qingyuan Forest CERN National Observation and Research Station Chinese Academy of Sciences CAS-CSI Joint Laboratory of Research and Development for Monitoring Forest Fluxes of Trace Gases and Isotope Elements Institute of Applied Ecology Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Center for Ecological Research Northeast Forestry University

Background Understanding of the ratio of photosynthetic photon flux density（Qp） to global solar radiation（Rs）(Qp/Rs) is crucial for applying Rsto ecology-related *** studies reported Qp/Rsand its variations based on measurements from a single observatory tower,instead of multi-site-based measurements over complex *** may neglect spatial heterogeneity in the terrain,creating a gap in an understanding of how terrain affects Qp/Rsand how this effect interacts with meteorological *** Here the Qingyuan Ker Towers（three towers in a valley with different terrains:T1,T2,and T3） were utilized to measure Qpand Rsover mountainous forests of Northeast *** airborne LiDAR system was used to generate a digital elevation model,and sky view factor of sectors（SVFs） divided from the field of view of tower's pyranometer was calculated as a topographic factor to explain the variations of Qp/*** The results identified significant differences in Qp/Rsof the three towers at both daily and half-hour scales,with larger differences on clear days than on overcast ***/Rswas positively correlated with SVFsof T1 and T3,while this correlation was negative with that of *** effect of SVFson Qp/Rsinteracted with clearness index,water vapor pressure and solar zenith *** forest-based importance assessment demonstrated that explanation（R2） on Qp/Rswas improved when SVFswas included in the predictor variable set,indicating that incorporating terrain effects enhances the prediction accuracy of Qp/*** improvement in the R2values was more pronounced on clear days than on overcast days,suggesting that the effect of terrain on Qp/Rsdepended on sky *** All findings suggested that Qp/Rsis affected by terrain,and integrating terrain information into existing Qp/Rsmodels is a feasible solution to improve Qp/Rsestimates in mountainous areas.

关键词： Photosynthetic photon flux density Clearness index Water vapor pressure Solar zenith angle Terrain Sky view factor

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