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白细胞介素-2新型突变蛋白在炎症性肠病治疗中的价值

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中华炎性肠病杂志（中英文） 2022年第1期6卷 79-82页

作者：王二嫚刘占举同济大学附属第十人民医院消化内科上海200072

白细胞介素(IL)-2在免疫调节中具有双重作用,一方面可作用于效应细胞激活免疫反应,另一方面可作用于调节性T细胞发挥免疫抑制作用,因此成为炎症性肠病和自身免疫性疾病的治疗靶点之一。低剂量的IL-2已用于某些炎性和自身免疫性疾病的治... 详细信息

白细胞介素(IL)-2在免疫调节中具有双重作用,一方面可作用于效应细胞激活免疫反应,另一方面可作用于调节性T细胞发挥免疫抑制作用,因此成为炎症性肠病和自身免疫性疾病的治疗靶点之一。低剂量的IL-2已用于某些炎性和自身免疫性疾病的治疗,但因其不良反应限制了IL-2在临床上的应用。为了提高IL-2疗效减少不良反应,目前利用基因工程技术合成了多种IL-2突变蛋白,为IL-2在炎症性肠病和自身免疫性疾病中的应用提供了新的可能。

关键词：白细胞介素-2 突变蛋白炎性和自身免疫性疾病

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食物因素在肠易激综合征中的研究进展

胃肠病学 2012年第10期17卷 633-635页

作者：王二嫚颜秀娟(综述) 陈胜良(审校) 上海交通大学医学院附属仁济医院消化科、上海市消化疾病研究所 200001

肠易激综合征(IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性胃肠病,缺乏可解释症状的形态学和生化学异常,其病理生理学机制尚未完全明确。作为胃肠道与外界的直接联系,近年来食物在IBS中的作用受到广泛关注,为IBS的诊断和... 详细信息

肠易激综合征(IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性胃肠病,缺乏可解释症状的形态学和生化学异常,其病理生理学机制尚未完全明确。作为胃肠道与外界的直接联系,近年来食物在IBS中的作用受到广泛关注,为IBS的诊断和治疗提供了一条新思路。本文就食物因素在IBS中的研究进展作一综述。

关键词：肠易激综合征食物不耐受食物过敏诊断治疗

舒必利治疗胃内胆汁反流伴消化不良症状的临床研究

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胃肠病学 2014年第4期19卷 203-207页

作者：王二嫚颜秀娟冯晨晨刘青陈鑫李文婷陈胜良上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所 200001

背景：胃内胆汁反流可能是引起消化不良症状的原因之一.有研究显示小剂量舒必利能减少胃食管反流事件并改善反流症状.目的：评价小剂量舒必利对胃内胆汁反流伴消化不良症状的疗效和安全性.方法：连续纳入2013年l～7月于上海交通大学医... 详细信息

背景：胃内胆汁反流可能是引起消化不良症状的原因之一.有研究显示小剂量舒必利能减少胃食管反流事件并改善反流症状.目的：评价小剂量舒必利对胃内胆汁反流伴消化不良症状的疗效和安全性.方法：连续纳入2013年l～7月于上海交通大学医学院附属仁济医院消化内科就诊,以消化不良症状为主诉,内镜检查提示存在胃内胆汁反流的患者,随机分配入治疗组和对照组,分别接受质子泵抑制剂（PPI）＋舒必利100 mg/d和单用PPI治疗4周.治疗前后应用Leeds消化不良问卷（LDQ）、胆汁反流指数（BRI）和汉密尔顿焦虑、抑郁量表（HAMA、HAMD）对患者进行评估.记录治疗期间和治疗后不良反应发生情况.结果：治疗组3例女性患者因泌乳而停药,共125例患者完成研究.治疗4周后,两组LDQ、BRI评分均较治疗前显著降低,治疗组改善幅度优于对照组（P＜0.05）.治疗组合并精神心理障碍者的LDQ、BRI、HAMA、HAMD评分改善幅度亦均优于对照组（P＜0.05）.结论：小剂量舒必利与PPI联合可有效改善胃内胆汁反流伴消化不良症状患者的临床症状、胆汁反流严重程度以及部分患者合并的精神心理障碍,但个别女性可能出现促乳素升高.

关键词：胆汁反流消化不良焦虑抑郁舒必利

Renormalization of Dirac Delta Potentials Through Minimal Extension of Heisenberg Algebra

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Communications in Theoretical Physics 2017年第9期67卷 313-316页

作者： Fatih erman Department of Mathematics zmir Institute of Technology

We renormalize the model of multiple Dirac delta potentials in two and three dimensions by regularizing it through the minimal extension of Heisenberg algebra. We show that the results are consistent with the other re... 详细信息

关键词： renormalization dirac delta potentials minimal extension of Heisenberg algebra

Numerical Investigation on Characteristics of Supercritical CO_(2)Heat Transfer in Vertical Circular Tubes with Circumferentially Half-Side Heating

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Journal of Thermal Science 2024年第5期33卷 1744-1756页

作者： ZHANG Yan ZHANG Xinyi YAN Chenshuai WU Wenhua GAO erman School of Energy and Power Engineering Northeast Electric Power UniversityJilin 132012China

The design of heat exchangers in the advanced supercritical power conversion system cannot be separated from the study of heat transfer ***-side heating mode is often encountered for solar receiver and supercritical ***,the characteristics of supercritical CO_(2)(sCO_(2))convection heat transfer in vertical tubes with circumferentially half-side heating was numerically investigated through the SST k-ωturbulent model which matches well with the experimental ***,heat transfer between sCO_(2)upflow and downflow was *** to film boiling heat transfer at subcritical pressure,numerical results were processed according to the supercritical pseudo-phase transition hypothesis,with liquid-like phase in the tube core region and vapor-like film in the region near the heated tube *** structure of two layers was demarcated by pseudo-critical temperature T_(pc).Therefore,sCO_(2)heat transfer was assessed according to double thermal resistances caused by vapor-like film near the wall and core liquid-like *** findings suggest that wall temperature for upflow is higher than that for downflow,which is attributed to larger thermal resistance in the fluid domain for upflow than that for *** difference guarantees the excellent heat transfer performance for downflow than *** is also further concluded that the formation of vapor-like film near the wall due to pseudo-phase transition plays a key role in dominating wall temperature and inducing heat transfer deterioration in half-side heating *** present contribution is significant to the design of supercritical heat exchanger under half-side heating mode.

关键词： supercritical CO_(2) pseudo-phase transition half-side heating thermal resistance flow direction

Special Issue on Automotive Lightweight

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Automotive Innovation 2020年第3期3卷 193-194页

作者： A.erman Tekkaya Junying Min Institute of Forming Technology and Lightweight ComponentsTU Dortmund University44227 DortmundGermany School of Mechanical Engineering Tongji UniversityShanghai 201804China

Lightweight is one of the core technologies to realize energy saving,to improve the safety and driving performance of vehicles,and to provide added passenger comfort as *** is of special significance for increasing cruising range of electric or hybrid-powered *** these,lightweight components use less mass and hence reduce the primary energy requirement imbedded in the ***,lightweight has always been a central topic and an important direction in the automotive field whether in the past or in the future.

关键词： weight hence driving

Incorporating travel time reliability in predicting the likelihood of severe crashes on arterial highways using non-parametric random-effect regression

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 470-481页

作者： Emmanuel Kidando Ren Moses Eren erman Ozguven Thobias Sando Department of Civil and Environmental Engineering FAMU-FSU College of Engineering Florida State University Tallahassee FL 32310 USA Department of Civil and Environmental Engineering FAMU-FSU College of Engineering Florida A & M University Tallahassee FL 32310 USA School of Engineering University of North Florida Jacksonville FL 32256 USA

Travel time reliability(TTR) modeling has gain attention among researchers’ due to its ability to represent road user satisfaction as well as providing a predictability of a trip travel *** this significant effort,its impact on the severity of a crash is not well *** study analyzes the effect of TTR and other variables on the probability of the crash severity occurring on arterial *** address the unobserved heterogeneity problem,two random-effect regressions were applied;the Dirichlet random-effect(DRE)and the traditional random-effect(TRE) logistic *** difference between the two models is that the random-effect in the DRE is non-parametrically specified while in the TRE model is parametrically *** Markov Chain Monte Carlo simulations were adopted to infer the parameters’ posterior distributions of the two developed *** four-year police-reported crash data and travel speeds from Northeast Florida,the analysis of goodness-of-fit found the DRE model to best fit the ***,it was used in studying the influence of TTR and other variables on crash *** DRE model findings suggest that TTR is statistically significant,at 95 percent credible intervals,influencing the severity level of a crash.A unit increases in TTR reduces the likelihood of a severe crash occurrence by 25 ***,among the significant variables,alcohol/drug impairment was found to have the highest impact in influencing the occurrence of severe *** significant factors included traffic volume,weekends,speed,work-zone,land use,visibility,seatbelt usage,segment length,undivided/divided highway,and age.

关键词： Travel time reliability Crash severity Non-parametric distributed random-effect Gaussian distributed random-effect Dirichlet process prior

Disclination and molecular director studies on bowlic columnar nematic phase using mosaic-like morphologydecoration method

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Science China Chemistry 2009年第7期52卷 986-999页

作者： DONG YanMing CHEN DanMei ZENG erman HU XiaoLan ZENG ZhiQun Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China

Two bowlic cyclotriveratrylene CTV-1 and CTV-2, with different peripheral groups of -OCH3 and -OCH2CH3 for CTV-1 and -OCH3 and -OCH2COOCH3 for CTV-2, respectively, were synthesized by typical trimerization via a multistep sequence from vanillin. Both bowlic CTV molecules were thermotropic liquid crystals, and presented typical grainy textures of the nematic phase and homogeneous texture of the single domain nematic phase. It is of interest to observe the regular and beautiful mosaic-like morphologies after cooling from liquid crystalline phases, which appeared and vanished repeatedly in several circles of cooling and heating. The size of each mosaic was several dozens of micron. In nature, the mosaic-like morphologies are the optical pattern of cracks formed by the shrinking, due to the crystallization of frozen texture of nematic phases. By means of scanning electron microscopy, the mosaic-like morphologies were observed to consist of lamellae, and each mosaic is a rectangular multi-layer lamella, which is composed of packed single-layered lamellae. The fibrils in the diameter of about 1 μm were observed, which are the structural units of lamellae and would be the bundles of the bowlic molecular columns. The mosaic-like morphologies decorate the bowlic molecular columnar nematic phase, therefore, a novel mosaic-like morphologies decoration method was applied to reveal the director distribution of several kinds of point disclinations, such as s = +1(δ =0°and δ =90°) and s = ±1/2, and Nèel domain walls. It was shown that the bowlic molecular columnar nematic phase behaved as normal nematic phases; however, the basic structural units ordered were the bowlic molecular column or the bundles of bowlic molecular column (i.e. fibrils), but not the bowlic molecules themselves. The bowlic molecular columns acted as the rod-like molecules in a normal nematic phase. Therefore, a new term BCN (bowlic columnar nematic phase) is used to describe the anomalous nematic phase in thi

关键词： CTV bowlic molecules thermotropic liquid crystals bowlic columnar nematic phase BCN mosaic-like morphologies disclination

Hepaticojejunostomy with the “Hand-Fan” technique

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 210-214页

作者： Salih Pekmezci Kaya Saribeyoglu erman Aytac Buket Serdar Department of General Surgery Division of Hepatopancreatobiliary Surgery Cerrahpasa Medical Faculty Istanbul University Department of Medical Education Cerrahpasa Medical Faculty Istanbul University

A standard hepaticojejunostomy technique might be difficult to perform, especially when the bile duct is small and located deep in the liver hilum. Herein we present a new procedure, the Hand-Fan technique, that was used to enhance the exposure and ease the performance of these challenging anastomoses. Thirty-one patients who had had hepaticojejunostomy with this technique for bile duct injury and other benign biliary pathologies from July 2004 to June 2011 were included into the study. Median postoperative hospital stay was 7 days (6-25 days) and median follow-up time was 33 months (2-84 months). Liver function tests revealed that the blood bilirubin levels of the patients were normalized after hepaticojejunostomy. Follow-up showed that there were no signs of clinical recurrence or impaired bile flow. The Hand-Fan technique considerably facilitates challenging hepaticojejunostomies. Surgeon’s comfort is exceptional and the clinical results are satisfactory.

关键词： hepaticojejunostomy Hand-Fan technique biliodigestive anastomosis