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Influence of gelator structures on formation and stability of supramolecular hydrogels

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Chinese Chemical Letters 2007年第12期18卷 1548-1550页

作者： shunji Kono Yu Jiang wang Li Ming Tang Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084 PR China Department of Organic ＆ Polymeric Materials Graduate School of Science ＆ Engineering Tokyo Institute of Technology

A supramolecular hydrogel （defined as G1） formed from 1,2,4,5-benzene tetracarboxylic acid （BTCA） and 2-amino-3- hydroxypyridine possessed higher Tgel than that of another hydrogel （defined as G2） formed from BTCA and 3-hydroxypyridine. Based on the analysis of their xerogels by 1H NMR, IR and XRD, the higher stability of G1 was attributed to the formation of stronger hydrogen binding enhanced by the ortho amino group of 2-amino-3-hydroxypyridine.

关键词： Supramolecular hydrogel Gelation Hydrogen bond

The Establishment and Analysis of the Structural-Electromagnetic Coupling Model of the Electrostatically Controlled Deployable Membrane Antenna

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Chinese Journal of Electronics 2024年第2期33卷 479-487页

作者： shunji ZHANG Yongzhen GU wang ZHONG Qinggang ZHANG Qingdao University of Science and Technology Key Laboratory of Electronic Equipment Structure Design of Ministry of Education Xidian University

A new structural-electromagnetic coupling(SEC) analysis based on quadratic elements is proposed to solve the mismatch problem between structural elements and electromagnetic grids of the electrostatically controlled deployable membrane antenna(ECDMA). Firstly, the ECDMA reflector surface is meshed and redefined by a series of quadratic elements. Without grid transformation, the calculating formulas for the far-field pattern of ECDMA are derived by the physical-optics method. Then the structural deformation of ECDMA is analyzed and the far-field pattern calculating formulas including deformation errors are developed. Simulation and experiment results show that the quadratic elements are effective and efficient in SEC analysis of the ECDMA, moreover, the electromagnetic grid size demand and the grid discretization error are reduced greatly.

关键词： Couplings Electrodes Analytical models Deformation Electromagnetic fields Electromagnetics Optimization

Tribocatalysis: challenges and perspectives

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Science China Chemistry 2021年第10期64卷 1609-1613页

作者： Feng-Ru Fan shunji Xie Guan-Wu wang Zhong-Qun Tian State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Soft Matter ChemistryCollaborative Innovation Center of Chemistry far Energy Materials(iChEM)Department of ChemistryUniversity of Science and Technology'of ChinaHefei 230026China

With an increasing global energy demands and environmental pollution, the development of alternative clean energy technologies has aroused widespread research *** and converting natural energy from the environment, such as solar energy, mechanical energy, thermal energy, chemical and biological energy, is one of the main sources of clean energy.

关键词： catalysis pollution energy

Nickel and indium core-shell co-catalysts loaded silicon nanowire arrays for efficient photoelectrocatalytic reduction of CO_(2) to formate

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Journal of Energy Chemistry 2021年第3期30卷 422-428页

作者： Wenchao Ma Mingcan Xie shunji Xie Longfu Wei Yichen Cai Qinghong Zhang Ye wang State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsNational Engineering Laboratory for Green Chemical Productions of AlcoholsEthers and EstersCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina

Developing an efficient artificial photosynthetic system for transforming carbon dioxide and storing solar energy in the form of chemical bonds is one of the greatest challenges in modern ***,the limited choice of catalysts with wide light absorption range,long-term stability and excellent selectivity for CO_(2) reduction makes the process ***,a core-shell-structured nonnoble-metal Ni@In co-catalyst loaded p-type silicon nanowire arrays(SiNWs)for efficient CO_(2) reduction to formate is *** formation rate and Faradaic efficiency of formate over the Ni@In/SiNWs catalyst reach 58μmol h^(-1) cm^(-2) and 87% under the irradiation of one simulated sunlight(AM 1.5 G,100 mW cm^(-2)),respectively,which are about 24 and 12 times those over the pristine *** enhanced photoelectrocatalytic performance for CO_(2) reduction is attributed to the rational combination of Ni capable of effectively extracting the photogenerated electrons and In responsible for the selective activation of CO_(2).

关键词： CO_(2)reduction Photoelectrocatalysis Core-shell-structured co-catalyst Silicon nanowire arrays

Fgf8^(P2A-3×GFP/+):A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells

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Neuroscience Bulletin 2023年第12期39卷 1762-1774页

作者： Yi Pan Shuting Li shunji He Guangqin wang Chao Li Zhiyong Liu Mingliang Xiang Department of Otolaryngology and Head and Neck Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China

The cochlear auditory epithelium contains two types of sound receptors,inner hair cells(IHCs)and outer hair cells(OHCs).Mouse models for labelling juvenile and adult IHCs or OHCs exist;however,labelling for embryonic and perinatal IHCs or OHCs are ***,we generated a new knock-in Fgf8^(P2A-3×GFP/+)(Fgf8^(GFP)/+)strain,in which the expression of a series of three GFP fragments is controlled by endogenous Fgf8 cis-regulatory *** confirming that GFP expression accurately reflects the expression of Fgf8,we successfully obtained both embryonic and neonatal IHCs with high purity,highlighting the power of Fgf8^(GFP)/+.Furthermore,our fate-mapping analysis revealed,unexpectedly,that IHCs are also derived from inner ear progenitors expressing Insm1,which is currently regarded as an OHC ***,besides serving as a highly favorable tool for sorting early IHCs,Fgf8^(GFP)/+will facilitate the isolation of pure early OHCs by excluding IHCs from the entire hair cell pool.

关键词： Fgf8 Inner Hair Cell Inner Ear-Cochlea

TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway

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Journal of Molecular Cell Biology 2015年第1期7卷 48-61页

作者： Cencan Xing Bo Gong Yu Xue Yanchao Han Yixia wang Anming Meng shunji Jia State Key Laboratory of Biomembrane and Membrane Engineering Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

The zebrafish sensory posterior lateral line(pLL)has become an attractive model for studying collective cell migration and cell *** studies have indicated that chemokine,Wnt/β-catenin,Fgf,and Delta-Notch signaling pathways participate in regulating pLL ***,it remains unclear whether TGFβsignaling pathway is involved in pLL *** we report a critical role of TGFβ1 in regulating morphogenesis of the pLL primordium(pLLP).The tgfβ1a gene is abundantly expressed in the lateral line *** or knockout of tgfβ1a leads to a reduction of neuromast number,an increase of inter-neuromast distance,and a reduced number of hair *** aberrant morphogenesis in embryos depleted of tgfβ1a correlates with the reduced expression of atoh1a,deltaA,and n-cadherin/cdh2,which are known important regulators of the pLLP *** tgfβ1a depletion,knockdown of smad5 that expresses in the pLLP,affects pLLP development whereas overexpression of a constitutive active Smad5 isoform rescues the defects in embryos depleted of tgfβ1a,indicating that Smad5 mediates tgfβ1a function in pLLP ***,TGFβ/Smad5 signaling plays an important role in the zebrafish lateral line formation.

关键词： zebrafish lateral line neuromast TGFβ1a Smad5

OBIA:An Open Biomedical Imaging Archive

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1059-1065页

作者： Enhui Jin Dongli Zhao Gangao Wu Junwei Zhu zhonghuang wang Zhiyao Wei Sisi Zhang Anke wang Bixia Tang Xu Chen Yanling Sun Zhe Zhang Wenming Zhao Yuanguang Meng National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Chinese People’s Liberation Army(PLA)Medical School Beijing 100853China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Obstetrics and Gynecology Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

With the development of artificial intelligence(AI)technologies,biomedical imaging data play an important role in scientific research and clinical application,but the available resources are *** we present Open Biomedical Imaging Archive(OBIA),a repository for archiving biomedical imaging and related clinical *** adopts five data objects(Collection,Individual,Study,Series,and Image)for data organization,and accepts the submission of biomedical images of multiple modalities,organs,and *** order to protect personal privacy,OBIA has formulated a unified de-identification and quality control *** addition,OBIA provides friendly and intuitive web interfaces for data submission,browsing,and retrieval,as well as image *** of September 2023,OBIA has housed data for a total of 937 individuals,4136 studies,24,701 series,and 1,938,309 images covering 9 modalities and 30 anatomical ***,OBIA provides a reliable platform for biomedical imaging data management and offers free open access to all publicly available data to support research activities throughout the *** can be accessed at https://***/obia.

关键词： Open Biomedical Imaging Archive Database Biomedical imaging De-identification Quality control

Plant genomic resources at National Genomics Data Center:assisting in data-driven breeding applications

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aBIOTECH 2024年第1期5卷 94-106页

作者： Dongmei Tian Tianyi Xu Hailong Kang Hong Luo Yanqing wang Meili Chen Rujiao Li Lina Ma zhonghuang wang Lili Hao Bixia Tang Dong Zou Jingfa Xiao Wenming Zhao Yiming Bao Zhang Zhang Shuhui Song National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences&China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences&China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Genomic data serve as an invaluable resource for unraveling the intricacies of the higher plant systems,including the constituent elements within and among *** various efforts in genomic data archiving,integrative analysis and value-added curation,the National Genomics Data Center(NGDC),which is a part of the China National Center for Bioinformation(CNCB),has successfully established and currently maintains a vast amount of database *** dedicated initiative of the NGDC facilitates a data-rich ecosystem that greatly strengthens and supports genomic research ***,we present a comprehensive overview of central repositories dedicated to archiving,presenting,and sharing plant omics data,introduce knowledgebases focused on variants or gene-based functional insights,highlight species-specific multiple omics database resources,and briefly review the online application *** intend that this review can be used as a guide map for plant researchers wishing to select effective data resources from the NGDC for their specific areas of study.

关键词： Plant-omics data Data repositories Data integration Knowledgebase Plant genomics

prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish

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Journal of Genetics and Genomics 2018年第8期45卷 443-453页

作者： Yixia wang Yanchao Han Pengfei Xu Shihui Ding Guangyuan Li Hongbin Jin Yaping Meng Anming Meng shunji Jia State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University

Prpf4 （pre-mRNA processing factor 4）, a key component of spliceosome, plays critical roles in pre-mRNA splicing and its mutations result in retinitis pigmentosa due to photoreceptor defects. In this study, we characterized a zebrafish prpf4t243 mutant harboring a Tol2 transposon-based gene trap cassette in the third intron of the prpf4 gene. Cells in the brain and spinal cord gradually undergo p53-dependent apoptosis after 28 hpf in prpf4t243 mutants, suggesting that a widespread function of prpf4 in neural cell survival. In addition, prpf4 is essential for survival of posterior lateral line primordial （pLLP） cells, prpf4 deficiency perturbs Fgf, Wnt/β-catenin and chemokine signaling pathways and impairs pLLP migration. RNA-Seq analysis suggests that prpf4 deficiency may impair spliceosome assembly, leading to compensatory upregulation of core spliceosomal genes and alteration of pre-mRNA splicing. Taken together, our studies uncover an essential role of prpf4 in pre-mRNA splicing, cell survival and pLLP migration.

关键词： prpf4 Splicing Apoptosisp LLP Zebrafish