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Analysis of professor wang yongyan's experience in treating hemorrhagic diseases based on traditional Chinese medicine inheritance support system

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TMR Theory and Hypothesis 2018年第3期1卷 63-71页

作者： Jun-Yu Wei Ze-wang Liu Ling-Yu Qi Chao Zhou Department of Oncology Weifang Traditional Chinese HospitalWeifangChina Yantaishan Hospital YantaiChina College of First Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250014ShandongChina

Based on the data analysis platform provided by TCMISS(V2.5),this paper analyzes the rule of prescribing drugs used by Professor yongyan wang for the treatment of apoplexy and deepens the understanding of his academic research on syndrome differentiation and *** wang’s medical records were summarized and sorted into the"Chinese Medicine inheritance Assistance system".Through the functions of"frequency statistics","drug use mode","rule analysis"and so on,the characteristics of professor yongyan wang's prescription for treating apoplexy were statistically *** is helpful to understand and inherit Professor wang's academic thoughts by analyzing the data of professor wang's medical records of apoplexy.

关键词： Apoplexy Syndrome differentiation TCM inheritance platform

A discussion about influenza from the perspective of"latent dryness"

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Journal of Traditional Chinese Medicine 2023年第5期43卷 839-840页

作者： wang yongyan WU Shengxian CHINA Academy Of Chinese Medical Sciences Beijing 100700China Dongzhimen Hospital Beijing University of Traditional Chinese MedicineBeijing 100700China

WU Qian discussed dryness:"Dry domination causing cold,transforming Qi into dampness,and retaliation of abnormal changes of climate or evolutive phases to fire."As the natural environment changes in the 21st century,the average annual temperature is greater than 2℃higher than before with the global population experiencing extreme heat causing a“latent dryness”within the body。

关键词： latent climate within

The scientific nature of traditional Chinese medicine in the post-modern era

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Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 195-200页

作者： yongyan wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

There is a growing need to understand traditional Chinese medicine(TCM)in modern scientific *** possesses the dual attributes of science and the *** present,medical science and technology are progressing,while humanistic ethics are being *** embodies the interaction between imagery and conceptual thinking,which can be explained from the following three aspects:imagery as an internal driving force for cultural rejuvenation,return to the true self and guarding of the root of life,and cosmology(harmony between man and nature).In the post-modern era,“people-oriented”medical values will lead to integrations between science and humanities,holism and reductionism,imagery-based thinking and conceptual thinking,systematic research and descriptive research,and evidence-based medicine and narrative medicine.

关键词： Sinology Image thinking Traditional Chinese medicine Discipline orientation Transformation and innovation

Quantifying the Mechanical Properties of White Sandstone Based on Computer Fractal Theory

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Computer Systems Science & Engineering 2021年第10期39卷 121-131页

作者： Yong wang yongyan wang Nan Qin Sa Huang Le Chang Shunzheng Hou School of Mechanical and Electrical Engineering Qingdao University of Science and TechnologyQingdao266061China

The work presented in this paper was conducted to quantify the relationship between the pore characteristics and mechanical properties of white *** study include tests carried out under the coupling effects of chemical corrosion,temperature,nuclear magnetic resonance,and mechanical *** fractal theory was employed to describe and quantify the characteristics of the growth of pores in white sandstone under the same coupling effect.A custom developed program code,in the MATLAB software platform,was used for calculating the growths of the pores in white sandstone when subjected to coupling *** correlation between the computer fractal dimension of the growth of the pores in rock and characteristics of mechanical damage was accordingly *** results showed that when the temperature was set at a level lower than 100°C,it caused damage to the rock and strength reduction,primarily due to the rates of chemical reactions,the generation,and evolution of pores in the rock mass under the coupling effects of chemical corrosion and ***,it was observed that the higher the value of the computer fractal dimension,the higher the growth of the pores,and the lower the uniaxial compressive strength of the white sandstone.

关键词： White sandstone pore characteristics mechanical properties MATLAB chemical corrosion temperature fractal dimension nuclear magnetic resonance

Research on the Novel Honeycomb-Like Cabin Based on Computer Simulation

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Computer Systems Science & Engineering 2021年第11期39卷 179-195页

作者： Yong wang yongyan wang Songmei Li Nan Qin Peng Du Tongtong Zhou School of Mechanical and Electrical Engineering Qingdao University of Science and TechnologyQingdao266061China

The antiknock capability and thermal protection performance of rescue capsules mainly depend on the structural design of the *** designing a new type of cabin structure,it can resist the impact of explosion shock waves and thermal *** this paper,a new honeycomb-like cabin is proposed;the model has a novel thermal insulation layer ***,the antiknock capabilities and thermal protection analysis are carried out by using computer ***“Autodyn”analysis module in ANSYS Workbench 17.0 has been used to simulate the explosion of TNT with a certain quality in a single *** pressure map over time and the pressure variation curve at different locations for a single room are *** the analysis module“Transient Structural,”the stress and deformation of the honeycomb-like cabin under the blast load are ***“Transient Thermal”analysis module in the finite element software is used to conduct a transient thermal analysis on the cabin *** temperature map and the temperature rise curve of each layer of the cabin cases are *** analysis results indicate that the honeycomb-like cabin design has a good antiknock capability and thermal protection performance,and it can meet the usage requirements of the rescue capsule under dangerous conditions.

关键词： The rescue capsule computer the honeycomb-like cabin the antiknock ability the thermal protection the thermal insulation layer

Shaoma Zhijing granule for children with tic disorders: A rapid health technology assessment

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 133-140页

作者： Xing Liao Xue Wu Zhong wang yongyan wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China

Objective:To rapidly assess the effectiveness,safety,economy,and applicability of Shaoma Zhijing granule(SZG)for the treatment of children with tic disorders(TD),and provide currently available best evidence for decision-makers of health ***:We conducted a rapid health technology assessment(RHTA)to explore the value of SZG.A systematic literature search in eight literature databases and on three clinical trial registration platforms was *** literature was screened according to eligibility *** screening process and data extraction were conducted by two reviewers,and the quality of the literature was also *** results were summarized,analyzed,and presented in tables or ***:A total of five randomized controlled trials(RCTs)were included in this study,of which one was published in English(in the Journal of Child Psychology and Psychiatry)and four in Chinese *** overall risk of bias for the five RCTs was evaluated as“some concerns.”SZG monotherapy or in combi-nation with tiapride was better than tiapride alone in improving traditional Chinese medicine(TCM)syndromes and tic symptoms,with a daily cost of¥*** events were mainly related to the digestive,respiratory,and neurological systems,but all were ***:Overall,the current RHTA of published,peer-reviewed literature has located a small body of evidence evaluating the use of SZG for the treatment of TD in *** has effects on improving TCM syndromes and tic symptoms;the daily cost is¥67.50e107.22;and all adverse events are ***-quality studies with long-term follow-up should be conducted,so as to provide local evidence and consistently guide and improve scientific decision-making.

关键词： Shaoma Zhijing granule Tic disorders Children Rapid health technology assessment Quality assessment

An MCIA-like complex is required for mitochondrial complex Ⅰ assembly and seed development in maize

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Molecular Plant 2022年第9期15卷 1470-1487页

作者： Gang wang yongyan wang Jiacheng Ni Rongrong Li Fengling Zhu Ruyin wang Qiuzhen Tian Qingwen Shen Qinghua Yang Jihua Tang Monika W.Murcha Guifeng wang National Key Laboratory of Wheat and Maize Crops Science CIMMYT--China Joint Center of Wheat and MaizeCenter for Crop Genome EngineeringCollege of AgronomyHenan Agricultural UniversityZhengzhou 450046China Shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai 200444China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China School of Molecular Sciences&The ARC Centre of Excellence in Plant Energy Biology The University of Western Australia35 Stirling HighwayCrawleyPerthWA 6009Australia The Shennong Laboratory ZhengzhouHenan 450002China

During adaptive radiation,mitochondria have co-evolved with their hosts,leading to gain or loss of subunits and assembly factors of respiratory *** mitochondrial complex Ⅰ harbors40 nuclearand 9 mitochondrial-encoded subunits,and is formed by stepwise assembly during which different intermediates are integrated via various assembly *** mammals,the mitochondrial complex Ⅰ intermediate assembly(MCIA)complex is required for building the membrane arm ***,plants have lost almost all of the MCIA complex components,giving rise to the hypothesis that plants follow an ancestral pathway to assemble the membrane arm ***,we characterize a maize crumpled seed mutant,crk1,and reveal by map-based cloning that CRK1 encodes an ortholog of human complex Ⅰ assembly factor 1,zNDUFAF1,the only evolutionarily conserved MCIA subunit in ***1 is localized in the mitochondria and accumulates in two intermediate complexes that contain complex Ⅰ membrane arm *** of zNDUFAF1 results in severe defects in complex Ⅰ assembly and activity,a cellular bioenergetic shift to aerobic glycolysis,and mitochondrial ***,we found that zNDUFAF1,the putative mitochondrial import inner membrane translocase ZmTIM17-1,and the isovaleryl-coenzyme A dehydrogenase ZmIVD1 interact each other,and could be co-precipitated from the mitochondria and co-migrate in the same assembly *** of either ZmTIM17-1 or ZmIVD1 could lead to the significantly reduced complex Ⅰ stability and activity as well as defective *** results suggest that zNDUFAF1,ZmTIM17-1 and ZmIVD1 probably form an MCIA-like complex that is essential for the biogenesis of mitochondrial complex Ⅰ and seed development in *** findings also imply that plants and mammals recruit MCIA subunits independently for mitochondrial complex Ⅰ assembly,highlighting the importance of parallel evolution in mitochondria adaptation to their hosts.

关键词： assembly factor CIA30 evolution maize MCIA complex mitochondria seed development

A partial pathway- and network-based transformation reveals the synergistic mechanism of JA and UA against cerebral ischemia-reperfusion injury

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Protein & Cell 2014年第11期5卷 873-877页

作者： Shanshan Guo Li Guo Yanan Yu Bing Li YingyingZhang Haixia Li Ping Wu Jie wang Ye Yuan Zhong wang yongyan wang Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical Sciences Beijing 100700 China

Dear Editor, Ischemic stroke falls under the category of complex diseases, which do not obey the single-gene dominant or single-gene recessive Mendelian pattern of inheritance but rather arises from the combination of numerous genetic variants and environmental factors （Cho et al., 2012）. Given this degree of complexity, a single compound could never be expected to manage or reverse the effects of a stroke. Recently there has been accumulating evidence suggesting that combination therapies could exert a significant effect on areas affected by a cerebral ischemic stroke. Combination therapies that simultaneously impact multiple targets have promise in the control of complex diseases by way of synergy （Li et al., 2011）.

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Validation of traditional Chinese medicine terminology:Crucial steps for inheritance,development,and in-depth internationalization of traditional Chinese medicine

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Science of Traditional Chinese Medicine 2024年第3期2卷 181-182页

作者： yongyan wang Luqi Huang China Academy of Chinese Medical Sciences BeijingChina

Traditional Chinese medicine(TCM)is a gem of the Chinese nation,a key to unlocking the treasure trove of Chinese civilization,and a precious gift to the people of China and the *** thousands of years of medical practice,it encapsulates profound philosophical thoughts and extensive practical *** society evolves,TCM faces challenges caused by confusion and inconsistencies in language expression,nomenclature,and terminology,which hinder efficient academic communication and international ***,validating and approving TCM terminology are crucial for the inheritance,development,and in-depth internationalization of TCM.

关键词： terminology steps hinder