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达格列净治疗糖尿病冠心病合并心功能不全的疗效观察

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西部医学 2024年第3期36卷 411-415页

作者：黄琴郭良敏王引利侯维维张舒慧成都市第三人民医院心内二科四川成都610014

目的探讨在常规治疗基础上,达格列净对糖尿病冠心病合并心功能不全患者心脏功能和疗效的影响。方法选取2018年5月—2021年6月我院收治的糖尿病冠心病合并心功能不全患者134例为研究对象,采用随机数字表通过简单随机的方法将其分为观... 详细信息

目的探讨在常规治疗基础上,达格列净对糖尿病冠心病合并心功能不全患者心脏功能和疗效的影响。方法选取2018年5月—2021年6月我院收治的糖尿病冠心病合并心功能不全患者134例为研究对象,采用随机数字表通过简单随机的方法将其分为观察组与对照组,每组67例。两组均给予基础降糖治疗、基础心力衰竭治疗以及冠心病治疗,观察组在上述治疗基础上,给予达格列净治疗,两组均连续治疗6个月,比较两组治疗前后心功能指标[N末端脑钠素前体(NT-proBNP)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)以及纽约心脏病协会(NYHA)分级及6 min步行测试],血糖指标[空腹血糖(FPG)及餐后2 h血糖(2 h FPG)、糖化血红蛋白(HbA1c)]、不良反应情况,随访180 d,比较两组不良心血管事件发生率。结果治疗后,观察组各项指标均较治疗前有明显改善(P0.05),对照组1例发生心源性死亡,观察组无死亡病例,观察组严重心律失常发生率低于对照组(P<0.05)。结论在常规治疗基础上,达格列净治疗糖尿病冠心病合并心功能不全疗效显著,在降低血糖、改善患者心功能方面效果明显,对于降低不良心血管事件发生率有重要应用价值,可在临床推广运用。

关键词：达格列净糖尿病冠心病心功能不全疗效

A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1457-1466页

作者： Yaqin Wei Xiangqing Xu Qiang Guo Song Zhao yinli Qiu Dongli wang Wenwen Yu Yani Liu KeWei wang School of Pharmacy Xuzhou Medical UniversityXuzhou 221004China Institute of Pharmaceutical Research Jiangsu Nhwa Pharmaceutical Co.Ltd.&Jiangsu Key Laboratory of Central Nervous System Drug Research and DevelopmentXuzhou 221116China Department of Pharmacology School of PharmacyQingdao University Medical CollegeQingdao 266073China Institute of Innovative Drug Qingdao UniversityQingdao 266021China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510515China

Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving *** this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in cognition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on *** administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like ***,D01 dose-dependently improves the cognitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or scopolamine-induced cognitive deficits in mice,but not ***,D01 reverses the long-term potentiation(LTP)inhibition induced by *** together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and cognitive deficits,thus holding potential for development as therapy of depression with cognitive deficits.

关键词： SERT 5-HT Kv7/KCNQ/M current D01 Depression Cognition

Occurrence,Spatial Distribution,Sources and Risk Assessment of Per-and Polyfluoroalkyl Substances in Surface Sediments of the Yellow River Delta Wetland

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Journal of Ocean University of China 2024年第5期23卷 1263-1274页

作者： SUN Yu SHEN Nan ZHANG Dahai CHEN Junhui HE Xiuping JI yinli wang Haiyang LI Xianguo Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China Key Laboratory of Marine Eco-Environmental Science and Technology First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Qingdao Key Laboratory of Analytical Technology Development and Offshore Eco-Environment Conservation Qingdao 266061China The Yellow River Delta Sustainable Development Institute of Shandong Province Dongying 257100China

Per-and polyfluoroalkyl substances(PFASs)are emerging persistent organic pollutants(POPs).In this study,47 surface sediment samples were collected from the Yellow River Delta wetland(YRDW)to investigate the occurrence,spatial distribution,potential sources,and ecological risks of ***-three out of 26 targeted PFASs were detected in surface sediment samples from the YRDW,with totalΣ23PFASs concentrations ranging from 0.23 to 16.30 ng g^(-1) dw and a median value of 2.27 ng g^(-1) *** acid(PFOA),perfluorobutanoic acid(PFBA)and perfluorooctanesulfonic acid(PFOS)were the main *** detection frequency and concentration of perfluoroalkyl carboxylic acids(PFCAs)were higher than those of perfluoroal-kanesulfonic acids(PFSAs),while those of long-chain PFASs were higher than those of short-chain *** emerging PFASs substitutes were dominated by 6:2 chlorinated polyfluoroalkyl ether sulfonic acid(6:2 Cl-PFESA).The distribution of PFASs is significantly influenced by the total organic carbon content in the *** concentration of PFASs seems to be related to human activities,with high concentration levels of PFASs near locations such as beaches and *** using a positive matrix factorization model,the potential sources of PFASs in the region were identified as metal plating mist inhibitor and fluoropolymer manufacturing sources,metal plating industry and firefighting foam and textile treatment sources,and food packaging material *** risk assessment indicated that PFASs in YRDW sediments do not pose a significant ecological risk to benthic organisms in the region overall,but PFOA and PFOS exert a low to moderate risk at individual stations.

关键词： per-and polyfluoroalkyl substances Yellow River Delta wetland sediment source identification risk assessment

Efficacy Evaluation of a Compound Plant Extract Used in Makeup Base

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China Detergent & Cosmetics 2021年第1期6卷 65-73页

作者： Huang Hongbin wang yinli Zeng Lanlan Feng Di Wu Jinhao Guangzhou Cadilan Cosmetics Technology Co. Ltd.China Beijing Technology and Business University China Beijing Yiweishi Testing Technology Co. China

Cytological test and human skin test were used to study the antioxidant,anti-aging and moisturizing effects of a compound plant extract,and to evaluate its *** cytological test results showed that the compound extract could significantly scavenge the reactive oxygen species(ROS)generated by H2O2 stimulation and protect cells from oxidative *** can significantly inhibit the expression of matrix metalloproteinase-1(MMP-1).The results of human skin test showed that the moisture content of cheek stratum corneum,R2 value and Q1 value of skin elasticity were significantly improved after 28 days of continuous use of the Makeup Base product added with the compound plant *** Ra value,Rz value and Rt value of skin texture around eyes have been significantly improved,which shows that the product has the effects of improving the moisture content of stratum corneum,improving skin elasticity and diminishing the fine lines around the eyes;the product has good safety.

关键词： makeup base natural plants compound extract efficacy study

未写出的政治哲学——阿伦特对康德判断力概念的政治阐释

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社会科学 2006年第9期 126-132页

作者：王寅丽华东师范大学哲学系

阿伦特将康德的《判断力批判》视为“他未写出的政治哲学”,她从康德对审美判断的考察中找到了一切实践判断得以可能的条件:趣味、共通感,扩大思考和范例的有效性,从而阐发了判断活动的政治意义。同时,阿伦特对康德判断力概念的接受也... 详细信息

阿伦特将康德的《判断力批判》视为“他未写出的政治哲学”,她从康德对审美判断的考察中找到了一切实践判断得以可能的条件:趣味、共通感,扩大思考和范例的有效性,从而阐发了判断活动的政治意义。同时,阿伦特对康德判断力概念的接受也暴露出她本人政治思想的形式化、非认识化和审美化的问题。

关键词：反思判断趣味共通感审美化

现代共和思想的时间意识:以波考克和阿伦特为例

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学术月刊 2017年第1期49卷 36-41页

作者：王寅丽华东师范大学哲学系副教授上海200241

作为当代共和主义复兴的代表人物,阿伦特和波考克的共和主张来自现象学和史学建构的不同背景。但在他们不同的理论诠释背后,隐含着对政治近似的本体论假定和时间想象。藉由波考克的公民人文主义话语,这种时间想象得以揭示,他把共和主义... 详细信息

作为当代共和主义复兴的代表人物,阿伦特和波考克的共和主张来自现象学和史学建构的不同背景。但在他们不同的理论诠释背后,隐含着对政治近似的本体论假定和时间想象。藉由波考克的公民人文主义话语,这种时间想象得以揭示,他把共和主义解释为现代早期与基督教神圣时间相抗衡的政治模式。而阿伦特的共和主义则试图以"开端时间"来抵御现代的"过程时间",并以开端的自我奠基来解决共和国的持久性问题。他们两人对时间性的共同关注,表明他们都反对把现代视为一种无休止的进步过程,或围绕着对"物的管理"展开的均质流动的时间。对他们来说,共和国体现了人以行动开辟空间来克服时间的努力,对政治的热情乃是出于人类在真正意义的世俗王国中寻求不朽的渴望。同时,他们关于共和主义的时间模式仍有差别,这种差别解释了他们对美国革命的不同态度。

关键词：时间意识公民人文主义开端时间世俗时间

Study on the Factors Affecting the Darkening of Liquid Foundations

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China Detergent & Cosmetics 2022年第1期7卷 60-64页

作者： Huang Hongbin wang yinli Zhang Jiaqi Wu Na Zeng Lanlan Guangzhou Cadlin Cosmetics Technology Co. Ltd.China

To explore the factors affecting the darkening of liquid foundations,the liquid foundations containing differently treated titanium dioxide and different types of filling powders were studied from three aspects,including sebum,sweat and *** darkening factors of liquid foundations were analyzed by comparing the luminance difference using color *** results showed that sebum is the main cause of the darkening effect,and the impact of sweat and light are less.

关键词： liquid foundation darkening sebum sweat light color spectrophotometer

海德格尔和阿伦特对奥古斯丁《忏悔录》第十卷的解读

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哲学分析 2023年第2期14卷 67-78,197页

作者：王寅丽上海科技大学人文科学研究院

海德格尔的《奥古斯丁与新柏拉图主义》和阿伦特的《爱与圣奥古斯丁》都以对奥古斯丁《忏悔录》第十卷的解读为重点,都是从“事实生命经验”的角度来解读第十卷,并通过奥古斯丁论幸福生活的阐释,分别引向对“诱惑”和“爱”的现象学阐明... 详细信息

海德格尔的《奥古斯丁与新柏拉图主义》和阿伦特的《爱与圣奥古斯丁》都以对奥古斯丁《忏悔录》第十卷的解读为重点,都是从“事实生命经验”的角度来解读第十卷,并通过奥古斯丁论幸福生活的阐释,分别引向对“诱惑”和“爱”的现象学阐明;海德格尔的“诱惑现象学”强调诱惑是真实经验生活的本质,而阿伦特的“爱”重视记忆带来的反思和自我构建。阿伦特在奥古斯丁论文中显示出的与海德格尔的思想差异,为她“爱世界”的政治思想作了准备。

关键词：奥古斯丁诱惑爱世界

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双分数跳-扩散过程下后定选择权定价

山西大学学报(自然科学版) 2017年第1期40卷 51-56页

作者：薛红王银利西安工程大学理学院

假定股票价格服从双分数布朗运动和泊松过程共同驱动的随机微分方程,股票预期收益率,无风险利率和股价波动率均为常数,建立双分数跳-扩散环境下金融数学模型,利用保险精算方法,结合双分数跳-扩散随机分析理论研究后定选择权定价问题,得... 详细信息

假定股票价格服从双分数布朗运动和泊松过程共同驱动的随机微分方程,股票预期收益率,无风险利率和股价波动率均为常数,建立双分数跳-扩散环境下金融数学模型,利用保险精算方法,结合双分数跳-扩散随机分析理论研究后定选择权定价问题,得出了双分数跳-扩散环境下后定选择权定价公式。

关键词：后定选择权双分数布朗运动跳-扩散过程保险精算方法