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The interaction between gut microbiota and chronic kidney disease and the prospects of probiotic intervention

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Food Science and Human Wellness 2024年

作者： Yang Meng Maozhen Zhao Haiyan Lu Huaxi yi zhe Zhang Lanwei Zhang College of Food Science and Engineering， Ocean University of China

Chronic kidney disease (CKD) is a progressive disease with high morbidity and mortality. Disturbed gut microbiota and toxin accumulation are the main pathologic features of CKD. Current treatments are limited to those that alleviate renal impairment in CKD patients， but few interventions are available that specifically target the regulatory mechanisms of gut microbiota. In this context， researchers urgently need new approaches that can significantly improve survival time and quality of life in these patients. In this review， we outline the involvement of the gut-kidney axis in kidney injury through disturbances of gut microbiota and dysregulation of endogenous metabolites， as well as the prominent contribution of gut microbiota in the discovery of CKD that can be used to prevent， diagnose， and treat CKD. Next， we describe several major metabolites associated with the host-gut microbiota that arise from the synthesis of microbial nutrient transformations and subsequent interactions with the kidney. Then， we summarize the role and potential targets of a compromised gut barrier in CKD. Finally， we discuss research advances in the prevention and treatments of CKD through probiotics modulation of gut microbiota structure to reduce enterogenous toxins and their maintenance of gut barrier function. A growing body of research suggests that intervention through probiotics may be a new and promising therapeutic strategy for CKD.

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Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou Tian-yi Ren Jia-Qi Li Ting-ying Jiao Meng-Yu wang Lei-Jie Huang Shuang-zhe Lin Yuan-Yang wang Xiao-zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

Intelligent diagnostic model for pterygium by combining attention mechanism and MobileNetV2

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1184-1192页

作者： Mao-Nian Wu Kai He yi-Bei Yu Bo zheng Shao-Jun Zhu Xiang-Qian Hong Wen-Qun Xi zhe Zhang School of Information Engineering Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina zhejiang Province Key Laboratory of Smart Management and Application of Modern Agricultural Resources Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Mathematical Information Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To evaluate the application of an intelligent diagnostic model for ***:For intelligent diagnosis of pterygium,the attention mechanisms—SENet,ECANet,CBAM,and Self-Attention—were fused with the lightweight MobileNetV2 model structure to construct a tri-classification *** study used 1220 images of three types of anterior ocular segments of the pterygium provided by the Eye Hospital of Nanjing Medical *** classification models—VGG16,ResNet50,MobileNetV2,and EfficientNetB7—were trained on the same dataset for *** evaluate model performance in terms of accuracy,Kappa value,test time,sensitivity,specificity,the area under curve(AUC),and visual heat map,470 test images of the anterior segment of the pterygium were ***:The accuracy of the MobileNetV2+Self-Attention model with 281 MB in model size was 92.77%,and the Kappa value of the model was 88.92%.The testing time using the model was 9ms/image in the server and 138ms/image in the local *** sensitivity,specificity,and AUC for the diagnosis of pterygium using normal anterior segment images were 99.47%,100%,and 100%,respectively;using anterior segment images in the observation period were 88.30%,95.32%,and 96.70%,respectively;and using the anterior segment images in the surgery period were 88.18%,94.44%,and 97.30%,***:The developed model is lightweight and can be used not only for detection but also for assessing the severity of pterygium.

关键词： deep learning attention mechanism pterygium intelligent diagnosis

Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-Xiang Zhao San-Gang Li Rong-Rong Su Li Yang Ming-zhe Liu Qing-Yue Xue Shan Liao Zhi Zhou Qing-Shan Tan Xian-Guo Tuo yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization *** system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement *** conducted under normal temperature conditions has demonstrated the system's high precision ***,it was observed that temperature variations can affect the measurement *** were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this *** feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature *** research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

选择性萃取对沉积物非残渣态、粘土矿物结构及吸附特性的影响

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高等学校化学学报 2008年第2期29卷 288-293页

作者：王晓丽李鱼王一喆董德明李绪谦吉林大学环境与资源学院长春130012 华北电力大学能源与环境研究中心北京102206 中国科学院长春应用化学研究所长春130022

用NH2OH·HCl,(NH4)2C2O4和H2O2对表层沉积物中非残渣态的Mn氧化物、Fe/Mn氧化物和有机质进行选择性化学萃取,同时提取粘土矿物,并对提取前后的表层沉积物样品进行了比表面积、FTIR、ES-EM和XRD等分析.结果表明,萃取后沉积物的比表面积... 详细信息

用NH2OH·HCl,(NH4)2C2O4和H2O2对表层沉积物中非残渣态的Mn氧化物、Fe/Mn氧化物和有机质进行选择性化学萃取,同时提取粘土矿物,并对提取前后的表层沉积物样品进行了比表面积、FTIR、ES-EM和XRD等分析.结果表明,萃取后沉积物的比表面积显著增大,沉积物颗粒的分散度随之增大,晶体边缘逐渐清晰,棱角逐渐分明,但沉积物的XRD和FTIR谱图变化不大,原因在于XRD和FTIR谱图中的特征峰主要是由矿物组分产生的.萃取后随着沉积物分散度的增大,晶体颗粒表面粗糙度减弱,沉积物的吸附能力降低,表明颗粒表面特征对重金属的吸附起到一定作用;而沉积物的比表面积与沉积物吸附能力之间的反比关系说明沉积物主要吸附组分对其吸附的贡献远远大于沉积物表面与孔隙结构的贡献.

关键词：表层沉积物选择性萃取 Fe/Mn氧化物粘土矿物吸附

Bilateral choroidal ganglioneuroma:a comprehensive analysis of vision decline in a 6-year-old boy

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1755-1759页

作者： yi-zhe Cheng Li-Mei Sun Min-Er Yuan Lin-Yan Zhang Shu-Ya Ke Xiao-Yan Ding State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Guangdong Provincial Clinical Research Center for Ocular Diseases Guangzhou 510060Guangdong ProvinceChina

Dear Editor,We write to present a 6-year-old boy with bilateral choroidal ganglioneuroma(CG)by comprehensive multimodal imaging(MMI)in a duration of 6-year *** our knowledge,this is the first case report with elaborate data to delineate the natural history of visual function and MMI in a boy with rare bilateral CG,confirmed by choroid biopsy.

关键词： comprehensive modal fir

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内模结构的汽车排气噪声有源控制研究及仿真

计算机仿真 2013年第7期30卷 156-159,169页

作者：王懿喆吴伟蔚上海工程技术大学上海201620

研究了基于内模反馈结构的汽车排气噪声有源控制方法,使用Shann。n-Bode方法和RLS自适应逆建模方法建立了次级通道的逆模型,并分析控制系统的鲁棒稳定性和鲁棒性能。针对模型误差对控制性能的影响提出一种基于粒子群优化算法调整反馈滤... 详细信息

研究了基于内模反馈结构的汽车排气噪声有源控制方法,使用Shann。n-Bode方法和RLS自适应逆建模方法建立了次级通道的逆模型,并分析控制系统的鲁棒稳定性和鲁棒性能。针对模型误差对控制性能的影响提出一种基于粒子群优化算法调整反馈滤波器参数的控制方法。在Matlab/Simulink中搭建了次级通道RLS自适应逆建模模型和汽车排气噪声有源控制模型,仿真结果表明使用粒子群优化算法对反馈滤波器参数进行在线调整的内模控制方法能够进一步提高汽车排气噪声有源控制的效果。

关键词：内模控制香农伯德方法自适应逆建模粒子群优化噪声有源控制

粘土矿物的掺杂对沉积物吸持Cu、Zn能力的影响

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吉林大学学报（地球科学版） 2010年第1期40卷 183-187页

作者：王晓丽李鱼王一喆杜显元王婷刘建林吉林大学植物科学学院长春130062 吉林大学环境与资源学院长春130012 华北电力大学能源与环境研究中心北京102206

通过考察粘土矿物及掺杂粘土矿物前后沉积物的吸附/解吸特性,分析了伊利石与蒙脱石对重金属污染沉积物中Cu与Zn稳定固定化的可行性。结果表明:伊利石与蒙脱石的掺杂均降低了沉积物吸持Cu的能力(最大下降量分别为5.4%和3.8%),伊利石的掺... 详细信息

通过考察粘土矿物及掺杂粘土矿物前后沉积物的吸附/解吸特性,分析了伊利石与蒙脱石对重金属污染沉积物中Cu与Zn稳定固定化的可行性。结果表明:伊利石与蒙脱石的掺杂均降低了沉积物吸持Cu的能力(最大下降量分别为5.4%和3.8%),伊利石的掺杂同样降低了沉积物吸持Zn的能力(最大下降量为4.4%),但蒙脱石掺杂后沉积物吸持Zn的能力明显增强,最高增加5.7%。因此,蒙脱石具有固定污染沉积物中Zn的能力,但不能提高污染沉积物中Cu的稳定性。

关键词：沉积物伊利石蒙脱石固定化吸持能力

马克思主义人力资本思想的理论基础及现实意蕴

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唐山师范学院学报 2007年第1期29卷 87-89页

作者：王轶喆西北大学公共管理学院陕西西安710069

马克思主义人力资本思想内在地统一于马克思主义劳动价值论和人的全面发展理论。作为手段,这个思想是其劳动价值论在实践意义上的延伸和发展,人力资本存量的不断积聚是经济社会全面进步和人的发展的物质前提和唯一活的手段;作为目的,这... 详细信息

马克思主义人力资本思想内在地统一于马克思主义劳动价值论和人的全面发展理论。作为手段,这个思想是其劳动价值论在实践意义上的延伸和发展,人力资本存量的不断积聚是经济社会全面进步和人的发展的物质前提和唯一活的手段;作为目的,这个思想是其人本思想和人的全面发展理论在实践意义上的延伸和发展,人力资本质量的全面提升是以人为本实现人真正占有自身本质的价值所在和必然回归。

关键词：马克思主义人力资本思想劳动价值论人本思想人的全面发展