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Enhancing thermoelectric performance in P-type Mg_(3)Sb_(2)-based Zintls through optimization of band gap structure and nanostructuring

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Journal of Materials Science & Technology 2024年第3期170卷 25-32页

作者： yi-bo Zhang Ji-Sheng Liang Chengyan Liu Qi Zhou zhe Xu Hong-bo Chen Fu-cong Li ying Peng Lei Miao Guangxi Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationSchool of Material Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory for Relativity Astrophysics Center on Nanoenergy ResearchGuangxi Key Laboratory of Processing for Nonferrous Metal and Featured MaterialsSchool of Physical Science&TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic TechnologySchool of Information and CommunicationGuilin 541004China

P-type Mg_(3)Sb_(2)-based Zintls have attracted considerable interest in the thermoelectric(TE)field due to their environmental friendliness and low ***,compared to their n-type counterparts,they show relatively low TE performance,limiting their application in TE *** this work,we simultaneously introduce Bi alloying at Sb sites and Ag doping at Mg sites into the Mg_(3)Sb_(2)to coopera-tively optimize the electrical and thermal properties for the first time,acquiring the highest ZT value of∼0.85 at 723 K and a high average ZT of 0.39 in the temperature range of 323-723 K in sample Mg_(2.94)Ag_(0.06)Sb_(1.9)Bi_(0.1).The first-principle calculations show that the codoping of Ag and Bi can shift the Fermi level into the valence band and narrow the band gap,resulting in the increased carrier concentration from 3.50×10^(17)cm^(-3)in the reference Mg 3 Sb 0.9 Bi 0.1 to∼7.88×10^(19)cm^(-3)in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi *** a result,a remarkable power factor of∼778.9μW m^(-1)K^(-2)at 723 K is achieved in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi ***,a low lattice thermal conductivity of∼0.48 W m^(-1)K^(-1)at 723 K is also obtained with the help of phonon scattering at the distorted lattice,point defects,and nano-precipitates in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi *** synergistic effect of using the multi-element co-doping/-alloying to optimize electrical properties in Mg_(3)Sb_(2)holds promise for further improving the TE performance of Zintl phase materials or even others.

关键词： Thermoelectric materials Band engineering Nanostructuring P-type Mg_(3)Sb_(2) Ag and Bi Co-doping

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Persistence of charge density wave against variation of band structures in V_(x)Ti_(1−x)Se_(2)(x=0–0.1)

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Nano Research 2024年第3期17卷 2129-2135页

作者： Zhanfeng Liu Tongrui Li Wen Zhu Hongwei Shou Mukhtar Lawan Adam Qilong Cui Yuliang Li Sheng wang Yunbo Wu Hongen Zhu yi Liu Shuangming Chen Xiaojun Wu Shengtao Cui Li Song zhe Sun National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China School of Chemistry and Materials Sciences CAS Key Laboratory of Materials for Energy Conversionand CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China School zhejiang Institute of Photonelectronics Jinhua 321004China

Charge density wave(CDW)is a phenomenon that occurs in materials,accompanied by changes in their intrinsic electronic *** study of CDW and its modulation in materials holds tremendous significance in materials research,as it provides a unique approach to controlling the electronic properties of ***_(2) is a typical layered material with a CDW phase at low *** V substitution for Ti in TiSe_(2),we tuned the carrier concentration in V_(x)Ti_(1-x)Se_(2) to study how its electronic structures ***-resolved photoemission spectroscopy(ARPES)shows that the band-folding effect is sustained with the doping level up to 10%,indicating the persistence of the CDW phase,even though the band structure is strikingly different from that of the parent compound TiSe_(2).Though CDW can induce the band fold effect with a driving force from the perspective of electronic systems,our studies suggest that this behavior could be maintained by lattice distortion of the CDW phase,even if band structures deviate from the electron-driven CDW *** work provides a constraint for understanding the CDW mechanism in TiSe_(2),and highlights the role of lattice distortion in the band-folding effect.

关键词： charge density wave band structure lattice distortion

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Utility of real-time 3D visualization system in the early stage of phacoemulsification training

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 577-582页

作者： zhe Xu Dan Chen Jing-Wei Xu yi-Xuan Feng Ce Shi Li Zhang Wen Xu Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina zhejiang Provincial Key Laboratory of Ophthalmology Hangzhou 310009Zhejiang ProvinceChina zhejiang Provincial Clinical Research Center for Eye Diseases Hangzhou 310009Zhejiang ProvinceChina zhejiang Provincial Engineering Institute on Eye Diseases Hangzhou 310009Zhejiang ProvinceChina

●AIM:To determine the teaching effects of a real-time three dimensional(3D)visualization system in the operating room for early-stage phacoemulsification training.●METHODS:A total of 10 ophthalmology residents of the first-year postgraduate were *** the residents were novices to cataract ***-time cataract surgical observations were performed using a custom-built 3D visualization *** training lasted 4wk(32h)in all.A modified International Council of Ophthalmology’s Ophthalmology Surgical Competency Assessment Rubric(ICO-OSCAR)containing 4 specific steps of cataract surgery was *** self-assessment(self)and expert-assessment(expert)were performed through the microsurgical attempts in the wet lab for each participant.●RESULTS:Compared with pre-training assessments(self 3.2±0.8,expert 2.5±0.6),the overall mean scores of posttraining(self 5.2±0.4,expert 4.7±0.6)were significantly improved after real-time observation training of 3D visualization system(P<0.05).Scores of 4 surgical items were significantly improved both self and expert assessment after training(P<0.05).●CONCLUSION:The 3D observation training provides novice ophthalmic residents with a better understanding of intraocular microsurgical *** is a useful tool to improve teaching efficiency of surgical education.

关键词： 3D visualization system phacoemulsification training wet lab

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Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway

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Food Science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang zhe Zhang Xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi yi Pimin Gong Lanwei Zhang Department of Nutrition and Food Hygiene School of public healthQingdao UniversityQingdao 266071China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic *** model ApoE^(-/-)mice were orally administered with *** F1-7 for 12 *** probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory *** widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after *** F1-7 *** analysis proved that ALC was associated with atherosclerotic inflammatory *** using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB ***,our results revealed that *** F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

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Screening of Anti-SIV Drugs from Chinese Medicinal Herbs

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Chinese Journal of Integrative Medicine 1995年第1期1卷 134-136页

作者： Guan Chong-fen(关崇芬) wang yi-zhe(王忆浙) (Institute of Basic Theory, China Academy of Traiditional Chinese Medicine, Beijing)(100700)Wu Xiao-xian (吴小闲) He Fu-qiu(何伏秋) Tu Xin-ming(涂新明) (Institute of Laboratory Animal Science, Chinese Academy o Institute of Basic Theory China Academy of Traiditional Chinese Medicine Beijing Institute of Laboratory Animal Science Chinese Academy of Medical Sciences Beijing

The inhibitory activities of more than 40 species of Chinese medicinal herbs or their singlechemical components against simian immunodeficiency virus (SIV) have been studied. The study revealedthat four species of medicinal herbs and a single chemical component had a more than 50% inhtbition ef-fect on SIV antigen expression. and the inhibitory rate of five other herbs on SIV antigen expression wasbetween 30%-50%. The results suggest Chinese medicinal herbs could inhibit SIV activity.

关键词： acquired immunodeticiency syndrome Chinese medicinal herbs. simian immunodefi-ciency virus

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新型的鱼眼坑加工刀柄

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煤矿机械 2018年第2期39卷 78-79页

作者：王毅哲吴焱陕西工业职业技术学院陕西咸阳712000 中船重工第十二研究所陕西咸阳713102

鱼眼坑即锪孔加工时,一般在镗床或者铣床上采用普通的圆柱铣刀进行加工。对于比较深的,或者外圆上的鱼眼坑加工时,需要较长刀具,往往出现刀具悬臂刚度不高,精度低、加工效率低的情况。根据加工大型剖分式滑动轴承外圆上的鱼眼坑的生产实... 详细信息

鱼眼坑即锪孔加工时,一般在镗床或者铣床上采用普通的圆柱铣刀进行加工。对于比较深的,或者外圆上的鱼眼坑加工时,需要较长刀具,往往出现刀具悬臂刚度不高,精度低、加工效率低的情况。根据加工大型剖分式滑动轴承外圆上的鱼眼坑的生产实践,针对传统的几种加工方法进行了分析和改进。设计出一种新型安装面铣刀的鱼眼坑加工刀柄,可以有效提高刀具刚度,提升加工效率,改善加工精度。

关键词：刀柄鱼眼坑镗床加工

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The transgenerational effects of maternal low-protein diet during lactation on offspring

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Journal of Genetics and Genomics 2024年第8期51卷 824-835页

作者： Lin-Jian Gu Li Li Qian-Nan Li Ke Xu Wei Yue Jing-yi Qiao Tie-Gang Meng Ming-zhe Dong Wen-Long Lei Jia-Ni Guo zhen-Bo wang Qing-Yuan Sun State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute of Laboratory Animal Sciences CAMS&PUMCBeijing 100021China Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health Guangdong-Hong Kong Metabolism&Reproduction Joint LaboratoryReproductive Medicine CenterGuangdong Second Provincial General HospitalGuangzhouGuangdong 510317China

Environmental factors such as diet and lifestyle can influence the health of both mothers and ***,its transgenerational transmission and underlying mechanisms remain largely ***,using a maternal lactation-period low-protein diet(LPD)mouse model,we show that maternal LPD during lactation causes decreased survival and stunted growth,significantly reduces ovulation and litter size,and alters the gut microbiome in the female LPD-F1 *** transcriptome of LPD-F1 metaphase II(MII)oocytes shows that differentially expressed genes are enriched in female pregnancy and multiple metabolic ***,maternal LPD causes early stunted growth and impairs metabolic health,which is transmitted over two *** methylome alteration of LPD-F1 oocytes can be partly transmitted to the F2 ***,our results reveal that LPD during lactation transgenerationally affects offspring health,probably via oocyte epigenetic changes.

关键词： Lactationdiet Maternal low-proteindiet DNAmethylation Transgenerational effect Oocyte

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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun Zhang Meng-Xia Zhang Xiao-Xiang Meng Jing Zhu Jia-Jun wang yi-Fan He Ye-Hua Li Si-Cong Zhao zhe-Min Shi Li-Na zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

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应激诱导小胶质细胞激活在抑郁症中的机制研究及中药的调节作用

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中国中药杂志 2023年第16期48卷 4285-4294页

作者：孙怿泽赵海滨王哲义北京中医药大学北京100029 山东大学齐鲁医院(青岛) 山东青岛266035 北京中医药大学东方医院北京100078

抑郁症患病率高,疾病负担重,应激事件在抑郁症的发生发展中起到关键的推动和促发作用,但由于其复杂性和异质性,其病理机制至今仍未被完全阐明。近年来,神经炎症作为抑郁症的病理机制受到广泛关注,激活的小胶质细胞被认为是神经炎症标记... 详细信息

抑郁症患病率高,疾病负担重,应激事件在抑郁症的发生发展中起到关键的推动和促发作用,但由于其复杂性和异质性,其病理机制至今仍未被完全阐明。近年来,神经炎症作为抑郁症的病理机制受到广泛关注,激活的小胶质细胞被认为是神经炎症标记物,是应激诱导抑郁症的重要机制。应激可能通过模式识别受体(pattern recognition receptor,PRR)、肠道菌群、下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴等途径诱发小胶质细胞活化。小胶质细胞激活与炎症因子、血清素代谢、神经可塑性等神经生物学因素之间相互串扰,导致抑郁发生。目前有大量研究发现中药可通过干预小胶质细胞活化以发挥抗抑郁作用,可能是抑郁症的关键靶标和潜在治疗策略。该文系统回顾了应激诱发小胶质细胞激活在抑郁症中的研究进展,并概述了抗抑郁中药针对小胶质细胞的作用机制,以期为中药通过小胶质细胞激活途径干预抑郁症提供实验研究的证据和思路。

关键词：抑郁症小胶质细胞应激综述免疫炎症中药

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Challenges and recent advances in HfO_(2)-based ferroelectric films for non-volatile memory applications

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Chip 2024年第3期3卷 50-72页

作者： Ming-Hao Shao Rui-Ting Zhao Houfang Liu Wen-Jia Xu yi-Da Guo Da-Peng Huang Yu-zhe Yang Xin-Ru Li Wancheng Shao Peng-Hui Shen Junwei Liu Kuanmao wang Jinguo zheng Zhao-yi Yan Jian-Lan Yan Tian Lu yi Yang Tian-Ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084China

The emergence of data-centric applications such as artificial intelligence(AI),machine learning,and the Internet of Things(IoT),has promoted surges in demand for storage memories with high operating speed and nonvolatile ***_(2)-based ferroelectric memory technologies,which emerge as a promising alternative,have attracted considerable attention due to their high performance,energy efficiency,and full compatibility with the standard complementary metal-oxide-semiconductors(CMOS)*** nonvolatile storage elements,such as ferroelectric random access memory(FeRAM),ferroelectric field-effect transistors(FeFETs),and ferroelectric tunnel junctions(FTJs),possess different data access mechanisms,individual merits,and specific application boundaries in next-generation memories or even beyond von Neumann *** paper provides an overview of ferroelectric HfO2 memory technologies,addresses the current challenges,and offers insights into future research directions and prospects.

关键词： Ferroelectric memory Ferroelectric random-access memory Ferroelectricﬁeld effect transistor Ferroelectric tunneling junction Hafnium oxide

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