检索结果-南通市图书馆

妇科盆腔炎性疾病临床治疗中喹诺酮类抗菌药的效果分析

在线全文

学校读者我要写书评

暂无评论

中国现代药物应用 2024年第9期18卷 9-12页

作者：王蒙杨晨王宜芹日照市妇幼保健院妇产科 276827

目的研讨妇科盆腔炎性疾病采用喹诺酮类抗菌药治疗的效果。方法选取60例妇科盆腔炎性疾病患者,经抽签法分组模式将患者分为对照组和研究组,每组30例。对照组采用中成药治疗,研究组在对照组基础上进行喹诺酮类抗菌药治疗。比较两组体征... 详细信息

目的研讨妇科盆腔炎性疾病采用喹诺酮类抗菌药治疗的效果。方法选取60例妇科盆腔炎性疾病患者,经抽签法分组模式将患者分为对照组和研究组,每组30例。对照组采用中成药治疗,研究组在对照组基础上进行喹诺酮类抗菌药治疗。比较两组体征与症状评分、治疗效果及炎性因子[C反应蛋白(CRP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果两组治疗前高热、腹部疼痛、小腹坠胀、尿道炎症、白带异常、月经失调、精神不振、疲惫无力、失眠评分不具有差异性(P>0.05);治疗后研究组高热、腹部疼痛、小腹坠胀、尿道炎症、白带异常、月经失调、精神不振、疲惫无力、失眠评分均低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率96.67%较对照组的76.67%更高(P<0.05)。研究组治疗后CRP(16.38±9.80)mg/L、IL-1(61.29±11.31)pg/ml、TNF-α(39.42±10.75)pg/ml、IL-6(63.47±10.25)pg/ml低于对照组的(23.77±9.45)mg/L、(72.37±11.20)pg/ml、(50.59±10.80)pg/ml、(70.85±10.37)pg/ml,差异有统计学意义(P<0.05)。结论喹诺酮类抗菌药应用于妇科盆腔炎性疾病中可提升治疗效果,降低炎性因子水平,改善体征与症状。

关键词：妇科盆腔炎性疾病喹诺酮左氧氟沙星

Synthesis of 2-Phenyl-10-substituted Hymenialdisine Derivatives

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第6期27卷 977-980页

作者： WU yi wang Yu qin Yong SONG Hao Department of Chemistry of Medicinal Natural Products West China School of Pharmacy Sichuan University Chengdu 610041 P. R. China

A series of novel 2-phenyl-10-substituted hymenialdisine derivatives was synthesized via the micro-wave-assisted Suzuki-Miyaura cross-coupling reactions of the 2-phenyl derivative of hymenialdisine and boronic acid, which enabled the successful introduction of electron-donating and electron-withdrawing groups to the 2-phenyl- hymenialdisine derivatives in good yields.

关键词： Hymenialdisine Suzuki-Miyaura reaction 2-Phenyl-10-substituted hymenialdisine derivative

住宅楼外墙间凹空间顶部悬空楼板模架搭设技术

在线全文

学校读者我要写书评

暂无评论

建筑技术 2024年第11期55卷 1307-1311页

作者：李彬彬王沁怡兰静北京建工集团有限责任公司北京100055

当高层塔式住宅楼每层户数相对较多时,为最大限度地保证每个住户均能获取较好采光、通风,设计单位通常在平面布局方面布置外墙间凹空间。但是当将屋面设备用房布置在外墙间凹空间上方时,该区域悬空楼板的模架将会给施工带来一定的难度... 详细信息

当高层塔式住宅楼每层户数相对较多时,为最大限度地保证每个住户均能获取较好采光、通风,设计单位通常在平面布局方面布置外墙间凹空间。但是当将屋面设备用房布置在外墙间凹空间上方时,该区域悬空楼板的模架将会给施工带来一定的难度。以北京市某住宅项目的高层塔式住宅楼为例,通过实践总结提出一种设置通长型钢梁,并在型钢梁上搭设悬空楼板模板支撑体系的方案,以解决外墙间凹空间悬空楼板模架的搭设问题。

关键词：外墙间凹空间悬空楼板模板支撑体系型钢梁盘扣式模板支架

在线全文

学校读者我要写书评

暂无评论

流域自然资源禀赋综合分析评价

地矿测绘 2024年第3期40卷 37-40,46页

作者：李纯刘旭辉钟锐汪祎勤云南省测绘资料档案馆(云南省基础地理信息中心) 云南昆明650000

以云南省九大高原湖泊流域和赤水河流域(云南段)为研究单元,基于第三次全国国土变更调查和相关行业数据,统计流域内耕地、林地、草地、湿地、建设用地、水域等自然资源数量、质量、潜力情况,开展自然资源禀赋单项和综合分析。验证了以... 详细信息

以云南省九大高原湖泊流域和赤水河流域(云南段)为研究单元,基于第三次全国国土变更调查和相关行业数据,统计流域内耕地、林地、草地、湿地、建设用地、水域等自然资源数量、质量、潜力情况,开展自然资源禀赋单项和综合分析。验证了以流域为研究单元时,自然资源禀赋计算方法的可行性和存在的问题,分析评价结果可为流域自然资源管理、国土空间规划等提供数据支撑。

关键词：流域高原湖泊自然资源禀赋指标

面向高质量发展与高水平对外开放的高层次国际标准化人才培养创新体系构建

在线全文

学校读者我要写书评

暂无评论

中国标准化 2024年第15期 49-57,64页

作者：苏宏业谢磊徐巍华王一钦浙江大学浙江省自动化学会

本文主要探讨构建面向高质量发展与高水平对外开放的高层次国际标准化人才培养创新体系的内涵及路径。首先介绍高质量发展与高水平对外开放的背景和内涵,并强调培养高层次国际标准化人才的必要性。接着,分析当前高层次国际标准化人才培... 详细信息

本文主要探讨构建面向高质量发展与高水平对外开放的高层次国际标准化人才培养创新体系的内涵及路径。首先介绍高质量发展与高水平对外开放的背景和内涵,并强调培养高层次国际标准化人才的必要性。接着,分析当前高层次国际标准化人才培养体系存在的问题和挑战,并提出创新实践的方法和建议,包括完善国际标准与人才对接机制、加强国际合作与交流、提升师资队伍水平、加强课程体系建设、鼓励学生参与实际项目、加强终身教育与培训等。最后,通过案例分析,总结成功因素和经验教训,并提出对高层次国际标准化人才培养体系创新实践的建议。

关键词：高质量发展高水平开放国际标准化高层次人才培养体系改革

维普期刊数据库博看期刊

Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第8期67卷 2647-2660页

作者： Jiangao Li Niu Niu Deliang wang Xue Liu yi qin Lei wang Ben Zhong Tang Dong wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target Clinical Pharmacologythe State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

关键词： phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy

NLRP3 inflammasomes contribute to hyperhomocysteinemia-induced inflammation and atherosclerosis

在线全文

学校读者我要写书评

暂无评论

中国病理生理杂志 2016年第8期32卷 1492-1493页

作者： wang Ren-qing MU Na-na LOU Xiao-ying wang yi-qin TAN Hong-mei Department of Pathophysiology Zhongshan School of MedicineSun Yat-sen University

AIM: NLRP3 inflammasome was identified as the cellular machinery responsible for activation of inflammatory processes. The present study investigated whether the activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia（ HHcy）-induced inflammation and atherosclerosis. METHODS: Apo E-/-mice were fed regular diet,high fat（ HF） diet or HF plus high methionine（HM） diet for 10 weeks. NLRP3 sh RNA or scramble sh RNA viral suspension was injected twice at the 2nd and the 6th weeks after HFHM treatment. The whole aortas and aortic root sections were stained with Oil Red O for atherosclerotic lesion. Plasma lipids,homocysteine（ Hcy）,IL-1β and IL-18 levels were measured. We also examined the effect of Hcy on NLRP3 inflammasomes activation in THP-1 differentiated macrophages in the presence or absence of NLRP3 si RNA,caspase-1 inhibitor Z-WEHD-FMK,or antioxidant Nacetyl-L-cysteine（ NAC）. RESULTS: HFHM treatment induced HHcy in Apo E-/-mice. Increased plasma levels of IL-1β and IL-18,aggravated macrophage infiltration into atherosclerotic lesion,and accelerated development of atherosclerosis were detected in HHcy mice,which were associated with the activation of NLRP3 inflammasomes. Silencing the NLRP3 gene significantly suppressed NLRP3 inflammasomes activation, reduced plasma levels of proinflammatory cytokines, attenuated macrophage infiltration, and improved HHcy-induced atherosclerosis. Moreover,we found that Hcy activated NLRP3 inflammasomes and promoted subsequent production of IL-1β and IL-18 in macrophages,which were blocked by NLRP3 gene silencing,Z-WEHD-FMK,or NAC. CONCLUSION:These data suggest that the activation of NLRP3 inflammasomes contributes to HHcy-induced inflammation and atherosclerosis. Hcy activates NLRP3 inflammasomes in reactive oxygen species dependent pathway in macrophages.

关键词： NLRP3 inflammasomes contribute to hyperhomocysteinemia-induced inflammation and atherosclerosis Hcy

Assessment on gas-polyethylene terephthalate solid interface partial discharge properties of C4F7N/CO_(2)gas mixture for eco-friendly gas insulating transformer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High Voltage 2024年第1期9卷 35-45页

作者： Song Xiao yifan wang Chenhua Ren Haoran Xia Yue Zhao Jingzi qin Xiaoxing Zhang yi Luo yi Li State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanHubeiChina Beijing International S&T Cooperation Base for Plasma Science and Energy Conversion Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina State Grid Anhui Electric Power Company Anhui Electric Power Research Institute HefeiAnhuiChina Hubei Engineering Research Center for Safety Monitoring of New Energy and Power Grid Equipment School of Electrical and Electronic EngineeringHubei University of TechnologyWuhanHubeiChina

The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliability and gas–solid interface discharge decomposition characteristics of the gas–solid film insulation structure in GIT is *** authors simulated the gas–solid film insulation structure in GIT and explored the interface partial discharge(PD)characteristics of C4F7N/CO_(2)gas mixture with polyethylene terephthalate(PET).The effect of gas pressure,mixing ratio on gas–solid interface gas decomposition,PET degradation was investigated,and the interaction mechanism was *** is found that the interface PD generated three degradation regions on a PET *** gas–solid interface reaction in the electrode contact region and the discharge development trace was significantly higher than that of halation *** content of gas decomposition products decreases with the increase of gas pressure and the PD intensity of SF6-PET is inferior to that of C_(4)F_(7)N/CO_(2)under the same *** results provide reference for the development and application of C_(4)F_(7)N/CO_(2)based GIT.

关键词： interface solid insulation

Effect of the yaw angle on turbulent flow structures around the submarine model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2024年第3期36卷 421-434页

作者： yi-jing Hu yi Qu qin Wu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China Beijing Institute of Electronic System Engineering Beijing100854China

The objective of this paper is to investigate the turbulent flow structures around the submarine model and evaluate the effect of the yaw angle on the turbulent flow *** large eddy simulation based on the boundary data immersion method is used to *** computational domain consists of 1.2×10^(8)uniformly distributed Cartesian orthogonal grid nodes to capture the basic flow characteristics around the *** pressure coefficient,friction coefficient and wake velocity distribution are in good agreement with the experimental *** different types of vortex structures were mainly captured around the model,including horseshoe vortex,sail tip vortex and crossflow separation *** the increase of the yaw angle,the asymmetry of the horseshoe vortex and the tip vortex gradually increases,and the vortex strength of the vortex leg on the windward of the horseshoe vortex and the vortex strength of the tip vortex also increase *** the crossflow separation vortex,the flow separation zone gradually expands and migrates downstream with the increase of the yaw angle.

关键词： Vortex structure submarine model boundary data immersion method yaw angle