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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen yanhui He Yuyu Shi Fafeng Cheng Qingguo wang Changxiang Li Xueqian wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

对面向位置服务的多尺度空间数据组织与自适应可视化研究的分析

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高技术通讯 2013年第1期23卷 60-65页

作者：王艳慧首都师范大学三维信息获取与应用教育部重点实验室北京100048

针对移动位置服务系统对空间信息多尺度组织和管理技术的迫切需求，系统探讨了位置服务中的空间信息多尺度表达、传输、发布和自适应可视化技术的研究问题，重点评述了国内外研究现状、进展及存在的主要问题，指出了未来研究的重点，以... 详细信息

针对移动位置服务系统对空间信息多尺度组织和管理技术的迫切需求，系统探讨了位置服务中的空间信息多尺度表达、传输、发布和自适应可视化技术的研究问题，重点评述了国内外研究现状、进展及存在的主要问题，指出了未来研究的重点，以及发展针对移动位置服务特点的信息组织技术，解决矢量数据的多尺度表达及其在数据库中的分级分块组织，减缓地理空间信息量大、无线带宽较窄和移动资源有限之间的矛盾，实现移动位置服务的个性化和智能化的研究方向。

关键词：位置服务多尺度表达增量传输增量发布自适应可视化

Characteristics of thunderstorms and lightning flashes in the Chinese inland plateau

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Research in Cold and Arid Regions 2010年第3期2卷 271-277页

作者： TingLong Zhang Tong Zhang Yang Zhao XiangZhen Kong yanhui wang Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou Gansu 730000 China

The electrical characteristics of thunderstorms in three different altitude regions of the Chinese inland plateau have been analyzed in this paper. The results show, according to the polarity of the surface electric （E） field, that the thunderstorms can be divided into two categories in the study regions： one showing the normal tripole electrical charge structure （normal-type）, and the other showing the special tripole charge structure with a larger-than-usual lower positive charge center （LPCC） at the base of thunderstorm （special-type）, where the induced surface E field is controlled by the LPCC when a thunderstorm is overhead. We find that the two types of thunderstorms have different occurrences in different regions, and the percentage of special-type thunderstorms increases with the altitude. On the whole, the flash rate of thunderstorms is quite low, and the mean value is about 1-3 fl/min, while the flash rate of special-type is slightly greater than that of the normal-type thunderstorm. The statistical results of cloud-to-ground flash （CG） numbers indicate that the ratio of ＋CG flash increases with the altitude, with the value about 14.7 percent through 25.4 percent.

关键词： thunderstorm flash rate cloud-to-ground flash

A method on laser power stabilization in optical detection cesium atomic clock

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A method on laser power stabilization in optical detection c...

金刚石和立方氮化硼超硬磨料表面处理技术应用及发展

第九届中国卫星导航学术年会

作者： Ziyu Chen Chang Liu Shuhui wang yanhui wang School of Electronics Engineering and Computer Science Peking University

Laser detection avoid the limitation on cesium clocks’ lifespan due to electron multipliers. However, the laser inevitably induces light shift. By measuring the frequency shifts under various light powers, we study the light shift. The dependence of the light shift on the light power is 2×10/mW. The Allan deviation of the output power of the laser diode is 4.5×10 at 10 s under free running. The temperature coefficient of the clock is 1× 10/℃. For a high-performance cesium clock, the light shift is one of the main restricts to accuracy and long-term stability. In order to improve the clock’s long-term frequency stability, accuracy and temperature coefficient, we propose a method for laser power stabilization. This method uses a liquid crystal variable retarder to tune the polarization of the light, in order to feedback control the light power with respect to the photoelectric detector. We theoretically analyze the method, and find that the drift of light power mainly results from the temperature drift of electronic elements. The temperature drift is below 1×10/℃, manifesting the theoretical feasibility. We build an experimental system and measure the light power for 20 days. The stability of light power is 6×10 at 10 s, and 3×10 at 10 s. Moreover, the temperature coefficient reduces to 2×10/℃ from 1×10/℃. Therefore, the method effectively improves the performance of the clock. Besides, it can be easily applied to other experiments that requires laser power stabilization.

关键词： atomic clock light shift Laser power stabilization stability liquid crystal variable retarder

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金刚石与磨料磨具工程 2009年第1期29卷 5-12页

作者：王艳辉亚稳材料制备科学与技术国家重点实验室燕山大学材料学院秦皇岛066004

本文综合介绍了金刚石和立方氮化硼超硬磨料表面处理技术及应用情况及新的表面处理技术发展情况,包括真空微蒸发镀钛技术及应用进展;微粉专用真空微蒸发镀覆技术及应用;基于镀钛技术而发展的复合镀Ti-N i技术及应用;刚玉涂覆的超硬磨料... 详细信息

本文综合介绍了金刚石和立方氮化硼超硬磨料表面处理技术及应用情况及新的表面处理技术发展情况,包括真空微蒸发镀钛技术及应用进展;微粉专用真空微蒸发镀覆技术及应用;基于镀钛技术而发展的复合镀Ti-N i技术及应用;刚玉涂覆的超硬磨料及应用;基于原子层镀覆技术发展的超硬磨粒、微粉及纳米粉的镀硅镀钛技术及应用。

关键词：金刚石立方氮化硼表面处理镀钛镀硅复合镀

Severe pseudo-stenosis of intracranial segment of verte-bral artery:a case report

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Journal of Translational Neuroscience 2023年第1期8卷 24-28页

作者： Yanlun Gao yanhui wang Yingchun Du Mingming Yao Chuanjie Wu Department of Cerebrovascular Diseases the First People’s Hospital of PingdingshanPingdingshan 467000China Department of Gastroenterology the First People’s Hospital of PingdingshanPingdingshan 467000China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Objective:To describe the clinical fea-tures of a case of ischemic stroke caused by pseudo severe stenosis of vertebral artery(VA).Methods:The clinical history and image data of a 52-year-old man with ischemic stroke were ***:Computerized tomography angiography(CTA)revealed stenosis of V1 and V4 of the left *** confirmed that the anterior blood flow recov-ered after stent implantation,and the V4 segment of the left VA was normal without ***:It is spec-ulated that the upper stenosis is due to local hemodynamic changes rather than real *** case suggests that the interpretation of stenosis on CTA should consider cere-bral vascular anatomy and hemodynamic changes.

关键词： vertebral artery stenosis ischemic stroke hemodynamic computerized tomography angiography

基于频率耦合阻抗模型的并网变流器全工况小信号稳定性分析

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中国电机工程学报 2020年第22期40卷 7212-7220页

作者：刘威谢小荣王衡王艳辉电力系统及发电设备控制与仿真国家重点实验室(清华大学电机系) 北京市海淀区100084 国网新疆电力有限公司新疆维吾尔自治区乌鲁木齐市830063 国网内蒙古东部电力有限公司内蒙古自治区呼和浩特市010010

近年来,可再生能源发电系统参与的振荡问题严重威胁电力系统的安全运行。阻抗模型作为分析此类问题的重要工具之一,受到广泛关注。然而,当前阻抗法常用于特定工况下的系统稳定性分析。为了研究工况对稳定性的影响,该文在考虑频率耦合效... 详细信息

近年来,可再生能源发电系统参与的振荡问题严重威胁电力系统的安全运行。阻抗模型作为分析此类问题的重要工具之一,受到广泛关注。然而,当前阻抗法常用于特定工况下的系统稳定性分析。为了研究工况对稳定性的影响,该文在考虑频率耦合效应的同时,分别对"白箱"和"黑/灰箱"两种情况下的变流器系统进行了全工况小信号稳定性分析,并给出系统在不同电网阻抗下的稳定运行范围,为并网变流器的稳定运行提供了重要的参考。

关键词：并网变流器全工况稳定性分析频率耦合阻抗模型 “黑/灰箱”系统

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瓶颈与突围:战国秦汉户籍制度研究的新进展

中国史研究动态 2022年第6期 40-45页

作者：王彦辉东北师范大学历史文化学院吉林长春130024

自有文字记载以来,中国历代王朝就高度重视人口的调查和统计。至迟到战国中后期,各诸侯国就相继建立了严密的户籍制度,其中,存留户籍资料较多者尤以秦国为最。户籍制度的产生是和官僚制度的建立同步的,马克斯·韦伯等西方学者称誉中国... 详细信息

自有文字记载以来,中国历代王朝就高度重视人口的调查和统计。至迟到战国中后期,各诸侯国就相继建立了严密的户籍制度,其中,存留户籍资料较多者尤以秦国为最。户籍制度的产生是和官僚制度的建立同步的,马克斯·韦伯等西方学者称誉中国在秦汉就建立了具有现代意义的官僚制度,并感叹这一制度在几千年的历史中成功地管理了广大分散的农民。殊不知帝制中国的官僚行政是以各类簿籍文书为凭借的,冨谷至就形象地称之为“文书行政的汉帝国”。

关键词：户籍制度官僚行政官僚制度帝制中国战国秦汉马克斯·韦伯诸侯国汉帝国

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契约的谱系及其规范协调

江汉论坛 2021年第3期 120-127页

作者：王艳慧中国人民大学法学院北京100081 中国人民大学未来法治研究院北京100081 东北林业大学文法学院黑龙江哈尔滨150040

契约来源于人们的生活实践,是典型的经验事实。随着人类从工业时代、商业时代、金融时代、信息时代逐步进入智能时代,契约的形式不断创新,契约关系日趋复杂,呈现为从个别性契约到关系性契约的谱系。关系性契约的高度生活依赖性和义务—... 详细信息

契约来源于人们的生活实践,是典型的经验事实。随着人类从工业时代、商业时代、金融时代、信息时代逐步进入智能时代,契约的形式不断创新,契约关系日趋复杂,呈现为从个别性契约到关系性契约的谱系。关系性契约的高度生活依赖性和义务—责任二阶性对契约法观念和契约法规范提出双重变革要求:在法观念上应当从理想走向现实,从关注契约内部转向内外兼顾;在法规范上需提供开放性的法源,在规范适用上需采取多元的解释方法。现代复杂条件下的契约法规范承担矫正正义和分配正义的双重任务,契约法规范理论应统合合同法与相邻规范,构建整合之契约法理论。

关键词：契约谱系规范协调生活事实整合之契约法理论