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Effect of the same mechanical loading on osteogenesis and osteoclastogenesis in vitro

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Chinese Journal of Traumatology 2015年第3期18卷 150-156页

作者： Yong Guo yang wang Yinqin Liu Haitao wang Chun Guo Xizheng Zhang Chaoyong Bei College ofBioteehnology Guilin Medical University Guilin 541004 China Department of Medicine Luohe Medical College Luohe 462000 China Institute of Medical Equipment Academy of Military Medical Sciences Tianjin 300161 China Department of Orthopedic Affiliated Hospital of Guilin Medical University. Guilin 541000 China

Purpose: To investigate the influence of the same mechanical loading on osteogenesis and osteoclastogenesis in vitro . Methods: Primary osteoblasts, bone marrow-derived mesenchymal stem cells (BMSCs, cultured in osteoinductive medium) and RAW264.7 cells cultured in osteoclast inductive medium were all subjected to a 1000 μstrain (μs) at 1 Hz cyclic mechanical stretch for 30 min (twice a day). Results: After mechanical stimulation, the alkaline phosphatase (ALP) activity, osteocalcin protein level of the osteoblasts and BMSCs were all enhanced, and the mRNA levels of ALP and collagen type I increased. Additionally, extracellular-deposited calcium of both osteoblasts and BMSCs increased. At the same time, the activity of secreted tartrate-resistant acid phosphatase, the number of tartrate-resistant acid phosphatase-positive multinucleated cells, matrix metalloproteinase-9 protein levels of RAW264.7 cells and the extracellular calcium solvency all decreased. Conclusion: The results demonstrated that 1000 μs cyclic mechanical loading enhanced osteoblasts activity, promoted osteoblastic differentiation of BMSCs and restrained osteoclastogenesis of RAW264.7 cells in vitro .

关键词：成骨细胞分化破骨细胞体外培养机械负荷 RAW264.7细胞骨髓间充质干细胞基质金属蛋白酶-9 骨髓基质干细胞

OTDR-based optical fiber bending and tensile loss analysis

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Optoelectronics Letters 2023年第3期19卷 164-169页

作者： Wang Yang wang Xijun LI Xiaoling Information Management Department Northwest A&F UniversityYangling 712100China

When optical fiber is deployed in practical engineering,bending and stretching of fiber optics is inevitable,which will affect optical communication.The fiber losses of different bending radii are simulated by COMSOL software.In order to verify the accuracy of simulation results,an experiment was designed to measure the losses of single-mode fiber under different bending radii and tension forces.The results show that the sensitive bending diameter of fiber loss is between 5 mm and 10 mm.The tensile effect has little influence on the fiber loss,but when the tensile force is greater than 160 N,the fiber breaks.This study provides an important reference for fiber layout in practical engineering.

关键词： fiber optical OTDR

N-doped carbon nanotube encapsulated nZVI as a high-performance bifunctional catalyst for oxidative desulfurization

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Particuology 2023年第10期81卷 109-118页

作者： Ge Zhang Fan yang Wang Yang Yongfeng Li State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijingChina Beijing NAURA Vacuum Technology Co. LtdBeijingChina

Great efforts have been made to remove sulfur from fossil fuels to protect the environment.We proposed synthesis of high efficiency oxidation desulfurization(ODS)catalysts by encapsulating nano zero valent iron(nZVI)in self-catalyzed carbon nanotubes.The synthetic strategy features facile hydrothermal and pyrolysis process.The specific surface area,pore structure,and microstructure of the catalysts were characterized by series techniques,and the catalytic ability was evaluated by the reduction of sulfur after oxidation and reflux-extraction.The optimized nZVI@CNT catalyst exhibits outstanding catalytic performance(within 120 min,the oxidative removal rate of DBT reached 96%)and enhanced stability(a 80%retention of initial performance after six cycles.),revealing the effective optimization and modulation between carbon nanotubes and iron particles.This excellent ODS activity originated from the defects of N-doped nanotubes as well as excellent particle dispersion and material transport capacity,which excites highly active free radicals with the assistance of H_(2)O_(2).In addition,the unique two-dimensional tube channel and mesoporous structure promoted the diffusion and transfer of reactants and electrons,leading to high density of active sites.The different experimental conditions confirmed that the material is a bifunctional catalyst integrating adsorption and catalysis.This work provides an creative ideas for the rational design and synthesis of advanced ODS catalysts for fuel oil.

关键词： Carbon nanotubes Oxidative desulfurization Dispersion Nanoscale zero valent iron

Cancer challenges worldwide and in China:preparing for the inevitable

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Science China(Life Sciences) 2022年第2期65卷 442-444页

作者： Jing Zhou Wang Yang Qiang Liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

As socioeconomic development is closely associated with changes in various risk factors for cancer,a timely and worldwide depiction of temporal and geographic cancer burden can provide insights on the effective prevention and treatment of this disease.Recently,the International Agency for Research on Cancer issued an update regarding the status of the global cancer burden for 36 forms of cancer in 185 countries(Sung et al.,2021).The report revealed that the worldwide cancer burden had increased rapidly between 2018 and 2020.Notably,female-specific breast cancer has replaced lung cancer as the most commonly diagnosed form,and its incidence rate is increasing rapidly,especially in Asia.Against this background,the study will review and compare global cancer statistics between 2018 and 2020(Sung et al.,2021;Bray et al.,2018),Cancer Country Profiles China 2020(World Health Organization(WHO),2020)。

关键词： Cancer prevention preparing

Towards High-Energy and Anti-Self-Discharge Zn-Ion Hybrid Supercapacitors with New Understanding of the Electrochemistry

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Nano-Micro Letters 2021年第6期13卷 268-283页

作者： yang Li Wang Yang Wu yang Ziqi wang Jianhua Rong Guoxiu wang Chengjun Xu Feiyu Kang Liubing Dong College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443People’s Republic of China Centre for Clean Energy Technology University of Technology SydneySydneyNSW 2007Australia Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055People’s Republic of China

Aqueous Zn-ion hybrid supercapacitors(ZHSs)are increasingly being studied as a novel electrochemical energy storage system with prominent electrochemical performance,high safety and low cost.Herein,high-energy and anti-self-discharge ZHSs are realized based on the fibrous carbon cathodes with hierarchically porous surface and O/N heteroatom functional groups.Hierarchically porous surface of the fabricated free-standing fibrous carbon cathodes not only provides abundant active sites for divalent ion storage,but also optimizes ion transport kinetics.Consequently,the cathodes show a high gravimetric capacity of 156 mAh g^(−1),superior rate capability(79 mAh g^(−1)with a very short charge/discharge time of 14 s)and exceptional cycling stability.Meanwhile,hierarchical pore structure and suitable surface functional groups of the cathodes endow ZHSs with a high energy density of 127 Wh kg−1,a high power density of 15.3 kW kg^(−1)and good anti-self-discharge performance.Mechanism investigation reveals that ZHS electrochemistry involves cation adsorption/desorption and Zn_(4)SO_(4)(OH)_(6)·5H_(2)O formation/dissolution at low voltage and anion adsorption/desorption at high voltage on carbon cathodes.The roles of these reactions in energy storage of ZHSs are elucidated.This work not only paves a way for high-performance cathode materials of ZHSs,but also provides a deeper understanding of ZHS electrochemistry.

关键词： Zn-ion hybrid supercapacitor Carbon material Fibrous cathode Hierarchical pore structure High-energy

On the hardness of NTRU problems

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Frontiers of Computer Science 2022年第6期16卷 135-144页

作者： yang wang Mingqiang wang School of Mathematics Shandong UniversityJinan250100China Key Laboratory of Cryptologic Technology and Information Security Shandong UniversityJinan250100China

The hardness of NTRU problem affects heavily on the securities of the cryptosystems based on it.However,we could only estimate the hardness of the specific parameterized NTRU problems from the perspective of actual attacks,and whether there are worst-case to average-case reductions for NTRU problems like other lattice-based problems(e.g.,the Ring-LWE problem)is still an open problem.In this paper,we show that for any algebraic number field K,the NTRU problem with suitable parameters defined over the ring of integers R is at least as hard as the corresponding Ring-LWE problem.Hence,combining known reductions of the Ring-LWE problem,we could reduce worst-case basic ideal lattice problems,e.g.,SIVPγproblem,to average-case NTRU problems.Our results also mean that solving a kind of average-case SVPγproblem over highly structured NTRU lattice is at least as hard as worst-case basic ideal lattice problems in K.As an important corollary,we could prove that for modulus q=Õ(n^(5.5)),average-case NTRU problem over arbitrary cyclotomic field K with[K:Q]=n is at least as hard as worst-case SIVP_(γ)problems over K with γ=Õ(n^(6)).

关键词： lattice-based cryptography algebraic nmber fields NTRU Problems Ring-LWE computational compleity

Clinical development of chimeric antigen receptor-T cell therapy for hematological malignancies

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中华医学杂志（英文版） 2023年第19期136卷 2285-2296页

作者： Zhihuan yang Ying wang China 300020

Cellular therapies have revolutionized the treatment of hematological malignancies since their conception and rapid development. Chimeric antigen receptor (CAR)-T cell therapy is the most widely applied cellular therapy. Since the Food and Drug Administration approved two CD19-CAR-T products for clinical treatment of relapsed/refractory acute lymphoblastic leukemia and diffuse large B cell lymphoma in 2017, five more CAR-T cell products were subsequently approved for treating multiple myeloma or B cell malignancies. Moreover, clinical trials of CAR-T cell therapy for treating other hematological malignancies are ongoing. Both China and the United States have contributed significantly to the development of clinical trials. However, CAR-T cell therapy has many limitations such as a high relapse rate, adverse side effects, and restricted availability. Various methods are being implemented in clinical trials to address these issues, some of which have demonstrated promising breakthroughs. This review summarizes developments in CAR-T cell trials and advances in CAR-T cell therapy.

关键词： Cellular immunotherapy Chimeric antigen receptor T cell Hematological malignancy

High mass loading NiCo_(2)O_(4) with shell-nanosheet/core-nanocage hierarchical structure for high-rate solid-state hybrid supercapacitors

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Green Energy & Environment 2022年第4期7卷 723-733页

作者： Wang Yang Liqiang Hou Peng wang Yun Li Rui Li Bo Jiang Fan yang Yongfeng Li State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Changping102249China

Rational design of advanced structure for transition metal oxides(TMOs) is attractive for achieving high-performance supercapacitors.However, it is hampered by sluggish reaction kinetics, low mass loading, and volume change upon cycling. Herein, hierarchical Ni Co_(2)O_(4) architectures with 2D-nanosheets-shell and 3D-nanocages-core(2D/3D h-NCO) are directly assembled on nickel foam via a facile one-step way.The 2D nanosheets are in-situ generated from the self-evolution of initial NCO nanospheres. This 2D/3D hierarchical structures ensure fast ion/electron transport and maintain the structural integrity to buffer the volume expansion. The 2D/3D h-NCO electrode with an ultrahigh mass loading(30 mg cm^(-2)) achieves a high areal capacity of 4.65 C cm^(-2)(equivalent to 1.29 mAh cm^(-2)) at a current density of 4 mA cm^(-2), and retains 3.7 C cm^(-2) even at 50 mA cm^(-2). Furthermore, the assembled solid-state hybrid supercapacitor yields a high volumetric energy density of 4.25 mWh cm^(-3) at a power density of 39.3 mW cm^(-3), with a high capacity retention of 92.4% after 5000 cycles. Therefore, this work provides a new insight to constuct hierarchical electrodes for energy storage application.

关键词： Transition-metal oxides Hierarchical structure High mass loading Free-standing Supercapacitors

Enhanced confinement synthesis of atomically dispersed Fe-N-C catalyst from resin polymer for oxygen reduction

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Journal of Energy Chemistry 2022年第2期31卷 630-636页

作者： Ailing Song Hao Tian Wang Yang Wu yang Yuhan Xie Hao Liu Guoxiu wang Guangjie Shao State Key Laboratory of Metastable Materials Science and Technology Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseCollege of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004HebeiChina Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyBroadwaySydneyNSW 2007Australia Joint International Laboratory on Environmental and Energy Frontier Materials School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China

Due to larger atom utilization,unique electronic properties and unsaturated coordination,atomically dispersed non-precious metal catalysts with outstanding performances have received great attention in electrocatalysis.Considering the challenge of serious aggregation,rational synthesis of an atomic catalyst with good dispersion of atoms is paramount to the development of these catalysts.Herein,we report an enhanced confinement strategy to synthesize a catalyst comprised of atomically dispersed Fe supported on porous nitrogen-doped graphitic carbon from the novel and more cross-linkable Melamine-Glyoxal Resin.Densified isolated grid trapping,excessive melamine restricting,and nitrogen anchoring are strongly combined to ensure the final atomic-level dispersion of metal atoms.Experimental studies revealed enhanced kinetics of the obtained catalyst towards oxygen reduction reaction(ORR).This catalytic activity originates from the highly active surface with atomically dispersed iron sites as well as the multi-level three-dimensional structure with fast mass and electron transfer.The enhanced confinement strategy endows the resin-derived atomic catalyst with a great prospect to develop for commercialization in future.

关键词： Non-precious metal catalysts Atomic catalyst Oxygen reduction reaction Confinement synthesis