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Selective hydrogenation improves interface properties of high-k dielectrics on 2. semiconductors

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Nano Research 2022年第5期15卷 4646-4652页

作者： Yulin Yang Tong Yang Tingting Song jun Zhou Jianwei Chai lai Mun Wong Hongyi Zhang Wenzhang Zhu Shijie {2. ming Yang Fujian Provincial Key Laboratory of Optoelectronic Technology and Devices School of Optoelectronic and Communication EngineeringXiamen University of TechnologyXiamen 361024China department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina College of Physics and Space Science China West Normal UniversityNanchong 637002China Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis 138634Singapore

The integration of high-k dielectrics with two-dimensional(2.)semiconductors is a critical step towards high-performance nanoelectronics,which however remains challenging due to the high density of interface states and the damage to the monolayer 2. *** this study,we propose a selective hydrogenation strategy to improve the interface properties while the 2. semiconductors are not *** the interface of monolayer molybdenum disulfide(MoS_(2.)and silicon nitride as an example,we show substantially improved interface properties for electronic applications after the interfacial hydrogenation,as evidenced by reduced inhomogeneous charge redistribution,increased band offset,and nearly intact electronic properties of MoS_(2..Importantly,this hydrogenation process selectively occurs only at the silicon nitride surface and is compatible with the current semiconductor fabrication *** further show that this strategy is general and applicable to other interfaces between high-k dielectrics and 2. semiconductors such as hafnium dioxide(HfO_(2.)on the monolayer MoS_(2..Our results demonstrate a simple yet viable way to improve the integration of high-k dielectrics on a broad range of 2. transition metal disulfide semiconductors,shedding light on practical electronic and optoelectronic applications.

关键词： two-dimensional(2.)materials high-k dielectrics molybdenum disulfide interfacial properties transition metal disulfide(TMD)

Antinociceptive effect of berberine on visceral hypersensitivity in rats

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World Journal of Gastroenterology 2013年第28期19卷 4582-4589页

作者： Qing-Lin Tang Min-Ling lai Yuan-Fu Zhong Ai-Min wang {2.-Kai Su ming-Qing Zhang department of Gastroenterology 175th Hospital of PLA Affiliated Southeast Hospital of Xiamen University

AIM: To assess the protective effect of berberine administration and the role of nitric oxide (NO) in visceral hypersensitivity. METHODS: Fifty male Sprague-Dawley rats were randomly assigned to five groups. An inflammatory bowel disease model was induced in rats by intracolonic instillation of 1 mL 4% acetic acid at 8 cm proximal to the anus for 30 s and restraint stress. After subsidence of inflammation on day 7 of the experiment, the rats were subjected to rectal distension, performed by a balloon (6-Fr, 2.mm external diameter, disposable silicon balloon-urethral catheter for pediatric use) which was rapidly inflated with increasing volumes of prewarmed (37 ℃) water (0.1, 0.2. 0.3, 0.4, 0.6, 0.8 and 1 mL) for 30 s at four-minute intervals, and then the abdominal withdrawal reflex (AWR) and the level of fecal output were measured, respectively. AWR scores either 0, 1, 2. 3 or 4 were obtained by blinded observers. Rats had been pretreated with berberine or aminoguanidine (NO synthetase inhibitor) or berberine + aminoguanidine before measurement. RESULTS: The rats in the placebo group showed a hypersensitive response to rectal distension (2.69 ± 0.08 vs 1.52.± 0.08, P = 0.000) and defecated more frequently than those in the control group (5.0 ± 0.16 vs 0.44 ± 0.16, P = 0.000). Comparing the berberine with placebo group, the AWR scores were reduced for all distension volumes and were significant at 0.2.1 mL (1.90 ± 0.08 vs 2.69 ± 0.08, P = 0.000), while the numbers of hard pellets, soft pellets, formless stools, and total fecal output in the placebo group were significantly larger than in the berberine group (5.0 ± 0.16 vs 2.56 ± 0.16, P = 0.000). Administration of aminoguanidine or berberine + aminoguanidine before VH score measurement reversed the antinociceptive effect of berberine (2.52.± 0.08 vs 1.90 ± 0.08, P = 0.000; 2.50 ± 0.08 vs 1.90 ± 0.08, P = 0.000). The numbers of hard pellets, soft pellets, formless stool, and total of fecal output in aminoguanidine gr

关键词： Berberine Irritable bowel syndrome Visceral hypersensitivity Nitric oxide

Ex vivo-expanded bone marrow stem cells home to the liver and ameliorate functional recovery in a mouse model of acute hepatic injury

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 66-73页

作者： Shi-Zhu Jin,Bing-Rong Liu,jun Xu,Fu-lai Gao,Zong-Jing Hu,Xin-Hong {2.,Feng-Hua Pei,Yu Hong,Hong-Yan Hu and ming-Zi Han department of Gastroenterology and Hepatology,and department of Science Research Management,Second Affiliated Hospital,Harbin Medical University,Harbin 150080,china department of Gastroenterology and Hepatology,Fourth Affiliated Hospital,Harbin Medical University,Harbin 150001,china [a] department of Gastroenterology and Hepatology Second Affliated Hospital Harbin Medical University Harbin 150080 Harbin China [b] department of Science Research Management Second Affliated Hospital Harbin Medical University Harbin 150080 Harbin China [c] department of Gastroenterology and Hepatology Fourth Affliated Hospital Harbin Medical University Harbin 150001 Harbin China

BACKGROUND:Stem cell transplantation provides a theoretical approach for liver regeneration medicine;it may promote liver regeneration and ***,the transplantation of bone marrow-mesenchymal stem cells expanded ex vivo as a therapy for liver disease has rarely been *** study aimed to explore whether bone marrow stem cells expanded ex vivo home to the liver and foster hepatic recovery after CCl 4 ***:Bone marrow cells from BALB/c mice were expanded ex vivo by multiple-passage cultivation,characterized by cytoflow immunofluorescence,and pre-labeled with PKH2. before intravenous infusion into animals treated with CCl *** integration of bone marrow cells into the liver was examined microscopically,and plasma hepatic enzymes were determined ***:Cultured bone marrow cells exhibited antigenic profiles comparable to those of primary medullary stem *** immunofluorescence showed colocalization of these cells with proliferative activity and albumin expression in the liver of CCl 4 -treated *** showed increased in situ cell proliferation (50±14 vs 2.±3 cells/high-power field,P2. vs 2.±5 cells/high-power field,P<0.05) in the liver,as well as reduced serum aminotransferase levels (P<0.05) and better survival rates (P<0.05) in animals receiving cultured bone marrow cells relative to ***:Ex vivo-expanded bone marrow cells are capable of relocating to and proliferating in the chemically- injured *** of these pluripotent stem cells appears to improve serum indices of liver function and survival rate in mice after CCl4-induced hepatic damage.

关键词： stem cell therapy stem cell culture acute hepatic injury

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

大鼠VDAC1腺病毒过表达载体构建及功能鉴定

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南昌大学学报（医学版） 2024年第1期64卷 20-24页

作者：赵嘉仪袁明明王利军赖松青邹华西黄琼刘季春黄璜南昌大学第一附属医院心脏大血管外科南昌330006 南昌大学焕奎书院南昌330006

目的构建电压依赖性阴离子通道蛋白1(VDAC1)腺病毒过表达载体,并观察其在H9C2.胞中的表达情况,为探究VDAC1在心肌细胞缺血再灌注损伤中的作用机制奠定基础。方法构建ADV6-NC腺病毒及ADV6-VDAC1腺病毒,取第6代H9c2.肌样细胞用于转染。... 详细信息

目的构建电压依赖性阴离子通道蛋白1(VDAC1)腺病毒过表达载体,并观察其在H9C2.胞中的表达情况,为探究VDAC1在心肌细胞缺血再灌注损伤中的作用机制奠定基础。方法构建ADV6-NC腺病毒及ADV6-VDAC1腺病毒,取第6代H9c2.肌样细胞用于转染。转染细胞分为3组:空白对照组、阴性对照组(转染ADV6-NC腺病毒)和实验组(转染ADV6-VDAC1腺病毒)。通过qPCR和蛋白免疫印迹实验检测各组细胞VDAC1的表达情况。结果成功构建ADV6-NC及ADV6-VDAC1,实验组的VDAC1表达量明显高于空白对照组和阴性对照组,差异具有统计学意义(P2.胞在体外持续高效表达VDAC1。

关键词：电压依赖性阴离子通道蛋白1 肌细胞质粒构建腺病毒载体

Site-specific conjugation of bifunctional chelator BAT to mouse IgG1 Fab~1 fragment

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Acta Pharmacologica Sinica 2006年第2期27卷 237-241页

作者： jun LI~1 Xue-hao wang Xiao-{2. wang Zhao-lai CHEN Division of Hepatic Surgery.department of Surgery,the First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital.Nanjing 2.002..china Division of Hepatic Surgery Department of Surgery the First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital Nanjing 210029 China

Aim:To perform a site-specific conjugation of Fab’ fragments of a mouse mono-clonal antibody(MoAb)B43(of IgG1subtype)to a bifunctional chelator 6-[p-(bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-N,N′,N″,N′″-tetraacetic acid(BAT)via the thiol groups in the hinge distal to the antigen-binding site of the Fab~***:B43 was cleaved using a simple 2.step ***,stable F(ab~1)2.as produced by pepsin ***~1 with tree thiol in thehinge region was then obtained by cysteine reduction of F(ab~1)***,a site-specific conjugation of Fab~1 to thiol-specific BAT was performed in a ***:The Fab~1 fragment had approximately 1.8 free thiol groups permolecule after cysteine *** conjugation efficiency and the chemicalyield were approximately 1.2. moles chelator/Fab′ and 74% of the initial concentra-tion of Fab′,*** F(ab′)2.Fab′ and Fab′-BAT all maintained reason-able antigen-binding properties.67Cu labeling of the conjugate under standardconditions did not impair the immunoreactivity of Fab′-***:This isa simple and efficient method for producing immunoreactive conjugates of Fab′-BAT,which can be used to make radiometal-labeled conjugates for further diag-nostic and therapeutic applications.

关键词： conjugation BAT chelator monoclonal antibody

S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1110-1127页

作者： Mengyao Hao Rong Fu jun Tai Zhenhuan Tian Xia Yuan Yang Chen mingjin {2. Huimin Jiang ming Ji Fangfang lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China department of Otolaryngology Head and Neck SurgeryChildren's Hospital Capital Institute of PediatricsBeijing 100020China department of Thoracic Surgery Peking Union Medical College HospitalPeking Union Medical CollegeDong Cheng DistrictBeijing 100730China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China department of Pharmacology School of PharmaceuticalGuangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao SAR 999078China

Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment *** median survival time for IPF patients is approximately 2.3 years and there is no effective intervention to treat IPF other than lung *** important components of lung tissue,endothelial cells(ECs)are associated with pulmonary ***,the role of endothelial dysfunction in pulmonary fibrosis(PF)is incompletely ***-1-phosphate receptor 1(S1PR1)is a G protein-coupled receptor highly expressed in lung *** expression is markedly reduced in patients with ***,we generated an endothelial-conditional S1pr1 knockout mouse model which exhibited inflammation and fibrosis with or without bleomycin(BLM)*** activation of S1PR1 with an S1PR1 agonist,IMMH002.exerted a potent therapeutic effect in mice with bleomycin-induced fibrosis by protecting the integrity of the endothelial *** results suggest that S1PR1 might be a promising drug target for IPF therapy.

关键词： Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY72. IMMH002 Protein stability

Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation

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Neural Regeneration Research 2021年第6期16卷 1011-1016页

作者： Hui-Ling wang Fei-lai Liu Rui-Qing Li {2.-Yue Wan Jie-Ying Li Jing Shi {2.-Li Wu jun-Hua Chen Wei-Juan Sun Hong-Xia Feng Wei Zhao Jin Huang Ren-Chao Liu Wen-Xue Hao Xiao-Dong Feng Rehabilitation Center the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhouHenan ProvinceChina department of Rehabilitation Medicine Fujian University of Chinese MedicineFuzhouFujian ProvinceChina department of Rehabilitation Medicine Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia,but the underlying mechanism has not yet been fully *** have shown that autophagy plays an important role in the formation and development of cognitive impairment,and the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway plays an important role in autophagy *** investigate the role played by the PI3K/Akt signaling pathway in the electroacupuncture treatment of cerebral ischemia/reperfusion rat models,we first established a rat model of cerebral ischemia/reperfusion through the occlusion of the middle cerebral artery using the suture *** at 2.hours after modeling,electroacupuncture was delivered at the Shenting(GV2.)and Baihui(GV2.)acupoints,with a dilatational wave(1-2. Hz frequency,2.mA intensity,6 V peak voltage),for 30 minutes/day over 8 consecutive *** results showed that electroacupuncture reduced the infarct volume in a rat model of cerebral ischemia/reperfusion injury,increased the mRNA expression levels of the PI3K/Akt signaling pathwayrelated factors Beclin-1,mammalian target of rapamycin(mTOR),and PI3K,increased the protein expression levels of phosphorylated Akt,Beclin-1,PI3K,and mTOR in the ischemic cerebral cortex,and simultaneously reduced p53 mRNA and protein expression *** the Morris water maze test,the latency to find the hidden platform was significantly shortened among rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** the spatial probe test,the number of times that a rat crossed the target quadrant was increased in rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** stimulation applied to the Shenting(GV2.)and Baihui(GV2.)acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory *** study was approved by the Animal Ethics Committee

关键词： acupuncture brain central nervous system factor neurological function pathways protein stroke

Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression

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World Journal of Gastroenterology 2014年第29期20卷 10082-10093页

作者： Qing-Yu Zhang Ran Li Guo-Fang Zeng Bin Liu Jie Liu Yang Shu Zhong-Kao Liu Zhi-Dong Qiu Dong-jun wang Hui-{2. Miao ming-Yi Li Run-Zhi Zhu Key Laboratory of Hepatic Disease Affiliated Hospital of Guangdong Medical College department of General Surgery Jiamusi University

AIM: To investigate the effects of dihydromyricetin (DHM) on the migration and invasion of human hepatic cancer cells.

关键词： Dihydromyricetin Migration Invasion Hepatic cancer Matrix metalloproteinase-9