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Late Triassic Intracontinental Deformation of South Tianshan,Central Asia:Evidence from Syn-tectonic Sedimentation and Detrital Zircon Provenances of the Kuqa Depression

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 548-568页

作者： QIN Xiang CHEN Xuanhua SHAO Zhaogang ZHANG Yiping wang Yongchao LI Bing SU He wang Ye LIU kui HAN Lele China Aero Geophysical Survey and Remote Sensing Center for Natural Resources Beijing 100083China Key Laboratory of Airborne Geophysics and Remote Sensing Geology MNRBeijing 100083China Chinese Academy of Geological Sciences Beijing 100037China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China

The Tianshan range,a Paleozoic orogenic belt in Central Asia,has undergone multiple phases of tectonic activities characterized by the N-S compression after the early Mesozoic,including the far-field effects of the Cenozoic Indian-Asian ***,there are limited reports on the tectonic deformation and initiation of Triassic intracontinental deformation in the Tianshan *** this structural context is crucial for interpreting the early intracontinental deformation history of the Eurasian continent during the early *** strata and syn-tectonic sediments provide a rich source of information on tectonic activities and have been extensively used in the studies of orogenic *** on detail fieldwork conducted in this study,the middle-late Triassic Kelamayi Formation of the northern Kuqa Depression in the southern Tianshan fold-thrust belt has been identified as the typical syn-tectonic growth *** youngest detrital zircon component in two lithic sandstone samples from the bottom and top of the Kelamayi growth strata yielded U-Pb ages of 223.4±3.1 and 215.5±2.9 Ma,respectively,indicating that the maximum depositional age of the bottom and top of the Kelamayi growth strata is 226-220 and 218-212 *** geochronological distribution of detrital samples from the Early-Middle Triassic and Late Triassic revealed abrupt changes,suggesting a new source supply resulting from tectonic activation in the Tianshan *** coupling relationship between the syn-tectonic sedimentation of the Kelamayi Formation and the South Tianshan fold-thrust system provides robust evidence that the Triassic intracontinental deformation of the South Tianshan range began at approximately 226-220 Ma(during the Late Triassic)and ended at approximately 218-212 *** findings provide crucial constraints for understanding the intraplate deformation in the Tianshan range during the Triassic.

关键词： growth strata basin-mountain coupling Triassic Indosinian event Kuqa Depression South Tianshan

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数字流域研究平台建设雏议

水利学报 2006年第2期37卷 233-239页

作者：王兴奎张尚弘姚仕明郑钧清华大学水沙科学教育部重点实验室北京100084

本文建议数字流域研究平台的建设,应是在三维虚拟仿真场景的支撑下,以原型观测的历史数据和实时信息为基础,以实体模型试验为纽带,以数学模型计算为工具,复演流域的历史进程,研究流域的现状,预报流域的未来发展。文中重点对综合研究方... 详细信息

本文建议数字流域研究平台的建设,应是在三维虚拟仿真场景的支撑下,以原型观测的历史数据和实时信息为基础,以实体模型试验为纽带,以数学模型计算为工具,复演流域的历史进程,研究流域的现状,预报流域的未来发展。文中重点对综合研究方法的协调进程和虚拟仿真系统开发的关键技术进行了论述,对相应的解决方案提出了建议,以都江堰为例探讨了系统的应用前景。

关键词：数字流域三维仿真集成平台

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明渠均匀流的摩阻流速及流速分布

水利学报 2005年第8期36卷 950-955页

作者：刘春晶李丹勋王兴奎清华大学水沙科学教育部重点实验室北京100084

在水槽系统上对明渠恒定均匀流进行了系列实验,利用实测流速资料,对明渠均匀流摩阻流速的各种方法(雷诺应力法、对数流速分布法、阻力平衡法等)的计算结果进行了对比,并分析了流速分布。结果表明:(1)利用阻力平衡法计算摩阻流速时应考... 详细信息

在水槽系统上对明渠恒定均匀流进行了系列实验,利用实测流速资料,对明渠均匀流摩阻流速的各种方法(雷诺应力法、对数流速分布法、阻力平衡法等)的计算结果进行了对比,并分析了流速分布。结果表明:(1)利用阻力平衡法计算摩阻流速时应考虑边壁影响;(2)包含尾流函数的对数-尾流公式比单一对数公式可以更好的符合实测数据。用单一对数公式描述垂线流速分布时,应采用较小的Karman常数;(3)现有大量明渠均匀流实测资料中,用常用的Karman常数(κ=0.4)时单一对数公式仍可以较好的表示全水深流速分布是因为采用了较大的摩阻流速。

关键词：明渠流流速分布摩阻流速试验研究

基于黎曼近似解的溃堤洪水一维-二维耦合数学模型

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水科学进展 2012年第2期23卷 214-221页

作者：姜晓明李丹勋王兴奎清华大学水沙科学与水利水电工程国家重点实验室北京100084

采用一维-二维耦合数学模型对溃堤洪水进行模拟,可以发挥两者优势,提高计算效率。将基于黎曼近似解Godunov格式的一维、二维水流数学模型通过堰流公式进行耦合,实现交界面的水力要素交互;一维、二维模型均采用中心形式的有限体积法求解... 详细信息

采用一维-二维耦合数学模型对溃堤洪水进行模拟,可以发挥两者优势,提高计算效率。将基于黎曼近似解Godunov格式的一维、二维水流数学模型通过堰流公式进行耦合,实现交界面的水力要素交互;一维、二维模型均采用中心形式的有限体积法求解,分别采用HLL格式和Roe格式计算界面通量,具有一致的空间同步性。通过经典算例验证了模型的可靠性和稳定性,应用耦合模型对1998年松花江干流胖头泡溃堤洪水进行了模拟计算,较好地模拟了溃堤洪水的演进过程与淹没范围,对200年一遇洪水的分洪效果进行了分析,为此区域的分洪利用及松花江中上游防洪调度提供参考依据。

关键词：水动力学有限体积法一维、二维耦合模型溃堤洪水松花江防洪

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong wang wang Kai-Yu Qian Shuai Yuan Gang wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang Tao Liu xing Huang Hang Zheng xing-Huan wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

Polyoxometalate as the assembly material to self-assembled Ni(OH)_(2) nanosheets with electrocatalytic performance

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Nano Research 2024年第8期17卷 7061-7067页

作者： Danyang He Tianyang Li Luozhen Jiang Fei wang Zihao xing Nan wang Zhiyu Jia Guo-Yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Shanghai Advanced Research Institute Chinese Academy of ScienceShanghai 201210China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of ChemistryNortheast Normal UniversityChangchun 130024China

Developing non-noble metal-based electrocatalyst with high catalytic activity is essential for advancing hydrogen energy *** study introduces a hydrothermal method for synthesizing order Ni(OH)_(2) nanosheets,with H_(3)O_(40)PW_(12)(denoted as PW_(12))loaded onto reduced graphene oxide(rGO)coated on nickel foam(referred to as PW_(12)-Ni(OH)_(2)/rGO).This method contrasts with the electrodeposition of Ni(OH)_(2),where PW_(12) is added to the synthetic system to direct the assembly and morphology of the Ni(OH)_(2) through a hydrothermal *** this work,the nickel foam acts dual roles as both the substrate and the source of nickel for the formation of Ni(OH)_(2).The PW_(12)-Ni(OH)_(2)/rGO nanosheets,when successfully prepared and loaded onto the nickel foam(NF),exhibited superior electrocatalytic activity for the hydrogen evolution reaction(HER)in an alkaline electrolyte,achieving a current density of 10 mA·cm^(-2) at an overpotential of 69 ***,we endeavored to expand the application of this material towards the oxygen evolution reaction(OER)by preparing PW_(12)-(Fe/Co)Ni(OH)_(2)/rGO through the addition of metal *** nanocomposite displayed outstanding electrocatalytic activity in alkaline electrolytes,with a current density of 10 mA·cm^(-2)at an overpotential of 211 mV,and demonstrated excellent stability over a 50 h period in a 1 M KOH *** results presented in this paper offer an effective strategy for the preparation of polyoxometalate-based inorganic materials with diverse functionalities,applicable to both HER and OER.

关键词： polyoxometalate Ni(OH)_(2) assembly hydrogen evolution reaction oxygen evolution reaction

Superhydrophilic nickel hydroxide ultrathin nanosheets enable high-performance asymmetric supercapacitors

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Rare Metals 2024年第1期43卷 138-147页

作者： Yi-Ran wang Fei Zhang Jian-Min Gu Xiao-Yu Zhao Ran Zhao xing wang Tian-Hui Wu Jing wang Ji-Dong wang De-Song wang State Key Laboratory of Metastable Materials Science and Technology(MMST) Hebei Key Laboratory of Applied ChemistryYanshan UniversityQinhuangdao 066004China Department of Food and Pharmaceutical Engineering Suihua UniversitySuihua 152000China School of Chemical Science and Engineering Tongji UniversityShanghai 200092China School of Sciences Hebei University of Science and TechnologyShijiazhuang 050018China

Superhydrophilic surfaces have been applied for supercapacitor;however,during energy storage reaction,how the wettability affects the process of electrochemical reaction specifically is still ***,we demonstrate superhydrophilic surface for promotion of electrochemical reactions by liquid affinity and further explain the mechanism,where the transition of the wettability state caused by the change in surface free energy is the main reason for the obvious increase in specific *** citric acid assistance strategy,an intrinsically hydrophobic Ni(OH)_(2)thick nanosheets(HNHTNs,16 nm)can be transitioned into superhydrophilic Ni(OH)_(2)ultrathin nanosheets(SNHUNs,6.8 nm),where the water contact angle was 0°and the surface free energy increased from 8.6to 65.8 mN·m^(-1),implying *** with HNHTNs,the specific capacitance of SNHUNs is doubled:from 1230 F·g^(-1)(HNHTNs)to 2350 F·g^(-1)(2A·g^(-1))and,even at 20 A·g^(-1),from 833 F·g^(-1)(HNHTNs)to 1670 F·g^(-1).The asymmetric capacitors assembled by SNHUNs and activated carbon show 52.44 Wh·kg^(-1)at 160W·kg^(-1)and excellent stability with~90%retention after5000 cycles(~80%retention after 9500 cycles).The promotion of electrochemical performances is ascribed to the change of surface wettability caused by surface free energy,which greatly increase affinity of electrode to the surrounding liquid environment to reduce the interface resistance and optimize the electron transport path.

关键词： Asymmetric supercapacitor Superhydrophilic interface Transition metal hydroxides Ultrathin nanosheets High specific capacitance

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浅水流动阻力特性的试验研究

水科学进展 2008年第3期19卷 378-382页

作者： M.ASIM 王龙李丹勋王兴奎清华大学水沙科学与水利水电工程国家重点实验室北京100084

为研究浅水流动的阻力特性,专门设计了一个试验模型,其规模较大,测量设施齐全。通过多种流量和加糙条件的试验得出:加糙密度将直接影响水流的阻力,小流量时的阻力系数变化明显,随流量的加大,加糙的影响逐渐减弱;阻力系数随相对粗糙度的... 详细信息

为研究浅水流动的阻力特性,专门设计了一个试验模型,其规模较大,测量设施齐全。通过多种流量和加糙条件的试验得出:加糙密度将直接影响水流的阻力,小流量时的阻力系数变化明显,随流量的加大,加糙的影响逐渐减弱;阻力系数随相对粗糙度的加大而增加,不受流量变化的影响;表面流速分布均匀,其平均值与断面平均流速相关性良好。

关键词：浅水流动阻力系数相对粗糙度表面流速试验研究

Artificial Intelligence and Network Pharmacology Reveal the Medication Rules of Professor wang Yu-Ying in the Treatment of Climacteric Syndrome

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 180-190页

作者： Meng-Yuan Hu Tian-xing Yi Qi-Rui Liu Xin-Yu Zhang Ai-Ping Chen Yu-Ying wang Yi Lu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina

Objective: The objective of this study was to explore the medication rules and academic ideas of Professor wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.

关键词： Artificial intelligence climacteric syndrome medication rules network pharmacology Professor wang Yu-Ying