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Construction of a bivalent vaccine candidate against HAdV4/HAdV7 based on capsid-display strategy via Red-homologous recombination and counter-selection methodology

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Biosafety and Health 2024年第2期6卷 70-79页

作者： Peng wang Yunting Shao xichun Yang Wenning Zhang Jianguang Zhou Fang Huang Shuang Liu Jiping Zheng Chengjun Wu Shanhu Li Department of Cell Engineering Beijing Institute of BiotechnologyBeijing 100850China School of Basic Medical Sciences Faculty of MedicineDalian University of TechnologyDalian 116024China Lab of Microbiological Engineering School of Life and Health SciencesHainan UniversityHaikou 570228China

Human adenoviruses(HAdvs)are major respiratory ***,human adenovirus type 4(HAdV4)and human adenovirus type 7(HAdV7)are known for causing fever and pneumonia,with docu-mented cases of fatalities among the *** recent years,HAdV4/HAdv7 has been implicated in caus-ing substantial outbreaks,leading to increased morbidity in multiple *** HAdV4 and HAdV7 infections have been reported in North America,Asia,Europe,Africa,South America,Oceania,and the Middle *** fatalities occurred in North America(the United States)and Asia(China and Singapore).Engineered recombinant adenoviruses have played a crucial role as vaccine *** this study,we con-structed a recombinant adenovirus,Ad4ITRmut-Ad7E3,and evaluated it in vitro and in *** observed that the replication rate of Ad4ITRmut-Ad7E3 was lower than that of the RI-67 strain,indicating that the mutation of inverted terminal repeats(ITRs)weakened the replication ability of *** of BALB/c mice with the bivalent Ad4ITRmut-Ad7E3 vaccine strain,administered by intraperitoneal injection and oral gavage,resulted in the elicitation of neutralizing antibodies targeting HAdV4 and *** finding not only pro-vides a novel method and technique for the efficient construction of a polyvalent recombinant adenovirus vac-cine candidate against HAdV4 and HAdv7 but also against other prevalent adenovirus serotypes such as HAdV3,HAdV11,HAdV14,and HAdv55,from various regions.

关键词： Bivalent adenovirus vaccine Capsid-display strategy ITRs modification Hexon epitope replacement

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GIS组件分类与检索技术的研究和应用

武汉大学学报（信息科学版） 2001年第3期26卷 232-238页

作者：边馥苓王喜春武汉大学遥感信息工程学院武汉市珞喻路129号430079

讨论了组件分类和匹配原理 ,并对签名匹配法进行了研究 ,把它作为从已知的组件中获取可重用组件的方法。最后提出了在国土信息管理领域中GIS组件库的解决方案。

关键词： GIS 软件重用组件库签名匹配组件分类组件检索地理信息系统

Sequential versus simultaneous use of vinorelbine and capecitabine at the same dosage as first-line chemotherapy for patients with metastatic breast cancer

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The Chinese-German Journal of Clinical Oncology 2010年第9期9卷 528-535页

作者： Shiyang Gu, Ping Zhang, Zhen Jia, Biyun wang, Jian Zhang, Zhonghua wang, Haiyi Guo, Jialei wang, Xinmin Zhao, xichun Hu Department of Medical Oncology, Fudan University Shanghai Cancer Hospital Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China Department of Medical Oncology Fudan University Shanghai Cancer Hospital Shanghai China Department of Oncology Shanghai Medical College Fudan University Shanghai China

Objective:It remains unclear whether simultaneous use of two chemotherapeutic drugs is better than sequential *** trial was designed to explore efficacy and safety of sequential vs simultaneous use of vinorelbine and capecitabine at the same dosage as first-line therapy in metastatic breast cancer (MBC).Methods:This was a un-icenter, randomized phase II *** randomized into the simultaneous group (group A) were simultaneously administered with vinorelbine and capecitabine while those in the sequential group (group B) received vinorelbine followed by capecitabine at the same ***:Sixty-six patients were screened and 30 patients were randomized into either ***'re significant differences in the clinical benefit rate (CBR) with 80.0% for group A vs 53.3% for group B (P=0.028).With a median follow up time of 13.5 months, there were no significant differences between the two groups in PFS (median PFS:7.70 months for group A vs 7.23 months for group B, P=0.436).Grade III or IV neutropenia (83.3% vs 50.0%, P=0.006), all grades of fatigue (56.7% vs 30.0%, P=0.037) and anorexia (53.3% vs 23.3%, P=0.017) were significantly more frequent in simultaneous ***:Simultaneous administration of vinorelbine and capecitabine can bring about improvements in CBR, but cannot translate into long-term benefits, such as progression-free survival (PFS) or overall survival (OS).These findings, combined with a relatively better tolerability in sequential group, showed that both simultaneous and sequential administrations are reasonable options for MBC patients.

关键词： vinorelbine capecitabine simultaneous administration sequential administration metastatic breast cancer(MBC) phase II clinical trial

我国汽车车身涂装15年来的技术进步及其展望

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涂料工业 2000年第4期30卷 23-29页

作者：王锡春中国第一汽车集团公司工艺研究所 130011

回顾我国汽车车身涂装 40多年的历程 ,列举近 1 5年的 1 0大成就 ,展望 2 1世纪车身涂装的发展趋势 ,找出差距 ,提出笔者的建议。

关键词：车身涂装汽车涂料技术进步

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预焙槽焦粒焙烧启动中的关键技术探讨

轻金属 2003年第6期 29-30页

作者：王喜春李东根焦作万方铝业股份有限公司河南焦作454171

本文针对一些电解铝厂在焦粒焙烧启动中存在的问题 ,对分流技术、焙烧时间、升温速度、降电压和温度的时机。

关键词：预焙槽焦粒焙烧启动焙烧时间升温速度分流技术炉膛建立

风机故障穿越特性对大规模风电直流外送系统暂态过电压的影响及参数优化

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电网技术 2021年第12期45卷 4612-4620页

作者：王熙纯刘纯林伟芳解鸿斌新能源与储能运行控制国家重点实验室(中国电力科学研究院有限公司) 北京市海淀区100192

随着高比例新能源发电越来越成为当前力争实现“碳达峰、碳中和”目标下的主力电源,特高压直流输电工程的陆续投运和大规模新能源的集中接入使得直流故障引发的暂态过电压问题日益凸显,严重威胁电网设备安全,影响特高压直流输电外送能... 详细信息

随着高比例新能源发电越来越成为当前力争实现“碳达峰、碳中和”目标下的主力电源,特高压直流输电工程的陆续投运和大规模新能源的集中接入使得直流故障引发的暂态过电压问题日益凸显,严重威胁电网设备安全,影响特高压直流输电外送能力。新能源机组在暂态过程中的故障穿越特性作为与过电压水平密切相关的重要因素,亟待展开深入研究。从直流故障扰动后系统出现暂态过电压的机理出发,详细介绍了风电机组的低电压穿越特性及相关变量参数,通过某特高压直流输电工程中直驱永磁风机的算例展开了机组故障穿越控制参数对电压暂态特性的敏感性分析,并提出了风电机组控制策略和模型参数的优化建议。研究成果可为当前高占比新能源并网形势下电网的安全稳定运行提供参考。

关键词：暂态过电压低电压穿越风电机组参数优化

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一汽涂装技术的进步

涂料工业 1989年第3期19卷 33-35页

作者：王锡春何凤云第一汽车制造厂

简介了一汽涂装线的技术改造和进步。叙述了新建的CA141车身涂装线的主要工艺流程和投产两年来的使用效果。扼要介绍了该厂自行设计、制造和安装的CA141车箱涂蜓线以及车轮涂装线采用阴极电泳涂装线的改造工程。

关键词：汽车涂装涂装线涂装技术

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基于特定域软件架构的水资源管理系统域分析

计算机工程与应用 2006年第2期42卷 211-214页

作者：王喜春黄介生姜海武汉大学水资源与水电工程科学国家重点实验室武汉430072

根据在水资源管理系统应用开发中的现状和遇到的问题,通过对相关解决技术如领域工程,软件体系架构技术等的研究与分析,介绍了双重生命周期模型,提出了开发水资源管理系统的不同开发模式,以及领域工程所处的位置。与此同时,在水资源管理... 详细信息

根据在水资源管理系统应用开发中的现状和遇到的问题,通过对相关解决技术如领域工程,软件体系架构技术等的研究与分析,介绍了双重生命周期模型,提出了开发水资源管理系统的不同开发模式,以及领域工程所处的位置。与此同时,在水资源管理领域提出了一种结合了特定域软件架构(DSSA)和FODA的优点的域分析方法。以便于在水资源管理系统中降低应用开发复杂度,提高软件生产率,支持动态的灵活可扩展的软件体系架构模型。

关键词：特定域软件架构水资源管理系统域分析

Anti-Tumor and Anti-Diabetic Effects of Sarsasapogenin

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Medicinal Plant 2024年第1期15卷 59-61页

作者： Mingxinzhi wang Jingchao wang Quan QUAN xichun HUANG Xinyu LIU Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

In this paper,the pharmacological effects and molecular mechanisms of sarsasapogenin,such as anti-oxidant,anti-inflammatory and anti-diabetic effects,are reviewed in order to provide a theoretical basis for the subseq... 详细信息

关键词： Sarsasapogenin Anti-tumor Anti-diabetic Anti-inflammatory