检索结果-南通市图书馆

中华医学杂志(英文版) 2024年第8期137卷 2024 Mar 19页

作者： wang xiaoshuang wang Jing Cheng Tao Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100005 China

Internal m6A and m7G RNA modifications in hematopoietic system and acute myeloid leukemia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2024年第9期137卷 2024 Mar 28页

作者： Zhang Xiaoxu Ma Yanni Yu Jia Su Rui wang xiaoshuang State Key Laboratory of Common Mechanism Research for Major Diseases State Key Laboratory for Complex Severe and Rare Diseases Institute of Basic Medical Sciences Chinese Academy of Medical Sciences / Peking Union Medical College Beijing China Department of Systems Biology Beckman Research Institute of City of Hope Monrovia CA USA The Institute of Blood Transfusion Chinese Academy of Medical Sciences / Peking Union Medical College Chengdu Sichuan China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences Beijing China Department of Biochemistry and Molecular Biology Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China

Epitranscriptomics focuses on the RNA-modification-mediated post-transcriptional regulation of gene expression. The past decade has witnessed tremendous progress in our understanding of the landscapes and biological functions of RNA modifications, as prompted by the emergence of potent analytical approaches. The hematopoietic system provides a lifelong supply of blood cells, and gene expression is tightly controlled during the differentiation of hematopoietic stem cells (HSCs). The dysregulation of gene expression during hematopoiesis may lead to severe disorders, including acute myeloid leukemia (AML). Emerging evidence supports the involvement of the mRNA modification system in normal hematopoiesis and AML pathogenesis, which has led to the development of small-molecule inhibitors that target N6-methyladenosine (m6A) modification machinery as treatments. Here, we summarize the latest findings and our most up-to-date information on the roles of m6A and N7-methylguanine in both physiological and pathological conditions in the hematopoietic system. Furthermore, we will discuss the therapeutic potential and limitations of cancer treatments targeting m6A.

关键词： N6-methyladenosine N7-methylguanine Hematopoiesis Acute myeloid leukemia Therapeutic target RNA modifications

A Novel Multiple DBC-staked units Package to Parallel More Chips for SiC Power Module

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

CES Transactions on Electrical Machines and Systems 2024年第1期8卷 72-79页

作者： xiaoshuang Hui Puqi Ning Tao Fan Yuhui Kang Kai wang Yunhui Mei Guangyin Lei Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100049China the school of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100190China IEEE the School of Electrical Engineering Tiangong UniversityTianjin 300387China the Academy for Engineering and Technology Fudan UniversityShanghai 200433China

Silicon carbide(SiC) power modules play an essential role in the electric vehicle drive system. To improve their performance, reduce their size, and increase production efficiency, this paper proposes a multiple staked direct bonded copper(DBC) unit based power module packaging method to parallel more chips. This method utilizes mutual inductance cancellation effect to reduce parasitic inductance. Because the conduction area in the new package is doubled, the overall area of power module can be reduced. Entire power module is divided into smaller units to enhance manufacture yield, and improve design freedom. This paper provides a detailed design, analysis and fabrication procedure for the proposed package structure. Additionally, this paper offers several feasible solutions for the connection between power terminals and DBC untis. With the structure, 18dies were paralleled for each phase-leg in a econodual size power module. Both simulation and double pulse test results demonstrate that, compared to conventional layouts, the proposed package method has 74.8% smaller parasitic inductance and 34.9% lower footprint.

关键词： Silicon carbide Electric vehicle Power modules Package

REDH:A database of RNA editome in hematopoietic differentiation and malignancy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第3期137卷 283-293页

作者： Jiayue Xu Jiahuan He Jiabin Yang Fengjiao wang Yue Huo Yuehong Guo Yanmin Si Yufeng Gao Fang wang Hui Cheng Tao Cheng Jia Yu xiaoshuang wang Yanni Ma State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Institute of Blood Transfusion Chinese Academy of Medical SciencesChengduSichuan 610052China

Background:The conversion of adenosine(A)to inosine(I)through deamination is the prevailing form of RNA editing,impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic species.Millions of high-confidence RNA editing sites have been identified and integrated into various RNA databases,providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic targets.However,the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still lacking.Methods:We downloaded RNA sequencing(RNA-seq)data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information(NCBI)Gene Expression Omnibus(GEO)database,and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also used.We performed sequence alignment,identified RNA editing sites,and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic diseases.Results:We established a new database,"REDH",represents RNA editome in hematopoietic differentiation and malignancy.REDH is a curated database of associations between RNA editome and hematopoiesis.REDH integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts(human).Through the Differentiation,Disease,Enrichment,and knowledge modules,each A-to-I editing site is systematically integrated,including its distribution throughout the genome,its clinical information(human sample),and functional editing sites under physiological and pathological conditions.Furthermore,REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy control.Conclusions:REDH is accessible at http://***/.This user-friendly database would aid in understanding the mechanisms of RNA editing in hema

关键词： RNA editing Hematopoietic differentiation Hematopoietic malignancy Database management systems

Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu xiaoshuang Zuo Cheng Ju Xuankang wang Yangguang Ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous repair.These proteins are thus candidate targets for spinal cord injury therapy.Our previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model animals.However,the specific mechanism and potential targets involved remain to be clarified.In this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive days.We found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal cord.Bioinformatics analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed molecules.Immunofluorescence staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord tissue.The expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve rsican.Furthermore,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB 202190.This suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulation.In summary,our findings show that photobiomodu

关键词： chondroitin sulfate proteoglycans Erk MAPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

英国社群档案建设的进展、特征与思考——以英国“社群档案和遗产奖”为例

在线全文

学校读者我要写书评

暂无评论

档案学研究 2024年第3期 135-141页

作者：加小双姚静王春蕾中国人民大学信息资源管理学院北京100872 中国人民大学档案事业发展研究中心北京100872

英国社群档案建设具有悠久历史和丰富实践,追踪其最新动态有助于认识和把握当前特征和今后趋势。本文采用网络调查法和案例分析法,以英国“社群档案和遗产奖”获奖项目为分析样本,对英国社群档案的发展概况进行总结,将其划分为萌芽、兴... 详细信息

英国社群档案建设具有悠久历史和丰富实践,追踪其最新动态有助于认识和把握当前特征和今后趋势。本文采用网络调查法和案例分析法,以英国“社群档案和遗产奖”获奖项目为分析样本,对英国社群档案的发展概况进行总结,将其划分为萌芽、兴起、发展、转型四个阶段,提炼英国社群档案建设的主要特征,包括文化记忆机构的自治与合作、主流与边缘群体的记忆构建、新技术应用和数字档案建设,由此引发在国家与社会的融合、档案与记忆的关联、人文与技术的碰撞等方面关于英国社群档案建设的思考。

关键词：英国文化遗产社群档案记忆构建数字化

1990-2019年中国哮喘患病、疾病负担趋势及其危险因素研究

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2024年第13期27卷 1594-1600页

作者：屈媛媛曹淼王静程丽何小双石河子大学第一附属医院呼吸与危重症医学科新疆维吾尔自治区石河子市832000 石河子大学医学院预防医学系新疆维吾尔自治区石河子市832000

背景哮喘是最常见的慢性呼吸道疾病之一,了解其流行现状、趋势及危险因素,对采取有针对性的哮喘防控措施具有重要意义。目的本研究分析1990—2019年我国哮喘患病、疾病负担情况及其趋势,并进行哮喘危险因素的顺位分析,为我国哮喘的有效... 详细信息

背景哮喘是最常见的慢性呼吸道疾病之一,了解其流行现状、趋势及危险因素,对采取有针对性的哮喘防控措施具有重要意义。目的本研究分析1990—2019年我国哮喘患病、疾病负担情况及其趋势,并进行哮喘危险因素的顺位分析,为我国哮喘的有效防控提供借鉴。方法本研究基于全球疾病负担数据库(GBD)2019,通过伤残调整寿命年(DALY)、早死损失寿命年(YLL)、伤残损失寿命年(YLD)和患病率分析我国1990—2019年不同性别、不同年龄的疾病负担变化趋势,并通过标化DALY率和死亡率的人群归因分值(PAF)分析哮喘危险因素的顺位变化情况。结果2019年我国哮喘年龄标化DALY率、YLL率、YLD率分别为102.81人年/10万、24.50人年/10万和78.31人年/10万,标化患病率为1974.16人年/10万,男性的哮喘年龄标化DALY率、YLL率、YLD率均高于女性,1~9岁和≥65岁组的哮喘年龄标化DALY率、YLL率、YLD率高于其他人群。1990—2019年,≥40岁人群的YLL粗率在逐渐下降,DALY粗率、YLD粗率和患病率在<65岁人群中都有所交叉,但之后呈现出逐年下降的趋势。哮喘二级危险因素的顺位为烟草使用、高BMI和职业性危害。吸烟始终居于造成哮喘疾病负担危险因素的首位,2019年高BMI上升至造成哮喘疾病负担的第二危险因素,且高BMI死亡率的PAF上升至第一位。结论1990—2019年,我国哮喘人群的人均健康损失总体呈下降趋势,1~9岁和≥65岁人群的哮喘疾病负担仍处于较高水平。男性哮喘疾病负担高于女性。哮喘相关危险因素的PAF发生了变化,职业性危害的重要性相对下降,烟草使用、高BMI的影响日益突出。哮喘防治重点可侧重于高危人群(1~9岁、≥65岁、男性、烟草使用、有职业暴露)筛查、戒烟教育、体质量控制以及职业场所监测管理。

关键词：哮喘发病率患病率疾病负担趋势分析危险因素伤残调整寿命年

我国城镇污泥新污染物的赋存特征、治理现状及防控策略

在线全文

学校读者我要写书评

暂无评论

科技导报 2024年第11期42卷 18-28页

作者：李江邹晓爽王斌侯立安贵州大学资源与环境工程学院喀斯特地质资源与环境教育部重点实验室(贵州大学)贵阳550025 贵州喀斯特环境生态系统教育部野外科学观测研究站贵阳550025 贵州大学土木工程学院贵阳550025 中国人民解放军96901部队23分队北京100094

综述了我国城镇污泥中新污染物的赋存特征,梳理了污泥处理处置对新污染物的去除特征,提出了污泥中新污染物治理现状的不足,凝练了污泥新污染物治理研究仍存在的关键科学问题,由此提出了防控策略。从各类新污染物在污泥中的存在水平来看... 详细信息

综述了我国城镇污泥中新污染物的赋存特征,梳理了污泥处理处置对新污染物的去除特征,提出了污泥中新污染物治理现状的不足,凝练了污泥新污染物治理研究仍存在的关键科学问题,由此提出了防控策略。从各类新污染物在污泥中的存在水平来看,抗生素检出率较高,浓度高达μg/g dw;全氟化合物和内分泌干扰物浓度处于ng/g dw级别;微塑料存在水平普遍较高,丰度范围为1600.00~56400.00个/kg dw。污泥厌氧消化和好氧堆肥处理技术能够有效控制和削减污泥中存在的新污染物。不同新污染物的去除效果受污染物的理化性质、生物利用性等污染物自身条件的影响。未来可进一步研究多种新污染物共存体系的去除路径及降解机制,可采用优化堆肥条件和引入特定的微生物菌种相结合的策略来提高新污染物的降解效率,从而获得较安全的堆肥产物。土地利用是污泥堆肥产物的最终去向,我国亟须开展对污泥土地利用过程中各类新污染物的生态风险评价,并建立相应的限量控制标准,以便为污泥土地安全利用提供科学依据。

关键词：城镇污泥新污染物赋存特征控制技术防控策略

在线全文

学校读者我要写书评

暂无评论

红黑着色的相场两相流并行投影算法

重庆大学学报 2024年第6期47卷 75-85页

作者：王小双张良奇肖姚曾忠重庆大学航空航天学院重庆400044

提出一种交错并行的有限体积投影算法求解基于相场法的两相流控制方程组。该算法的实施主要依赖于压力泊松方程的显式推进设计,从而突破投影算法求解不可压Navier-Stokes方程的效率瓶颈。同时,提出了一种交错扫描策略来更新节点上的变量... 详细信息

提出一种交错并行的有限体积投影算法求解基于相场法的两相流控制方程组。该算法的实施主要依赖于压力泊松方程的显式推进设计,从而突破投影算法求解不可压Navier-Stokes方程的效率瓶颈。同时,提出了一种交错扫描策略来更新节点上的变量,以实现更紧凑的时空耦合。本算法与相场模型相结合,能够高效、准确地捕获相界面的动态拓扑变化。测试算例结果表明:网格量为131 072,采用8线程CPU并行时,新提出并行算法的效率达到串行标准投影算法的80倍以上。

关键词：两相流相场法有限体积法投影算法并行计算

1990-2019年我国居民肺癌死亡水平与疾病负担趋势预测研究

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中华肿瘤防治杂志 2024年第2期31卷 65-73页

作者：辛雯艳郭晓莉何小双王蓓徐丽娜石河子大学第一附属医院呼吸内科新疆石河子832000 石河子大学医学院新疆石河子832000

目的探讨我国居民1990-2019年肺癌疾病负担与危险因素,并对流行趋势预测分析,为进一步防控提供依据。方法数据来源于全球疾病负担(GBD)研究,根据中国和全球肺癌的死亡人数、死亡率和标化死亡率(ASMR)描述死亡水平;采用伤残调整寿命年综... 详细信息

目的探讨我国居民1990-2019年肺癌疾病负担与危险因素,并对流行趋势预测分析,为进一步防控提供依据。方法数据来源于全球疾病负担(GBD)研究,根据中国和全球肺癌的死亡人数、死亡率和标化死亡率(ASMR)描述死亡水平;采用伤残调整寿命年综合评估疾病负担;对职业和非职业共16种危险因素负担进行归因分析。运用Joinpoint找出最优模型,即采用对数线性回归模型计算年度变化百分比(APC)和平均年度变化百分比(AAPC),并进行趋势分析。采用贝叶斯年龄-时期-队列(BAPC)模型预测我国不同性别居民肺癌2020-2035年的死亡情况。结果1990和2019年中国肺癌死亡人数分别为25.63万例和75.72万例,变化率为195.39%,AAPC=3.84%(95%CI:3.60~4.08),大约是全球(AAPC=2.27%)的2倍;死亡率从21.65/10万增长到53.23/10万,变化率为145.83%,AAPC=3.08%(95%CI:2.80~3.36),大约是全球(AAPC=0.98%)的3倍;ASMR呈上升趋势,AAPC=0.78%(95%CI:0.56~1.01),但全球呈下降趋势。2019年我国肺癌标化伤残损失寿命年(YLD)、早死损失寿命年(YLL)率和伤残调整寿命年(DALY)率较1990年分别增长了44.49%、8.96%和9.28%,AAPC分别为1.31%(95%CI:1.09~1.53)、0.32%(95%CI:0.09~0.55)和0.33%(95%CI:0.10~0.56);我国肺癌负担男性更高,且增幅更明显。2019年我国肺癌排名前3的危险因素为吸烟、环境PM2.5和二手烟,高空腹血糖水平从1990年的第6位上升至第4位,其标化DALY率上升幅度最大。预测结果显示,2020-2035年,中国男性肺癌的ASMR平缓波动,而女性表现为上升趋势。结论我国居民肺癌的死亡水平和疾病负担较全球严重,其中由高空腹血糖水平引起的负担顺位有所上升。预测2020-2035年女性肺癌标化死亡率将上升。全面掌握我国肺癌负担趋势及其影响因素,并有效预测发展趋势,可以为我国肺癌防控工作提供理论支持。

关键词：肺癌疾病负担贝叶斯年龄-时期-队列模型预测