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RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac^(4)C modification

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International Journal of Oral Science 2024年第1期16卷 73-84页

作者： xiaochen wang Rongsong Ling Yurong Peng Weiqiong Qiu Demeng Chen Center For Translational Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Institute for Advanced Study Shenzhen UniversityShenzhenChina

Existing studies have underscored the pivotal role of N-acetyltransferase 10(NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squamous cell carcinoma(HNSCC) remain unexplored. In this study, we identified a significant upregulation of RNA-binding protein with serine-rich domain 1(RNPS1) in HNSCC, where RNPS1 inhibits the ubiquitination degradation of NAT10 by E3 ubiquitin ligase, zinc finger SWIM domain-containing protein 6(ZSWIM6), through direct protein interaction, thereby promoting high NAT10 expression in HNSCC. This upregulated NAT10 stability mediates the enhancement of specific tRNA ac^(4)C modifications, subsequently boosting the translation process of genes involved in pathways such as IL-6 signaling, IL-8 signaling, and PTEN signaling that play roles in regulating HNSCC malignant progression, ultimately influencing the survival and prognosis of HNSCC patients. Additionally, we pioneered the development of TRMC-seq, leading to the discovery of novel t RNA-ac^(4)C modification sites, thereby providing a potent sequencing tool for tRNAac^(4)C research. Our findings expand the repertoire of tRNA ac^(4)C modifications and identify a role of tRNA ac^(4)C in the regulation of mRNA translation in HNSCC.

关键词： NAT1 thereby translation

An improved deviation model for transonic stages in axial compressors

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Chinese Journal of Aeronautics 2024年第7期37卷 93-108页

作者： xiaochen wang Xuesong LI Xiaodong REN Chunwei GU Xiaobin QUE Guoyu ZHOU Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China China United Gas Turbine Technology Co.Ltd. Beijing 102209China

Deviation model is an important model for through-flow analysis in axial *** analysis in classical deviation models is developed under the assumption of onedimensional flow,which is controlled by the continuity *** consider three-dimensional characteristics in transonic flow,this study proposes an improved theoretical analysis method combining force analysis of the blade-to-blade flow with conventional analysis of the continuity *** of shock structures on transverse force,streamwise velocity and streamline curvature in the blade-to-blade flow are analyzed,and support the analytical modelling of density flow ratio between inlet and outlet ***,a novel deviation model for transonic stages in axial compressors is proposed in this *** empirical coefficients are corrected based on the experimental data of a linear cascade,and the prediction accuracy is validated with the experimental data of a three-stage transonic *** novel model provides accurate predictions for meridional flow fields at the design point and performance curves at design speed,and shows obvious improvements on classical models by Carter and C¸etin.

关键词： Axial compressor Transonic flow Deviation model Through-flow method Aerodynamic performance

Acylfluorination of enynes via phosphine and silver catalysis

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Chinese Chemical Letters 2024年第8期35卷 260-264页

作者： Yu Mao Yilin Liu xiaochen wang Shengyang Ni Yi Pan Yi wang State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

This work describes intermolecular acylfluorination of gem-difluoroenynes using acyl fluorides as both acyl source and fluorine ***-substituted allenones or furans could be selectively achieved via phosphine and silve... 详细信息

关键词： Phosphine catalysis Silver catalysis Difunctionalization Allenone Furan Trifluoromethyl

Cadaverine and putrescine exposure influence carbon and nitrogen cycling genes in water and sediment of the Yellow River

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Journal of Environmental Sciences 2024年第8期142卷 236-247页

作者： wanghong Su Qiaoling Yu Jiawei Yang Qian Han Sijie wang Petr Hedenec xiaochen wang Ruijun Wan-Yan Huan Li School of Public Health Lanzhou UniversityLanzhou 730000China 2 Institute for Tropical Biodiversity and Sustainable DevelopmentUniversity Malaysia Terengganu21030Kuala NerusTerengganuMalaysia State Key Laboratory of Grassland Agro-ecosystems Center for Grassland MicrobiomeCollege of pastoral agriculture science and technology Lanzhou UniversityLanzhou 730000China

The response patterns of microbial functional genes involved in biogeochemical cycles to cadaver decay is a central topic of recent environmental ***,the response mechanisms and pathways of the functional genes associated with the carbon(C)and nitrogen(N)cycling to cadaveric substances such as cadaverine and putrescine remain *** study explored the variation of functional genes associated with C fixation,C degradation and N cycling and their influencing factors under cadaverine,putrescine and mixed *** results showed only putrescine significantly increased the alpha diversity of C fixation genes,while reducing the alpha diversity of N cycling genes in *** the C cycling,the mixed treatment significantly decreased the total abundance of reductive acetyl-CoA pathway genes(i.e.,acsB and acsE)and lig gene linked to lignin degradation in water,while only significantly increasing the hydroxypropionate-hydroxybutylate cycle(i.e.,accA)gene abundance in *** the N cycling,mixed treatment significantly decreased the abundance of the nitrification(i.e.,amoB),denitrification(i.e.,nirS3)genes in water and the assimilation pathway gene(i.e.,gdhA)in *** factors(i.e.,total carbon and total nitrogen)were all negatively associated with the genes of C and N ***,cadaverine and putrescine exposure may inhibit the pathway in C fixation and N cycling,while promoting C *** findings can offer some new insight for the management of amine pollution caused by animal cadavers.

关键词： Carbon cycling Nitrogen cycling Cadaverine Putrescine Pollution management

Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration

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Research 2024年第2期2023卷 95-103页

作者： Yiyu Zhang Da Wei xiaochen wang Boyi wang Ming Li Haiping Fang Yi Peng Qihui Fan Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejang 325000China Songshan Lake Materials Laboratory DongguanGuangdong 523808China School of Science East China University of Science and TechnologyShanghai 200237China Oujang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the *** effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain,yet little is known about their migration *** this work,we study microglial motion with and without the presence of external *** discover that the cells are promptly attracted by the applied forces(i.e.,mechanotaxis),which is a tactic behavior as yet unconfirmed in ***,in both the explorative and the targeted migration,microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion.A closer examination reveals that microglial run-and-tumble is more sophisticated,e.g.,they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis,probably via the responses of mechanosensitive ion *** differences reflect the sharp contrast between microglia and bacteria cells(eukaryotes ***)and their environments(compact tissue ***).Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells(human monocyte and macrophage).This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments.

关键词： analogy closer prompt

The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts

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Journal of Genetics and Genomics 2024年第7期51卷 735-748页

作者： Tongyu Zhang Yingxi Zhu xiaochen wang Danyang Chong Haiquan wang Dandan Bu Mengfei Zhao Lei Fang Chaojun Li Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research CenterMedical School of Nanjing UniversityNational Resource Center for Mutant MiceNanjingJiangsu 210093China State Key Laboratory of Reproductive Medicine and Offspring Health China International Joint Research Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

In mammals,the neonatal heart can regenerate upon injury within a short time after birth,while adults lose this *** reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal ***,we reveal that cardiac metabolic reprogramming could be regulated by altering global protein *** performing 4D label-free proteomics and lysine lactylation(Kla)omics analyses in mouse hearts at postnatal days 1,5,and 7,2297 Kla sites from 980 proteins are identified,among which 1262 Kla sites from 409 proteins are *** clustering analysis reveals that the proteins with altered Kla sites are mainly involved in metabolic *** expression and Kla levels of proteins in glycolysis show a positive correlation while a negative correlation in fatty acid ***,we verify the Kla levels of several differentially modified proteins,including ACAT1,ACADL,ACADVL,PFKM,PKM,and ***,our study reports a comprehensive Kla map in the neonatal mouse heart,which will help to understand the regulatory network of metabolic reprogramming and cardiac regeneration.

关键词： Lactylation Metabolicrep rogramming Postnatal heart regeneration Cell proliferation

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多视角看大模型安全及实践

计算机研究与发展 2024年第5期61卷 1104-1112页

作者：王笑尘张坤张鹏北京智谱华章科技有限公司北京100086

随着人工智能领域大模型(large model)的广泛应用,大模型,尤其是大语言模型(large language model,LLM)的安全问题受到了广泛关注.大模型作为一种新兴技术,与之相关的安全态势分析以及安全体系建设均亟待挖掘与探索.从社会关系以及技术... 详细信息

随着人工智能领域大模型(large model)的广泛应用,大模型,尤其是大语言模型(large language model,LLM)的安全问题受到了广泛关注.大模型作为一种新兴技术,与之相关的安全态势分析以及安全体系建设均亟待挖掘与探索.从社会关系以及技术应用2个视角,分析了大模型安全的整体趋势.同时,基于大模型自身的特点,梳理了大模型安全能力建设的实践思路,为大模型研发、大模型应用构建提供了安全体系构建的参考方案.介绍的大模型安全能力实践方案包括安全评估基准建设、模型价值观对齐方法、模型线上服务安全系统建设3个部分.

关键词：大模型大模型线上服务安全系统人工智能伦理大模型安全形势分析

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我国特种工程塑料产业发展现状及对策建议

塑料工业 2024年第9期52卷 34-39页

作者：王晓晨中石化(上海)石油化工研究院有限公司上海201028

特种工程塑料属于国家经济先导性产业,对于新能源汽车、5G通讯、航空航天、医疗等领域的发展起到关键推动作用。本文综述了国内特种聚酰胺[耐高温尼龙(PPA)/长碳链尼龙(LCPA)]、聚酰亚胺(PI)、聚苯硫醚(PPS)、液晶高分子聚合物(LCP)、... 详细信息

特种工程塑料属于国家经济先导性产业,对于新能源汽车、5G通讯、航空航天、医疗等领域的发展起到关键推动作用。本文综述了国内特种聚酰胺[耐高温尼龙(PPA)/长碳链尼龙(LCPA)]、聚酰亚胺(PI)、聚苯硫醚(PPS)、液晶高分子聚合物(LCP)、聚醚醚酮(PEEK)、聚砜(PSF)的市场及技术发展现状,分析了特种工程塑料高端产品国产化瓶颈(单体制备、分离纯化技术、聚合工艺和关键装备)。针对国内发展特种工程塑料存在的技术壁垒高、原料短缺、产业结构不合理等问题,从强化创新、促进市场融合、污染防控等方面提出了发展建议。

关键词：特种工程塑料聚酰胺聚酰亚胺聚苯硫醚液晶高分子聚醚醚酮聚砜

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苯乙烯衍生精细化学品技术现状及发展趋势

石油化工 2024年第10期53卷 1528-1535页

作者：王晓晨中石化(上海)石油化工研究院有限公司上海201208

选取甲基苯乙烯、二乙烯基苯两类已有产业基础的和环氧苯乙烷、四苯乙烯两类实验室研究较为充分的精细化学品作为苯乙烯下游衍生发展重点,综述了苯乙烯市场产业与技术进展,梳理重点生产工艺,分析技术关键难点,展望该领域未来市场发展前... 详细信息

选取甲基苯乙烯、二乙烯基苯两类已有产业基础的和环氧苯乙烷、四苯乙烯两类实验室研究较为充分的精细化学品作为苯乙烯下游衍生发展重点,综述了苯乙烯市场产业与技术进展,梳理重点生产工艺,分析技术关键难点,展望该领域未来市场发展前景,为苯乙烯产业高质量发展提供产业及技术发展建议。

关键词：苯乙烯甲基苯乙烯二乙烯基苯环氧苯乙烷四苯乙烯

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