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Calorie restriction and its impact on gut microbial composition and global metabolism

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Frontiers of Medicine 2018年第6期12卷 634-644页

作者： Xiaojiao Zheng shouli wang Wei Jia Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China University of Hawaii Cancer Center HonoluluHI 96813USA

Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. We also propose mechanisms for its beneficial effect. Results showed that probiotic and butyrate-producing microbes increased their relative abundance, whereas proinflammatory strains exhibited suppressed relative abundance following CR. Analyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites were changed due to CR. Examples of dramatic CR-induced changes in host metabolism included a decrease in the rate of lipid biosynthesis and an increase in the rates of fatty acid catabolism, β-oxidation, glycogenolysis, and gluconeogenesis. The observed phenotypes and the further verification of the direct link between gut microbiota and metabolome may benefit patients that are at risk for developing metabolic disease. Thus, improved gut microbiota composition and metabolome are potential biomarkers for determining the effectiveness of dietary interventions for age-related and metabolic diseases.

关键词： caloric restriction gut microbiota metabolome

吴茱萸碱磷脂复合物自微乳给药系统的胃溃疡靶向效应及保护作用评价

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中草药 2024年第1期55卷 171-180页

作者：温健刘文宋朔尧李和蓉金阳张环石惠云王守莉贵州医科大学药学院贵州贵阳550025 易慧生物技术(上海)有限公司上海200120 贵州医科大学贵州省药物制剂重点实验室贵州贵阳550004

目的对吴茱萸碱磷脂复合物自微乳给药系统(evodiamine phospholipid complex self-emulsifying drug delivery system,Evo-PC-SMEDDS)的胃溃疡靶向效应进行评价,并验证其药效。方法通过分析荧光成像结果与激光共聚焦显微镜荧光成像结果... 详细信息

目的对吴茱萸碱磷脂复合物自微乳给药系统(evodiamine phospholipid complex self-emulsifying drug delivery system,Evo-PC-SMEDDS)的胃溃疡靶向效应进行评价,并验证其药效。方法通过分析荧光成像结果与激光共聚焦显微镜荧光成像结果,对该制剂的胃溃疡靶向性做出评价;通过胃组织形态学观察、HE染色结果,评价Evo-PC-SMEDDS对乙醇诱导的大鼠胃溃疡模型的改善作用,并计算胃溃疡指数、胃溃疡抑制率对胃溃疡情况进行量化和评分;通过测定胃分泌物与氧化应激相关因子,推测Evo-PC-SMEDDS可能的作用机制。结果动物荧光成像结果显示,Evo-PC-SMEDDS在大鼠体内存在胃滞留。通过激光共聚焦显微镜观察到,荧光探针FITC标记的Evo-PC-SMEDDS集中分布于模型大鼠的溃疡黏膜表面。药效学结果与HE染色分析结果均显示,Evo-PC-SMEDDS对乙醇诱导的大鼠胃溃疡模型有较好的保护作用,且测得给药组大鼠胃组织中的MPO和NO含量显著降低(P<0.01)。且与吴茱萸碱组相比,其胃组织中GSH水平显著提高(P<0.01),SOD活力更强,MDA含量更低。结论Evo-PC-SMEDDS在胃内滞留时间达到6 h,明显长于在正常大鼠的胃内滞留时间,推断Evo-PC-SMEDDS以胃内滞留方式实现溃疡部位的特异性分布。Evo-PC-SMEDDS对乙醇诱导的大鼠胃溃疡具有显著的保护作用,可通过口服给药方式及时、有效地抑制胃溃疡大鼠胃组织中过氧化脂质的产生,抑制胃液中H+分泌和胃蛋白酶的活性,减轻大鼠的胃溃疡损伤程度。

关键词：自微乳给药系统吴茱萸碱荧光成像激光扫描共聚焦显微镜胃溃疡靶向递送胃黏膜保护

基于COMSOL的7075铝合金微弧氧化时间及正向电压对氧化膜层的影响

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烟台大学学报（自然科学与工程版） 2024年第3期37卷 326-333页

作者：柴永生闫俊鹏张龙王守丽烟台大学机电汽车工程学院山东烟台264005

研究了微弧氧化时间及正向电压对7075铝合金膜层厚度以及生长趋势的影响。以7075铝合金为研究对象,在多物理场仿真软件COMSOL Mutiphysics的帮助下建立铝合金成膜过程中的物理模型,基于有限元的方法求解出了微弧氧化成膜过程中的膜层厚... 详细信息

研究了微弧氧化时间及正向电压对7075铝合金膜层厚度以及生长趋势的影响。以7075铝合金为研究对象,在多物理场仿真软件COMSOL Mutiphysics的帮助下建立铝合金成膜过程中的物理模型,基于有限元的方法求解出了微弧氧化成膜过程中的膜层厚度变化。仿真得到特定时间或者特定电压下的膜层厚度分布图,根据仿真结果绘制了电压-膜层厚度曲线、时间-膜层厚度曲线。由仿真结果可以看出:当正向电压分别为350、400、450 V时,膜层的最大厚度分别为38.804、50.150、61.496μm;当微弧氧化时间分别为15、25、35、45 min时,膜层的最大厚度分别为25.075、41.792、58.508、75.225μm,且膜层厚度均呈现由中间向两侧逐渐减小的现象。根据仿真结果可以得出以下结论:随着正向电压的升高,膜层厚度增大;随着氧化时间的增加,膜层的厚度也增加。在膜层厚度分布上,越靠近阴极的位置膜层越厚,远离阴极的位置膜层比较薄,且不同参数下膜层的最厚点与最薄点出现的位置不变。

关键词：微弧氧化 COMSOL 正向电压氧化时间 7075铝合金

戊己丸对吲哚美辛诱导大鼠胃溃疡的保护作用研究

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中华中医药学刊 2024年第6期42卷 129-134,I0019-I0025页

作者：张环刘文伍天苔李和蓉金阳张明杜华康王守莉石惠云贵州医科大学药学院贵州贵阳550025 贵州医科大学贵州省药物制剂重点实验室贵州贵阳550004 贵州医科大学基础医学院贵州贵阳550025

目的研究戊己丸对吲哚美辛诱导的大鼠胃溃疡的保护作用,并初步探索其可能的作用机制。方法 36只SD大鼠随机分为正常组、模型组、阳性对照组(奥美拉唑,20 mg/kg)、戊己丸低、中、高(2.52、5.04、10.08 g/kg生药量)剂量组,每组6只。各组... 详细信息

目的研究戊己丸对吲哚美辛诱导的大鼠胃溃疡的保护作用,并初步探索其可能的作用机制。方法 36只SD大鼠随机分为正常组、模型组、阳性对照组(奥美拉唑,20 mg/kg)、戊己丸低、中、高(2.52、5.04、10.08 g/kg生药量)剂量组,每组6只。各组大鼠灌胃相应药物或0.5%羧甲基纤维素钠(Carboxymethyl Cellulose, CMC-Na)水溶液,1次/d,连续7 d,于末次给药1 h后,除正常组外,其余各组均给予吲哚美辛(60 mg/kg)灌胃造模;6 h后处死大鼠,收集血清和胃组织。通过改良Guth法计算胃溃疡指数和溃疡抑制率,染色观察比较各组大鼠胃组织病理学变化;使用试剂盒测定胃组织中丙二醛(Malonaldehyde, MDA)、超氧化物歧化酶(Superoxide Dismutase, SOD)和环氧合酶1(Cyclooxygenase-1,COX-1),血清中一氧化氮(Nitric Oxide, NO)、肿瘤坏死因子(Tumor Necrosis Factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)和白细胞介素-10(Interleukin-10,IL-10)的含量;TUNEL染色法比较各组大鼠胃组织细胞凋亡情况;免疫组化法测定胃组织中环氧合酶2(Cyclooxygenase-2,COX-2)、NF-κB(p65)蛋白的表达水平。结果与正常组相比,模型组大鼠胃组织黏膜层、黏膜下层、肌层及浆膜部分结构受损,胃溃疡指数和胃组织细胞凋亡百分比显著升高(P<0.01);MDA、TNF-α、IL-6水平显著升高(P<0.01),COX-1、NO、IL-10和SOD水平显著降低(P<0.01);COX-2和NF-κB(p65)蛋白表达显著升高(P<0.01);与模型组相比,各给药组均能改善胃组织损伤状况;戊己丸中、高剂量组和奥美拉唑组均能显著降低(P<0.01)胃溃疡指数和升高溃疡抑制率,升高COX-1、NO、IL-10水平,降低MDA、COX-2、TNF-α、IL-6和NF-κB(p65)水平,各给药组均明显降低大鼠胃组织细胞凋亡百分比,其中戊己丸中剂量组表现出良好的作用。结论戊己丸对吲哚美辛诱导的大鼠胃溃疡有明显的保护作用,其作用机制可能与改善氧化应激抑制、炎症反应和减少细胞凋亡有关。

关键词：戊己丸胃溃疡吲哚美辛非甾体抗炎药

调神为主针刺联合穴位贴敷对老年失眠患者的影响

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光明中医 2024年第9期39卷 1827-1829页

作者：白薇王炳然刘琪王首力郭政亚妮姬佳宇肖宇王梅北京市通州区新华街道社区卫生服务中心中医科

目的观察调神为主针刺联合穴位贴敷治疗老年失眠的疗效及对焦虑抑郁的影响。方法将100例老年失眠患者随机分为2组，每组50例。2组均给予调神为主针刺，治疗组在此基础上加用穴位贴敷，疗程为4周。观察2组治疗前后的匹兹堡睡眠质量指数... 详细信息

目的观察调神为主针刺联合穴位贴敷治疗老年失眠的疗效及对焦虑抑郁的影响。方法将100例老年失眠患者随机分为2组，每组50例。2组均给予调神为主针刺，治疗组在此基础上加用穴位贴敷，疗程为4周。观察2组治疗前后的匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)和抑郁自评量表(SDS)评分。结果治疗后，2组患者PSQI评分均显著降低(P<0.05);治疗4周、结束后1个月，治疗组PSQI评分均显著低于对照组(P<0.05)。治疗后，2组患者SAS、SDS评分均显著降低(P<0.05),且治疗组SAS、SDS评分显著低于对照组(P<0.05)。结论调神为主针刺联合穴位贴敷治疗老年心肾不交型失眠疗效确切，且能改善患者焦虑抑郁，疗效优于单纯针刺。

关键词：不寐老年失眠心肾不交证调神针刺疗法穴位贴敷疗法

Comparison of interventional and conservative treatment on in-hospital outcomes in elderly patients with acute myocardial infarction

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Journal of Geriatric Cardiology 2005年第1期2卷 24-27页

作者： Yaling HAN Yi LI Quanming JING shouli wang Xiaozeng wang Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China

Objectives To compare the in-hospital outcomes of elderly patients with acute myocardial infarction (AMI)treated by interventional or conservative protocols. Patients and Methods One handred and seventy-six consecutive patients hospitalized for AMI were involved, including 95 patients underwent emergent percutaneous coronary intervention (PCI) within 24 h after the onset of AMI and 81 patients received conservative non-invasive *** characteristics and in-hospital cardiac events of these two divisions were analyzed. Results In the PCI group, success rate of procedure and lesions was 98.9% and 98.5%, respectively. Procedure related complication were occurred in 6 cases(6.3%) and no patient died during operative procedures. PCI group had a lower in-hospital mortality (11.6% vs 24.7%, P＜0.05) and overall cardiac events rate (2A.2%vs56.8%, P＜0.01) compared with conservative group. Patients complicated by pump failure at admission in PCI group had a lower mortality compared with their counterpart in conservative group(27.3% vs 60.9%, P＜0.05). The average hospital duration between the two groups was no significant differences. The coronary care unit (CCU) duration of the PCI group was less than that of conservative group (4±5d vs 8±5d, P＜0.05). Conclusions In elderly patients with AMI, interventional treatment can significantly decrease the in-hospital mortality and cardiac events rate compared with conservative treatment, thus gains a better short-term outcome.

关键词： myocardial infarction, acute elderly angioplasty, percutaneous, transluminal

Human BDCA2^＋CD123^＋CD56^＋ dendritic cells （DCs） related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset

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Protein & Cell 2015年第4期6卷 297-306页

作者： Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu shouli wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang Key Laboratory of Immunity and Infection Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Protein and Peptide Pharmaceuticals Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Graduate School of the Chinese Academy of Sciences Beijing 100080 China Department of Cardiology 306th Hospital of PLA Beijing 100101 China Department of Gynecology and Obstetrics Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Experimental Diagnostic and Specialty Medicine.Hematopathology & Hematology Sections Molecular Pathology Laboratory S. Orsola-Malpighi Hospital Bologna University Bologna 40126 Italy

Dendritic cells （DCs） comprise two functionally distinct subsets： plasmacytoid DCs （pDCs） and myeloid DCs （mDCs）. pDCs are specialized in rapid and massive se- cretion of type I interferon （IFN-I） in response to nucleic acids through Toll like receptor （TLR）-7 or TLR-9. In this report, we characterized a CD56^＋ DC population that express typical pDC markers including CD123 and BDCA2 but produce much less IFN-I comparing with pDCs. In addition, CD56^＋ DCs cluster together with mDCs but not pDCs by genome-wide transcriptional profiling. Accordingly, CD56^＋ DCs functionally resemble mDCs by producing IL-12 upon TLR4 stimulation and priming naive T cells without prior activation. These data suggest that the CD56^＋ DCs represent a novel mDC subset mixed with some pDC features. A CD4^＋CD56^＋ hematological malignancy was classified as blastic plasmacytoid dendritic cell neoplasm （BPDCN） due to its expression of characteristic molecules of ***, we demonstrated that BPDCN is closer to CD56^＋ DCs than pDCs by global gene-expression pro- filing. Thus, we propose that the CD4^＋CD56^＋ neoplasm may be a tumor counterpart of CD56^＋ mDCs but not pDCs.

关键词： dendritic cells CD56^+ DC pDC mDCBPDCN

Effect of short-term high-dose atorvastatin on systemic inflammatory response and myocardial ischemic injury in patients with unstable angina pectoris undergoing percutaneous coronary intervention

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Chinese Medical Journal 2014年第21期127卷 3732-3737页

作者： Sun Fei Yin Zhao Shi Quanxing Zhao Bei wang shouli Department of Cardiology the 306th Hospital of People's Liberation Army Beijing 100101 China

Background Percutaneous coronary intervention （PCI） could develop periprocedural myocardial infarction and inflammatory response and statins can modify inflammatory responses *** aim of this study was to evaluate whether short-term high-dose atorvastatin therapy can reduce inflammatory response and myocardial ischemic injury elicited by *** From March 2012 to May 2014,one hundred and sixty-five statin-naive patients with unstable angina referred for PCI at Department of Cardiology of the 306th Hospital,were enrolled and randomized to 7-day pretreatment with atorvastatin 80 mg/d as high dose group （HD group,n=56） or 20 mg/d as normal dose group （ND group,n=57） or an additional single high loading dose （80 mg） followed 6-day atorvastatin 20 mg/d as loading dose group （LD group,n=52）.Plasma C-reactive protein （CRP） and interleukin-6 （IL-6） levels were determined before intervention and at 5 minutes,24 hours,48 hours,72 hours,and 7 days after *** kinase-myocardial isoenzyme （CK-MB） and cardiac troponin I （cTnl） were measured at baseline and then 24 hours following *** Plasma CRP and IL-6 levels increased from baseline after PCI in all *** reached a maximum at 48 hours and IL-6 level reached a maximum at 24 hours after *** CRP levels at 24 hours after PCI were significantly lower in the HD group （（9.14±3.02） mg/L） than in the LD group （（11.06±3.06） mg/L） and ND group （（12.36±3.08） mg/L,P ＜0.01）; this effect persisted for 72 ***-6 levels at 24 hours and 48 hours showed a statistically significant decrease in the HD group （（16.19±5.39） ng/L and （14.26±4.12） ng/L,respectively）） than in the LD group （（19.26±6.34） ng/L and （16.03±4.08） ng/L,respectively,both P ＜0.05） and ND group （（22.24±6.98） ng/L and （17.24±4.84） ng/L,respectively）.IL-6 levels at 72 hours and 7 days showed no statistically significant difference among the study *** PCI caused a significant increase in CK-MB and cTnl at 24 hours after

关键词： atorvastatin percutaneous coronary intervention C-reactive protein interleukin-6

Safety and feasibility of transradial coronary intervention in Chinese elderly patients

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Journal of Geriatric Cardiology 2007年第1期4卷 14-16页

作者： Quanmin JING Yaling HAN shouli wang Yingyan MA Bo LUAN Huiquan ZHAO Department of Cardiology Shenyang General Hospital of Chinese PLAShenyang 110016China The Liaoyang Third Hospital Liaoyang 110000China

Objective To assess the feasibility and safety of transradial approach in Chinese elderly patients undergoing coronary *** In this prospective study,764 elderly patients with coronary artery disease received percutaneous coronary intervention via either a transradial approach(TRA group)or a transfemoral approach(TFA group).The procedural success rate,success rate of artery access,puncture time,fluoroscopy time,dose of contrast,local complications and post-procedural pulmonary embolism were recorded and compared between 2 *** There was no significant difference of the procedural success rate between the TRA group and the TRF group(96.3%vs.98.2%,P>0.05);there were also no differences of success rate of cannulation,mean fluoroscopy time and mean dose of contrast between the 2 *** mean puncture time was longer in the TRA group than in the TFA group(3.8±2.1 min vs.2.0±3.4 min,P<0.05).However,there were fewer access site-related complications in the TRA group than in the TFA ***-procedural pulmonary embolism occurred in 2 patients in the TFA group but none in the TRA *** Transradial coronary intervention was feasible and safe in most Chinese elderly patients when performed by experienced operators.

关键词： percutaneous coronary intervention radial artery stent elderly Chinese