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Functional characterization of the catalytic and bromodomain of FgGCN5 in development,DON production and virulence of Fusarium graminearum

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Journal of Integrative Agriculture 2020年第10期19卷 2477-2487页

作者： wang qian-nan HUANG Pan-pan ZHOU Shan-yue The Key Lab of Integrated Crop Pests Management of Shandong Province/College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109P.R.China

FgGCN5,a GCN5 homolog in Fusarium graminearum,plays a critical role in hyphal vegetative growth,asexual and sexual reproduction,deoxynivalenol(DON)biosynthesis and plant *** nuclear localized GCN5,four conserved sequence motifs(I-IV)are presented in the catalytic domain and a bromodomain in the *** a lysine acetyltransferase,conserved negatively charged residues are present to neutralize the protons from lysine ***,the role of conserved motifs/domains and residues in FgGCN5 are ***,we generated deletion mutant strains for each the conserved motifs/domains and a glutamate residue 130(E130)replacement *** of each conserved motif in the catalytic domain and replacement of E130 site resulted in manifold defects in hyphae growth,asexual and sexual development,DON biosynthesis,and plant *** defects in the mutant strains were similar to deletion *** deletion of the bromodomain led a significant reduction in DON production and virulence,with no effects on hyphae growth,asexual or sexual ***5 was further found to localize to the nucleus in conidia and hyphae *** conclusion,FgGCN5 encodes a nuclear localized *** conserved motifs in the catalytic domain and E130 are essential for correct functions of the *** conserved bromodomain is impotant for DON production and pathogen *** was the first report to identify the functions of conserved motifs/domains in FgGCN5,which will contribute to our understanding of the mechanism(s)by which FgGCN5 regulates ***.

关键词： FgGCN5 catalytic domain bromodomain DON virulence

QoS Routing Optimization Based on Deep Reinforcement Learning in SDN

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Computers, Materials & Continua 2024年第5期79卷 3007-3021页

作者： Yu Song Xusheng qian nan Zhang Wei wang Ao Xiong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Marketing Service Center State Grid Jiangsu Electric Power Co.Ltd.Nanjing220000China Customer Service Center State Grid Co.Ltd.Nanjing211161China

To enhance the efficiency and expediency of issuing e-licenses within the power sector, we must confront thechallenge of managing the surging demand for data traffic. Within this realm, the network imposes stringentQuality of Service (QoS) requirements, revealing the inadequacies of traditional routing allocation mechanismsin accommodating such extensive data flows. In response to the imperative of handling a substantial influx of datarequests promptly and alleviating the constraints of existing technologies and network congestion, we present anarchitecture forQoS routing optimizationwith in SoftwareDefinedNetwork (SDN), leveraging deep reinforcementlearning. This innovative approach entails the separation of SDN control and transmission functionalities, centralizingcontrol over data forwardingwhile integrating deep reinforcement learning for informed routing decisions. Byfactoring in considerations such as delay, bandwidth, jitter rate, and packet loss rate, we design a reward function toguide theDeepDeterministic PolicyGradient (DDPG) algorithmin learning the optimal routing strategy to furnishsuperior QoS provision. In our empirical investigations, we juxtapose the performance of Deep ReinforcementLearning (DRL) against that of Shortest Path (SP) algorithms in terms of data packet transmission delay. Theexperimental simulation results show that our proposed algorithm has significant efficacy in reducing networkdelay and improving the overall transmission efficiency, which is superior to the traditional methods.

关键词： Deep reinforcement learning SDN route optimization QoS

2020-2023年山东省潍坊市腹泻人群肠炎沙门菌分子分型及耐药性分析

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预防医学论坛 2024年第6期30卷 431-436页

作者：张凤娟汪忆梦王倩楠马淑青郑婵幸子李春苗潍坊市疾病预防控制中心微生物检验科山东261061 山东大学附属儿童医院(济南市儿童医院)输血科

目的分析2020-2023年山东省潍坊市腹泻人群中分离的肠炎沙门菌临床分离株的分子分型及抗生素耐药性,为肠炎沙门菌的预警和防控提供数据支持。方法收集2020-2023年山东省潍坊市国家致病菌识别网哨点医院的沙门菌菌株,进行血清分型,随机选... 详细信息

目的分析2020-2023年山东省潍坊市腹泻人群中分离的肠炎沙门菌临床分离株的分子分型及抗生素耐药性,为肠炎沙门菌的预警和防控提供数据支持。方法收集2020-2023年山东省潍坊市国家致病菌识别网哨点医院的沙门菌菌株,进行血清分型,随机选取48株肠炎沙门菌,采用脉冲场凝胶电泳(PFGE)、多位点序列分型(MLST)、基于全基因组测序(WGS)技术的单核苷酸多态性(SNP)方法进行分子分型,采用微量肉汤法对肠炎沙门菌进行17种抗生素的药物敏感性实验。结果48株肠炎沙门菌经PFGE聚类得到24个带型,相似度为48.61%~100.00%,34个菌株形成10个簇;MLST型别均为ST 11;WGS-SNP系统发育树只可见3簇;48株菌株药物耐药率最高的为萘啶酸100.0%耐药,中介率最高的为环丙沙星(89.6%),100.0%敏感的药物有头孢他啶/阿维巴坦和替加环素;总多重耐药率为97.9%,共形成17种耐药谱,以氨苄西林(AMP)+氨苄西林-舒巴坦(AMS)+多黏菌素E(CT)+萘啶酸(NAL)+链霉素(STR)为优势耐药谱。结论2020-2023年山东省潍坊市肠炎沙门菌的多重耐药现象比较严重,PFGE带型与耐药谱之间无明显的一致性,WGS-SNP系统发育树能更好地区分不同耐药性的菌株,甚至相同耐药性的菌株。

关键词：腹泻肠炎沙门菌分子分型耐药性药敏试验

MnS–MnO heterogeneous nanocube@N,S-doped carbon as a highly efficient bifunctional water splitting electrocatalyst

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Rare Metals 2024年第5期43卷 1977-1988页

作者： Xue-qian wang Xiang-Ying Ma wang-Zhi Wu Hui-Bing He nan-nan wang Ren-Ji Zheng Shao-Jian Ma Yan-Qiu Zhu Pei-Kang Shen Jin-Liang Zhu School of Resources Environment and MaterialsState Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite StructuresCollege of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China School of Chemistry and Chemical Engineering Guangxi MinzuUniversity Nanning 530006 China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

A stable,efficient,and economical bifunctional electrolytic catalyst would be incredibly beneficial for the development of hydrogen production by electrocatalytic water *** this study,we synthesized a novel MnS–MnO heterogeneous nanocube@N,S-doped carbon(MnS–MnO@NSC).MnS–MnO nanocubes possess rich heterogeneous interfaces and plentiful catalytic active sites to promote electrochemical reactions,while the N,S-doped carbon shell possesses excellent conductivity and catalytic properties and protects the ***–MnO@NSC exhibited excellent electrochemical properties as an effective bifunctional electrocatalyst for the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in KOH *** the HER,the overpotential was as low as 124 mV at a current density of 10 mA·cm^(-2)while in the OER,it was only 340 mV at 100 mA·cm^(-2)under the same *** addition,a MnS–MnO@NSC||MnS–MnO@NSC electrolyzer exhibited almost comparable activity and higher steadiness than those exhibited by the state-of-the-art Pt/C||RuO_(2)/C system for full water splitting in KOH solution.

关键词： Manganese sulfide Manganese oxide Doped carbon Heterogeneous nanocube Water splitting

Contrasting strategies of optimizing carrier concentration in bulk InSe for enhanced thermoelectric performance

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Rare Metals 2024年第9期43卷 4425-4432页

作者： Hao-nan Shi Shu-Lin Bai Yu-Ping wang Li-Zhong Su qian Cao Cheng Chang Li-Dong Zhao School of Materials Science and Engineering Beihang University School of Materials Science and Engineering Taiyuan University of Science and Technology Huabei Cooling Device Co.Ltd.

Indium selenide (InSe),as a wide-bandgap semiconductor,has received extensive attention in the flexible electronics field in recent years due to its exceptional plasticity and promising thermoelectric ***,the low carrier concentration severely limits its thermoelectric performance *** this work,we conducted contrasting strategies that can be employed to increase the carrier concentration of InSe,including bandgap narrowing and heterovalent ***,the carrier concentration initially increases as a result of the reduced bandgap upon Te alloying and then slightly decreases due to the weak electronegativity of *** Br doping realizes high carrier concentration by pushing the Fermi level into the conduction bands and activating the multiple *** the other hand,both Te and Br obviously suppress the thermal conductivity due to the point defect *** contrast,Br doping realizes a higher thermoelectric performance with a maximum ZT of～0.13 at 773 K benefiting from the better optimization of carrier *** work elucidates the strategies for enhancing carrier concentration at anion sites and demonstrates the high efficiency of halogen doping in ***,the carrier concentration of InSe is promising to be further optimized,and future work should focus on employing approaches such as cation doping or secondphase compositing.

关键词： Bandgap Carrier concentration Heterovalent doping InSe Thermoelectric

Interfacial Oxygen Octahedral Coupling-Driven Robust Ferroelectricity in Epitaxial Na_(0.5)Bi_(0.5)TiO_(3)Thin Films

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Research 2024年第2期2023卷 149-157页

作者： Haojie Han Qinghua Zhang Wei Li Yiqun Liu Jiasheng Guo Yue wang qian Li Lin Gu Ce-Wen nan Jing Ma State Key Laboratory of New Ceramics and Fine Processing Schoolof Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The oxygen octahedral rotation(OOR)forms fundamental atomic distortions and symmetries in perovskite oxides and definitely determines their properties and ***,epitaxial strain and interfacial structural coupling engineering have been developed to modulate the OOR patterns and explore novel properties,but it is difficult to distinguish the 2 ***,different symmetries are induced in Na_(0.5)Bi_(0.5)TiO_(3)(NBT)epitaxial films by interfacial oxygen octahedral coupling rather than epitaxial *** NBT film grown on the Nb:SrTiO_(3)substrate exhibits a paraelectric tetragonal phase,while with La_(0.5)Sr_(0.5)MnO_(3)as a buffer layer,a monoclinic phase and robust ferroelectricity are obtained,with a remanent polarization of 42μC cm^(-2)and a breakdown strength of 7.89 MV cm^(-1),which are the highest record among NBT-based ***,the interfacial oxygen octahedral coupling effect is demonstrated to propagate to the entire thickness of the film,suggesting an intriguing long-range *** work provides a deep insight into understanding the structure modulation in perovskite heterostructures and an important avenue for achieving unique functionalities.

关键词： effect. interfacial coupling

High-performance and wavelength-transplantable on-chip Fourier transform spectrometer using MEMS in-plane reconfiguration

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Photonics Research 2024年第8期12卷 1730-1740页

作者： HENG CHEN HUI ZHANG JING ZHOU CHEN MA qian HUANG HANXING wang QINGHUA REN nan wang CHENGKUO LEE YIMING MA School of Microelectronics Shanghai UniversityShanghai 201800China Shanghai Collaborative Innovation Center of Intelligent Sensing Chip Technology Shanghai UniversityShanghai 201800China Department of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

On-chip spectrometers with high compactness and portability enable new applications in scientific research and industrial *** transform(FT)spectrometers have the potential to realize a high signal-to-noise *** we propose and demonstrate a generalized design for high-performance on-chip FT *** spectrometer is based on the dynamic in-plane reconfiguration of a waveguide coupler enabled by an integrated comb-drive actuator *** electrostatic actuation intrinsically features ultra-low power *** coupling gap is crucial to the spectral *** in-plane reconfiguration surmounts the lithography accuracy limitation of the coupling gap,boosting the resolution to 0.2 nm for dual spectral spikes over a large bandwidth of 100 nm(1.5–1.6μm)within a compact footprint of 75μm×1000μ***,the in-plane tuning range can be large enough for arbitrary wavelengths to ensure the effectiveness of spectrum *** a result,the proposed spectrometer can be easily transplanted to other operation bands by simply scaling the structural *** a proof-of-concept,a mid-infrared spectrometer is further demonstrated with a dual-spike reconstruction resolution of 1.5 nm and a bandwidth of 300 nm(4–4.3μm).

关键词： waveguide tuning lithography

Overexpression of the peroxidase gene ZmPRX1 increases maize seedling drought tolerance by promoting root development and lignification

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The Crop Journal 2024年第3期12卷 753-765页

作者： Xiuzhen Zhai Xiaocui Yan Tinashe Zenda nan wang Anyi Dong qian Yang Yuan Zhong Yue Xing Huijun Duan State Key Laboratory of North China Crop Improvement and Regulation Key Laboratory of Crop Germplasm Resources in North China Ministry of EducationCollege of AgronomyHebei Agricultural UniversityBaoding 071001HebeiChina

Drought is a main abiotic stress factor hindering plant growth,development,and crop ***,it is crucial to understand the mechanisms by which plants cope with drought ***,the function of the maize peroxidase gene ZmPRX1 in drought stress tolerance was investigated by measurement of its expression in response to drought treatment both in a ZmPRX1 overexpression line and a mutant *** higher root lignin accumulation and seedling survival rate of the overexpression line than that of the wild type or mutant support a role for ZmPRX1 in maize drought tolerance by regulating root development and ***,yeast one-hybrid,Dule luciferase and ChIP-qPCR assays showed that ZmPRX1 is negatively regulated by a nuclear-localized ZmWRKY86 transcription *** gene could potentially be used for breeding of drought-tolerant cultivars.

关键词： Drought tolerance Maize ZmPRX1 Root development Lignin biosynthesis

Spatial Distribution Pattern and Influencing Factors of Bed-and-breakfasts(B&Bs)from the Perspective of Urban-rural Differences:A Case Study of Jiaodong Peninsula,China

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Chinese Geographical Science 2024年第4期34卷 752-763页

作者： wang Xinyue MA qian Management College Ocean University of ChinaQingdao 266100China

There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial *** identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural B&B agglomeration *** study used density-based spatial clustering of applications with noise(DBSCAN)and the multi-scale geographically weighted regression(MGWR)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural B&Bs on the Jiaodong Peninsula of China from 2010 to *** results showed that:1)both urban and rural B&Bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to ***,urban B&Bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural B&Bs continued to expand in terms of quantity and *** B&B clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level *** the number of rural B&B clusters steadily increased over time,their clustering scale was comparatively lower than that of urban B&Bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban B&B clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the main urban ***,rural B&Bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)Transport emerged as a common influencing factor for both urban and rural B&Bs,with the density of road network having the strongest explanatory power for their spatial *** terms of differences,populati

关键词： urban-rural bed-and-breakfasts(B&Bs) spatiotemporal evolution density-based spatial clustering of applications with noise(DBSCAN)model multi-scale geographically weighted regression(MGWR) Jiaodong Peninsula China