检索结果-南通市图书馆

中性粒细胞/淋巴细胞比值及降钙素原对糖尿病酮症酸中毒患者合并细菌感染的预测价值研究

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2021年第6期24卷 669-673页

作者：李黎冯潇宇王敏华四川省巴中市中心医院内分泌科 636000

背景糖尿病酮症酸中毒(DKA)是一种可导致死亡的糖尿病急性并发症,国内外研究显示其最常见的诱因为感染。目的探讨中性粒细胞/淋巴细胞比值(NLR)及降钙素原(PCT)对DKA患者合并细菌感染的预测价值。方法回顾性分析2015-01-01至2020-01-01... 详细信息

背景糖尿病酮症酸中毒(DKA)是一种可导致死亡的糖尿病急性并发症,国内外研究显示其最常见的诱因为感染。目的探讨中性粒细胞/淋巴细胞比值(NLR)及降钙素原(PCT)对DKA患者合并细菌感染的预测价值。方法回顾性分析2015-01-01至2020-01-01巴中市中心医院内分泌科收治的127例DKA住院患者的临床资料,其中合并细菌感染患者64例(DKA合并细菌感染组)、未合并细菌感染患者63例(DKA无细菌感染组)。分析DKA合并细菌感染组患者的细菌培养结果。比较两组患者实验室检查结果,绘制NLR、PCT及二者联合预测DKA合并细菌感染的受试者工作特征(ROC)曲线。结果64例DKA合并细菌感染患者中,金黄色葡萄球菌感染12例(18.8%),大肠埃希菌感染10例(15.6%),肺炎克雷伯菌感染10例(15.6%),铜绿假单胞菌感染8例(12.5%),流感嗜血杆菌感染3例(4.7%),其他类型细菌感染21例(32.8%)。DKA合并细菌感染组患者血糖、NLR、PCT高于DKA无细菌感染组,动脉血pH值、血清HCO-3低于DKA无细菌感染组(P<0.05)。NLR、PCT单独预测DKA患者合并细菌感染的ROC曲线下面积(AUC)分别为0.707[95%CI(0.617,0.797)]、0.715[95%CI(0.624,0.805)],最佳截断值分别为12.94、2.57μg/L,灵敏度分别为59.4%、46.9%,特异度分别为76.2%、93.7%。采用二元Logistic回归分析建立NLR联合PCT检测的回归方程PRE(P):Ln[P/(1-P)]=-1.235+0.046×NLR+0.335×PCT,使用该模型预测DKA患者合并细菌感染的AUC为0.761[95%CI(0.680,0.843)],最佳截断值为0.458,灵敏度为60.9%,特异度为82.5%。结论NLR、PCT均可作为单独预测DKA患者合并细菌感染的临床指标,且二者联合对DKA患者合并细菌感染的预测效能更高。

关键词：糖尿病酮症酸中毒细菌感染中性粒细胞/淋巴细胞比值降钙素原诊断预测

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

脊柱原发性未分化多形性肉瘤1例

中国医学影像技术 2023年第6期39卷 956-957页

作者：周姣龚池闫港王明华贵州医科大学附属医院核医学科贵州贵阳550004

患者女,39岁,左侧肢体麻木伴活动障碍3月余;既往体健。查体:T8~T9椎旁压痛,无放射痛,左侧肱二头肌、肱三头肌力5级,左侧手内肌肌力0级。椎体MRI:C6~T3水平椎管内6.0cm×0.9cm×0.9cm条带状异常信号,呈T1WI等低信号、T2WI及脂肪抑制序列... 详细信息

患者女,39岁,左侧肢体麻木伴活动障碍3月余;既往体健。查体:T8~T9椎旁压痛,无放射痛,左侧肱二头肌、肱三头肌力5级,左侧手内肌肌力0级。椎体MRI:C6~T3水平椎管内6.0cm×0.9cm×0.9cm条带状异常信号,呈T1WI等低信号、T2WI及脂肪抑制序列高信号,增强后明显不均匀强化;邻近脊膜可见强化,相邻蛛网膜下腔变窄呈刀尖样改变,脊髓受压右移.

关键词：脊柱肿瘤肉瘤诊断显像

Three-wavelength rearrangeable 3×3 photonic switch

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Three-wavelength rearrangeable 3×3 photonic switch

2007亚洲光电子会议光电子器件与集成分会场

作者： Haifeng Zhou* Xiaoqing Jiang Jianyi Yang minghua wang Department of Information and Electronic Engineering Zhejiang University Hangzhou China 310027

By using overlapping-imaging characteristic of the multimode interference （MMI） and the area modulation method, this paper presents a three-wavelength 3×3 rearrangeable switch, which consists of the two cascaded building blocks: a 2×2 tunable splitter and a full shuffle 1×3 switch with only one compound modulation region. Its operation characteristics are analyzed by utilizing 2-D BPM simulation. The simulated extinction ratio is higher than 30dB for all operating wavelengths 1545 nm, 1550 nm and 1555 nm. Good 3-D performances can be expected after optimization and improved fabrication.

关键词： Multimode interference optical switch area modulation multi-wavelength waveguide integrated optics

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

现代煤化工发展现状及问题分析

化工进展 2017年第8期36卷 2882-2887页

作者：王明华蒋文化韩一杰神华科学技术研究院有限责任公司北京102211

在油品对外依存度、进口天然气价格和化学品成本竞争等因素影响下,我国现代煤化工已初步具备产业化发展的条件,是石化产业原料多元化的路径之一,能够带动和促进煤炭等行业转型升级。现代煤化工产业在快速发展的同时,存在很大的制约和挑... 详细信息

在油品对外依存度、进口天然气价格和化学品成本竞争等因素影响下,我国现代煤化工已初步具备产业化发展的条件,是石化产业原料多元化的路径之一,能够带动和促进煤炭等行业转型升级。现代煤化工产业在快速发展的同时,存在很大的制约和挑战,如在低油价下竞争力较弱,受环境制约较大和用水矛盾突出等。本文在全面总结分析我国现代煤化工产业所取得成果的基础上,对产业发展所面临的低油价下竞争力、环境保护、碳排放、水资源等问题进行了剖析研究,并提出了解决途径;最后通过解析现代煤化工产业在国家"十三五"计划期间的发展环境,对产业新的发展方式进行了展望,并就发展方式、竞争能力、产业布局、科技创新、标准规范和政策等方面给出了建议。

关键词：现代煤化工产业竞争力碳排放环境保护水资源

Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma(ESCC)

在线全文

学校读者我要写书评

暂无评论

Targeted bisulfite sequencing identified a panel of DNA meth...

基于NSFC-OFDM的非协作式虚拟MIMO

2017中国长三角遗传学大会

作者： Weilin Pu Chenji wang Sidi Chen Dunmei Zhao Yinghui Zhou Yanyun Ma Ying wang Caihua Li Zebin Huang Li Jin Shicheng Guo Jiucun wang minghua wang State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Institutes of Biomedical SciencesFudan University Department of Biochemistry and Molecular Biology Medical CollegeSoochow University Ministry of Education Key Laboratory of Contemporary Anthropology School of Life SciencesFudan University

Background:DNA methylation has been implicated as a promising biomarker for precise cancer ***,limited DNA methylation-based biomarkers have been described in esophageal squamous cell carcinoma(ESCC).Method:A high-throughput DNA methylation dataset(100 samples) of ESCC from the cancer genome atlas(TCGA) project was analyzed and validated along with another independent dataset(12 samples) from the gene expression omnibus(GEO) *** methylation status of peripheral blood mononuclear cells and peripheral blood leucocytes from healthy controls was also utilized for biomarker *** candidate CpG sites as well as their adjacent regions were further validated in 94 pairs of ESCC tumor and adjacent normal tissues from the Chinese Han population using the targeted bisulfite sequencing *** regression and several machine learning methods were applied for evaluation of the diagnostic ability of our *** the discovery stage,five CpG sites were selected as candidate biomarkers for further analysis as shown below:cg05249644,P=2.20 × 10;cgl5830431,P = 3.60 × 10;cg20655070,P = 3.60 × 10;cg26671652,P = 5.77 × 10;and cg27062795,P = 3.60 × *** the validation stage,the methylation status of both the five CpG sites and their adjacent genomic regions were *** diagnostic model based on the combination of these five genomic regions yielded a robust performance(Sensitivity = 0.75,Specificity = 0.88,AUC = 0.85).Eight statistical models along with five-fold cross-validation were further applied,in which the SVM model reached the best accuracy in both training and test dataset(Accuracy = 0.82 and 0.80,respectively).In addition,subgroup analyses revealed a significant difference in diagnostic performance between the alcohol use and non-alcohol use ***:Methylation profiles of the five genomic regions covering cg05249644(STK3),cgl5830431,cg20655070,cg26671652(ZNF418) and cg27062795(ZNF542) can be used for effective met

关键词： Esophageal squamous cell carcinoma DNA methylation Biomarker Diagnosis Targeted bisulfite sequencing

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

重庆邮电大学学报（自然科学版） 2017年第3期29卷 327-334页

作者：曾玖贞王超王彦邓贤君王明华南华大学电气工程学院湖南衡阳421001 湖南大学电气与信息工程学院长沙410082

针对多用户配对虚拟MIMO(multiple input multiple output)安全性差,对信道估计器依赖性强的问题,提出一种基于非相干空频码(non-coherent space frequency code,NSFC)和正交频分复用(orthogonal frequency division multiplexing,OFDM)的非协作式虚拟MIMO。在分析NSFC成对错误概率的基础上,给出能满足全分集阶数和最大编码增益的编码准则。为了获得平行子信道传输效果,利用信道循环矩阵奇异值分解(singular value decomposition,SVD)后得到的酉矩阵分别进行预编码和预解码。基于最优NSFC和OFDM预编解码,提出一种新颖的虚拟MIMO策略。该虚拟MIMO在收发两端均无需信道瞬时信息,以非协作方式在单天线内模拟多天线收发效果。理论和仿真分析结果表明,虚拟MIMO系统能有效逼近实际理想MIMO的系统容量和误比特率性能,显著降低了虚拟MIMO系统的检测门限。

关键词：虚拟多输入输出非协作非相干空频码正交频分复用

Identification of hyper-methylated tumor suppressor genes-based diagnostic panel for esophageal squamous cell carcinoma(ESCC) in a Chinese Han population

在线全文

学校读者我要写书评

暂无评论

Identification of hyper-methylated tumor suppressor genes-ba...

湿疹并发急性细菌性骨关节感染1例并文献复习

2017中国长三角遗传学大会

作者： Chenji wang Weilin Pu Dunmei Zhao Sidi Chen Yinghui Zhou Zhenglei He Xulong Feng Ying wang Caihua Li Li Jin Shicheng Guo Jiucun wang minghua wang Department of Biochemistry and Molecular Biology Medical CollegeSoochow University State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan University Ministry of Education Key Laboratory of Contemporary Anthropology School of Life SciencesFudan University

Background:DNA methylation-based biomarkers were suggested to be promising for early cancer ***,DNA methylation-based biomarkers for esophageal squamous cell carcinoma(ESCC),especially in Chinese Han populations have not been identified and evaluated ***:Candidate tumor suppressor genes(N=65) were selected through literature searching and four public high-throughput DNA methylation microarray datasets including 136 samples totally were collected for initial *** bisulfite sequencing was applied in an independent cohort of 94 pairs of ESCC and normal tissues from a Chinese Han population for eventual ***:ADHFE1,EOMES,SALL1 and TFPI2 were identified and validated in the ESCC samples from a Chinese Han *** four candidate regions were validated to be significantly hypermethylated in ESCC samples(ADHFE1,p = 1.70×10;EOMES,p = 2.90×10;SALLl,p = 3.90×10;TFPI2,p = 3.40 × 10).Logistic regression based prediction model shown a robust ESCC classification performance(Sensitivity = 66%,Specificity = 87%,AUC = 0.81).Moreover,advanced classification method had better performances(random forest and naive Bayes).Interestingly,the diagnostic performance could be improved in non-alcohol use subgroup(AUC = 0.84).Conclusion:Methylation panels of ADHFEl,EOMES,SALL1 and TFPI2 could be an effective methylation-based assay for ESCC diagnosis.

关键词： Esophageal squamous cell carcinoma DNA methylation Biomarker Diagnosis Targeted bisulfite sequencing

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国感染与化疗杂志 2018年第4期18卷 383-388页

作者：袁瑾懿丁蕾王明华赵旭复旦大学附属华山医院抗生素研究所卫计委抗生素临床药理重点实验室上海200040 山东大学附属济南市中心医院感染性疾病科

目的了解湿疹并发急性细菌性骨关节感染的临床特征。方法复习国内外发表湿疹并发细菌性骨关节感染的文献,结合近期收治的1例相关病例进行分析。结果报道1例湿疹并发急性甲氧西林敏感金黄色葡萄球菌(金葡菌)左侧骶髂关节感染伴骶骨旁脓... 详细信息

目的了解湿疹并发急性细菌性骨关节感染的临床特征。方法复习国内外发表湿疹并发细菌性骨关节感染的文献,结合近期收治的1例相关病例进行分析。结果报道1例湿疹并发急性甲氧西林敏感金黄色葡萄球菌(金葡菌)左侧骶髂关节感染伴骶骨旁脓肿。综合1988-2013年文献中该疾病报道,湿疹并发急性细菌性骨关节感染共33例。该疾病患者年龄分布以学龄前儿童为主(54.5%),成年患者仅占21.2%。患者以男性为多,男女比1.75∶1。感染部位以髋关节为主(42.4%),膝关节、骶髂关节、脊柱、指骨远端等亦有发病。最常见病原菌为金葡菌(78.8%),其中甲氧西林敏感株与甲氧西林耐药株比例为3∶2,其次为链球菌属细菌(12.1%)。结论湿疹并发细菌感染多局限于皮肤软组织,并发细菌性骨关节感染少见,主要为金葡菌导致。金葡菌与湿疹合并感染密切相关,并发感染患者应予以针对金葡菌的抗感染治疗。

关键词：湿疹金黄色葡萄球菌骨关节感染

在线全文

学校读者我要写书评

暂无评论

辣椒抗马铃薯Y病毒(PVY)研究进展

分子植物育种 2018年第3期16卷 813-820页

作者：李宁姚明华王飞尹延旭湖北省农业科学院经济作物研究所武汉430064

马铃薯Y病毒(Potato virus Y,PVY)是限制辣椒生产的主要病毒病害之一,该病毒是马铃薯Y病毒组(Potyvirus)的典型代表,能够侵染辣椒等茄科作物,造成重大的经济损失。应用抗病资源、选育抗病品种是克服PVY对辣椒危害最为经济有效的方法。... 详细信息

马铃薯Y病毒(Potato virus Y,PVY)是限制辣椒生产的主要病毒病害之一,该病毒是马铃薯Y病毒组(Potyvirus)的典型代表,能够侵染辣椒等茄科作物,造成重大的经济损失。应用抗病资源、选育抗病品种是克服PVY对辣椒危害最为经济有效的方法。文中综述了辣椒PVY病毒的发现、流行和检测与分类,并针对辣椒抗PVY育种工作描述了抗性鉴定方法、抗原筛选、抗性遗传、分子定位和标记开发的研究进展,介绍了PVY抗性基因与病毒的互作机理,并就辣椒抗PVY育种中存在的问题及未来研究方向进行了讨论。

关键词：辣椒 PVY 分子标记