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Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients With Metabolic Syndrome

International Journal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Cui-Hao song Rui wang Zhen-Kai Zhao Yuan Zhang Jie Sun Xu Zhang Xiang-Yu Ding Jia Bai Xiao-Qiang liang Xuan-Jin Wei Xiao-ling liu Tao Yang Xin-lin liang cheng-Xin li Bi-Wen lin Department of Dermatology PLA General HospitalBeijing 100853China Department of Clinical Laboratory PLA General HospitalBeijing 100853China Department of Dermatology Southern Medical UniversityGuangzhouGuangdong 510515China

Objective:Psoriasis is associated with a high prevalence of metabolic syndrome(MS),and patients with concomitant psoriasis and MS are more severely affected and less responsive to ***,the molecular mechanisms behind these effects are *** studies have shown that leptin may serve as a molecular link between psoriasis and MS,suggesting that high leptin concentrations may exacerbate ***,the molecular mechanism of this effect is still *** aimed to investigate the effect of leptin on autophagy in patients with ***:From January 2021 to June 2022 in PLA General Hospital,we enrolled 51 patients with psoriasis,including 21 patients with MS and 30 without MS,and 30 healthy controls who had undergone nevus *** measured the epidermal leptin,P62,and LC3B concentrations of patients by immunohistochemistry,and measured the serum leptin concentration by enzyme-linked immunosorbent *** then performed correlation analyses to compare these proteins’concentrations between patients with concomitant psoriasis and MS,patients with psoriasis alone,and healthy control ***,we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1,LC3B,and P62;the differentiation markers K10,K16,and K17;and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat ***,we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR *** expression levels of K10,K16,and K17 of HaCat cells were again ***-way analysis of variance was used for the comparison of means of multiple samples,and LSD-t post hoc test was used for comparison between the 2 *** counting data were analyzed by the chisquare *** were evaluated by Pearson correlation ***:The serum leptin concentration was significantly highe

关键词： psoriasis metabolic syndrome leptin autophagy keratinocyte differentiation signal pathway PI3K/AKT/mTOR

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纳米N-A降黏剂的制备及性能评价

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石油化工 2024年第4期53卷 545-552页

作者：宋宏志王少华孙玉豹汪成龚页境李岗中海油田服务股份有限公司油田生产事业部天津300459 中国海洋石油集团有限公司稠油热采重点实验室天津300459 中海石油(中国)有限公司海南分公司海南海口570300

针对普通纳米降黏剂对特稠油降黏效果差、洗油效率低等问题,制备了纳米N-A降黏剂,采用FTIR,TEM等方法表征了降黏剂的微观结构,考察了降黏剂的降黏效果、界面张力以及洗油效率。实验结果表明,纳米N-A降黏剂组成为:50%(w)纳米二氧化硅溶胶... 详细信息

针对普通纳米降黏剂对特稠油降黏效果差、洗油效率低等问题,制备了纳米N-A降黏剂,采用FTIR,TEM等方法表征了降黏剂的微观结构,考察了降黏剂的降黏效果、界面张力以及洗油效率。实验结果表明,纳米N-A降黏剂组成为:50%(w)纳米二氧化硅溶胶+40%(w)分散剂EB-1+4.2%(w)表面修饰剂+5.8%(w)增效剂。该降黏剂分散性能良好,粒径分布在20~60 nm之间,在降黏剂含量为1%(w)、油水质量比为7∶3、200℃,矿化度为0,8829.26 mg/L条件下老化48 h,特稠油降黏后黏度分别为6280,7213 mPa·s,降黏率分别达到83.77%,81.36%,降黏性能保持率分别为96.80%,95.39%。50℃下静置90 d后降黏性能保持率大于90%,可降低油水界面张力至0.076 mN/m,乳化液滴最大粒径9.5μm,洗油效率为30.9%,相对普通降黏剂,驱油效率提高22.3百分点。

关键词：纳米材料特稠油降黏剂表面活性剂

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On-board measurements of gaseous pollutant emission characteristics under real driving conditions from light-duty diesel vehicles in Chinese cities

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Journal of Environmental Sciences 2016年第8期28卷 28-37页

作者： Gang wang Shuiyuan cheng Jianlei Lang song li liang Tian Key Laboratory of Beijing on Regional Air Pollution Control Beijing University of Technology Beijing 100124 China. Collaborative Innovation Center of Electric Vehicles Beijing 100081 China

A total of 15 light-duty diesel vehicles（LDDVs） were tested with the goal of understanding the emission factors of real-world vehicles by conducting on-board emission measurements. The emission characteristics of hydrocarbons（HC） and nitrogen oxides（NOx） at different speeds, chemical species profiles and ozone formation potential（OFP） of volatile organic compounds（VOCs） emitted from diesel vehicles with different emission standards were analyzed. The results demonstrated that emission reductions of HC and NOxhad been achieved as the control technology became more rigorous from Stage I to Stage IV. It was also found that the HC and NOxemissions and percentage of O2 dropped with the increase of speed, while the percentage of CO2 increased. The abundance of alkanes was significantly higher in diesel vehicle emissions, approximately accounting for 41.1%–45.2%, followed by aromatics and alkenes. The most abundant species were propene,ethane, n-decane, n-undecane, and n-dodecane. The maximum incremental reactivity（MIR）method was adopted to evaluate the contributions of individual VOCs to OFP. The results indicated that the largest contributors to O3 production were alkenes and aromatics, which accounted for 87.7%–91.5%. Propene, ethene, 1,2,4-trimethylbenzene, 1-butene, and1,2,3-trimethylbenzene were the top five VOC species based on their OFP, and accounted for 54.0%-64.8% of the total OFP. The threshold dilution factor was applied to analyze the possibility of VOC stench pollution. The majority of stench components emitted from vehicle exhaust were aromatics, especially p-diethylbenzene, propylbenzene, m-ethyltoluene, and p-ethyltoluene.

关键词： light-duty diesel vehicles Emission factor Hydrocarbon Nitrogen oxide Volatile organic compounds Ozone formation potential

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CO_(2)点阵激光联合红蓝光治疗中重度痤疮的临床疗效

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中国激光医学杂志 2024年第1期33卷 29-34,60页

作者：宋婷王媛丽王莉杨娟程娴宋璞空军军医大学西京皮肤科西安市710000

目的本研究旨在分析CO_(2)点阵激光联合红蓝光治疗中重度痤疮的有效性和安全性。方法回顾性分析2017年1月至2021年12月,中重度痤疮患者78例,根据治疗方式不同,分为对照组(n=38)和观察组(n=40)。对照组仅应用红蓝光治疗,蓝光波长415 nm,... 详细信息

目的本研究旨在分析CO_(2)点阵激光联合红蓝光治疗中重度痤疮的有效性和安全性。方法回顾性分析2017年1月至2021年12月,中重度痤疮患者78例,根据治疗方式不同,分为对照组(n=38)和观察组(n=40)。对照组仅应用红蓝光治疗,蓝光波长415 nm,功率密度45 mW/cm^(2),照射时间17 min;红光波长633 nm,功率密度105 mW/cm^(2),能量密度126 J/cm^(2),照射时间20 min。在前4周,每周红、蓝光联合治疗1次,共4次;后4周,红、蓝光交替治疗各2次,共4次,共治疗8周为一个疗程。观察组在红蓝光治疗前应用点阵激光治疗,点阵激光能量参数,采用Deep模式:能量密度20 J/cm^(2);Superficial模式:能量密度90~120 mJ/cm^(2),Density:覆盖率40%~60%,重复1~2次。点阵激光完成后,清除皮肤渗液,用预冷生理盐水敷患处30 min后,进行红蓝光治疗。在治疗第8周末,痤疮综合分级系统量表(global acne grading system,GAGS)两组临床疗效、痤疮分级、皮肤屏障功能、生活质量。同时,记录两组每次治疗后1周内脱屑、瘙痒、红斑、鳞屑、水疱、色素等不良反应发生情况。治疗后3个月,观察痤疮复发情况。结果在治疗第8周末,观察组总有效率为90.0%(36/40),高于对照组60.5%(23/38),差异具有统计学意义(P1周内,观察组不良反应发生率低于对照组,但两组比较差异无统计学意义(P>0.05)。治疗后3个月,观察组复发率低于对照组,差异具有统计学意义(P2)点阵激光联合红蓝光治疗中、重度痤疮临床疗效明显,能早期改善痤疮症状,提升生活质量,且安全、低复发。

关键词：痤疮皮肤点阵激光红蓝光治疗仪联合治疗

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532 nm响应增强的AlGaAs光电阴极

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物理学报 2024年第11期73卷 368-376页

作者：王东智张益军李诗曼童泽昊唐嵩石峰焦岗成程宏昌富容国钱芸生曾玉刚南京理工大学电子工程与光电技术学院南京210094 微光夜视技术重点实验室西安710065 中国科学院长春光学精密机械与物理研究所长春130033

AlGaAs光电阴极具有响应速度快和光谱响应范围可调的特性,可被应用于水下光通信领域.为了解决AlGaAs发射层较低的光吸收限制其量子效率提高的问题,利用分布式布拉格反射镜(DBR)结构对特定波长光的反射作用,将透过光重新反射回发射层进... 详细信息

AlGaAs光电阴极具有响应速度快和光谱响应范围可调的特性,可被应用于水下光通信领域.为了解决AlGaAs发射层较低的光吸收限制其量子效率提高的问题,利用分布式布拉格反射镜(DBR)结构对特定波长光的反射作用,将透过光重新反射回发射层进一步提高吸收率,从而增强阴极在532 nm波长处的响应能力.通过求解一维连续性方程,建立了具有DBR结构的AlGaAs光电阴极光谱响应模型.采用时域有限差分法,分析了DBR结构中子层周期对数、子层材料以及发射层、缓冲层厚度对发射层吸收率的影响,对比了有无DBR结构AlGaAs光电阴极的光吸收分布.结果表明,周期对数为20、子层材料为Al_(0.7)Ga_(0.3)As/AlAs的DBR结构对532 nm光的反射效果最优.基于该DBR结构,发射层和缓冲层厚度分别为495 nm和50 nm时,发射层对532 nm光具有最佳吸收率.通过对外延生长的AlGaAs光电阴极进行激活实验,结果表明具有DBR结构的AlGaAs光电阴极在532 nm波长处的光谱响应率相比无DBR结构的AlGaAs光电阴极光谱响应率提升了约1倍.

关键词： AlGaAs光电阴极分布式布拉格反射镜光谱响应光吸收

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近60a黄河上游流域不同强度降水及大气湿润指数变化的新特征

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干旱区地理 2024年第8期47卷 1327-1337页

作者：程瑛宋兴宇付正旭黎倩王一丞韩兰英兰州中心气象台甘肃兰州730020 陕西师范大学陕西西安710000

深入研究黄河上游流域降水及大气湿润度旨在为其生态环境保护提供科学依据。选用1961-2020年黄河上游流域36个测站降水、气压、气温、风速、相对湿度等资料,采用最小二乘法、Mann-Kendall突变检验和相关分析等方法,分析了黄河上游流域近... 详细信息

深入研究黄河上游流域降水及大气湿润度旨在为其生态环境保护提供科学依据。选用1961-2020年黄河上游流域36个测站降水、气压、气温、风速、相对湿度等资料,采用最小二乘法、Mann-Kendall突变检验和相关分析等方法,分析了黄河上游流域近60 a不同强度降水量、雨日及大气湿润指数的变化特征。结果表明:(1)黄河上游流域年降水量总体呈现西南多、东北少的特征,近60 a以4.9 mm·(10a)^(-1)的速度增加,尤以夏季增加最显著。(2)除小雨雨日减少外,小雨雨量、中雨雨日、雨量及大-暴雨雨日、雨量均呈增加趋势,其中产流区夏季中雨雨量增加最为显著。(3)黄河上游流域各区域湿润指数均呈现一致的下降趋势,其中源头区下降最多,其突变发生在1989年。(4)随着气候变暖,黄河上游流域潜在蒸散量增加的速率比降水增加的速率大,进而造成空气中水分散失增加,大气湿润度下降,对植被生长的潜在风险增加。

关键词：降水量雨日湿润指数变化特征黄河上游流域

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西瓜果实网条突变体的转录组分析

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植物遗传资源学报 2024年第8期25卷 1385-1395页

作者：王志强杜慧莹李程郭松田梅杨万邦于蓉宁夏农林科学院园艺研究所

以条纹自交系西瓜（TD）和网条突变体西瓜（WT）为材料，通过分离群体的条纹性状比例探索西瓜的条性状遗传基础；以转录组测序及表达差异分析为基础，探索网条突变体西瓜在不同发育阶段的表达谱变化，筛选出条纹自交系与网条突变体西瓜... 详细信息

以条纹自交系西瓜（TD）和网条突变体西瓜（WT）为材料，通过分离群体的条纹性状比例探索西瓜的条性状遗传基础；以转录组测序及表达差异分析为基础，探索网条突变体西瓜在不同发育阶段的表达谱变化，筛选出条纹自交系与网条突变体西瓜之间表达差异显著的基因57个，主要富集于光合作用天线蛋白通路、生物碱生物合成通路、氨基酸代谢通路等7种代谢途径；通过加权基因共表达网络对核心基因的进一步分析，初步挖掘出部分网条突变体西瓜中有关生物胁迫抗性的基因变化情况，进一步筛选确定西瓜深绿条纹基因（ClGS,watermelon dark-green stripe）、类半胱氨酸蛋白酶抑制剂5编码基因、UDP-葡萄糖基转移酶编码基因、类长春碱合成酶编码基因、叶绿素a-b结合蛋白编码基因可能是决定西瓜网条果皮性状的核心基因；qRT-PCR验证结果表明，条纹自交系西瓜与网条突变体西瓜在基因表达上存在明显差异。本研究为西瓜不同果皮条纹育种提供了新的种质资源，也为阐明西瓜不同果皮条纹性状形成的分子调控机制提供了一定的理论依据。

关键词：西瓜果皮条纹转录组加权基因共表达网络突变体

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盾构法联络通道T接头局部冻结加固效果及影响因素研究

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隧道建设（中英文） 2024年第1期44卷 90-99页

作者：程雪松徐连坤耿佳李晓凡宋彦杰逯建栋王书雄天津大学建筑工程学院天津300072 天津大学滨海土木工程结构与安全教育部重点实验室天津300072 中铁第六勘察设计院集团有限公司天津300308 天津市地下铁道集团有限公司天津300392

为研究盾构法联络通道T接头局部冻结区域的薄弱位置,探究主隧道管片材料、洞门间隙注浆体热导率、是否注浆改良土体和冻结管环数等因素对局部冻结的影响,依托天津地铁10号线某联络通道T接头局部冻结加固工程,采用数值模拟对局部冻结温... 详细信息

为研究盾构法联络通道T接头局部冻结区域的薄弱位置,探究主隧道管片材料、洞门间隙注浆体热导率、是否注浆改良土体和冻结管环数等因素对局部冻结的影响,依托天津地铁10号线某联络通道T接头局部冻结加固工程,采用数值模拟对局部冻结温度场的分布规律进行分析。研究结果表明:1)对于沿洞门处的土体,联络通道顶底部冻结效果差于联络通道侧面;主隧道钢管片向主隧道底部比向顶部延伸的更长,因而联络通道底半环冻结效果略差于顶半环。2)影响局部冻结时间的主要因素为主隧道管片材料和洞门间隙注浆体的热导率。3)主隧道部分采用钢管片工况,钢管片起到通道壁后远近土体导热“桥梁”的作用;当洞门间隙注浆体的热导率较低(如0.93 W/(m·K))时,注浆体不能及时地向主隧道钢管片输送冷量,联络通道壁后近处土体中大量冻结冷量沿钢管片传递至远处土体,使通道壁后较近处土体温度较高,因而比主隧道全部采用钢筋混凝土管片工况冻结时间长。4)随着洞门间隙注浆体热导率的增大,其向主隧道管片输送冷量的效率得到提升,主隧道附近土体的冻结效果得到改善,冻结时长有所缩短;间隙注浆体热导率由0.93 W/(m·K)提升至1.8 W/(m·K)时,可以将主隧道部分采用钢管片工况冻结时间由17 d缩短至12 d,所需冻结时长相比主隧道全部采用钢筋混凝土管片工况反而缩短1 d,即主隧道部分采用钢管片工况的冻结时间对洞门间隙注浆体热导率的改变更为敏感。

关键词：局部冻结盾构法联络通道 T接头温度场有限元分析

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Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Wenda Zhang Weimin Yuan Zhixing ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P. U. Fynbo Lluis Galbany Saurabh W. Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu Mingjun liu Xing liu Yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao Junfeng wang song wang Tinggui wang Zhongxiang wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui li Junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan liming song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao wang Juan wang Lei wang Wenxin wang Yilong wang Yusa wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University National Astronomical Observatories Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas Chinese Academy of Sciences South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Universite' Paris Cite' CNRS Astroparticule et Cosmologie Universite' Paris Cite' CEA Paris-Saclay School of Astronomy and Space Sciences IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research University of Chinese Academy of Sciences The University of Tokyo ESA/ESTEC Noordwijk 2201 AZ The Netherlands Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics Key Laboratory of Particle Astrophysics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology Hefei School of Astronomy and Space Sciences University of Science and Technology of China Institute of High Energy Physics Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chinese Academy of Science

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 keV,300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for4d,followed by a steep decay till becoming undetectable10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

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Ecohydrological change mechanism of a rainfed revegetation ecosystem at southeastern edge of Tengger desert,Northwest China

引用

Science China Earth Sciences 2004年第z1期47卷 71-77页

作者： XIAO Honglang cheng Guodong li Xinrong song Yaoxuan wang Xinping Shapotou Desert Experimental Research Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Shapotou Desert Experimental Research Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Shapotou Desert Experimental Research Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Shapotou Desert Experimental Research Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Shapotou Desert Experimental Research Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China

Study is made on a 45 km-long artificial ecosystem without irrigation in Tengger desert on the basis of long-term ecological monitoring and ecohydrological *** in water allocation, utilization, cycle and balance patterns in more than 40-year evolution of the soil-plant system are analyzed. The formation of a drought horizon in shrub rhizosphere and its effect, ecohydrological function of the crust and its effect on the soil-plant system change are discussed. Driven by water self-regulation and water stress, the soil-plant system is going to develop towards the steppe desert to ensure more effective use and optimum collocation of water resource.

关键词： ecohydrology, artificial ecosystem, soil-plant evolution, water balance, drought horizon, bio-crust, Chinese desert.

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