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Biotin-modified Galactosylated Chitosan-gene Carrier in Hepatoma Cells Targeting Delivery

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 522-531页

作者：程明荣张锋李清王华 Department of General Surgery Nanxiang Branch of Ruijin HospitalShanghai 201802China Minhang District Pujin Community Health Service Center Shanghai 201112China Hepatobiliary Surgery Center Tongji Hospital Affiliated to Tongji UniversityShanghai 200065China

Our previous studies have successfully grafted biotin and galactose onto chitosan(CS)and synthesized biotin modified galactosylated chitosan(Bio-GC).The optimum N/P ratio of Bio-GC and plasmid DNA was 3:*** this N/P ratio,the transfection efficiency in the hepatoma cells was the highest with a slow release ***-GC nanomaterials exhibit the protective effect of preventing the gene from nuclease degradation,and can target the transfection into hepatoma cells by combination with galactose and biotin *** transfection rate was inhibited by the competition of galactose and ***-GC nanomaterials were imported into cells’cytoplasm by their receptors,followed by the imported exogenous gene transfected into the ***-GC nanomaterials can also cause inhibitory activity in the hepatoma cells in the model of orthotopic liver transplantation in mice,by carrying the gene through the blood to the hepatoma *** together,bio-GC nanomaterials act as gene vectors with the activity of protecting the gene from DNase degradation,improving the rate of transfection in hepatoma cells,and transporting the gene into the cytoplasm in vitro and in ***,they are efficient hepatoma-targeting gene carriers.

关键词： gene vector hepatocellular carcinoma nanoparticles sustained release gene therapy

运动针灸疗法治疗气滞血瘀型颈型颈椎病的临床观察

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新疆中医药 2020年第2期38卷 28-30页

作者：马文王利昕乌鲁木齐市中医医院软伤科新疆乌鲁木齐830001

目的探讨运动针灸疗法在气滞血瘀型颈型颈椎病临床治疗中的应用效果。方法选择2018年6月至2019年6月期间于乌鲁木齐市中医医院就诊的气滞血瘀型颈型颈椎病患者64例,采用随机数字表法分为治疗组与对照组,每组各32例。对照组采取常规针灸... 详细信息

目的探讨运动针灸疗法在气滞血瘀型颈型颈椎病临床治疗中的应用效果。方法选择2018年6月至2019年6月期间于乌鲁木齐市中医医院就诊的气滞血瘀型颈型颈椎病患者64例,采用随机数字表法分为治疗组与对照组,每组各32例。对照组采取常规针灸治疗,治疗组则采取运动针灸疗法治疗,疗程10d。比较两组临床疗效、颈椎疼痛情况、生活质量及复发率。结果治疗组治疗总有效率(93.75%)高于对照组(75.00%),3个月内复发率(3.13%)低于对照组(25.00%),差异有统计学意义(P0.05),治疗组治疗后NPQ、MPQ评分为(19.21±7.26)分、(9.82±3.25)分,均低于对照组的(27.12±8.84)分、(12.29±3.71)分,SF-36评分为(86.34±8.68)分,高于对照组的(80.49±8.27)分,差异有统计学意义(P<0.05)。结论运动针灸疗法治疗气滞血瘀型颈型颈椎病效果确切,能够加快疼痛缓解,降低复发率,减轻疾病对患者生活质量的影响。

关键词：颈型颈椎病运动针灸疗法临床疗效颈痛程度复发率

Battlefield target intelligence system architecture modeling and system optimization

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Journal of Systems Engineering and Electronics 2024年第5期35卷 1190-1210页

作者： li Wei wang Yue JIA lijuan PENG Senran HE Ruixi School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

To address the current problems of poor generality,low real-time,and imperfect information transmission of the battlefield target intelligence system,this paper studies the battlefield target intelligence system from the top-level perspective of multi-service joint ***,an overall planning and analysis method of architecture modeling is proposed with the idea of a bionic analogy for battlefield target intelligence system architecture modeling,which reduces the difficulty of the planning and design *** method introduces the Department of Defense architecture framework(DoDAF)modeling method,the multi-living agent(MLA)theory modeling method,and other combinations for planning and modeling.A set of rapid planning methods that can be applied to model the architecture of various types of complex systems is ***,the liveness analysis of the battlefield target intelligence system is carried out,and the problems of the existing system are presented from several *** the technical prediction of the development and construction is given,which provides directional ideas for the subsequent research and development of the battlefield target intelligence *** the end,the proposed architecture model of the battlefield target intelligence system is simulated and verified by applying the colored Petri nets(CPN)simulation *** analysis demonstrates the reasonable integrity of its logic.

关键词： battlefield target intelligence system architecture modeling bionic design system optimization simulation verification

Comparative analysis of goat and bovine milk proteins in the improvement of sarcopenia based on host-microbial interactions

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Food Science and Human Wellness 2024年

作者： Ruoyu wang Yuxin Ma Meng Sun Lutong li Zhaofeng Zhang Department of Nutrition and Food Hygiene， School of Public Health， Peking University Department of Social Medicine and Health Education， School of Public Health， Peking University Beijing's Key Laboratory of Food Safety Toxicology Research and Evaluation

Introduction: Diet intervention， especially supplementation with high-quality protein， is considered to be a critical strategy in sarcopenia. However， different sources and types of protein have different health impacts. Objectives: The aim of this study is to explore the differences in the ameliorative effects and mechanisms of different sources and types of proteins on sarcopenia， providing an optimal path for the prevention and treatment of sarcopenia. Methods: A sarcopenia model was established by intraperitoneal injection of dexamethasone (5 mg/kg). Sixty male C57BL/6 mice (8 months old) were randomly divided into the normal control， sarcopenia， goat whey protein， goat milk casein， bovine whey protein， and bovine milk casein groups. Animals were treated for eight consecutive weeks. Organism-level and molecular phenotypes， 16S rRNA gene sequencing， and untargeted metabolomics profiling based on GC-TOF/MS were employed to investigate the correlation between host metabolism， microbial metabolism， autophagy and inflammation and their influence on sarcopenia in C57BL/6 male mice. Results: All four proteins increased muscle mass， and goat whey protein improved muscle strength in sarcopenic mice. Goat and bovine milk proteins promoted muscle regeneration by increasing MyoD1 and MyoG expression， and the former had a more distinct effect in inducing autophagy and decreasing inflammation than the latter. In addition， goat whey protein and casein could modulate host-microbial arginine co-metabolism. Notably， goat milk proteins responded well to sarcopenia comorbidities， including sarcopenic obesity， osteosarcopenia， and osteoarthritis. Conclusions: The study confirmed that goat milk proteins were more effective than bovine milk proteins for the control of sarcopenia. Moreover， we found that whey protein and casein could modulate host-microbial arginine co-metabolism， which shows their potential as precision nutritional supplements for the management of sarcopenia. Our

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低压电力线传输衰减模型的建模与仿真

电力系统保护与控制 2014年第22期42卷 68-74页

作者：邵天宇王立欣白瑾珺张刚哈尔滨工业大学电气工程及自动化学院黑龙江哈尔滨150001

信号在电力线的衰减是影响电力线通信可靠性的最主要因素之一。为了准确分析高频信号在电力线的传输中往往要受到集肤效应以及电介损耗的影响,给出一种针对三线制电力线的高频信号传输的RLCG模型。详细分析电力线RLCG模型的建立基础,对... 详细信息

信号在电力线的衰减是影响电力线通信可靠性的最主要因素之一。为了准确分析高频信号在电力线的传输中往往要受到集肤效应以及电介损耗的影响,给出一种针对三线制电力线的高频信号传输的RLCG模型。详细分析电力线RLCG模型的建立基础,对基本单元长度电力线的频率特性进行测量,并利用遗传算法对其内部参数进行辨识。以RVV 3 G 2.5 mm2的普通家用三芯电力线为建模对象,并对RLCG模型得到的仿真结果与实际测量结果进行比较分析。实验与仿真结果表明,电力线RLCG模型在频域和时域上均能准确地反映电力线的高频传输特性,可以为电力载波通信系统的研究提供基础。

关键词：电力线通信集肤效应电介损耗 RLCG模型信号衰减

三七总皂苷的药理作用及其抗皮肤光老化的作用机制

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皮肤病与性病 2015年第3期37卷 151-153页

作者：王鑫丽农祥昆明医科大学第一附属医院皮肤性病科云南昆明650032

大量研究表明长期紫外线照射可引起皮肤光老化,如何预防光老化成为当前研究热点,特别是植物活性成分抗皮肤光老化机制的研究越来越受到国内外学者的关注。三七总皂苷是从天然植物三七花中提取的活性成分之一,其在心血管系统、中枢神经... 详细信息

大量研究表明长期紫外线照射可引起皮肤光老化,如何预防光老化成为当前研究热点,特别是植物活性成分抗皮肤光老化机制的研究越来越受到国内外学者的关注。三七总皂苷是从天然植物三七花中提取的活性成分之一,其在心血管系统、中枢神经系统、泌尿系统、血液系统等方面具有明显的药理作用,近年来研究表明三七总皂苷还具有抗皮肤光老化的作用,现就其抗皮肤光老化作用机制做一综述。

关键词：皮肤光老化植物提取物三七总皂苷药理作用

有导致出血的性施虐-受虐行为的男男性行为者行为特征研究

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中华流行病学杂志 2010年第2期31卷 142-145页

作者：李洋张北川李秀芳臧运书王丽欣陈官芝于增照青岛大学医学院附属医院皮肤科 266003 青岛大学医学院附属医院性健康中心 266003 青岛市市立医院皮肤科

目的探讨有导致出血的性施虐-受虐行为的男男性行为者（MSM）的行为特征，并分析与HW／AIDS高危行为等之间关系。方法采用改良型“滚雪球”抽样法（定向抽样法）进行横断面调查。从MSM有效问卷中获取有导致出血的性施虐-受虐行为者，并... 详细信息

目的探讨有导致出血的性施虐-受虐行为的男男性行为者（MSM）的行为特征，并分析与HW／AIDS高危行为等之间关系。方法采用改良型“滚雪球”抽样法（定向抽样法）进行横断面调查。从MSM有效问卷中获取有导致出血的性施虐-受虐行为者，并在无此行为者中选取比较组进行研究，采用SPSS13．0软件进行统计分析。结果有导致出血的性施虐-受虐行为组累计同性性伴数（M=20）、肛交（M=10）、口交（M=10）、手交（肘=15）同性性伴数及近6个月同性性伴数（M=4）、肛交（肘=3）、手交（M=3）同性性伴数均高于或显著高于比较组。有导致出血的性施虐-受虐行为组近6个月性交中安全套曾破裂或滑脱（22．6％）、曾罹患性传播感染（28．O％）、曾参与群交（34．8％）、近6个月曾在MSM活动场所与陌生同性性交（62．2％）、有过主动或被动的吻肛（64．0％）、拳交（18．9％）、指交行为（66．7％）、性交过程中曾出血（58．3％）、首次性交对象为未成年人（33．8％）、曾有过强烈自杀念头（33．3％）及自杀未遂行为（23．6％）的百分率，均高于或显著高于比较组。结论有导致出血的性施虐一受虐行为的MSM与HIV/AIDS相关的高危行为，显著多于无此行为者，该人群是在健康干预工作中需特殊关注的亚人群。

关键词：男男性行为者艾滋病性施虐-受虐行为高危行为

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高速数据采集模拟通道设计相关问题的研究

电测与仪表 2007年第5期44卷 44-46,57页

作者：王立欣林雨波门亮哈尔滨工业大学哈尔滨150001

基于数据采集系统模拟通道的设计要求,针对高速模拟通道中元件的寄生参数、电源噪声和PCB板上的高频串扰等实际问题进行研究。采用阻容网络实现宽带信号的准确衰减,保证了通带内幅频特性的平坦度;采用宽带缓冲器件LH0033实现了阻抗变换... 详细信息

基于数据采集系统模拟通道的设计要求,针对高速模拟通道中元件的寄生参数、电源噪声和PCB板上的高频串扰等实际问题进行研究。采用阻容网络实现宽带信号的准确衰减,保证了通带内幅频特性的平坦度;采用宽带缓冲器件LH0033实现了阻抗变换,使用BNX005对电源进行EMI滤波,通过合理地线布局,减少高频信号在地线上的耦合,有效抑制了噪声,提高了模拟通道的抗干扰能力。实验结果表明采取上述措施后,50MHz的增益衰减由-2.5dB变为-0.26dB,电源噪声和信号噪声明显降低。

关键词：模拟通道寄生参数阻抗变换电源EMI滤波器

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月球直射辐照度仪同光轴装调及传递定标

光子学报 2024年第4期53卷 158-170页

作者：王鑫蕊李新潘琰李萍张权韦玮秦萌萌中国科学院合肥物质科学研究院安徽光学精密机械研究所合肥230031 中国科学技术大学合肥230026

采用激光水平仪与平面反射镜相结合的方式,在实验室模拟月球对追踪相机与探测镜头进行同光轴装调,避免未同光轴导致测试不到信号或者信号太小造成数据不准确的问题,实验结果显示实验室同光轴装调误差在±0.03°以内。为保证仪器定标系... 详细信息

采用激光水平仪与平面反射镜相结合的方式,在实验室模拟月球对追踪相机与探测镜头进行同光轴装调,避免未同光轴导致测试不到信号或者信号太小造成数据不准确的问题,实验结果显示实验室同光轴装调误差在±0.03°以内。为保证仪器定标系数的准确性,采用已溯源于国家计量基准的标准灯传递定标微光灯的方式,利用激光测距仪与激光水平仪、平面反射镜相结合的方式保证传递定标精度,解决了直接使用标准灯定标带来的探测器非线性响应误差和长定标距离误差的难题。为地基对月观测仪器建立高精度的月球辐射模型提供了一种思路与解决方法。

关键词：辐射定标月球直射辐照度仪激光水平仪同光轴传递定标