检索结果-南通市图书馆

Prediction of pathological complete response and prognosis in locally advanced rectal cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2520-2530页

作者： Yi-Jun Xu Dan Tao Song-Bing Qin Xiao-Yan Xu Kai-Wen Yang Zhong-Xu xing Ju-Ying Zhou Yang Jiao li-li wang Department of Radiation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Radiation Oncology The Fourth Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death *** chemoradiotherapy(nCRT)is standard for locally advanced rectal cancer(LARC).Except for pathological examination after resection,it is not known exactly whether LARC patients have achieved pathological complete response(pCR)before *** date,there are no clear clinical indicators that can predict the efficacy of nCRT and patient *** To investigate the indicators that can predict pCR and long-term outcomes following nCRT in patients with *** Clinical data of 128 LARC patients admitted to our hospital between September 2013 and November 2022 were retrospectively *** were categorized into pCR and non-pCR *** analysis(using the χ^(2) test or Fisher’s exact test)and logistic multivariate regression analysis were used to study clinical predictors affecting *** 5-year disease-free survival(DFS)and overall survival(OS)rates were calculated using Kaplan-Meier analysis,and differences in survival curves were assessed with the log-rank *** Univariate analysis showed that pretreatment carcinoembryonic antigen(CEA)level,lymphocyte-monocyte ratio(LMR),time interval between neoadjuvant therapy completion and total mesorectal excision,and tumor size were correlated with *** results showed that CEA≤5 ng/mL(P=0.039),LMR>2.73(P=0.023),and time interval>10 wk(P=0.039)were independent predictors for *** analysis demonstrated that patients in the pCR group had significantly higher 5-year DFS rates(94.7%vs 59.7%,P=0.002)and 5-year OS rates(95.8%vs 80.1%,P=0.019)compared to the non-pCR *** deposits(TDs)were significantly correlated with shorter DFS(P=0.002)and OS(P<0.001).CONCLUSION Pretreatment CEA,LMR,and time interval contribute to predicting nCRT efficacy in LARC *** pCR demonstrates longer DFS and *** correlate with poor pr

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Pathological complete response Carcinoembryonic antigen Inflammation-related markers Tumor deposit Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于ADAMS的混匀仪振动系统优化分析

引用

机械设计与制造 2023年第7期389卷 187-191页

作者：王立新万卓李晶彭洋洋郑州大学机械与动力工程学院河南郑州450001 广东顺德创新设计研究院广东佛山528311

为了降低混匀仪ThermoMixer C振动系统中轴承和球铰所受的接触力,利用CREO三维建模软件对其振动系统进行建模,然后将含间隙接触的模型导入ADAMS虚拟样机中,分析不同球铰间隙和摩擦因数下轴承和球铰的接触力情况,并运用正交试验方法设计2... 详细信息

为了降低混匀仪ThermoMixer C振动系统中轴承和球铰所受的接触力,利用CREO三维建模软件对其振动系统进行建模,然后将含间隙接触的模型导入ADAMS虚拟样机中,分析不同球铰间隙和摩擦因数下轴承和球铰的接触力情况,并运用正交试验方法设计25组仿真试验。结果表明球铰间隙在大于0.05mm时与接触力成正相关,间隙的增大会降低系统运行的稳定性,摩擦因数与接触力在一定范围内成负相关,并且摩擦因数对结果的影响弱于球铰间隙。发现0.05mm的球铰间隙和0.1的摩擦因数为最优参数组合,其接触力及峰值波动情况均小于原本结构,达到了优化的目的。

关键词：混匀仪优化分析球铰间隙摩擦因数正交试验接触力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

戈尔巴乔夫时期苏共党内政治生活的历史镜鉴

引用

聊城大学学报（社会科学版） 2022年第1期 98-104页

作者：王润涵王立新大连理工大学马克思主义学院辽宁大连116024 南京特殊教育师范学院江苏南京210038

戈尔巴乔夫时期苏共党内政治生活的混乱表现在:否定党的领导,党的权威丧失;党员理想信念淡漠,党内思想混乱;否定民主集中制,削弱党中央权威;派别斗争激烈,党内组织松散;权力缺乏监督,党内腐败蔓延。其原因在于"斯大林体制"弊端影响深远... 详细信息

戈尔巴乔夫时期苏共党内政治生活的混乱表现在:否定党的领导,党的权威丧失;党员理想信念淡漠,党内思想混乱;否定民主集中制,削弱党中央权威;派别斗争激烈,党内组织松散;权力缺乏监督,党内腐败蔓延。其原因在于"斯大林体制"弊端影响深远,戈尔巴乔夫推行错误的改革路线,国内外错误思潮的影响和戈尔巴乔夫个人信仰和领导力的缺失。无产阶级政党开展党内政治生活,必须通过坚持共产党的领导,强化党的思想建设,完善党内民主制度,健全党内规章制度,加强党的作风建设等方式保证党内政治生活的正常开展。

关键词：苏共戈尔巴乔夫党内政治生活教训

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

宫内发育迟缓致胰岛素抵抗的分子机制研究进展

引用

实用儿科临床杂志 2010年第20期25卷 1586-1588页

作者：关育红邢燕王新利北京大学第三医院儿科北京100191

宫内发育迟缓儿在出生后早期即可表现出对胰岛素敏感性降低,在生长发育过程中这种敏感性降低可能会持续存在,直至成年后发生胰岛素抵抗,进而出现一系列代谢性疾病的表现。其发生机制目前尚未完全清楚,研究显示胰岛素靶器官中信号传导通... 详细信息

宫内发育迟缓儿在出生后早期即可表现出对胰岛素敏感性降低,在生长发育过程中这种敏感性降低可能会持续存在,直至成年后发生胰岛素抵抗,进而出现一系列代谢性疾病的表现。其发生机制目前尚未完全清楚,研究显示胰岛素靶器官中信号传导通路上相关信号分子表达发生改变,可能在众多疾病的发生发展中发挥重要作用。

关键词：宫内发育迟缓胰岛素信号通路磷脂酰肌醇3激酶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

引用

Science China life Sciences 2024年

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo li Chunwei Xu Wenxian wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular Oncology Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers, the non-squamous and squamous subtypes （nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology, and potential genomic correlates affecting responses to immune checkpoint inhibitor （ICI）-based treatments. In our inhouse training cohort （n=85）, the presence of the LRP1B deleterious mutation （LRP1B-del） was associated with longer and shorter progression-free survival （PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs, respectively (Pinteraction=0.008). These results were validated using a larger public ICI cohort (n=208, Pinteractionlizumab over docetaxel (hazard ratio （HR）=0.70, P=0.046), whereas this benefit was negligible in those without LRP1B-del （HR=1.05, P=0.64）. Conversely, sqNSCLCs without LRP1Bdel benefited more from atezolizumab （HR=0.60, P=0.002） than those with LRP1B-del （HR=1.30, P=0.31）. Consistent results were observed in the in-house CHOICE-01 cohort, in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone (Pinteraction=0.008). This multi-cohort study delineates the antithetical impacts of LRP1Bdel in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy alone. Our findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs, emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Long-term Consumption of Highland Barley Tea Promotes Healthy Aging of Skeletal Muscle

引用

Food Science and Human Wellness 2024年

作者： li Yan Chenzhipeng Nie Qingwei Zheng Mingcong Fan Waleed AL-Ansi Haifeng Qian li wang State Key Laboratory of Food Science and Technology， School of Food Science and Technology， Jiangnan University

Highland barley tea (HBT) is made from roasted barley seeds and is abundant in β-glucan， amino acids， minerals， phenolics， and other natural active ingredients. These natural compounds found in whole grains have been shown to slow aging and positively affect skeletal muscle function. As a result， studying the effects of HBT on the skeletal muscle health of the elderly population is critical from a scientific and societal standpoint for improving their health status and reducing the medical burden on society. The antioxidant activity and the content of natural active substances were used as indicators to screen the optimal process of HBT brewing. The effects of long-term HBT consumption on aging in mice were investigated by using HBT as a substitute for drinking water in naturally aging mice for a 5-month intervention. Afterward， various factors were measured， such as basic physiological indices， inflammation， plasma metabolites， skeletal muscle function， and exercise capacity， to evaluate the effects of HBT on aging in mice. Long-term consumption of HBT reduced body and spleen weight， increased body weight percentage of skeletal muscle， and reduced plasma inflammation levels in aging mice. Metabolomic results showed increased plasma levels of the mitochondrial marker short-chain acylcarnitine and some amino acids. Additionally， there was a decrease in bile and long-chain acylcarnitine. The level of fibrosis in the gastrocnemius muscle of aging mice was suppressed， and the percentage of type I muscle fibers was increased， improving the endurance of the mice. Thus， long-term consumption of HBT may reduce body weight and increase skeletal muscle mitochondrial activity and exercise capacity in aging mice by reducing inflammation levels and alleviating mitochondrial damage.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肝癌患者血浆RASSF1A及p16基因异常甲基化检测

引用

中国公共卫生 2010年第7期26卷 819-821页

作者：何青芳严冬王立新浙江省疾病预防控制中心慢病所杭州310051 浙江大学医学院附属第一医院

目的探讨血浆RASSF1A基因(Ras association domain family 1 gene)和p16基因的启动子区异常甲基化与原发性肝癌关系。方法采用甲基化特异性PCR(MSP)法,对100例原发性肝癌(HCC)患者、30例乙肝患者、30例肝硬化患者和30名健康体检者血浆中... 详细信息

目的探讨血浆RASSF1A基因(Ras association domain family 1 gene)和p16基因的启动子区异常甲基化与原发性肝癌关系。方法采用甲基化特异性PCR(MSP)法,对100例原发性肝癌(HCC)患者、30例乙肝患者、30例肝硬化患者和30名健康体检者血浆中RASSF1A和p16基因的启动子区异常甲基化状况进行检测。结果 HCC患者血浆RASSF1A和p16基因异常甲基化检出率分别为38.0%(38/100)和65.0%(65/100),而乙肝患者、肝硬化患者和健康体检者均未检出,与HCC组比较,差异均有统计学意义(P=0.000);Logistic回归分析发现,患者年龄、性别、血浆甲胎蛋白(AFP)、HBsAg、p16基因(RASSF1A基因)甲基化状况等与血浆中RASSF1A基因(p16基因)异常甲基化检测结果无关(P>0.05)。结论原发性肝癌患者血浆DNA中可检测到RASSF1A基因和p16基因的甲基化;RASSF1A基因和p16基因的甲基化检测对肝癌筛查有重要意义。

关键词：肝肿瘤 RASSF1A基因 p16基因甲基化血浆

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

炮兵战场目标选择仿真研究

引用

计算机仿真 2012年第12期29卷 17-20页

作者：王立欣贾希胜李文生史宪铭军械工程学院河北石家庄050003

研究作战目标优化选择问题,由于信息化战争炮兵战场目标繁多,目标选择难度越来越大,必须根据作战意图和部队作战能力,进行针对性识别。为了提高目标选择决策的科学性与有效性,建立了炮兵战场目标选择指标体系模型,设计了证据理论融合目... 详细信息

研究作战目标优化选择问题,由于信息化战争炮兵战场目标繁多,目标选择难度越来越大,必须根据作战意图和部队作战能力,进行针对性识别。为了提高目标选择决策的科学性与有效性,建立了炮兵战场目标选择指标体系模型,设计了证据理论融合目标评价信息的具体步骤,用仿真方法引入目标选择识别,通过融合后的各指标综合评价值作为输入数据,构建了基于BP神经网络的目标选择仿真模型。利用案例实验输出的目标选择结果与目标实际选择结果基本一致,说明先用方法对目标选择判别具有实用性和准确性,能够为炮兵战场指挥员开展目标选择提供定量决策依据。

关键词：炮兵目标选择证据理论神经网络

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

WIA-PA中基于DSDV的多路径路由协议研究

引用

计算机工程与设计 2011年第10期32卷 3338-3341页

作者：王立新赵元庆谷川安阳师范学院教务处河南安阳455002 安阳师范学院计算机与信息工程学院河南安阳455002

应用于工业的无线网络有着强实时性和高可靠性的要求,路由协议是WIA-PA网络的关键技术。基于DSDV的多路径路由协议,它采用了基于链路稳定性的路由选择标准和节点不相交路径策略,选择一条最高稳定性的路由传输数据,确定次稳定性、不相交... 详细信息

应用于工业的无线网络有着强实时性和高可靠性的要求,路由协议是WIA-PA网络的关键技术。基于DSDV的多路径路由协议,它采用了基于链路稳定性的路由选择标准和节点不相交路径策略,选择一条最高稳定性的路由传输数据,确定次稳定性、不相交路径作为备份路由。与DSDV相比,多路径算法在网络的稳定性和数据传输的性能上有了显著的提高。

关键词：工业无线网络目的节点序列距离矢量协议链路稳定性多路径节点不相交

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Species recognition and the divergences in the chemical and ultrasonic signals between two coexisting Rattus species

引用

Current Zoology 2024年第4期70卷 531-538页

作者： Wei-Chao wang Zhi-Ming li Yi Chen Jin-Hua Zhang Jian-Xu Zhang Yao-Hua Zhang The State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAs Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

The ability to recognize and differentiate between conspecifics and heterospecifics as well as their signals is critical for the coexistence of closely related *** the genus Rattus,species are morphologically similar and multiple species often ***,we investigated the interspecific recognition and signal differentiation of two sympatric rat species,the brown rat(Rattus norvegicus,RN)and the Asian house rat(Rattus tanezumi,RT).In a two-way choice test,both RN and RT females showed a preference for conspecific male rats to heterospecific *** females showed a significant preference for accessible urine of males of same species to those of other species,but not for the inaccessi-ble *** the other hand,there were significant differences in the structural characteristics of the ultrasonic vocalization emitted by males of these two rat *** dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE)and isoelectric focusing electrophoresis unveiled that major urinary proteins(MUPs)in voided urine were more highly expressed in RN males versus RT *** interspecific dif-ferences of urinary volatile compounds were also *** conclusion,female rats had the ability to distinguish between males of either species.

关键词： Asian house rats brown rats closely related species pheromones ultrasonic vocalization.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：