检索结果-南通市图书馆

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

The issues on the commercialization of perovskite solar cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Futures

Materials Futures 2024年第2期3卷 1-35页

作者： lixiu Zhang Yousheng wang Xiangchuan Meng Jia Zhang Pengfei Wu Min wang Fengren Cao Chunhao Chen Zhaokui wang Fu Yang Xiaodong li Yu Zou Xi Jin Yan Jiang Hengyue li Yucheng liu Tongle Bu Buyi Yan Yaowen li Junfeng Fang lixin Xiao Junliang Yang Fuzhi Huang Shengzhong liu Jizhong Yao liangsheng liao liang li Fei Zhang Yiqiang Zhan Yiwang Chen Yaohua Mai liming Ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190People’s Republic of China Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510632People’s Republic of China Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang 330031People’s Republic of China School of Information Science and Technology Fudan UniversityShanghai 200433People’s Republic of China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072People’s Republic of China School of Physical Science and Technology Soochow UniversitySuzhou 215006People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Institute of optoelectronics Fudan UniversityShanghai 200433People’s Republic of China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123People’s Republic of China School of Physics and Electronic Science East China Normal UniversityShanghai 200241People’s Republic of China State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871People’s Republic of China College of Biophotonics South China Normal UniversityGuangzhou 510631People’s Republic of China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Physics and Electronics Central South UniversityChangsha 410083People’s Republic of China School of Materials Science and Engineering Shaanxi Normal UniversityXi’an 710119People’s Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Microquanta semiconductor Hangzhou 311121People’s Republic of China

Perovskite solar cells have aroused a worldwide research upsurge in recent years due to their soaring photovoltaic performance,ease of solution processing,and low *** power conversion efficiency record is constantly being broken and has recently reached 26.1%in the lab,which is comparable to the established photovoltaic technologies such as crystalline silicon,copper indium gallium selenide and cadmium telluride(CdTe)solar ***,perovskite solar cells are standing at the entrance of industrialization,where huge opportunities and risks ***,towards commercialization,challenges of up-scaling,stability and lead toxicity still remain,the proper handling of which could potentially lead to the widespread adoption of perovskite solar cells as a low-cost and efficient source of renewable *** review gives a holistic analysis of the path towards commercialization for perovskite solar cells.A comprehensive overview of the current state-of-the-art level for perovskite solar cells and modules will be introduced first,with respect to the module efficiency,stability and current status of *** will then discuss the challenges that get in the way of commercialization and the corresponding strategies to address them,involving the upscaling,the stability and the lead toxicity *** into the future direction of commercialization of perovskite photovoltaics was also provided,including the flexible perovskite cells and modules and perovskite indoor ***,the future perspectives towards commercialization are put forward.

关键词： commercializations perovskite solar cells state-of-the-art level challenges and perspectives indoor photovoltaics

Seismicity Analysis of the Beijing Area from an Enhanced Long-Term Earthquake Catalog

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年

作者： Huiying Ge Hongyi li Tongli wang Shengzhong Zhang Bowen Cui Key Laboratory of Intraplate Volcanoes and Earthquakes， Ministry of Education， China University of Geosciences (Beijing) School of Geophysics and Information Technology， China University of Geosciences (Beijing) Beijing Earthquake Agency Information Network and Data Center， China University of Geosciences (Beijing)

Beijing， a major central city， is located at the junction of Northeast Asia and North China， bordered by the Taihang Mountains to the west and the Yanshan Mountain Range to the north. In this study， continuous waveform data from 29 seismic stations operated by the China Earthquake Networks Center (CENC) covering the period from 2010 to 2020 are collected to construct an enhanced catalog for the Beijing area through the integration of both template matching and machine learning methodologies. We first selected 1，884 earthquakes with high signal-to-noise ratios (SNRs) as template events from 3，405 earthquakes， utilizing the graphics processing unit-based match and locate (GPU-M&L) for earthquake detection and location， and a total of 10，392 events were detected. Then， DeepDenoiser， a deep learning-based technique for noise reduction， was applied to extract seismic signals from continuous raw data， and we identified 7，516 seismic events， approximately 2.2 times the number listed in the CENC earthquake catalog. We then employed PhaseNet， a deep neural network-based method， to pick seismic arrival-time， and HypoDD for relocation. Repeating earthquakes were identified by a segmented cross-correlation method through both time and frequency domains. Our study obtains an enhanced catalog for the Beijing area， adding approximately 5，000 earthquakes primarily in the 0-1 magnitude range. The distribution of earthquakes in the Beijing region is mainly concentrated in three main clusters， revealing a potential concealed fault in the Jiudu River area and new evidence of a southern extension of the Xiaotangshan-Dongbeiwang fault zone. Our results provide a reliable and comprehensive data foundation for assessing earthquake risks and enhancing disaster prevention and mitigation strategies in the Beijing region.

关键词：

川西昌台地区晚三叠世双壳生物群的分布与火山活动的相关性

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

成都理工大学学报（自然科学版） 2006年第3期33卷 294-298页

作者：庞艳春林丽朱利东王新利马叶情成都理工大学沉积地质研究院成都610059

川西昌台地区晚三叠世的海相火山活动频繁,每次火山活动的间歇期都沉积有一套深色岩系,主要为泥质板岩、粉砂质板岩和钙质板岩。这套沉积岩系产有丰富的双壳类化石,这套岩系底部与火山岩接触的层位,其所含的双壳类化石类别单一,个体较大... 详细信息

川西昌台地区晚三叠世的海相火山活动频繁,每次火山活动的间歇期都沉积有一套深色岩系,主要为泥质板岩、粉砂质板岩和钙质板岩。这套沉积岩系产有丰富的双壳类化石,这套岩系底部与火山岩接触的层位,其所含的双壳类化石类别单一,个体较大,数量丰富,呈介壳形式产出,矿化明显。根据薄片鉴定结果、稀土元素分布模式以及微量元素的含量分析,认为川西昌台地区晚三叠世生物群的分布与火山活动密切相关,火山活动为海底热液的存在提供了通道,火山活动末期的热液环境参数包括还原性、高温、高金属离子浓度(金属硫化物)等。

关键词：川西昌台火山活动热液活动双壳生物群

High toughness and CMAS resistance of REAlO_(3)/RE_(2)Zr_(2)O_(7)(RE=La,Nd,Sm,Eu,Gd,and Dy)composites with eutectic composition for thermal barrier coatings

在线全文

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2024年第6期13卷 800-809页

作者： Zijian Zhang Jian Sun Guanghua liu Yi Han Wei liu Yi li Wei wang Xiangyang liu Peng Zhang Wei Pan Chunlei Wan State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China China United Gas Turbine Technology Co. Ltd.Beijing 100015China College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China

Although rare earth zirconates(RE_(2)Zr_(2)O_(7))have garnered attention as viable candidates for thermal barrier coatings(TBCs),they suffer from low fracture toughness and accelerated calcium–magnesium–alumina–silicate(CMAS)melt corrosion at high service temperatures,which impedes their practical *** this work,we developed a series of REAlO_(3)/RE_(2)Zr_(2)O_(7)(RE=La,Nd,Sm,Eu,Gd,and Dy)composites with a eutectic composition that not only significantly enhanced the fracture toughness by more than 40%relative to that of RE_(2)Zr_(2)O_(7)but also exhibited improved resistance to CMAS *** increase in toughness arises from multiple mechanisms,such as ferroelastic toughening,fine-grain strengthening,and residual stress toughening,all of which trigger more crack defects and energy ***,the CMAS penetration depth of the REAlO_(3)/RE_(2)Zr_(2)O_(7)composites is approximately 36%lower than that of RE_(2)Zr_(2)O_(7).Al–O constituents in composites can capture CaO,SiO_(2),and MgO in CMAS melts and increase their viscosity,resulting in enhanced CMAS corrosion *** thermophysical properties of the REAlO_(3)/RE_(2)Zr_(2)O_(7)composites were also investigated,and their coefficient of thermal expansion and thermal conductivity are comparable to those of 7–8 wt%Y_(2)O_(3)partially stabilized ZrO2(YSZ),indicating their potential as TBC materials.

关键词： fracture toughness thermal property calcium-magnesium-alumina-silicate(CMAS)corrosion REAlO_(3)/RE_(2)Zr_(2)O_(7) eutectic composition

Online identification and extraction method of regional large-scale adjustable load-aggregation characteristics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Energy Interconnection 2024年第3期7卷 313-323页

作者： Siwei li liang Yue Xiangyu Kong Chengshan wang Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072P.R.China Beijing Fibrlink Communications Co. Ltd.Beijing 100071P.R.China

This article introduces the concept of load aggregation,which involves a comprehensive analysis of loads to acquire their external characteristics for the purpose of modeling and analyzing power *** online identification method is a computer-involved approach for data collection,processing,and system identification,commonly used for adaptive control and *** paper proposes a method for dynamically aggregating large-scale adjustable loads to support high proportions of new energy integration,aiming to study the aggregation characteristics of regional large-scale adjustable loads using online identification techniques and feature extraction *** experiment selected 300 central air conditioners as the research subject and analyzed their regulation characteristics,economic efficiency,and *** experimental results show that as the adjustment time of the air conditioner increases from 5 minutes to 35 minutes,the stable adjustment quantity during the adjustment period decreases from 28.46 to 3.57,indicating that air conditioning loads can be controlled over a long period and have better adjustment effects in the short ***,the experimental results of this paper demonstrate that analyzing the aggregation characteristics of regional large-scale adjustable loads using online identification techniques and feature extraction algorithms is effective.

关键词： Load aggregation Regional large-scale Online recognition Feature extraction method

在线全文

学校读者我要写书评

暂无评论

某抽水蓄能电站地下洞室群围岩三维稳定分析

科学技术与工程 2014年第32期22卷 73-78页

作者：于新华王丽新陈建胜杨科辉中国电建集团中南勘测设计研究院有限公司水能资源利用关键技术湖南省重点实验室长沙410014

某抽水蓄能电站地下厂房为大跨度、高边墙地下洞室群,地质条件复杂,分布软弱夹层,高边墙及洞室间岩体的稳定性是洞室设计的关键因素。根据水压致裂法地应力测试数据计算侧压力系数,构造初始地应力场,按照开挖顺序建立三维弹塑性计算模型... 详细信息

某抽水蓄能电站地下厂房为大跨度、高边墙地下洞室群,地质条件复杂,分布软弱夹层,高边墙及洞室间岩体的稳定性是洞室设计的关键因素。根据水压致裂法地应力测试数据计算侧压力系数,构造初始地应力场,按照开挖顺序建立三维弹塑性计算模型,分析地下洞室群围岩应力与变形特征、塑性区分布,评价了地下厂房洞室群围岩稳定性,为洞室设计提供科学依据和基础数据。

关键词：抽水蓄能电站地下洞室群三维模型围岩稳定

基于CMS模型的印尼对中国园艺产品出口额增长因素分析

在线全文

学校读者我要写书评

暂无评论

科技和产业 2017年第1期17卷 93-99页

作者：王立新李房玲东华大学旭日工商管理学院上海200051

报告了印尼对中国园艺产品出口贸易的现状,采用2010-2014年UN COMTRADE数据,应用恒定市场份额模型(CMS模型)的简化形式,即单一市场份额模型分析印尼对中国园艺产品出口额增长的主要影响因素。结果表明印尼园艺产品出口额增长最主要的影... 详细信息

报告了印尼对中国园艺产品出口贸易的现状,采用2010-2014年UN COMTRADE数据,应用恒定市场份额模型(CMS模型)的简化形式,即单一市场份额模型分析印尼对中国园艺产品出口额增长的主要影响因素。结果表明印尼园艺产品出口额增长最主要的影响因素是竞争力效应,其次是结构效应,次结构效应的影响最小。从发展优势来看,商品竞争力效应和综合竞争力效应占主要的因素,其次是动态结构效应,最后是产品结构效应和增长效应。为了提高印尼园艺产品的出口额,建议印尼政府能够把出口原料转为出口半成品或最终产品,增加印尼园艺产品的出口附加值。

关键词： CMS模型单一市场份额模型园艺产品出口影响因素

Rational design of a single-component mRNA vaccine against orthopoxvirus and SARS-CoV-2

在线全文

学校读者我要写书评

暂无评论

Science China(life Sciences) 2024年第6期67卷 1311-1313页

作者： Yilong Yang Xiaofan Zhao Yu li Xiaodong Zai xinyi wang Yue Zhang Xiaolin wang Peng Lv Jun Zhang lihua Hou Junjie Xu Wei Chen Laboratory of Advanced Biotechnology Beijing Institute of BiotechnologyAcademy of Military Medical SciencesBeijing 100071China

Dear Editor,In the era of COVID-19,the prevalence of viruses from other families poses new threats to *** the eradication of smallpox in 1980,the global outbreak of monkeypox in 2022(Lum et al.,2022;Nuzzo et al.,2022)alerted that the re-emerging orthopoxvirus(OPXV)remained a persistent threat to global *** includes a number of viruses with a broad host range,including variola virus(VARV),monkeypox virus(MPXV),vaccinia virus(VACV).

关键词： vaccine Rational