检索结果-南通市图书馆

Bromocriptine protects perilesional spinal cord neurons from lipotoxicity after spinal cord injury

Neural Regeneration Research 2024年第5期19卷 1142-1149页

作者： Ying Peng Zhuoxuan li Zhiyang Zhang Yinglun Chen Renyuan wang Nixi Xu Yuanwu Cao Chang Jiang Zixian Chen Haodong lin Trauma Center Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthopedics Zhongshan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Medicine Shanghai Geriatric Medical CenterShanghaiChina

Recent studies have revealed that lipid droplets accumulate in neurons after brain injury and evoke lipotoxicity,damaging the ***,how lipids are metabolized by spinal cord neurons after spinal cord injury remains ***,we investigated lipid metabolism by spinal cord neurons after spinal cord injury and identified lipid-lowering compounds to treat spinal cord *** found that lipid droplets accumulated in perilesional spinal cord neurons after spinal cord injury in *** droplet accumulation could be induced by myelin debris in HT22 *** debris degradation by phospholipase led to massive free fatty acid production,which increased lipid droplet synthesis,β-oxidation,and oxidative *** oxidative phosphorylation increased reactive oxygen species generation,which led to increased lipid peroxidation and HT22 cell *** was identified as a lipid-lowering compound that inhibited phosphorylation of cytosolic phospholipase A2 by reducing the phosphorylation of extracellular signal-regulated kinases 1/2 in the mitogen-activated protein kinase pathway,thereby inhibiting myelin debris degradation by cytosolic phospholipase A2 and alleviating lipid droplet accumulation in myelin debris-treated HT22 *** function,lipid droplet accumulation in spinal cord neurons and neuronal survival were all improved in bromocriptine-treated mice after spinal cord *** results suggest that bromocriptine can protect neurons from lipotoxic damage after spinal cord injury via the extracellular signal-regulated kinases 1/2-cytosolic phospholipase A2 pathway.

关键词： bromocriptine central nervous system cytosolic phospholipase A2 high-content screening lipid droplet lipid metabolism lipotoxicity mitogen-activated protein kinase spinal cord injury spinal cord neurons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CATCAM: a 28 nm constant-time alteration TCAM enabling less than 50 ns update latency

引用

Science China(Information Sciences) 2024年第4期67卷 345-346页

作者： Chenchen DENG Tianzhu XIONG Zhaoshi li Zhiwei liU Yao wang Jianfeng ZHU Jun YANG Shaojun WEI Leibo liU Beijing National Research Center for Information Science and Technology Tsinghua University National ASIC System Engineering Center School of Integrated CircuitsSoutheast University School of Integrated Circuits Tsinghua University

Ternary content-addressable memory(TCAM) is an indispensable component of lookup tables in switches or ***, it suffers from expensive and inflexible update operations and cannot fulfill the demand for rule updates in switches enabling software-defined networking(SDN). The main reason is that TCAM stores rules from top to bottom in decreasing order of priority for disambiguation. Updating a TCAM is similar to the insertion sort that takes O(n) time,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

引用

Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE Yue FANG Mingxia YAO Xiaohu ZHOU Di wang Feng CHEN Gang liANG Dong li Ning HOU Yue Key Laboratory of Bioresource Research and Development of liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of a rapid and efficient system for CR genes identification based on hairy root transformation in Brassicaceae

引用

Horticultural Plant Journal 2024年第4期10卷 1049-1060页

作者： Wenlin Yu Lu Yang Yuanyuan Xiang Rongde li Xueqing Zhou Longcai Gan Xianyu Xiang Yunyun Zhang Lei Yuan Yanqing Luo Genze li Youning wang Yinhua Chen Peng Chen Chunyu Zhang National Key Laboratory of Crop Genetic Improvement and College of Plant Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China National Key Laboratory for Tropical Crop Breeding Sanya Nanfan Research InstituteHainan UniversitySanyaHainan 572025China National Agro-Tech Extension and Service Center Beijing 100125China Industrial Crops Research Institute Yunnan Academy of Agricultural SciencesKunmingYunnan 650221China College ofAgronomy NorthwestA&F UniversityYanglingShaanxi712100China

Many economically important crops and vegetables belonging to the cruciferous family are heavily endangered by clubroot disease caused by Plasmodiophora brassicae *** of clubroot resistant cultivars based on mapping and cloning of resistant genes is commonly regarded as the most cost-effective and efficient way to fight against this *** traditional way of R gene functional validation requires stable transformation that is both time-and *** this study,a rapid and efficient hairy-root transgenic protocol mediated by Agrobacterium rhizogenes was *** transformation positive rate was over 80%in Brassica napus showed by GUS reporter gene and this transformation only took 1/6 of the time compared with stable *** system was applicable to different *** varieties and other cruciferous crops including Brassica rapa and Brassica *** particular,two known CR genes,CRA3.7.1 and CRA8.2.4 were used respectively,as example to show that the system works well for CR gene study combined with subsequent *** infection in *** importantly,it works both in over-expression that led to disease resistance,as well as in RNAi which led to disease susceptible ***,this system can be used in batch-wise identification of CR genes,and also offered the possibility of manipulating key genes within the *** genome that could improve our knowledge on host-pathogen interaction.

关键词： Brassicaceae Agrobacterium rhizogenes Hairy root transformation Clubroot Gene function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

放牧对温带典型草原植物物种多样性及土壤养分的影响

引用

草地学报 2019年第6期27卷 1694-1701页

作者：宋洁王凤歌温璐王立新李金雷武胜男徐智超内蒙古大学生态与环境学院内蒙古呼和浩特010021 内蒙古大学草地生态学国家重点实验室内蒙古呼和浩特010021

为探讨放牧强度对植物多样性及土壤养分的影响,本文以内蒙古温带典型草原毛登牧场为研究对象,选取围封、中度放牧、重度放牧3个放牧强度的试验样地,运用方差分析法研究不同放牧强度下植物多样性和土壤养分含量的差异性,采用典范对应分... 详细信息

为探讨放牧强度对植物多样性及土壤养分的影响,本文以内蒙古温带典型草原毛登牧场为研究对象,选取围封、中度放牧、重度放牧3个放牧强度的试验样地,运用方差分析法研究不同放牧强度下植物多样性和土壤养分含量的差异性,采用典范对应分析揭示植物多样性与土壤养分间的关系。结果表明,植物群落物种组成受放牧强度影响变化显著,部分优势种重要值降低;放牧强度增大对植物群落多样性指数影响不显著,围封样地植物群落Pielou均匀度指数显著大于中度放牧、重度放牧样地(P<0.05);围封样地土壤全钾(0~20 cm)、土壤有机质(0~40 cm)含量显著(P<0.05)大于中度放牧、重度放牧样地,硝态氮、铵态氮、全磷含量在不同强度放牧样地间差异不显著。典范对应分析结果表明,放牧干扰下温带典型草原多年生禾本科草本植物多样性与全钾、土壤有机质、铵态氮含量呈正相关,多年生非禾本科草本植物多样性与硝态氮、全磷含量呈正相关。

关键词：温带典型草原放牧强度土壤养分植物多样性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

引用

Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： HU Wei Qiong ZHOU Wei Guang ZHOU Guang Wei liAO Jia Xi SHI Jia xing XIE FengYang li Shou Heng wang Yong FENG Xian Hong GU Xiu li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

火力与制导资源联合分配的快速构造算法组合设计

引用

中国科学：信息科学 2024年第6期54卷 1458-1473页

作者：王加根辛斌李冠呈北京理工大学自动化学院北京100081 自主智能无人系统全国重点实验室北京理工大学北京100081 中国长峰机电技术研究设计院北京100854

火力与制导资源联合分配问题是军事运筹学研究中典型的NP完全问题,其求解具有较高的实时性要求.精确求解算法难以适用,而近来提出的构造算法的时间开销也相对较大,严重影响算法的实际应用.为了解决该问题,本文将其建模为多阶段传感器–... 详细信息

火力与制导资源联合分配问题是军事运筹学研究中典型的NP完全问题,其求解具有较高的实时性要求.精确求解算法难以适用,而近来提出的构造算法的时间开销也相对较大,严重影响算法的实际应用.为了解决该问题,本文将其建模为多阶段传感器–武器–目标分配(sensor-weapon-target assignment,S-WTA)问题,并分解成两类作战资源分配子问题.在武器分配阶段采用了一种基于威胁值确定分配优先级的快速构造算法,在传感器分配阶段提出了一种新的基于阶段顺序确定分配优先级的快速构造算法,该算法能充分利用约束条件,大幅度减小时间开销.本文在两种基本构造算法与基于边际损失的构造算法的基础上进一步提出了构造算法序列化组合,对多阶段S-WTA问题进行求解.计算实验验证了新提出的基本构造算法的快速性以及构造算法序列化组合相比于各种基本构造算法的性能优势.

关键词：异构资源联合分配传感器– 武器– 目标分配启发式算法构造算法协同作战

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

危化品事故多层级链式推演模型及案例分析

引用

中国安全科学学报 2024年第3期34卷 162-170页

作者：何青伦姜文宇王飞李鑫王智清华大学工程物理系北京100084 清华大学深圳国际研究生院安全科学与技术研究所广东深圳518000 佛山市城市安全研究中心广东佛山528000

为提升危化品企业的风险防控能力,支撑事故发生后迅速地进行应急决策研判,基于灾害链理论,从热辐射、毒气、超压3类危化品事故关键致灾因子出发,提出灾害链多层级链式推演模型。采用流体扩散模型和Probit模型,分别构建危化品容器起火概... 详细信息

为提升危化品企业的风险防控能力,支撑事故发生后迅速地进行应急决策研判,基于灾害链理论,从热辐射、毒气、超压3类危化品事故关键致灾因子出发,提出灾害链多层级链式推演模型。采用流体扩散模型和Probit模型,分别构建危化品容器起火概率及顺序预测算法和危化品爆炸点火时刻估计算法,实现对危化品事故中燃烧和爆炸演化过程的定量计算分析。并以广东省某树脂生产厂为研究案例,建立1条由危化品泄漏事故引发的灾害链,推演分析灾害链各节点的演化时间和发生概率。分析结果表明:灾害链推演模型能有效定量化分析实际危化品厂区事故的演化过程、预测事故节点发生概率及时间,并在一定程度上帮助检验危化品厂区布局安全。

关键词：危化品事故灾害链链式推演蒙特卡罗 Probit模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of inter-seasonal nitrogen allocation increases yield and resource-use efficiency in a water-limited wheat-maize cropping system in the North China Plain

引用

The Crop Journal 2024年第3期12卷 907-914页

作者： Xiaonan Zhou Chenghang Du Haoran li Zhencai Sun Yifei Chen Zhiqiang Gao Zhigan Zhao Yinghua Zhang Zhimin wang Ying liu College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100193China Ministerial and Provincial Co-Innovation Centre for Endemic Crops Production with High-Quality and Efficiency in Loess Plateau Taigu 030801ShanxiChina

Winter wheat–summer maize cropping system in the North China Plain often experiences droughtinduced yield reduction in the wheat season and rainwater and nitrogen(N)fertilizer losses in the maize *** study aimed to identify an optimal interseasonal water-and N-management strategy to alleviate these *** ratios of allocation of 360 kg N ha^(-1)between the wheat and maize seasons under one-time presowing root-zone irrigation(W0)and additional jointing and anthesis irrigation(W2)in wheat and one irrigation after maize sowing were set as follows:N1(120:240),N2(180:180),N3(240:120)and N4(300:60).The results showed that under W0,the N3 treatment produced the highest annual yield,crop water productivity(WPC),and nitrogen partial factor productivity(PFPN).Increased N allocation in wheat under W0 improved wheat yield without affecting maize yield,as surplus nitrate after wheat harvest was retained in the topsoil layers and available for the subsequent *** W2,annual yield was largest in the N2 *** risk of nitrate leaching increased in W2 when N application rate in wheat exceeded that of the N2 treatment,especially in the wet *** to W2N2,the W0N3 maintained 95.2%grain yield over two *** WPCwas higher in the W0 treatment than in the W2 ***,following limited total N rate,an appropriate fertilizer N transfer from maize to wheat season had the potential of a“triple win”for high annual yield,WPCand PFPN in a water-limited wheat–maize cropping system.

关键词： Cropping system Water-saving irrigation North China Plain Nitrogen optimization Sustainable intensification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2819-2834页

作者： Jikai Deng Shimin Yang Yingjian li Xue Tan Jiejie liu Yanying Yu Qiang Ding Chengpeng Fan Hongyun wang Xianyin Chen Qianyun liu Xiao Guo Feiyu Gong li Zhou Yu Chen State Key Laboratory of Virology RNA InstituteCollege of Life Sciences and Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhanChina School of Medicine Tsinghua UniversityBeijingChina School of Basic Medical Sciences Wuhan UniversityWuhanChina Animal Bio-Safety Level Ⅲ Laboratory/Institute for Vaccine Research Wuhan University School of MedicineWuhanChina

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune ***,the K-D-K-E catalytic motif of 2′-O-MTase is highly conserved across numerous viruses,including flaviviruses,vaccinia viruses,coronaviruses,and extends even to ***,we observed a stronger 2′-O-MTase activity in SARS-CoV-2 compared to SARS-CoV,despite the presence of a consistently active catalytic *** further identified critical residues(Leu-36,Asn-138 and Ile-153)which served as determinants of discrepancy in 2′-O-MTase activity between SARS-CoV-2 and *** residues significantly enhanced the RNA binding affinity of 2′-O-MTase and boosted its versatility toward RNA *** interest,a triple substitution(Leu^(36)→Ile^(36),Asn^(138)→His^(138),Ile^(153)→Leu^(153),from SARS-CoV-2 to SARS-CoV)within nsp16 resulted in a proportional reduction in viral 2′-O-methylation and impaired viral ***,it led to a significant upregulation of type I interferon(IFN-I)and proinflammatory cytokines both in vitro and vivo,relying on the cooperative sensing of melanoma differentiation-associated protein 5(MDA5)and laboratory of genetics and physiology 2(LGP2).In conclusion,our findings demonstrated that alterations in residues other than K-D-K-E of 2′-O-MTase may affect viral replication and subsequently influence *** changes in nsp16 residues is crucial as it may aid in identifying and assessing future alteration in viral pathogenicity resulting from natural mutations occurring in nsp16.

关键词： pathogenesis impaired alterations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：