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Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan wang Yun-Qing Zhou Li-juan Luo Cui-Jin wang Nan Shen Hao Li Ji-Wen wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1

Permanent lining castable with low bulk density and thermal conductivity:bauxite castable for tundish obtained by adding pearlescent sand

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Journal of Iron and Steel Research International 2024年第3期31卷 634-646页

作者： Yi wang Jian Yang Bao wang Hai-jun Zhang juan Han Pei-yan Pei Wen-long Lv Jian-an Zhou The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Research Institute of Metallurgical Construction MCCWuhan 430081HubeiChina

The low thermal conductivity and light mass of castables for tundish permanent linings are crucial for minimizing the heat loss of molten *** consideration of the low bulk density and thermal conductivity of pearlescent sand,the thermal insulation performance of castables was attempted to be improved by adding pearlescent *** sand was modified to prevent the strength of its porous structure from *** modification mechanism of pearlescent sand and the effect of pearlescent sand on the performance of bauxite castables were *** results suggested that the addition of the modified pearlescent sand significantly raised the apparent porosity and decreased the bulk density of bauxite *** 1000℃,the bulk density of more than 60%of the modified pearlescent sand-bauxite castable was only 2.03 g/cm^(3).The mechanical properties and thermal shock resistance of the modified pearlescent sand-bauxite castable were inferior to those of conventional bauxite castable but were adequate to meet the use conditions of casta-bles for tundish permanent *** high temperatures of 200-800℃,the thermal conductivity of more than 60%of the modified pearlescent sand-bauxite castable was smaller than that of conventional bauxite *** addition of the modified pearlescent sand can greatly reduce the thermal conductivity and bulk density of bauxite castable.

关键词： Pearlescent sand-Hydrophobic modification Bauxite castable Thermal insulation performance Mechanical property

Lattice-distorted Pt wrinkled nanoparticles for highly effective hydrogen electrocatalysis

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Nano Research 2024年第5期17卷 3819-3826页

作者： Xue Li Xiang Han Zhenrui Yang Shun wang Yun Yang juan wang Jiadong Chen Zhongwei Chen Huile Jin Wenzhou Key Lab of Advanced Energy Storage and Conversion Zhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute of New Materials and Industry Technology College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooOntario N2L 3G1Canada

Modulating Pt surfaces through the introduction of lattice distortion emerges as immensely effective strategy that enhances the kinetics of alkaline hydrogen evolution and oxidation *** this study,we fabricated lattice-distorted Pt wrinkled nanoparticles(LD-Pt WNPs)for efficient hydrogen *** LD-Pt WNPs not only outperform the Pt/C benchmark in hydrogen oxidation reaction,achieving an excellent mass-specific current of 968.5 mA·mg_(Pt)^(-1)(9 times that of Pt/C),but also demonstrate outstanding hydrogen evolution reaction activity with a small overpotential of 58.0 *** experiments and density functional theory calculations reveal that lattice defects introduce an abundance of unsaturated coordination atoms while modifying the d-band center of *** dual effect optimizes the binding strength of crucial H and OH intermediates,leading to a significant reduction in the energy barrier of the reaction bottleneck,commonly known as the Volmer *** work unveils a fresh viewpoint on projecting and developing high efficiency electrocatalysts through defect engineering.

关键词： distortion nanoparticle hydrogen evolution reaction defect engineering hydrogen oxidation reaction

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混沌系统的非线性连续预测变结构控制与同步

物理学报 2002年第12期51卷 2707-2712页

作者：刘福才王娟石淼高秀伟燕山大学电气工程学院秦皇岛066004 中国科学院大连化学物理研究所大连116021

在连续时间混沌系统的控制与同步问题统一处理的基础上 ,给出一种可实现两个相同或不同连续时间混沌系统的控制与同步的预测变结构控制方法 .其控制器由针对对象标称非线性模型设计的连续预测控制器和针对对象不确定性设计的滑模变结构... 详细信息

在连续时间混沌系统的控制与同步问题统一处理的基础上 ,给出一种可实现两个相同或不同连续时间混沌系统的控制与同步的预测变结构控制方法 .其控制器由针对对象标称非线性模型设计的连续预测控制器和针对对象不确定性设计的滑模变结构控制器组成 .所提出的方案具有变结构控制鲁棒性强的优点 ,实现了系统对参考信号的追踪控制 .

关键词：混沌同步滑模变结构鲁棒性非线性连续预测控制混沌系统

Spectral-interferometry-based diff-iteration for high-precision micro-dispersion measurement

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Photonics Research 2024年第6期12卷 1362-1370页

作者： WEI DU JINGSHENG HUANG YANG wang MAOZHONG ZHAO juan LI JUNTAO HE JINDONG wang WENFU ZHANG TAO ZHU Key Laboratory of Optoelectronic Technology&System(Ministry of Education) Chongqing UniversityChongqing 400044China State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China

Precise measurement of micro-dispersion for optical devices(optical fiber,lenses,etc.)holds paramount significance across domains such as optical fiber communication and dispersion interference ***,due to its complex system,complicated process,and low reliability,the traditional dispersion measurement methods(interference,phase shift,or time delay methods)are not suitable for the accurate measurement of micro-dispersion in a wide spectral ***,we propose a spectral-interferometry-based diff-iteration(SiDi)method for achieving accurate wide-band micro-dispersion *** an optical frequency comb,based on the phase demodulation of the dispersion interference spectrum,we employ the carefully designed SiDi method to solve the dispersion curve at any position and any *** approach is proficient in precisely measuring micro-dispersion across a broadband spectrum,without the need for cumbersome wavelength scanning processes or reliance on complex high-repetition-rate combs,while enabling adjustable *** efficacy of the proposed method is validated through simulations and *** employed a chip-scaled soliton microcomb(SMC)to compute the dispersion curves of a 14 m single-mode fiber(SMF)and a 0.05 m *** to a laser interferometer or the theoretical value given by manufacturers,the average relative error of refractive index measurement for single-mode fiber(SMF)reaches 2.8×10^(-6) and for glass reaches 3.8×10^(-6).The approach ensures high precision,while maintaining a simple system structure,with realizing adjustable resolution,thereby propelling the practical implementation of precise measurement and control-dispersion.

关键词： interferometer dispersion iteration

Uncertainties of ENSO-related Regional Hadley Circulation Anomalies within Eight Reanalysis Datasets

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Advances in Atmospheric Sciences 2024年第1期41卷 115-140页

作者： Yadi LI Xichen LI juan FENG Yi ZHOU Wenzhu wang Yurong HOU International Center for Climate and Environment Sciences(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 101408China College of Global Change and Earth System Science(GCESS) Beijing Normal UniversityBeijing 100875China

El Nino-Southern Oscillation(ENSO),the leading mode of global interannual variability,usually intensifies the Hadley Circulation(HC),and meanwhile constrains its meridional extension,leading to an equatorward movement of the jet *** studies have investigated the response of HC to ENSO events using different reanalysis datasets and evaluated their capability in capturing the main features of ENSO-associated HC ***,these studies mainly focused on the global HC,represented by a zonal-mean mass stream function(MSF).Comparatively fewer studies have evaluated HC responses from a regional perspective,partly due to the prerequisite of the Stokes MSF,which prevents us from integrating a regional *** this study,we adopt a recently developed technique to construct the three-dimensional structure of HC and evaluate the capability of eight state-of-the-art reanalyses in reproducing the regional HC response to ENSO *** show that all eight reanalyses reproduce the spatial structure of HC responses well,with an intensified HC around the central-eastern Pacific but weakened circulations around the Indo-Pacific warm pool and tropical *** spatial correlation coefficient of the three-dimensional HC anomalies among the different datasets is always larger than ***,these datasets may not capture the amplitudes of the HC responses *** uncertainty is especially large for ENSO-associated equatorially asymmetric HC anomalies,with the maximum amplitude in Climate Forecast System Reanalysis(CFSR)being about 2.7 times the minimum value in the Twentieth Century Reanalysis(20CR).One should be careful when using reanalysis data to evaluate the intensity of ENSO-associated HC anomalies.

关键词： regional Hadley circulation ENSO atmosphere-ocean interaction reanalysis data

Engineering FeOOH/Ni(OH)_(2) heterostructures on Ni_(3)S_(2)surface to enhance seawater splitting

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Rare Metals 2024年第5期43卷 1989-1998页

作者： Chen Yang Ya-Dong Li Li-juan Cao Xi-Long wang Han-Pu Liang Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China

The construction of highly stable and efficient electrocatalysts is desirable for seawater splitting but remains challenging due to the high concentration of Cl-in ***,FeOOH/Ni(OH)_(2)heterostructure supported on Ni_(3)S_(2)-covered nickel foam(Fe–Ni/Ni_(3)S_(2)/NF)was fabricated by hydrothermal and etching methods,as well as anodic oxidation *** electronic structure of FeOOH and Ni(OH)_(2)could be modulated after depositing FeOOH nanoparticles on Ni(OH)_(2)nanosheet,which greatly boosted the catalytic *** the catalyst used as an electrode for oxygen evolution reaction(OER),it needed low overpotentials of 266 and 368 m V to achieve current densities of 100 and 800 m A·cm^(-2),respectively,in 1 mol·L^(-1)KOH+seawater *** can operate continuously at 100 m A·cm^(-2)for 400 h without obvious ***,in situ generated SO_(4)^(2-)from inner Ni_(3)S_(2)during electrolysis process would accumulate on the surface of active sites to form passivation layers to repel Cl^(-),which seemed to be responsible for superior *** study not only synthesizes an OER catalyst for highly selective and stable seawater splitting,but also gives a novel approach for industrial hydrogen production.

关键词： Anodic oxidation Heterostructure Oxygen evolution reaction Seawater splitting

Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

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World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng wang Jian-Ling Jiang Rui Li juan-juan wang Chun-Hong Gu Jia Zeng Xiao-Hui Wei Mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

Role of immune cell interactions in alcohol-associated liver diseases

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