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基于数字孪生技术的中医智能辅助诊疗系统构建研究

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中华中医药学刊 2024年第9期42卷 18-22页

作者：孙宇衡王雨轩魏东升齐佳杰张世祺王基实李路珍高诗岳张哲辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110032

研究在厘清中医临床辅助决策系统研制进展与现存问题的基础上,借鉴人工智能对物理世界的智能管控经验,提出构建以中医经典著作原创思维为核心,以中医知识图谱和领域本体构建为肇始,将临床全域多场景数字化原态保护和中医经典著作“数字... 详细信息

研究在厘清中医临床辅助决策系统研制进展与现存问题的基础上,借鉴人工智能对物理世界的智能管控经验,提出构建以中医经典著作原创思维为核心,以中医知识图谱和领域本体构建为肇始,将临床全域多场景数字化原态保护和中医经典著作“数字孪生”活态传承突破作为重点,着力于实现临床决策、流程管控、人机交互全面智能化的中医智能辅助诊疗系统。该系统将在中医辨证的辅助决策过程中,基于病机演变特点,融合中医经典著作、图像资料、影音资料、心理行为等多模态数据,充分还原中医病机链变化的脉络和前人的临床思维模式,进一步解决辅助决策系统信息采集界面操作繁琐和临床医生问诊思路混乱的问题。数字孪生仿真功能将模拟多复诊多模态的患者情况,尤其聚焦于复诊时患者病情数据的动态变化,最终实现多模态时序数据的集成与融合来为临床判别提供参考,完成合作博弈下的中医智能诊疗过程。研究期望为构建中医辨证论治智能辅助诊疗系统提出新的思路,进一步促进中医药的智能化应用与传承。

关键词：中医经典辅助诊疗全域多场景多模态融合数字孪生人工智能

基于GWO-BP神经网络在舌诊图像颜色校正中的应用

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中医药信息 2024年第5期41卷 31-36,50页

作者：王基实杨珺涵张世祺高诗岳高爽杨关林张哲辽宁中医药大学辽宁沈阳110847 沈阳市第六人民医院辽宁沈阳110006 辽宁中医药大学附属医院辽宁沈阳110032

目的:基于灰狼优化算法(GWO)优化传统BP神经网络的舌诊图像颜色校正算法,解决移动舌诊APP存在的拍摄环境具有局限性、手机设备的依赖性及基于手机平台的颜色校正方法所使用的传统算法效果不佳等问题。方法:以24色标准色卡为标准,分别采... 详细信息

目的:基于灰狼优化算法(GWO)优化传统BP神经网络的舌诊图像颜色校正算法,解决移动舌诊APP存在的拍摄环境具有局限性、手机设备的依赖性及基于手机平台的颜色校正方法所使用的传统算法效果不佳等问题。方法:以24色标准色卡为标准,分别采集室内白炽灯不同光照强度场景与室外不同时刻阴天、晴天场景下的舌诊图像;同时选择灰度世界算法以及传统BP神经网络算法与本文算法进行对比,分别用上述三种算法对采集图像进行颜色校正,并对校正结果进行主观与客观颜色评价进行对比分析。结果:相比于灰度世界算法及BP神经网络算法,GWO-BP神经网络算法的颜色校正效果明显提高。结论:GWO-BP算法可有效地对手机拍摄的舌诊图像进行颜色校正,从而提高色值精确度。

关键词：舌诊图像颜色校正灰狼优化算法 BP神经网络

Over-expression of heme oxygenase-1 in peripheral blood predicts the progression and relapse risk of chronic myeloid leukemia

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Chinese Medical Journal 2014年第15期127卷 2795-2801页

作者： Wei Sixi wang Yating Chai Qixiang Fang Qin Zhang Yaming Lu Yinghao wang jishi Hematopoietic Stem Cell Transplantation Center of GuizhouProvince Department of Hematology Affiliated Hospital of Guiyang Medical College Guiyang Guizhou550004 China Department of Clinical Biochemistry Affiliated Hospital of Guiyang Medical College Guiyang Guizhou550004 China Department of Pharmacy Affiliated Hospital of Guiyang Medical College Guiyang Guizhou550004 China

Background There are limited eligible clinical markers at present to monitor the progress of chronic myeloid leukemia （CML）.Heme oxygenase-1 （HO-1）,as one of the most important oxidation-regulating enzymes in vivo,suggests the onset and progression of cancer when highly ***,HO-1 level is related with the occurrence and development of hematological *** the relationship between HO-1 expression and progression/relapse of CML has seldom been studied *** study aimed to investigate the relationship between them to find out a new molecular marker for *** A total of 60 peripheral blood and bone marrow （BM） samples from 25 CML patients in different phases were collected respectively to detect the expressions of HO-1 and bcr/abl using real-time *** blood test was performed to detect the changes of leukocyte and platelet *** proportion of primitive cells in BM was detected by flow *** relationship between high HO-1 expression and CML progression and relapse was explored by the analysis of variance by Wilcoxon test and linear regression *** diagnostic accuracy and cutoff values were determined by receiver operating characteristic *** Relative expression of HO-1 mRNA in CML patients peripheral blood was significantly higher than that of donors （P 〈0.0001）,which were 0.57±3.78 and （1.417±1.125）×10-6,***-1 expression level in CML patients was 0.061 5±0.062 4,which decreased to 0.009 4±0.006 7 upon CMoR,and remained remarkably higher 0.016 3±0.017 5 than that of normal donors （1.417±1.125）× 10-6,P 〈*** relapse occurred,HO-1 expression significantly increased from 0.020 6±0.021 0 to 3.852±10.285 in CMoR stage and undergoing *** to progression of CML,HO-1 expression level in CML patients increased from CP （0.009 5±0.017 6） to AP （0.028 0±0.055 7） and then to BP （0.276 7± 0.447 0）.And there was a linear correlation between HO-1 expression and proportion of p

关键词： heme oxygenase-1 chronic myeloid leukemia progression relapse receiver operating characteristic curve

Ligand-dependent aggregation-enhanced photoacoustic of atomically precise metal nanocluster

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Aggregate

Aggregate 2024年第1期5卷 196-203页

作者： Changlin Zhou Meng wang Qiaofeng Yao Yu Zhou Chuantao Hou Jianfei Xia Zonghua wang jishi Chen Jianping Xie College of Chemistry and Chemical Engineering Shandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsInstrumental Analysis Center of Qingdao UniversityQingdao UniversityQingdaoP.R.China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjinP.R.China Qingdao Boting Hydrogen Age Ocean Technol R&D Ctr. Qingdao Boting Technol Co.Ltd.Shandong Hydrogen Times Marine Technology Co.Ltd.QingdaoP.R.China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhouP.R.China

Atomically precise metal nanoclusters(MNCs),as a potential type of photoacoustic(PA)contrast agent,are limited in application due to their low PA conversion efficiency(PACE).Here,with hydrophilic Au25SR18(SR=thiolate)as model NCs,we present a result that weakly polar solvent induces aggregation,which effectively enhances PA intensity and *** PA intensity and PACE are highly dependent on the degree of aggregation,while the aggregation-enhanced PA intensity(AEPA)positively correlates to the protected *** an AEPA phenomenon indicates that aggregation actually accelerates the intramolecular motion of Au NCs,and enlarges the proportion of excited state energy dissipated through vibrational *** result conflicts with the restriction of intramolecular motion mechanism of aggregation-induced *** experiments show that the increased energy of AEPA originates from the aggregation inhibiting the intermolecular energy transfer from excited Au NCs to their surrounding medium molecules,including solvent molecule and dissolved oxygen,rather than restricting radiative *** study develops a new strategy for enhancing the PA intensity of Au NCs,and contributes to a deeper understanding of the origin of the PA signal and the excited state energy dissipation processes for MNCs.

关键词： aggregation-enhanced photoacoustic gold nanocluster intermolecular excited state energy transfer intramolecular motion ligand effect

外周血中NLR、MLR及PLR对多发性骨髓瘤患者预后的影响

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重庆医学 2024年第15期53卷 2261-2268页

作者：夏新兰刘谍安丽红李燕赵鹏张燕李梦醒王季石卢英豪贵州医科大学贵阳550004 贵州医科大学附属医院血液科贵阳550004

目的探讨外周血中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)及血小板与淋巴细胞比值(PLR)对多发性骨髓瘤(MM)患者预后的影响。方法选取2019年1月至2023年5月贵州医科大学附属医院收治的159例初发MM患者为研究对象。收... 详细信息

目的探讨外周血中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)及血小板与淋巴细胞比值(PLR)对多发性骨髓瘤(MM)患者预后的影响。方法选取2019年1月至2023年5月贵州医科大学附属医院收治的159例初发MM患者为研究对象。收集患者初次治疗前的一般资料、血液生化和骨髓常规结果,计算NLR、MLR和PLR。采用单因素和多因素Cox回归模型分析影响因素,受试者工作特征(ROC)曲线分析相关指标的预测价值,Kaplan-Meier生存曲线和Log-Rank检验进行生存分析。结果ROC曲线分析显示,NLR的临界值为2.682、MLR的临界值为0.317、PLR的临界值为147.786,将患者分为高/低NLR组(n=61,n=98)、高/低MLR组(n=76,n=83)、高/低PLR组(n=59,n=100)。与高NLR组比较,低NLR组血钙60岁是影响MM患者总生存(OS)的独立危险因素(P<0.05)。结论NLR、MLR、PLR可以作为辅助工具评估MM患者的预后。

关键词：多发性骨髓瘤完全缓解率预后中性粒细胞与淋巴细胞比值血小板与淋巴细胞比值单核细胞与淋巴细胞比值

Upregulated heme oxygenase-1 expression of mouse mesenchymal stem cells resists to chemotherapy-induced bone marrow suppression

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Chinese Medical Journal 2014年第7期127卷 1310-1316页

作者： Chen Shuya wang jishi Fang Qin Gao Rui Shi Qianying Zhang Hui Zhao Jiangyuan Department of Pharmacy Guiyang Medical College GuiyangGuizhou 550004 China Department of Hematology Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Guizhou Province Laboratory of Hematological Disease Diagnostic & Treat Centre Guiyang Guizhou 550004 China Guizhou Province Hematopoietic Stem Cell Transplantation Centre Guiyang Guizhou 550004 China Department of Pharmacy Affiliated Baiyun Hospital of Guiyang Medical College Guiyang Guizhou 550000 China

Background Bone marrow hematopoietic function suppression is one of the most common side effects of *** chemotherapy,the bone marrow structure gets destroyed and the cells died,which might cause the hematopoietic function *** oxygenase-1 （HO-1） is a key enzyme of antioxidative metabolism that associates with cell proliferation and resistance to *** aim of this study was to restore or resist the bone marrow from the damage of chemotherapy by the HO-1 expression of mouse mesenchymal stem cells （mMSCs） homing to the mice which had the chemotherapy-induced bone marrow *** One hundred and sixty female Balb/c mice （6-8-weeks old） were randomly divided into four *** group was performed in 40 *** control group was intraperitoneally injected for 5 days and tail intravenously injected on the 6th day with normal *** chemotherapy-induced bone marrow suppression was established by intraperitoneally injecting cyclophosphamide （CTX） into the mice which performed as the chemotherapy *** mMSCs were tail intravenously injected into 40 chemotherapically damaged mice which served as the mMSCs *** difference between the HO-1 group and the mMSCs group was the injected *** HO-1 group was tail intravenously injected into the mMSCs that highly expressed HO-1 which was stimulated by *** expression of HO-1 was analyzed by Western blotting and *** proliferation was measured using the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide *** examinations were performed 1 week after *** Compared with the control group,the expression levels of HO-1 mRNA and protein were significantly higher in the HO-1 group （all P ＜0.05）,even obviously than the mMSCs *** treatment induced apoptosis and inhibited *** injected,the white blood cell （WBC）,red blood cell （RBC） and platelet （PLT） declined fast and down to the bottom at the 7th *** bo

关键词： heme oxygenase-1 marrow mesenchymal stem cells hematopoietic function recovery

放疗在急性白血病合并髓外浸润的疗效和预后分析

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重庆医学 2024年第4期53卷 547-554页

作者：雷文彬刘麾张燕卢英豪黄懿陈莹高睿柴笑詹云熊杰王凌云刘蕾王季石赵鹏贵州医科大学贵阳550004 贵州医科大学附属医院血液科贵阳550004 贵阳市第一人民医院血液肿瘤科贵阳550002

目的探讨急性白血病合并髓外浸润患者的临床特点、治疗方法和预后。方法回顾性分析贵州医科大学附属医院2014年4月至2023年4月收治的47例急性白血病合并髓外浸润患者的临床特点、治疗方法,根据接受的治疗将患者分为放疗组(n=23)与未放疗... 详细信息

目的探讨急性白血病合并髓外浸润患者的临床特点、治疗方法和预后。方法回顾性分析贵州医科大学附属医院2014年4月至2023年4月收治的47例急性白血病合并髓外浸润患者的临床特点、治疗方法,根据接受的治疗将患者分为放疗组(n=23)与未放疗组(n=24);根据移植前是否有髓外浸润及移植后是否出现孤立髓外复发进行亚组分析,分为移植前放疗组与移植前未放疗组、移植后放疗组与移植后未放疗组;根据中枢神经系统白血病(CNSL)患者治疗方法分为鞘内注射组(n=12)与鞘内注射联合放疗组(n=13)。比较放疗、化疗等方法治疗后患者的局部缓解情况、生存时间及毒副反应。结果急性白血病合并髓外浸润患者中放疗组总生存时间(OS)优于未放疗组(中位OS:706 d vs.151 d,P=0.015);亚组分析显示移植前放疗组OS优于移植前未放疗组(中位OS:592 d vs.386 d,P=0.035);CNSL鞘内注射联合放疗组OS优于鞘内注射组(中位OS:547 d vs.388 d,P=0.045)。放疗组无事件生存时间(EFS)优于未放疗组(中位EFS:175 d vs.50 d,P=0.005)。COX比例风险模型显示,放疗和未放疗对急性白血病合并髓外浸润患者的OS有明显影响,移植前未放疗组相比移植前放疗组死亡风险增加了2.231倍(HR=3.231,95%CI:1.021~10.227,P=0.046)。相比未放疗组,放疗组局部缓解率更高,且具有更低的血液学毒性反应、感染和出血风险。结论放射治疗可迅速缓解急性白血病合并髓外浸润的局部症状,延长这部分患者的生存时间,且血液学毒性反应、感染和出血风险较低。

关键词：急性白血病髓外浸润放射治疗血液学毒性预后生存分析

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大别山红色文化的形成与发展

中国高校社会科学 2020年第3期 29-35,157,158页

作者：夏慧汪季石黄冈师范学院马克思主义学院湖北黄冈438000

悠久的文化传统、特殊的自然环境,以及不惧强暴的抗争精神和近代新思想新文化,是大别山红色文化形成的历史渊源和思想基础。作为以马克思主义为指导、以大别山精神为核心的革命文化,大别山红色文化从形成到发展都与新民主主义革命的历... 详细信息

悠久的文化传统、特殊的自然环境,以及不惧强暴的抗争精神和近代新思想新文化,是大别山红色文化形成的历史渊源和思想基础。作为以马克思主义为指导、以大别山精神为核心的革命文化,大别山红色文化从形成到发展都与新民主主义革命的历史融合为一。

关键词：大别山红色文化新民主主义革命中国共产党领导

Treatment of immune thrombocytopenia after allogeneic cord blood stem cell transplantation with rituximab: a case report

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The Chinese-German Journal of Clinical Oncology 2013年第6期12卷 300-302页

作者： Mengxing Li jishi wang Yan Zhang Zhiqiang Sun Yanju Li Xiaoli Zhou Department of Hematology The Affiliated Hospital of Guiyang Medical College

Immune thrombocytopenia (ITP) is a chronic disease resulting from increased platelet destruction and impaired platelet production. Secondary ITP can be a manifestation of chronic graft-versus-host disease (GVHD) and represent a lymphoproliferative disorder. A boy with chronic graft-versus-host disease after cord blood stem cell transplantation who had severe refractory immune-mediated thrombocytopenia received infusion of rituximab weekly, 375 mg/m2, for 4 weeks. Platelets count of the patient was recovered, and rituximab was well tolerated with no severe toxicity observed during treatment.

关键词： immune thrombocytopenia (ITP) graft-versus-host disease {GVHD) rituximab