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Targeted therapeutic options and future perspectives for HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2019年第1期4卷 347-368页

作者： jiani wang Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17PanjiayuannanliChaoyang District100021 BeijingChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17PanjiayuannanliChaoyang District100021 BeijingChina

Over the past 2 decades,there has been an extraordinary progress in the regimens developed for the treatment of human epidermal growth factor receptor 2(HER2)-positive breast ***,pertuzumab,lapatinib,and ado-trastuzumab emtansine(T-DM1)are commonly recommended anti-HER2 target agents by the *** and Drug *** review summarizes the most significant and updated research on clinical scenarios related to HER2-positive breast cancer management in order to revise the guidelines of everyday clinical *** this article,we present the data on anti-HER2 clinical research of neoadjuvant,adjuvant,and metastatic studies from the past 2 *** also highlight some of the promising strategies that should be critically ***,this review lists some of the ongoing clinical trials,findings of which may soon be available.

关键词： breast HER2 clinical

SEMI-PROXIMAL POINT METHOD FOR NONSMOOTH CONVEX-CONCAVE MINIMAX OPTIMIZATION

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Journal of Computational Mathematics 2024年第3期42卷 617-637页

作者： Yuhong Dai jiani wang Liwei Zhang LSEC ICMSECAMSSChinese Academy of SciencesBeijing 100190China School of Mathematical SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences Dalian University of TechnologyDalian 116024China

Minimax optimization problems are an important class of optimization problems arising from modern machine learning and traditional research *** there have been many numerical algorithms for solving smooth convex-concave minimax problems,numerical algorithms for nonsmooth convex-concave minimax problems are *** paper aims to develop an efficient numerical algorithm for a structured nonsmooth convex-concave minimax problem.A semi-proximal point method(SPP)is proposed,in which a quadratic convex-concave function is adopted for approximating the smooth part of the objective function and semi-proximal terms are added in each *** construction enables the subproblems at each iteration are solvable and even easily solved when the semiproximal terms are cleverly *** prove the global convergence of our algorithm under mild assumptions,without requiring strong convexity-concavity *** the locally metrical subregularity of the solution mapping,we prove that our algorithm has the linear rate of *** numerical results are reported to verify the efficiency of our algorithm.

关键词： Minimax optimization Convexity-concavity Global convergence Rate of con-vergence Locally metrical subregularity

Effect of Ultraviolet Aging on Asphalt Rheological Properties

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China Petroleum Processing & Petrochemical Technology 2013年第4期15卷 26-32页

作者： wang jiani Xue Zhongjun Tan Yiqiu Zhang Lei School of Civil Engineering Beijing Jiaotong University Beijing Major Projects Construction Headquarters Office School of Communications Science & Engineering Harbin Institute of Technology Beijing Road Engineering Quality Supervision Station

This paper simulated the ultraviolet aging process of asphalt and used dynamic mechanic analysis （DMA） method to evaluate the effect of ultraviolet aging on the asphalt theological properties. After having experienced ultravio- let aging, the low temperature performance of asphalt binder decreased significantly, with its complex modulus increased and phase angle decreased along with changing rheological properties as compared to the performance of original asphalt binder. The ultraviolet aging process would make asphalt binder more sensitive to brittle and fatigue failure. On the basis of the time-temperature superposition principle （TTSP）, the viscoelastic transition frequency （coT） is proposed to evaluate the effect of ultraviolet aging. It is found that with the increase in ultraviolet aging time, the cox moves to the lower frequency range gradually. Since the viscoelastic transition frequency is sensitive to the effect of aging, it can be used as an indicator of ultraviolet aging.

关键词： asphalt ultraviolet aging rheological properties viscoelastic transition frequency

Efficacy and safety of duloxetine in Chinese breast cancer patients with paclitaxel-induced peripheral neuropathy

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Chinese Journal of Cancer Research 2017年第5期29卷 411-418页

作者： jiani wang Qing Li Binghe Xu Tongtong Zhang Shanshan Chen Yang Luo Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective： Chemotherapy with paclitaxel is associated with significant neurotoxicity that may offset patients＇ quality of life and therapeutic benefits. This prospective, non-randomized control study evaluated the efficacy and safety of an antidepressant drug, duloxetine, at 30 or 60 mg/d, in the treatment of paclitaxel-induced peripheral neuropathy（PIPN） in Chinese breast cancer ***：A total of 102 patients with a median age of 50（range,25–60）years,treated in the Department of Medical Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,between November 2014 and January 2017 were finally *** by baseline characteristics,the patients were classified into two groups,receiving either duloxetine or alternative antineurotoxicity *** the course of the paclitaxel regimen,the eligibility criteria included sensory neuropathy,as evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse *** treatment consisted of receiving 30 mg duloxetine（for the first 4 weeks）and 60 mg duloxetine for an additional 8 weeks,or any other anti-neurotoxicity drug daily during the same crossover *** improvement associated with PIPN from the patient’s perspective were assessed by the Functional Assessment of Cancer Therapy-Taxane（FACT-Tax）Scales,which contained questions scored from 0 to 4（0,not at all;4,very much;total score range,0–44）.Results：Duloxetine was more effective in decreasing PIPN（odds ratio=5.426;95%confidence interval,1.898–15.514;P=0.002）.Between duloxetine group and control group,the median（25th–75th percentiles）decreasing difference in the FACT-Tax pain score was 4（2–6）vs.1（0–4）（P=0.005）.Conclusions：Duloxetine is a promising and safe option with tolerable toxicity at a dose of 60 mg/d for Chinese breast cancer patients with ***-neuropathy adverse events were mild and similar in both *** major toxicities of duloxetine included nausea,c

关键词： Duloxetine FACT-Tax Scales paclitaxel peripheral neuropathy

Political Aspirations,Participations and Influence of Turkish Muslims in Germany

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Asian Journal of Middle Eastern and Islamic Studies 2016年第2期10卷 99-120页

作者： wang Bo wang jiani Middle East Studies Institute Shanghai International Studies University

Germany invited large number of guest workers from Turkey to revitalize its economy after *** decades of development,the Muslim population has become the largest minority group in Germany making up 5%of today’s German *** main Muslim political aspiration is to be able to retain Turkish nationality but also access to German citizenship,and to promote the diversified development of German society to recognize their Muslim identity as *** order to achieve their own political aspirations,they participate in German politics through German political parties,civil society groups and mass *** activities not only have great influence on both domestic politics and diplomatic relations,but also in improving their living conditions in ***,the law in both countries will keep them from receiving German citizenship,let alone the dual *** of the inherent contradiction between Islam and Christianism,Germany has not yet become a truly pluralistic society.

关键词： Germany Turkish Muslim Political Aspiration Identity

Turkish Islamic Movement after Conservatives in Power

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Asian Journal of Middle Eastern and Islamic Studies 2017年第2期11卷 55-68,I0005页

作者： wang jiani wang Bo School of International Relations and Public Affairs Fudan University Middle East Studies Institute Shanghai International Studies UniversityChina

The Attempted Coup on July 15,2016 was a result of the struggle within the Turkish Islamic *** Islamic movement mobilizes in areas of both party politics and civil *** the area of party politics,the Turkish Islamic movement is led by Islamic parties,like the Justice and Development Party(AKP);while,in the area of civil society,it was led by Fethullah Gülen and the Gülen *** article focuses on the process of collaboration and subsequent confrontation between the AKP and Gülen Movement(GM).Analyzing the dynamics behind each groups’actions,how Islamic intellectuals strengthened their dominance through AKP and GM’s tactical alliance,and the groups’struggle for leadership of the Turkish Islamic movement,this article conceives that the collaboration between AKP and GM was based on their common interests to weaken Turkish secular elites;while their strife was caused by their divergence in strategies for propelling the Turkish Islamic movement,including different ideological construction,outcome expectations,and methods employed to accomplish their goals.

关键词： Attempted Coup Turkish Islamic Movement Justice and Development Party Gülen Movement Turkish Politics

Dose-dense paclitaxel plus carboplatin *** and cyclophosphamide with paclitaxel as adjuvant chemotherapy for high-risk triple-negative breast cancer

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Chinese Journal of Cancer Research 2020年第4期32卷 485-496页

作者： Qing Li jiani wang Yuxin Mu Tongtong Zhang Ying Han Jiayu wang Qiao Li Yang Luo Fei Ma Ying Fan Pin Zhang Binghe Xulj Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The objective of this open-label,randomized study was to compare dose-dense paclitaxel plus carboplatin(PCdd)with dose-dense epirubicin and cyclophosphamide followed by paclitaxel(ECdd-P)as an adjuvant chemotherapy for early triple-negative breast cancer(TNBC).Methods:We included Chinese patients with high recurrence risk TNBC who underwent primary breast cancer *** were randomly assigned to receive PCdd[paclitaxel 150 mg/m2 on d 1 and carboplatin,the area under the curve,(AUC)=3 on d 2]or ECdd-P(epirubicin 80 mg/m2 divided in 2 d and cyclophosphamide 600 mg/m2 on d 1 for 4 cycles followed by paclitaxel 175 mg/m2 on d 1 for 4 cycles)every 2 weeks with granulocyte colony-stimulating factor(G-CSF)*** primary endpoint was 3-year disease-free survival(DFS);the secondary endpoints were overall survival(OS)and ***:The intent-to-treat population included 143 patients(70 in the PCdd arm and 73 in the ECdd-P arm).Compared with the ECdd-P arm,the PCdd arm had significantly higher 3-year DFS[93.9%vs.79.1%;hazard ratio(HR)=0.310;95%confidence interval(95%CI),0.137-0.704;log-rank,P=0.005]and OS(98.5%vs.92.9%;HR=0.142;95%CI,0.060-0.825;log-rank,P=0.028).Worse neutropenia(grade 3/4)was found in the ECdd-P than the PCdd arm(47.9%V5.21.4%,P=0.001).Conclusions:PCdd was superior to ECdd-P as an adjuvant chemotherapy for early TNBC with respect to improving the 3-year DFS and *** also yielded lower hematological ***,PCdd might be a preferred regimen for early TNBC patients with a high recurrence risk.

关键词： Triple-negative breast cancer dose-dense adjuvant chemotherapy carboplatin paclitaxel

The molecular tumor burden index as a response evaluation criterion in breast cancer

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2494-2501页

作者： Zongbi Yi Fei Ma Guohua Rong Binliang Liu Yanfang Guan Jin Li Xiaoying Sun Wenna wang Xiuwen Guan Hongnan Mo jiani wang Haili Qian Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Geneplus-Beijing Institute BeijingChina Department of Medical Oncology Huanxing Cancer HospitalBeijingChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Circulating tumor DNA(ctDNA)is a potential biomarker of prognosis and therapeutic *** conducted this study to explore the role of the molecular tumor burden index(mTBI)in ctDNA as a therapeutic response and prognostic biomarker in a larger cohort prospective phase III randomized multicenter *** collected 291 plasma samples from 125 metastatic breast cancer patients from the CAMELLIA study(NCT01917279).Target-capture deep sequencing of 1021 genes was performed to detect somatic variants in ctDNA from the plasma *** pretreatment mTBI value was correlated with tumor burden(P=0.025).Patients with high-level pretreatment mTBI had shorter overall survival than patients with low-level pretreatment mTBI,and the median overall survival was 40.9 months and 68.4 months,respectively(P=0.011).Patients with mTBI decrease to less than 0.02%at the first tumor evaluation had longer progression-free survival and overall survival(P<0.001 and P=0.007,respectively).The mTBI has good sensitivity to identify complete response/partial response and progressive disease based on computed tomography scans(88.5%and 87.5%,respectively).The patients classified as molecular responders had longer progression-free survival and overall survival than the nonmolecular responders in the overall cohort(P<0.001 and P=0.036,respectively),as well as in the cohort in which computed tomography scans were defined as representing stable disease(P=0.027 and P=0.015,respectively).The mTBI in ctDNA detected in liquid biopsies is a potential biomarker of therapeutic response and prognosis in patients with metastatic breast cancer.

关键词： breast cancer index

Clinical benefit and safety profile of cross-line therapy with CDK4/6 inhibitors:a retrospective study of HR+/HER2–advanced breast cancer

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Cancer Biology & Medicine 2024年第10期21卷 934-950页

作者： Qi Zhao Mingxia Jiang Jiaxuan Liu Mengqi Zhang Maiyue He Shihan Zhou jiani wang Hongnan Mo Bo Lan Peng Yuan Pin Zhang Fei Ma Qiao Li Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic ***-line CDK4/6i therapy in which another CDK4/6i is continued after progression on a prior CDK4/6i may still offer advantageous therapeutic ***-line CDK4/6i therapy is an area of active investigation in the ongoing pursuit to improve outcomes for patients with HR+/human epidermal growth factor receptor 2(HER2)–***:This retrospective study enrolled 82 patients with HR+/HER2–ABC who were treated with cross-line CDK4/6is(abemaciclib,palbociclib,ribociclib,and dalpiciclib)after progression with another CDK4/*** primary endpoint was progression-free survival(PFS)according to version 1.1 of the Response Evaluation Criteria in Solid *** endpoints included toxicity,objective response rate,disease control rate,and overall *** events(AEs)were graded according to version 5.0 of the Common Terminology Criteria for Adverse Events,as promulgated by the *** of Health and Human ***:Eighty-two HR+/HER2–ABC patients who received cross-line CDK4/6i therapy from January 2022 to February 2024 were *** median age of the patients was 60 *** median PFS of all patients was 7.6 months(95%CI,5.9-9.2).Cox regression analysis identified lung metastasis and a switch to endocrine therapy following prior CDK4/6i therapy as independent predictive factors for ***,patients who previously received abemaciclib and switched to palbociclib upon disease progression had a median PFS of 10.7 *** strategy of transitioning to chemotherapy after progression on a prior CDK4/6i,then to a subsequent CDK4/6i merits further *** toxicity was the most common grade≥3 *** instances of fatal safety events were ***:Cross-line CDK4/6i therapy is associated

关键词： Breast cancer prior CDK4/6 inhibitor therapy cross-line CDK4/6 inhibitor therapy PFS