检索结果-南通市图书馆

Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 60-68页

作者： Liu Zhang Shailendra Shakya Li Wu jiangtao wang Guanghui Jin Huimin Sun Xianzhen Yin Lixin Sun Jiwen Zhang School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Center for Drug Delivery Systems Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Weihai Disu Pharmaceutical Manufacturer Weihai 264200China National Institutes for Food and Drug Control Beijing 100050China

The shapes of particles and their distribution in tablets, controlled by pretreatment and tableting process, determine the pharmaceutical performance of excipient like lubricant. This study aims to provide deeper insights to the relationship of the morphology and spatial distribution of stearic acid(SA) with the lubrication efficiency, as well as the resulting tablet property. Unmodified SA particles as flat sheet-like particles were firstly reprocessed by emulsification in hot water to obtain the reprocessed SA particles with spherical morphology. The three-dimensional(3 D) information of SA particles in tablets was detected by a quantitative and non-invasive 3 D structure elucidation technique, namely, synchrotron radiation X-ray micro-computed tomography(SR-μCT). SA particles in glipizide tablets prepared by using unmodified SA(GUT), reprocessed SA(GRT), as well as reference listed drug(RLD) of glipizide tablets were analyzed by SR-μCT. The results showed that the reprocessed SA with better flowability contributed to similarity of breaking forces between that of GRT and RLD. SA particles in GRT were very similar to those in RLD with uniform morphology and particle size, while SA particles in GUT were not evenly distributed. These findings not only demonstrated the feasibility of SR-μCT as a new method in revealing the morphology and spatial distribution of excipient in drug delivery system, but also deepened insights of solid dosage form design into a new scale by powder engineering.

关键词： Stearic acid Morphology Spatial distribution SR-μCT Glipizide tablets

Adaptive Sparse Group Variable Selection for a Robust Mixture Regression Model Based on Laplace Distribution

在线全文

学校读者我要写书评

暂无评论

Advances in Pure Mathematics 2020年第1期10卷 39-55页

作者： jiangtao wang Wanzhou Ye Department of Mathematics College of Science Shanghai University Shanghai China

The traditional estimation of Gaussian mixture model is sensitive to heavy-tailed errors;thus we propose a robust mixture regression model by assuming that the error terms follow a Laplace distribution in this article. And for the variable selection problem in our new robust mixture regression model, we introduce the adaptive sparse group Lasso penalty to achieve sparsity at both the group-level and within-group-level. As numerical experiments show, compared with other alternative methods, our method has better performances in variable selection and parameter estimation. Finally, we apply our proposed method to analyze NBA salary data during the period from 2018 to 2019.

关键词： Robust Mixture Regression Laplace Distribution Adaptive Sparse Group Lasso

胶质瘤组织细胞糖酵解相关酶表达及代谢物变化及与免疫抑制蛋白水平相关性

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华实验外科杂志 2024年第5期41卷 1052-1054页

作者：王江涛申汉威张喆陈玉升郭杨陈航河南省人民医院郑州大学人民医院河南大学人民医院神经外科郑州450003

目的:探讨胶质瘤组织细胞糖酵解相关酶表达及代谢物变化及与免疫抑制蛋白水平相关性。方法:选取2022年1月到2023年12月河南省人民医院诊治的神经胶质瘤组织和癌旁组织作为研究对象,采用荧光定量聚合酶链反应(PCR)分析癌旁组织和胶质瘤... 详细信息

目的:探讨胶质瘤组织细胞糖酵解相关酶表达及代谢物变化及与免疫抑制蛋白水平相关性。方法:选取2022年1月到2023年12月河南省人民医院诊治的神经胶质瘤组织和癌旁组织作为研究对象,采用荧光定量聚合酶链反应(PCR)分析癌旁组织和胶质瘤组织糖酵解相关酶表达水平,并采用试剂盒测定丙酮酸、乳酸等代谢物的变化。免疫荧光分析癌旁组织和胶质瘤组织CD8阳性T淋巴细胞的浸润水平;采用免疫组织化学分析癌旁组织和胶质瘤组织程序性死亡分子配体-1蛋白表达水平;组间计量数据比较采用t检验。结果:神经胶质瘤组织中己糖激酶2(HK2)、磷酸甘油激酶1(PGK1)、乳酸脱氢酶A(LDHA)和丙酮酸激酶2(PKM2)mRNA表达水平(1.53±0.19、1.70±0.22、1.81±0.18、1.79±0.22)明显高于癌旁组织(0.81±0.16、1.01±0.17、0.88±0.14、0.98±0.18),差异有统计学意义(t=24.950、19.180、27.900、18.850,P<0.05)。神经胶质瘤细胞组织中丙酮酸和乳酸水平[(56.24±14.27)、(8.31±1.96)mg/ml prot]明显高于癌旁组织(29.87±11.29)、(2.84±1.02)mg/ml prot],差异有统计学意义(t=9.721、16.570,P<0.05)。神经胶质瘤细胞组织中CD8淋巴细胞比例[(2.48±0.59)%]明显低于癌旁组织[(5.06±1.17)%],差异有统计学意义(t=13.160,P<0.05)。神经胶质瘤组织中程序性死亡分子配体-1和程序性死亡受体-1表达水平(1.57±0.19、1.62±0.19)明显高于癌旁组织(0.72±0.12、0.87±0.14),差异有统计学意义(t=16.3900、13.770,P<0.05)。HK2、PGK1、LDHA和PKM2 mRNA表达水平与程序性死亡分子配体-1蛋白表达水平呈正相关(r=0.145、0.105、0.217、0.209,P<0.05)。结论:胶质瘤组织中糖酵解酶己糖激酶2、磷酸甘油激酶1、乳酸脱氢酶A和丙酮酸激酶水平显著增加,与程序性死亡分子配体-1表达水平呈正相关。

关键词：神经胶质瘤糖酵解免疫抑制

An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第3期22卷 249-264页

作者： ZHOU jiangtao wang Jun wang Jiajing LI Deyun HOU Jing LI Jiankuan BAI Yun’e GAO Jianping School of Pharmaceutical Science Shanxi Medical UniversityJinzhong 030600China

Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and *** efficacy of CP-A in treating ulcerative colitis(UC)is,however,not *** study employed an in vitro lipopolysaccharide(LPS)-induced colonic epithelial cell model(NCM460)and an in vivo dextran sulfate sodium(DSS)-induced colitis mouse model to explore CP-A’s protective effects against experimental colitis and its underlying *** monitored the clinical symptoms in mice using various parameters:body weight,disease activity index(DAI),colon length,spleen weight,and histopathological ***,molecular markers were assessed through enzyme-linked immunosorbent assay(ELISA),quantitative real-time polymerase chain reaction(qRT-PCR),immunofluorescence(IF),immunohistochemistry(IHC),and Western blotting *** showed that CP-A significantly reduced reactive oxygen species(ROS),tumor necrosis factor-alpha(TNF-α),and interleukins(IL-6,IL-1β,IL-18)in LPS-induced cells while increasing IL-4 and IL-10 levels and enhancing the expression of Claudin-1,ZO-1,and occludin proteins in NCM460 ***,in vivo findings revealed that CPA administration markedly improved DAI,reduced colon shortening,and decreased the production of myeloperoxidase(MPO),malondialdehyde(MDA),ROS,IL-1β,IL-18,and NOD-like receptor protein 3(NLRP3)inflammasome-associated genes/proteins in UC ***-A treatment also elevated glutathione(GSH)and superoxide dismutase(SOD)levels,stimulated autophagy(LC3B,P62,Beclin-1,and ATG5),and reinforced Claudin-1 and ZO-1 expression,thereby aiding in intestinal epithelial barrier repair in colitis ***,the inhibition of autophagy via chloroquine(CQ)diminished CP-A’s protective impact against colitis in *** findings elucidate that CP-A’s therapeutic effect on experimental colitis possibly involves mitigating intestinal inflammation through autophagymediated N

关键词： Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome Autophagy

铝基复合材料搅拌摩擦加工制备工艺及其耐磨性能研究进展

在线全文

学校读者我要写书评

暂无评论

材料研究与应用 2024年第5期18卷 710-720页

作者：刘傲翔王江涛李星辰何明涛胡可军谢利刘超王明智江苏理工学院材料工程学院江苏常州213001

铝基复合材料具有密度低、加工性能良好、耐腐蚀等特点,在高性能制造方面拥有举足轻重的地位,被广泛应用于航空航天、船舶机械等领域。然而,在往复运动的工况条件下,工件之间的磨损对材料的性能影响最为显著,从而降低工件的服役寿命。因... 详细信息

铝基复合材料具有密度低、加工性能良好、耐腐蚀等特点,在高性能制造方面拥有举足轻重的地位,被广泛应用于航空航天、船舶机械等领域。然而,在往复运动的工况条件下,工件之间的磨损对材料的性能影响最为显著,从而降低工件的服役寿命。因此,提高工件耐磨性能和延长服役寿命,对于扩展铝合金的使用范围具有非常重要的意义。在制备铝基复合材料的工艺中,搅拌摩擦加工(Friction stir processing,FSP)技术是制备复合材料的新兴方式之一,所制备的复合材料具有优异的微观组织、不易产生界面反应等特点。所以,搅拌摩擦加工技术在铝基复合材料的生产中有巨大的应用潜力。针对搅拌摩擦加工制备铝基复合材料进行了综述,重点介绍了增强相的种类和含量,以及搅拌摩擦加工中的搅拌道次和焊接等参数,并且讨论了上述因素对铝基复合材料耐磨性能的影响。结果表明:随着增强相含量的增多,铝基复合材料的耐磨性能增强,但过多的含量反而会导致耐磨性能降低;随着搅拌道次的增加,有利于晶粒的细化,但是晶粒的细化程度过高,反而降低了铝基复合材料的耐磨性能。在此基础上,还研究了提高耐磨性能的机理。结果表明,在往复磨损过程中,材料的亚表层易形成动态再结晶,而动态再结晶尺寸对复合材料的耐磨性能有影响,过小的结晶尺寸会使耐磨性能下降。此外,还指出了搅拌摩擦加工制备铝基复合材料过程中存在的问题,如纳米增强相的团聚现象,以及选取适合FSP的工艺窗口等。最后,对FSP未来的研究趋势进行了展望。

关键词： FSP 铝合金铝基复合材料增强相种类增强相含量搅拌道次焊接参数耐磨性能

代谢重构参与肿瘤治疗相关心功能不全机制的研究进展

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

实用心脑肺血管病杂志 2024年第9期32卷 129-133页

作者：于坚刘新亚吴莉王江涛高梦娇张源明新疆医科大学新疆维吾尔自治区乌鲁木齐市830000 新疆医科大学第三临床医学院肿瘤心脏病科新疆维吾尔自治区乌鲁木齐市830000 新疆军区总医院心胸外科新疆维吾尔自治区乌鲁木齐市830000

近年随着抗肿瘤药物研发及综合诊治水平提高,肿瘤患者生存质量及生存率明显提高,但绝大部分抗肿瘤药物可直接造成心脏和血管损伤。因此,预防肿瘤治疗相关心血管毒性(CTR-CVT)尤为重要。目前,CTR-CVT包括肿瘤治疗相关心功能不全(CTRCD)... 详细信息

近年随着抗肿瘤药物研发及综合诊治水平提高,肿瘤患者生存质量及生存率明显提高,但绝大部分抗肿瘤药物可直接造成心脏和血管损伤。因此,预防肿瘤治疗相关心血管毒性(CTR-CVT)尤为重要。目前,CTR-CVT包括肿瘤治疗相关心功能不全(CTRCD)、心肌炎、高血压、心律失常、心包疾病等,而CTRCD包括心肌损伤、心肌病及心力衰竭等。研究表明,代谢重构与心血管疾病和肿瘤的发生发展密切相关。基于此,本文主要综述了代谢重构参与CTRCD的机制,并发现能量代谢、氨基酸代谢参与了阿霉素治疗相关心力衰竭的发生,脂肪酸代谢参与了环磷酰胺治疗相关心脏收缩功能障碍及雄激素剥夺疗法治疗相关心血管疾病的发生,线粒体损伤参与了5-氟尿嘧啶治疗相关心脏毒性的发生,线粒体功能障碍和心肌能量代谢改变与曲妥珠单抗治疗相关心功能障碍相关,细胞生物学过程改变可能参与了血管内皮生长因子-酪氨酸激酶抑制剂治疗相关心功能不全的发生,故针对代谢重构进行治疗可能对CTRCD有益。

关键词：肿瘤心功能不全代谢重构综述

Direct visualization of laser-driven dynamic fragmentation in tin by in situ x-ray diffraction

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第5期9卷 109-114页

作者： Jing Yang Xinxin wang Liang Xu Qiannan wang Yi Sun jiangtao Li Lin Zhang Yinghua Li Yuying Yu Pei wang Qiang Wu Jianbo Hu Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100094China

We present a novel method for investigating laser-driven dynamic fragmentation in tin using in situ X-ray *** experimental results demonstrate the feasibility of the method for simultaneously identifying the phase and temperature of fragments through analysis of the diffraction ***,we observe a deviation from the widely accepted isentropic release assumption,with the temperature of the fragments being found to be more than 100 K higher than expected,owing to the release of plastic work during dynamic *** findings are further verified through extensive large-scale molecular dynamics simulations,in which strain energies are found to be transferred into thermal energies during the nucleation and growth of voids,leading to an increase in *** findings thus provide crucial insights into the impact-driven dynamic fragmentation phenomenon and reveal the significant influence of plastic work on material response during shock release.

关键词： dynamic release diffraction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高频数据波动率非参数估计及窗宽选择

系统工程理论与实践 2018年第10期38卷 2491-2500页

作者：王江涛周勇上海财经大学统计与管理学院上海200433 华中师范大学经济与工商管理学院武汉430079 中国科学院数学与系统科学研究院北京100190

基于高频数据采用非参数的方法估量波动率,因其能更准确地度量波动率,一直是学者们研究的热点.然而,波动率的所有非参数估计都面临着窗宽的选择问题.由于最优窗宽中往往携带一些难以估计的未知参数,使得在应用过程中确定最优窗宽的具体... 详细信息

基于高频数据采用非参数的方法估量波动率,因其能更准确地度量波动率,一直是学者们研究的热点.然而,波动率的所有非参数估计都面临着窗宽的选择问题.由于最优窗宽中往往携带一些难以估计的未知参数,使得在应用过程中确定最优窗宽的具体数值存在困难,从而阻碍了这类估计量的使用.本文以已实现核估计作为波动率非参数估计的代表,构建了一种能自动从实际数据中确定最优窗宽的算法.理论分析的结果表明：算法具有稳定性,其所确定的窗宽是最优窗宽的无偏一致估计量,收敛速度为O（n^（-1/5））.实际数据检验的结果显示,算法是稳定的并且具有良好的适应性,由算法确定的窗宽不依赖初始值的选取.模拟数据的结果显示,相比传统确定窗宽的方法,算法确定的窗宽所对应的估计量具有更高的精度.文中的算法可推广到波动率其他的非参数估计量中,从而为这类估计量的使用铺平道路.

关键词：波动率已实现核估计窗宽选择算法设计

A Novel Data Schema Integration Framework for the Human-Centric Services in Smart City

在线全文

学校读者我要写书评

暂无评论

ZTE Communications 2015年第4期13卷 25-33页

作者： Ding Xia Da Cui jiangtao wang Yasha wang Peking University

Human-centric service is an important domain in smart city and includes rich applications that help residents with shopping, dining, transportation, entertainment, and other daily activities. These applications have generated a massive amount of hierarchical data with different schemas. In order to manage and analyze the city-wide and cross-application data in a unified way, data schema integration is necessary. However, data from human-centric services has some distinct characteristics, such as lack of support for semantic, matching, large number of schemas, and incompleteness of schema element labels. These make the schema integra- tion difficult using existing approaches. We propose a novel framework for the data schema integration of the human-centric services in smart city. The framework uses both schema metadata and instance data to do schema matching, and introduces human intervention based on a similarity entropy criteria to balance precision and efficiency. Moreover, the framework works in an incremental manner to reduce computation workload. We conduct an experiment with real-world dataset collected from multiple estate sale application systems. The results show that our approach can produce high-quality mediated schema with relatively less human in- terventions compared to the baseline method.

关键词： schema matching schema integration smart city human-centric service