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Trends in Mortality of Cirrhosis in China: An Analysis of the China Death Surveillance Database from 2008 to 2020

Journal of Clinical and Translational Hepatology 2024年第3期12卷 236-244页

作者： Xiaoxiao wang huixin Liu Jinlei Qi Lijun wang Peng Yin Feng Liu Lai Wei Yu wang Maigeng Zhou huiying Rao Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijingChina National Center for Chronic Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Beijing Tsinghua Changgung Hospital Tsinghua UniversityBeijingChina Chinese Foundation for Hepatitis Prevention and Control BeijingChina

Background and Aims:China accounts for 14.9%of total cirrhosis deaths worldwide.A detailed and comprehensive understanding of the contemporary status of cirrhosis mortality in China is crucial for establishing strategies for intervention and decreasing the disease burden of cirrhosis *** study aimed to report the cirrhosis mortality rates in our whole country or province over ***:Mortality data from 2008 to 2020 were retrieved from the Disease Surveillance Point System(DSPs)of the Chinese Center for Disease Control and *** crude mortality rate and age-standardized mortality rate of patients with cirrhosis were stratified by sex,residential location,and *** average annual percentage change(AAPC)in cirrhosis mortality rates from 2008 to 2020 was also ***:The crude mortality rate of cirrhosis was 4.57/100,000 people in *** with females and individuals living in urban areas,males and people living in rural areas had greater age-standardized *** crude mortality rate and age-standardized mortality rate in provinces in Southwest China(Guangxi,Yunnan,Guizhou,and Qinghai)were greater than those in other ***,with increasing age,the age-specific mortality rate increased *** 2008 to 2020,the mortality rate of cirrhosis in China decreased except for in males aged 50–59 years,females aged 45–49 years and females aged 80–84 ***:The mortality rate of patients with cirrhosis in China decreased from 2008 to *** the future,interventions of cirrhosis mortality control need to pay more attention to all males,females aged 45–49 and 80–84 years,and people living in rural areas and in provinces in Southwest China.

关键词： Cirrhosis Mortality Trend China

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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Do community responses influence OSS contributor retention? A survival analysis

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Science China(Information Sciences) 2024年第8期67卷 331-333页

作者： Zhe wang Zhixing LI Yue YU School of Public Policy and Management Tsinghua University College of Computer National University of Defense Technology

Open source software(OSS) projects usually employ a community-based model, where geographically distributed developers from around the world collaborate online [1].With the rise of social coding sites like Git Hub, contributing to OSS projects has become easier and more accessible, motivating many developers to join the OSS community [2]. The continued submission of high-quality contributions from these community developers has led to numerous corrections, improvements, and innovations in many successful OSS projects [1, 2].

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A review on the chemical speciation and influencing factors of heavy metals in Municipal Solid Waste landfill humus

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Waste Disposal and Sustainable Energy 2024年第2期6卷 209-218页

作者： Qiongyu Sun Bo Sun Defeng wang Yuyuan Pu Mingxiu Zhan Xu Xu Jinqing wang Wentao Jiao College of Metrology and Measurement Engineering China Jiliang UniversityHangzhou 310018Zhejiang ProvinceChina Zhongke Hualu Soil Remediation Engineering Co. LtdDezhou 253011Shandong ProvinceChina Zhejiang Environmental Protection Group Co. LtdHangzhou 310020Zhejiang ProvinceChina Institute for Thermal Power Engineering Zhejiang UniversityHangzhou 310027Zhejiang ProvinceChina Research Center for Eco-Environmental Sciences Chinese Academy of SciencesHaidian District18 Shuangqing RoadBeijing 100085China

Heavy metal pollution in landfill humus can cause serious environmental problems and may endanger soil ecosystems and human *** biological toxicity of heavy metals is not only related to their total amount but also influenced to a greater extent by the distribution of their chemical *** the different chemical speciation and proportions of heavy metals can provide a more comprehensive and accurate understanding of the pollution characteristics and biological toxic-ity of heavy metals in landfill *** on a review of the relevant literature,this paper systematically summarizes the recent research status of typical heavy metal chemical speciation in landfill *** chemical speciation is diverse and *** instance,heavy metals in residual states and organically bound states have little impact on organisms,while heavy metals in exchangeable states and Fe-Mn oxide states can easily migrate and *** chemical speciation of heavy metals is affected by many factors,among which the soil pH and organic matter content are some of the most important ***,the existing gaps in the current research on the chemical speciation of heavy metals in landfills are described and future research directions are *** work provides a theoretical reference for researching the restoration of heavy metal-contaminated humus soil and the resource utilization of humus soil.

关键词： Landflls Humus soil containing heavy metal-Chemical speciation Distribution characteristics Influencing factors

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The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients

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Food Science and Human Wellness 2024年第2期13卷 1079-1092页

作者： Qingqing Xu Weifei wang Dongxiao Sun-Waterhouse Qian Zou Menglei Yan Xuan Liu Dongming Lan Yonghua wang School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural and Agri-Food Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510610China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand Guangdong Youmei Institute of Intelligent Bio-manufacturing Co. Ltd.Foshan 528200China

The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diacylglycerols(DAGs)are potential good lipid sources for these *** oil-based DAG(LD)and linseed oil(LT)were ***-based emulsion((83.74±1.23)%)had higher lipolysis degree than LT-based emulsion((74.47±1.16)%)when monitoring the GI tract of normal population as previously *** conditions seriously decreased the digestive degree of LT-based emulsion((40.23±2.48)%-(66.50±3.70)%)while showed less influence on LD-based emulsion((64.18±2.41)%-(81.85±3.45)%).As opposed to LT-based emulsion,LD-based emulsion exhibited preference for releasing unsaturated fatty acids(especially oleic acid andα-linolenic acid)due to their different glycerolipid ***-based emulsion showed potential for providing lipids and nutrients(including essential fatty acids)for lipid indigestion patients.

关键词： Diacylglycerol In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency

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Cobalt single-atom catalyst tailored ceramic membrane for selective removal of emerging organic contaminants

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Environmental Science and Ecotechnology 2024年第5期21卷 219-229页

作者： Jiaxuan Yang Jing Zhao Hesong wang Yatao Liu junwen Ding Tianyi wang Jinlong wang Han Zhang Langming Bai Heng Liang State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090PR China Beijing Key Laboratory for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing100083PR China

Water reuse is an effective way to solve the issues of current wastewater increments and water resource ***,a promising method for water reuse,has the characteristics of low energy consumption,easy operation,and high adaptability to coupling with other water treatment ***,emerging organic contaminants(EOCs)in municipal wastewater cannot be effectively intercepted by ultrafiltration,which poses significant challenges to the effluent quality and sustainability of ultrafiltration ***,we develop a cobalt single-atom catalyst-tailored ceramic membrane(Co1-NCNT-CM)in conjunction with an activated peroxymonosulfate(PMS)system,achieving excellent EOCs degradation and anti-fouling *** interfacial reaction mechanism effectively mitigates membrane fouling through a repulsive interaction with natural organic *** generation of singlet oxygen at the Co-N3-C active sites through a catalytic pathway(PMS/PMS*/OH*/O*/OO*/1 O_(2))exhibits selective oxidation of phenols and sulfonamides,achieving>90%removal *** findings elucidate a multi-layered functional architecture within the Co1-NCNT-CM/PMS system,responsible for its superior performance in organic decontamination and membrane maintenance during secondary effluent *** highlights the power of integrating Co1-NCNT-CM/PMS systems in advanced wastewater treatment frameworks,specifically for targeted EOCs removal,heralding a new direction for sustainable water management.

关键词： Single-atom catalytic ceramic membrane Peroxymonosulfate activation Selective oxidation Interfacial response Multi-layer functional zones

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SPE和QuEChERS前处理方法结合LC-Q-TOF/MS检测苹果和番茄中282种农药残留对比研究

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分析试验室 2015年第4期34卷 383-387页

作者：王慧君薛亚薇康健彭兴常巧英范春林庞国芳北京工商大学食晶学院北京100048 中国检验检疫科学研究院北京100123 燕山大学环境与化学工程学院秦皇岛066004

利用液相色谱-四极杆/飞行时间质谱（LC-Q-TOF/MS）对比研究了固相萃取（SPE）和Qu ECh ERS两种前处理方法在282种农药残留检测上的效果。以苹果和番茄为基质,分别从基质效应、回收率、重复性、线性关系、检出限和定量限等方面进行了考... 详细信息

利用液相色谱-四极杆/飞行时间质谱（LC-Q-TOF/MS）对比研究了固相萃取（SPE）和Qu ECh ERS两种前处理方法在282种农药残留检测上的效果。以苹果和番茄为基质,分别从基质效应、回收率、重复性、线性关系、检出限和定量限等方面进行了考察与比较。SPE法和Qu ECh ERS法在苹果中呈现出弱基质效应的农药占比分别为87.2%和57.1%,在番茄中为65.6%和42.2%。与SPE相比,Qu ECh ERS法干扰物较多,基质效应较强;在5.0μg/kg添加水平下（n=5）,SPE和Qu ECh ERS在苹果中平均回收率在70%~120%的农药占比分别为99.3%和86.9%,在番茄中为92.9%和87.9%;在5.0μg/kg添加水平下（n=5）,SPE和Qu ECh ERS在苹果中重复性相对标准偏差（RSD）〈20%（n=5）农药占比分别为98.9%和86.5%,在番茄中为92.9%和87.6%;SPE和Qu ECh ERS两种方法在苹果中定量限≤10μg/kg的农药占比为100.0%和96.1%,在番茄中为100.0%和98.9%。两种前处理方法均能与高分辨质谱技术相结合并应用于果蔬农药残留的日常检测中,其中SPE净化效果较优,定量更为准确,但步骤稍显繁琐费时,而Qu ECh ERS方法简单快速,故在检测时可根据不同需要进行选择。

关键词： SPE Qu ECh ERS LC-Q-TOF/MS 农药多残留果蔬

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碳点比率荧光探针测定果蔬中的甲胺磷

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分析试验室 2024年第6期43卷 780-784页

作者：韩雍汪慧张晓燕陇东学院农林科技学院庆阳745000

以邻苯二胺与浓硫酸为原料,通过一步水热法合成了荧光碳点(oPD-CDs),构建了一种检测果蔬中甲胺磷(MTP)的oPD-CDs比率荧光传感器。在优化条件下,oPD-CDs传感器的荧光比值(F_(430)/F_(483))与甲胺磷浓度在0~160 ng/mL范围内呈良好的线性关... 详细信息

以邻苯二胺与浓硫酸为原料,通过一步水热法合成了荧光碳点(oPD-CDs),构建了一种检测果蔬中甲胺磷(MTP)的oPD-CDs比率荧光传感器。在优化条件下,oPD-CDs传感器的荧光比值(F_(430)/F_(483))与甲胺磷浓度在0~160 ng/mL范围内呈良好的线性关系,相关系数R^(2)为0.99,检出限(LOD)为14.3 ng/mL,加标回收率为92.0%~108.0%,相对标准偏差(RSDs)为0.7%~1.6%。该方法可用于果蔬中甲胺磷残留的检测。

关键词：农药残留荧光碳点甲胺磷快速检测

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小样本下大冶湖非光学活性水质参数反演与时空变化分析

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长江流域资源与环境 2024年第1期33卷 102-113页

作者：黄振辉杨小红王力哲厉芳婷刘君刘新龙王玲玲中国地质大学(武汉)计算机学院湖北武汉430074 武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079 湖北省测绘工程院湖北武汉430074 湖北省自然资源厅湖北武汉430071 武汉中地数字孪生技术有限公司湖北武汉430074 湖北省生态环境科学研究院湖北武汉430072

遥感技术为内陆湖泊水质监测提供了极大的便利,但是由于非光学活性水质参数在复杂的内陆水体生物光学环境中,很难直接找到其光学特性,导致这类参数的实测水质数据与遥感反射率之间难以用简单的回归模型拟合,尤其是在实测水质样本量较小... 详细信息

遥感技术为内陆湖泊水质监测提供了极大的便利,但是由于非光学活性水质参数在复杂的内陆水体生物光学环境中,很难直接找到其光学特性,导致这类参数的实测水质数据与遥感反射率之间难以用简单的回归模型拟合,尤其是在实测水质样本量较小时,传统机器学习容易出现欠拟合的现象,反演精度难以保证。针对非光学活性水质参数在反演中数据量较小、拟合困难等问题,提出了一种基于点积注意力模型的水质反演方法,通过58个水质实测数据和Sentinel-2遥感数据构建了点积注意力模型,实现大冶湖遥感水质反演。在同样的样本和影像数据下,对比了基于统计回归模型和多层感知机模型的遥感水质反演。实验表明,点积注意力模型的非光学活性水质参数浓度反演的准确性较高,总磷、总氮、高锰酸盐指数的决定系数R2分别能达到0.83,0.89,0.80。最后,将提出的模型运用到大冶湖非光学活性水质参数反演中,对该湖泊2018~2021年总磷、总氮、高锰酸盐指数3种非光学活性水质参数进行反演,统计并分析了近4年大冶湖水质参数浓度的时空变化特征,对大冶湖的营养状态进行了综合评价,为大冶湖水环境治理提供重要数据支撑。

关键词：水质反演非光学活性机器学习注意力机制哨兵2号

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Highly crystalline Y3Al5O12:Ce3+ phosphor-in-silica glass ceramics for high-power solid-state lighting

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Journal of Rare Earths 2024年第11期42卷 2051-2057页

作者： Shisheng Lin Hang Lin Hongyi Yang Pengfei wang Ping Sui Ju Xu Yao Cheng Yuansheng wang Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Xiamen Institute of Rare-earth Materials Haixi InstitutesChinese Academy of Sciences College of Chemistry and Materials Science Fujian Normal University

The pursuit of high-brightness solid-state lighting（SSL） stimulates the development of all-inorganic color converters with high *** is required that the fluorescent material is able to cope with the extreme condition generated from the irradiation of high-power-density excitation *** such,in this work,we developed a new composite color converter,i,e.,Y3Al5O12:Ce3+phosphor-in-silica glass ceramic(YAG:Ce3+PiSGC).Remarkably,the amorphous SiO2matrix spontaneously transforms into tetragonal SiO2crystallites during co-sintering with crystallization fraction reaching up to>90%（almost full ceramization）.The activation energy for crystallization Ecand Avrami index n of amorphous silica oxide are 298.5 kJ/mol and 1.71,indicating the diffusion-controlled glass crystallization *** fabricated prototype high-power phosphor-converted white light-emitting diode（pc-wLED） and phosphor-converted white laser diode（pc-wLD） based on YAG:Ce3+PiSGC show satisfactory photometric/colorimetric *** developed color co nverters have combined merits of environmental protection property,cost-effective manufacturing,good luminescent performance,and easy *** study highlights a new kind of opto-functional composite material and its application as an efficient color converter in high-power solid-state lightings.

关键词： Glass ceramics Laser-driven white light Rare earths White light-emitting diode Y3Al5O12:Ce3+

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