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Seco-cyclic phorbol derivatives and their anti-HIV-1 activities

Chinese Journal of Natural Medicines 2024年第4期22卷 365-374页

作者： HUANG Xiaolei HUANG Xusheng LI Qirun MA Mengdi CUI Yadong YANG Liumeng wang haibo LUO Ronghua CHEN Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian College of Pharmaceutical Science Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China

Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20,C3/C4,and C9 of phorbol.Concurrently,the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand complex.The influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further exploration.This research entailed the hydrolysis of phorbol,producing seco-cyclic phorbol derivatives.The anti-HIV-1 efficacy of these derivatives was assessed,and the affinity constant(Kd)for PKC-δprotein of selected seco-cyclic phorbol derivatives was determined through isothermal titration calorimetry.The findings suggest that the chemical modification of cyclopropanols could affect both the anti-HIV-1 activity and the PKC binding affinity.Remarkably,compound S11,with an EC_(50) of 0.27μmol·L^(−1) and a CC_(50) of 153.92μmol·L^(−1),demonstrated a potent inhibitory effect on the intermediate products of HIV-1 reverse transcription(ssDNA and 2LTR),likely acting at the viral entry stage,yet showed no affinity for the PKC-δprotein.These results position compound S11 as a potential candidate for further preclinical investigation and for studies aimed at elucidating the pharmacological mechanism underlying its anti-HIV-1 activity.

关键词： seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring Esterification Anti-HIV-1 agent

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Efficient unequal error protection for online fountain codes

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Journal of Systems Engineering and Electronics 2024年第2期35卷 286-293页

作者： SHI Pengcheng wang Zhenyong LI Dezhi LYU haibo School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China Shenzhen Academy of Aerospace Technology Shenzhen 518057China

In this paper,an efficient unequal error protection(UEP)scheme for online fountain codes is proposed.In the buildup phase,the traversing-selection strategy is proposed to select the most important symbols(MIS).Then,in the completion phase,the weighted-selection strategy is applied to provide low overhead.The performance of the proposed scheme is analyzed and compared with the existing UEP online fountain scheme.Simulation results show that in terms of MIS and the least important symbols(LIS),when the bit error ratio is 10-4,the proposed scheme can achieve 85%and 31.58%overhead reduction,respectively.

关键词： online fountain code random graph unequal error protection(UEP) rateless code

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Multiphysical contact of functionally graded magneto-electroelastic material with imperfect bonding interface

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Friction 2024年第4期12卷 632-654页

作者： Yijin SUI haibo ZHANG Jieliang ZHAO Wenzhong wang School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

Three-dimensional(3D)frictional contact model of functionally graded magneto-electro-elastic(FGMEE)material with a conducting spherical punch under electromagnetic fields is presented.Two types of imperfect bonding interface of layers,dislocation-like interface and force-like interface,are considered.Frequency response functions(FRFs)for multilayered MEE material with imperfect interface subjected to unit mechanical,electric,and magnetic loads are derived.The FRFs are used with the semi-analytical method(SAM)to solve present multiphysical contact problem.The present model is verified by comparing with literatures and the finite element method(FEM)and used to study the contact problem of FGMEE film imperfectly bonded on homogenous MEE half-space under electromagnetic fields.Parametric studies are conducted to reveal the effects of imperfect interfaces and also film properties including gradient index and thickness.

关键词： frictional contact magneto-electro-elastic material imperfect interface functionally graded electromagnetic fields

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MXene:Promising materials for magnesium-ion batteries

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Chinese Journal of Chemical Engineering 2024年第5期69卷 199-211页

作者： Liuyu Song haibo Li Pengkai wang Yu Shang Yue Yang Zhaoyu Wu School of Resources and Civil Engineering Northeastern UniversityShenyang 110004China

Magnesium-ion batteries(MIBs)have attracted extensive attention due to their high theoretical capacity,superior safety,and low cost.Nonetheless,the development of MIBs is hindered by the lack of cathode materials with long cycle life and rate capability.MXene stands out as a prime choice for MIB cathode or collector for anode-free magnesium batteries(AFMBs)because of its larger surface area,adjustable surface properties,and good electrical conductivity.In this paper,we summarized the preparation and layering methods of MXene and discussed the prospects of MXene as a cathode or collector for MIBs.This review will be immensely beneficial in critically analyzing the synthesis techniques and the applications of MXene material as MIB cathode or AFMB collector.In addition,the challenges of the preparation and layering were concluded,along with raising the research strategies of MXene for storing Mg ions.

关键词： MXene Nanomaterials Electrochemistry Optimization Magnesium-ion batteries(MIBs)

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Synthesis of porous flower-like SnO_(2)/CdSnO_(3) microstructures with excellent sensing performances for volatile organic compounds

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Frontiers of Materials Science 2024年第1期18卷 45-57页

作者： Jie Wan Gang wang haibo Ren Jiarui Huang Sang Woo Joo School of Materials Science and Engineering Anhui Polytechnic UniversityWuhu 241000China Key Laboratory of Functional Molecular Solids of the Ministry of Education College of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China School of Mechanical Engineering Yeungnam UniversityGyeongsanGyeoungbuk 712749Republic of Korea

Porous flower-like SnO_(2)/CdSnO_(3) microstructures self-assembled by uniform nanosheets were synthesized using a hydrothermal process followed by calcination,and the sensing performance was measured when a gas sensor,based on such microstructures,was exposed to various volatile organic compound(VOC)gases.The response value was found to reach as high as 100.1 when the SnO_(2)/CdSnO_(3) sensor was used to detect 100 ppm formaldehyde gas,much larger than those of other tested VOC gases,indicating the high gas sensitivity possessed by this sensor especially in the detection of formaldehyde gas.Meanwhile,the response/recovery process was fast with the response time and recovery time of only 13 and 21 s,respectively.The excellent gas sensing performance derive from the advantages of SnO_(2)/CdSnO_(3),such as abundant n-n heterojunctions built at the interface,high available specific surface area,abundant porosity,large pore size,and rich reactive oxygen species,as well as joint effects arising from SnO_(2) and CdSnO_(3),suggesting that such porous flower-like SnO_(2)/CdSnO_(3) microstructures composed of nanosheets have a high potential for developing gas sensors.

关键词： SnO_(2)/CdSnO_(3) porous flower-like microstructure volatile organic gas sensingproperty gas sensor

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Facile synthesis of hierarchical NaX zeolite from natural kaolinite for efficient Knoevenagel condensation

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Chinese Journal of Chemical Engineering 2024年第1期65卷 75-84页

作者： Wen Xiao Peng Dong Chan wang Jingdong Xu Tiesen Li haibo Zhu Tinghai wang Renwei Xu Yuanyuan Yue National Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350108China Qingyuan Innovation Laboratory Quanzhou 362801China Sinochem Quanzhou Energy Technology Co. Ltd.Quanzhou 362000China

Zeolite catalysts have found extensive applications in the synthesis of various fine chemicals.However,the micropores of zeolites impose diffusion limitations on bulky molecules,greatly reducing the catalytic efficiency.Herein,we explore an economic and environmentally friendly method for synthesizing hierarchical NaX zeolite that exhibits improved catalytic performance in the Knoevenagel condensation reaction for producing the useful fine chemical 2-cyano-3-phenylacrylate.The synthesis was achieved via a low-temperature activation of kaolinite and subsequent in-situ transformation strategy without any template or seed.Systematic characterizations reveal that the synthesized NaX zeolite has both intercrystalline and intra-crystalline mesopores,smaller crystal size,and larger external specific surface area compared to commercial NaX zeolite.Detailed mechanism investigations show that the inter-crystalline mesopores are generated by stacking smaller crystals formed from in-situ crystallization of the depolymerized kaolinite,and the intra-crystalline mesopores are inherited from the pores in the depolymerized kaolinite.This synthesis strategy provides an energy-saving and effective way to construct hierarchical zeolites,which may gain wide applications in fine chemical manufacturing.

关键词： Hierarchical NaX zeolite Template-free synthesis Natural kaolinite Knoevenagel condensation

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Applying heteroatom co-doped carbon nanotube for manifesting high performance in the electrochemical reduction of aqueous nitrogen oxide by gold nanoparticles

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Nano Research 2024年第3期17卷 1151-1164页

作者： Jane Chung haibo Yin Rong wang Yunlong wang Junyang Zhang Yue Peng Joung Woo Han Seongyun Ryu Junhua Li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China EHS Research Center Samsung Electronics Co.Ltd.Gyeonggi-do 18448Republic of Korea

Electrochemical NO-to-NH_(3) under ambient conditions could be a viable alternative having advantages in terms of energy consumption and exhaust gas recycling of NO,replacing a traditional ammonia synthesis method of the Haber–Bosch process.In synthesizing boron(B-)and nitrogen(N-)co-doped carbon nanotube(CNT)based gold(Au)catalysts,B-dopants elevate the conductivity of carbon nanotube by sp2 hybridization on graphene and implant B–N domains within the graphene layer,and result in facilitating the embedding amount of Au accompanied by high dispersibility with low particle size.Theoretical density functional theory(DFT)calculations elucidate that the electron cloud transmitted from B-dopant to the active site of Au induces the Lewis acidic site,and the O-distal pathway occurs following a spontaneous reaction.Increment of the electron-deficient B-doping area accompanied by N-defects and B–O edges retains the major valence state of Au as Au^(δ+),and suppresses hydrogen evolution reaction(HER)by repulsing the hindrance of H*.This record exhibits the highest faradaic efficiency(FE)of 94.7%,and NH_(3) yield rate of 1877.4μg·h^(-1)·mg_(cat)^(-1),which is the optimal yield over energy consumption in the field of the ambient reduction of aqueous NO.

关键词： boron heteroatom nitrogen defect gold nanoparticles valence states of gold electrochemical NO-to-NH3

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Effect of deformation parameters on the austenite dynamic recrystallization behavior of a eutectoid pearlite rail steel

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 833-841页

作者： haibo Feng Shaohua Li Kexiao wang Junheng Gao Shuize wang Haitao Zhao Zhenyu Han Yong Deng Yuhe Huang Xinping Ma Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute for Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Pangang Group Panzhihua Iron and Steel Research Institute Co.Ltd. Panzhihua 617000China

Understandings of the effect of hot deformation parameters close to the practical production line on grain refinement are crucial for enhancing both the strength and toughness of future rail steels.In this work,the austenite dynamic recrystallization(DRX)behaviors of a eutectoid pearlite rail steel were studied using a thermo-mechanical simulator with hot deformation parameters frequently employed in rail production lines.The single-pass hot deformation results reveal that the prior austenite grain sizes(PAGSs)for samples with different deformation reductions decrease initially with an increase in deformation temperature.However,once the deformation temperature is beyond a certain threshold,the PAGSs start to increase.It can be attributed to the rise in DRX volume fraction and the increase of DRX grain with deformation temperature,respectively.Three-pass hot deformation results show that the accumulated strain generated in the first and second deformation passes can increase the extent of DRX.In the case of complete DRX,PAGS is predominantly determined by the deformation temperature of the final pass.It suggests a strategic approach during industrial production where part of the deformation reduction in low temperature range can be shifted to the medium temperature range to release rolling mill loads.

关键词： eutectoid pearlite rail steel prior austenite grain size dynamic recrystallization single-pass hot deformation three-pass hot deformation

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High-tenacity in-situ Ti/Zr-based bulk metallic glasses composites fabricated by industrial high-pressure die casting

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Journal of Materials Science & Technology 2024年第3期170卷 177-185页

作者： Yang Li Wenbo Luo Ying Jin Zhiyong Xue Guiqing wang Yanan Ren Haoxin Li haibo Ke Baoan Sun Weihua wang Institute for Advanced Materials North China Electric Power UniversityBeijing 102206China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China

The glass-forming ability and mechanical properties of metallic glasses and their composites are well known to be sensitive to the preparation conditions and are highly deteriorated by industrial preparing conditions such as low-purity raw materials and low vacuum.Here,we showed that a series of in-situ bulk metallic glass composites(BMGCs)which exhibit excellent ductility and segmental work hardening were successfully developed utilizing a high vacuum high-pressure die casting(HV-HPDC)technology along with industrial-grade raw materials.The tensile properties of these BMGCs are systematically investigated and correlated with the alloy microstructure.As compared with the copper mold suction casting method,the volume fraction difference of the dendrite phase for the BMGCs with the same composition is not significant when fabricated by the HV-HPDC,whereas the size of theβ-phase is generally larger.Insitu BMGCs with the composition of Ti_(48)Zr_(20)(V_(12/17)Cu_(5/17))19 Be 13 obtained by the HV-HPDC process show ductility up to 11.3%under tension at room temperature and exhibit a certain amount of work hardening.Two conditions need to be met to enable the BMGCs,which are prepared by vacuum die-casting to retain favorable ductility:(1)The volume fraction ofβphase stays below 62%±2%;(2)The equiaxed crystals with a more uniform size in the range of 5-10μm.Meanwhile,the results of the present study provided guidance for developing BMGCs with good ductile properties under industrial conditions.

关键词： Vacuum die casting Bulk metallic glass composites Mechanical properties β-phase

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Effect of intermittent joint distribution on the mechanical and acoustic behavior of rock masses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1231-1244页

作者： Shuaiyang Fu haibo Li Liwang Liu Di Wu Ben wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

The mechanical characteristics and acoustic behavior of rock masses are greatly influenced by stochastic joints.In this study,numerical models of rock masses incorporating intermittent joints with different numbers and dip angles were produced using the finite element method(FEM)with the intrinsic cohesive zone model(ICZM).Then,the uniaxial compressive and wave propagation simulations were performed.The results indicate that the joint number and dip angle can affect the mechanical and acoustic properties of the models.The uniaxial compressive strength(UCS)and wave velocity of rock masses decrease monotonically as the joint number increases.However,the wave velocity grows monotonically as the joint dip angle increases.When the joint dip angle is 45°–60°,the UCS of the rock mass is lower than that of other dip angles.The wave velocity parallel to the joints is greater than that perpendicular to the joints.When the dip angle of joints remains unchanged,the UCS and wave velocity are positively related.When the joint dip angle increases,the variation amplitude of the UCS regarding the wave velocity increases.To reveal the effect of the joint distribution on the velocity,a theoretical model was also proposed.According to the theoretical wave velocity,the change in wave velocity of models with various joint numbers and dip angles was consistent with the simulation results.Furthermore,a theoretical indicator(i.***.fabric tensor)was adopted to analyze the variation of the wave velocity and UCS.

关键词： Stochastic joints Intrinsic cohesive zone model Uniaxial compressive strength(UCS) Wave propagation Fabric tensor

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