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Early osteoimmunomodulation by mucin hydrogels augments the healing and revascularization of rat critical-size calvarial bone defects

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Bioactive Materials 2023年第7期25卷 176-188页

作者： Song Chen huan wang Dachuan Liu Jianzhong Bai håvard Jostein haugen Bin Li hongji Yan Orthopedic Institute Department of Orthopedic SurgeryThe First Affiliated HospitalSchool of Biology&Basic Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsuChina Department of Biomaterials Institute for Clinical DentistryUniversity of OsloPO Box 1109 BlindernOslo0376Norway AIMES-Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institute and KTh Royal Institute of Technology 17177StockholmSweden Department of Neuroscience Karolinska Institute17177StockholmSweden Division of Glycoscience Department of ChemistrySchool of Engineering Sciences in ChemistryBiotechnology and HealthKTH Royal Institute of TechnologyAlbaNova University Center10691StockholmSweden

The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone regeneration.Recently developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in vivo.however,their immunoregulatory activity has not yet been studied in the context of tissue repair.herein,we synthesized mucin-monetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect model.We demonstrated that the composites can polarize macrophages towards the M2 phenotype at weeks 1 and 2.The early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment(revascularization of the host vasculature)at weeks 6 and 12.Overall,we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.

关键词： Mucin hydrogels Monetite osteoimmunomodulation Bone Revascularization

Exploring the contribution of oxygen reduction reaction to Mg corrosion by modeling assisted local analysis

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Journal of Magnesium and Alloys 2023年第1期11卷 100-109页

作者： Cheng wang Wen Xu Daniel höche Mikhail L.Zheludkevich Sviatlana V.Lamaka Institute of Surface Science Helmholtz-Zentrum HereonGeesthacht 21502Germany Institute for Materials Science Faculty of EngineeringKiel UniversityKiel 24103Germany

Oxygen reduction reaction(ORR)has been disclosed in recent studies as a significant secondary cathodic process during magnesium corrosion.This work elaborates on the contribution of ORR to the total corrosion process of pure Mg at different impurity levels in NaCl electrolyte with the assistance of local techniques.A finite element based numerical model taking into account the contribution of ORR during the corrosion of the Mg test materials has been designed in this study considering the local oxygen concentration.Respective computational simulations were calibrated based on the experimental data and evaluated accordingly.Finally,the simultaneous monitoring of local concentration of h_(2) and O_(2),and the combined modeling study reveal the relation between ORR and hydrogen evolution reaction.

关键词： Local oxygen concentration Oxygen reduction reaction Mg corrosion NaCl electrolyte hydrogen evolution reaction Numerical model

Full-band error control and crack-free surface fabrication techniques for ultra-precision fly cutting of large-aperture KDP crystals

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Frontiers of Mechanical Engineering 2017年第2期12卷 193-202页

作者： F. h. ZhANG S. F. wang C. h. AN J. wang Q. XU Department of Mechanical Engineering Harbin Institute of TechnologyHarbin 150001 China Chengdu Fine Optical Engineering Research Center Chengdu 610041China

Large-aperture potassium dihydrogen phos- phate （KDP） crystals are widely used in the laser path of inertial confinement fusion （ICF） systems. The most common method of manufacturing half-meter KDP crystals is ultra-precision fly cutting. When processing KDP crystals by ultra-precision fly cutting, the dynamic characteristics of the fly cutting machine and fluctuations in the fly cutting environment are translated into surface errors at different spatial frequency bands. These machin- ing errors should be suppressed effectively to guarantee that KDP crystals meet the full-band machining accuracy specified in the evaluation index. In this study, the anisotropic machinability of KDP crystals and the causes of typical surface errors in ultra-precision fly cutting of the material are investigated. The structures of the fly cutting machine and existing processing parameters are optimized to improve the machined surface quality. The findings are theoretically and practically important in the development of high-energy laser systems in China.

关键词： ultra-precision fly cutting large-aperture KDP crystals spatial frequency processing error

The vanilloid receptor and hypertension

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Acta Pharmacologica Sinica 2005年第3期26卷 286-294页

作者： Donna h wang Department of Medicine College of human Medicine East Lansing MI 48825 Michigan State University USA

Mammalian transient receptor potential (TRP) channels consist of six related pro-tein sub-families that are involved in a variety of pathophysiological function,anddisease development.The TRPV 1 channel,a member of the TRPV sub-family,isidentified by expression cloning using the"hot"pepper-derived vanilloid com-pound capsaicin as a ligand.Therefore,TRPV1 is also referred as the vanilloidreceptor (VR1) or the capsaicin receptor.VR1 is mainly expressed in a subpopula-tion of primary afferent neurons that project to cardiovascular and renal tissues.These capsaicin-sensitive primary afferent neurons are not only involved in theperception of somatic and visceral pain,but also have a"sensory-effector"function.Regarding the latter,these neurons release stored neuropeptides through a cal-cium-dependent mechanism via the binding of capsaicin to VR1.The most studiedsensory neuropeptides are calcitonin gene-related peptide (CGRP) and substanceP (SP),which are potent vasodilators and natriuretic/diuretic factors.Recent evi-dence using the model of neonatal degeneration of capsaicin-sensitive sensorynerves revealed novel mechanisms that underlie increased salt sensitivity andseveralexperimental models of hypertension.These mechanisms include insuffi-cient suppression of plasma renin activity and plasma aldosterone levels subse-quent to salt loading,enhancement of sympathoexcitatory response in the face ofa salt challenge,activation of the endothelin-1 receptor,and impaired natriureticresponse to salt loading in capsaicin-pretreated rats.These data indicate thatsensory nerves counterbalance the prohypertensive effects of several neurohor-monal systems to maintain normal blood pressure when challenged with saltloading.The therapeutic utilities of vanilloid compounds,endogenous agonists,and sensory neuropeptides are also discussed.

关键词： TRP family afferent neurons capsaicin calcitonin gene-related peptide substance P vanilloid receptor renin-angiotensin-aldosterone system endothelin,sympathetic nervous system salt-sensitive hypertension

hDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma

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Protein & Cell 2020年第7期11卷 472-482页

作者： Xiaoguang wang Brittany C.Waschke Rachel A Woolaver Samantha M.Y.Chen Zhangguo Chen Jing h.wang Department of Immunology and Microbiology University of Colorado Anschutz Medical CampusSchool of Medicine12800 E.19th AveMail Stop 8333AuroraCO 80045USA

Immunotherapy has been applied successully to treat B-cell lymphomas in preclinical models or clinical settings.however,immunotherapy resistance is a major challenge for B-cell lymphoma treatment.To overcome this issue,combinatorlal therapeutic strategies have been pursued to achieve a better efficacy for treating B-cell lymphomas.One of such strategies is to combine immunotherapy with histone deacetylase(hDAC)inhi-bitors.hDAC inhibitors can potentially increase tumor immunogenicity,promote antitumor immune respon-ses,or reverse immunosuppressive tumor environments.Thus,the combination of hDAC inhibitors and immunotherapy has drawn much attention in current cancer treatment.however,not all hDAC inhibitors are created equal and their net effects are highly dependent on the specific inhibitors used and the hDACs they target.hence,we suggest that optimal treatment effh-cacy requires personalized design and rational combination based on prognostic biomarkers and unique profiles of hDAC inhibitors.here,we discuss the possible mechanisms by which B-cell lymphomas acquire immunotherapy resistance and the effects of hDAC inhibitors on tumor cells and immune cells that could help overcome immunotherapy resistance.

关键词： cancer immunotherapy hDAC inhibitor B-cell lymphomas anti-PD1 resistance tumor immunogenicity

higher-Order Line Element Analysis of Potential Field with Slender heterogeneities

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Computers, Materials & Continua 2016年第3期51卷 145-161页

作者： h.-S.wang h.Jiang B.Yang School of Optoelectronics Beijing Institute of Technology Beijing 100081China Department of Mechanical and Aerospace Engineering University of Texas at Arlington ArlingtonTX 76019USA State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanHuBei 430074China

Potential field due to line sources residing on slender heterogeneities is involved in various areas,such as heat conduction,potential flow,and electrostatics.Often dipolar line sources are either prescribed or induced due to close interaction with other objects.Its calculation requires a higher-order scheme to take into account the dipolar effect as well as net source effect.In the present work,we apply such a higher-order line element method to analyze the potential field with cylindrical slender heterogeneities.In a benchmark example of two parallel rods,we compare the line element solution with the boundary element solution to show the accuracy as a function in terms of rods distance.Furthermore,we use more complicated examples to demonstrate the capability of the line element technique.

关键词： Electrostatics heat conduction Integral equation technique Line element method Mesh reduction method,Potential field problems

Effect of grain size on the intrinsic mechanical stability of austenite in transformation-induced plasticity steels:The competition between martensite transformation and dislocation slip

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Journal of Materials Science & Technology 2023年第31期162卷 38-43页

作者： D.P.Yang T.wang Z.T.Miao P.J.Du G.D.wang h.L.Yi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

The deformation accompanied by austenite to martensite trans-formation was first studied in Fe-Ni alloys,high-Mn steels,and austenitic stainless steels with a full austenite microstructure.The plasticity of these steels can be improved by the trans-formation during deformation and hence they were named as transformation-induced plasticity(TRIP)steels[1].Over the past few decades,a series of TRIP steels with multiphase microstructure for automotive applications were developed.These steels contain-ing a certain amount of austenite were called TRIP-assisted steels,such as low-alloy TRIP steels[2],carbide-free bainitic steels[3],δ-TRIP steels[4],quenching and partitioning steels[5],and medium-Mn steels[6].The mechanical property of TRIP steels is largely determined by the mechanical stability of austenite[7]which de-pends on the chemical composition[8],grain size[9],orientation[10],and morphology[11]of austenite grains,as well as the nature of neighboring phases[12].In most cases of TRIP-assisted steels,larger austenite grains transform to martensite earlier or faster than smaller austenite grains with the increase of macrostrain[13-18],indicating lower mechanical stability.however,larger austen-ite grains usually contain less C and Mn[13,17-19]and suffer more strain than smaller grains during deformation[20],it doesn’t mean that grain refinement increases the mechanical stability of austen-ite.

关键词： austenite martensite transformation

Simultaneous enhancement of mechanical and shape memory properties by heat-treatment homogenization of Ti_(2)Ni precipitates in TiNi shape memory alloy fabricated by selective laser melting

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Journal of Materials Science & Technology 2022年第6期101卷 205-216页

作者： h.Z.Lu L.h.Liu C.Yang X.Luo C.h.Song Z.wang J.wang Y.D.Su Y.F.Ding L.C.Zhang Y.Y.Li National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Musculoskeletal Oncology Department Sun Yat-Sen University Cancer CenterGuangzhouGuangdong ProvinceChina Shenyang Aircraft Design and Research Institute Shenyang 110035China Guangdong huayi Plumbing Fittings Industry Co. Ltd.Kaiping 529321China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA 6027Australia

The excellent shape memory and mechanical properties of Ti Ni shape memory alloys(SMAs) fabricated using selective laser melting(SLM) are highly desirable for a wide range of critical applications. In this study, we examined the simultaneous enhancement of mechanical and shape memory properties using heat-treatment homogenization of Ti_(2)Ni precipitates in a Ti_(50.6)Ni_(49.4)SMA fabricated using SLM. Specifically, because of the complete solution treatment, nanoscale spherical Ti_(2)Ni precipitates were homogeneously dispersed throughout the grain interior. Interestingly, the resultant SMA exhibited an ultrahigh tensile strength of 880 ± 13 MPa, a large elongation of 22.4 ± 0.4%, and an excellent shape memory effect, with a recovery rate of > 98% and ultrahigh recoverable strain of 5.32% after ten loading–unloading cycles. These simultaneously enhanced properties are considerably superior than those of most previously reported Ti Ni SMAs fabricated using additive manufacturing. Fundamentally, the enhancement in tensile strength is ascribed to precipitation strengthening and work hardening, and the large plasticity is mainly attributed to the homogeneous nanoscale globular Ti_(2)Ni precipitates, which effectively impeded the rapid propagation of microcracks. Furthermore, the enhanced shape memory properties are derived from the suppression of dislocation movement and formation of retained stabilized martensite by the presence of high-density dislocations, nanoscale Ti_(2)Ni precipitates, and abundant interfaces. The obtained results provide insight into the enhancement of the two types of properties in Ti Ni SMAs and will accelerate the wider application of SMAs.

关键词： Shape memory alloy Selective laser melting heat treatment Mechanical properties Shape memory properties

Nutritional and medical food therapies for diabetic retinopathy

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Eye and Vision 2020年第6期7卷 312-327页

作者： Ce Shi Peng wang Shriya Airen Craig Brown Zhiping Liu Justin h.Townsend Jianhua wang hong Jiang Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina Department of Ophthalmology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghaiChina College of Arts and Sciences University of MiamiMiamiFLUSA Department of Ophthalmology College of Medicinethe University of Arkansas for Medical SciencesFayettevilleARUSA Ophthalmic Center the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Neurology University of Miami Miller School of MedicineMiamiFLUSA

Diabetic retinopathy(DR)is a form of microangiopathy.Reducing oxidative stress in the mitochondria and cell membranes decreases ischemic injury and end-organ damage to the retina.New approaches are needed,which reduce the risk and improve the outcomes of DR while complementing current therapeutic approaches.homocysteine(hcy)elevation and oxidative stress are potential therapeutic targets in DR.Common genetic polymorphisms such as those of methylenetetrahydrofolate reductase(MThFR),increase hcy and DR risk and severity.Patients with DR have high incidences of deficiencies of crucial vitamins,minerals,and related compounds,which also lead to elevation of hcy and oxidative stress.Addressing the effects of the MThFR polymorphism and addressing comorbid deficiencies and insufficiencies reduce the impact and severity of the disease.This approach provides safe and simple strategies that support conventional care and improve outcomes.Suboptimal vitamin co-factor availability also impairs the release of neurotrophic and neuroprotective growth factors.Collectively,this accounts for variability in presentation and response of DR to conventional therapy.Fortunately,there are straightforward recommendations for addressing these issues and supporting traditional treatment plans.We have reviewed the literature for nutritional interventions that support conventional therapies to reduce disease risk and severity.Optimal combinations of vitamins B1,B2,B6,L-methylfolate,methylcobalamin(B12),C,D,natural vitamin E complex,lutein,zeaxanthin,alpha-lipoic acid,and n-acetylcysteine are identified for protecting the retina and choroid.Certain medical foods have been successfully used as therapy for retinopathy.Recommendations based on this review and our clinical experience are developed for clinicians to use to support conventional therapy for DR.DR from both type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM)have similar retinal findings and responses to nutritional therapies.

关键词： Diabetic retinopathy homocysteine Lutein N-acetyl cysteine Vitamins L-methylfolate

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