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温和条件下甲烷水合物强化生成技术

科学通报 2023年第4期68卷 424-432页

作者：刘哲石晓云何燕张国栋王飞青岛科技大学机电工程学院青岛266061

基于水合物的固体天然气技术在天然气储运、二氧化碳埋存、海水淡化等技术领域具有广阔的应用前景,而强化温和条件下的水合物生成动力学是推动该技术应用的关键.本文通过乳液聚合法制备了–N(CH3)3+@PSNS纳米促进剂,评价了其与螺旋搅拌... 详细信息

基于水合物的固体天然气技术在天然气储运、二氧化碳埋存、海水淡化等技术领域具有广阔的应用前景,而强化温和条件下的水合物生成动力学是推动该技术应用的关键.本文通过乳液聚合法制备了–N(CH3)3+@PSNS纳米促进剂,评价了其与螺旋搅拌协同作用对甲烷水合物生成动力学的影响,并揭示了协同促进机理.研究表明,螺旋搅拌诱导的双向对流强化了反应釜内气液传质,增强了水合物早期生长动力学,而纳米促进剂增加了水合物的多孔特性,强化了后期水合物生长动力学,提高了低倾角下水合物转化率,两者协同作用大幅改善了温和条件下的水合效率.在温和条件下(3.8 MPa),水合物储气量在25°和35°倾角下分别为107.96和140.43 m3/m3,与纯水体系相比分别增加59.16%和91.74%.该研究使得温和条件下水合物高效制备成为可能,对推动水合物基固体天然气技术的应用具有重要的指导意义.

关键词：水合物固体天然气生成动力学螺旋搅拌纳米促进剂

Study of the decorporation efficacy and toxicity of tetradentate 3-hydroxy- 2-pyridinone ligands at the cellular level

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Radiation Medicine and Protection 2020年第4期1卷 159-165页

作者： Xiaomei wang Cen shi Manni Gao Ying Xu Yang Jiao Jianmei Wan jianping Cao Zhifang Chai Juan Diwu State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China Beijing Nuclear Industry Hospital-Fangshan Campus Beijing102413China

Objective:A series of experiments were carried out to study the comparative decorporation efficacy and toxicity of three tetradentate hydroxypyridinone ligands(3LI-1-Cm-3,2-HOPO,5LIO-1-Cm-3,2-HOPO,and 7LIO-1-Cm-3,2-HOPO)with the variation of the linker length and the ***:Three ligands were obtained from a 4-step synthesis via the amidation of HOPO unit and different *** titrations were carried out to evaluate the formation constants of their corresponding uranyl ***-8 and colony formation assays were used to compare the cytotoxicity of the three ligands and uranyl using renal proximal tubular epithelial(NRK-52E)*** vitro uranium removal assays were performed to assess decorporation efficiencies of those ligands by co-incubating uranium and chelators with NRK-52E cells for 48 ***:Among the three ligands,5LIO-1-Cm-3,2-HOPO exhibits the highest uranyl affinity(logβ110?18.6(7))in comparison to the other two ligands(logβ110?14.9(2)for 3LI-1-Cm-3,2-HOPO and logβ110?16.7(1)for 7LIO-1-Cm-3,2-HOPO).The results of CCK-8 tests and colony formation assays further elucidate that 5LIO-1-Cm-3,2-HOPO and 7LIO-1-Cm-3,2-HOPO both show a similar level of cytotoxicity compared with ZnNa3-DTPA at relatively low ligand *** contrast,in the 3LI-1-Cm-3,2-HOPO treated group,the cell viability decreased markedly with the increase of the ligand concentrations,and the colony formation capability of NRK-52E cells was ***,the comparative decorporation efficacy of the three ligands was obtained from in vitro uranium removal assays,suggesting that these ligands could significantly inhibit the cellular uptake and prompt the cellular release of uranium from NRK-52E cells by the level of 81.9%,91.8%,and 87.1%,***:Our current results demonstrate that the linker/backbone species would significantly affect the decorporation efficacy and toxicity of the tetradentate 3-hydroxy-2-pyridinone ligands

关键词： Uranium Hydroxypyridinone Decorporation efficacy Cytotoxicity Metal complexation

Current management of chemotherapy-induced neutropenia in adults:key points and new challenges

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Cancer Biology & Medicine 2020年第4期17卷 896-909页

作者： Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia shi Jialei wang Xiaohua wang Zhiqiang wang Puyuan Xing Sheng Yang Chenfei Zhou 不详 Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Medical Oncology National Cancer CenterCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Oncology Jilin Province Cancer HospitalChangchun 130012China Department of Oncology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361004China Department of Oncology Cancer Hospital Harbin Medical UniversityHarbin 150081China Department of Oncology Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology General Hospital of Shenyang Military RegionShenyang 110016China Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalBeijing 100730China Department of Hematology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450008China Lymphoma and Myeloma Department Jiangxi Cancer HospitalNanchang 330029China Department of Medical Oncology Shandong Cancer HospitalShandong Academy of Medical SciencesJinan 250117China Department of Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China MSun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430070China Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Gastrointestinal Oncology Peki ng University Cancer Hospital&InstituteBeijing 100142China Department of

Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive *** timing and grade of CIN may play prognostic and predictive roles in cancer *** is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined *** are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain ***,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological *** consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with ***,current tools have *** CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of *** view of the current reports,our group discusses the key points,new challenges,and management of CIN.

关键词： Chemotherapy-induced neutropenia(CIN) febrile neutropenia cancer risk stratification granulocyte-colony stimulating factor(G-CSF)

A Knowledge Based Approach to Integrated Battle Damage Assessment and Repair Analysis

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International Journal of Plant Engineering and Management 2000年第2期5卷 66-76页

作者： shi Quan Li jianping wang Runsheng(Department of Management Engineering, shijiazhuang Mechanical Engineering College No.97, West Heping Rkad, shijiazhuang ,Hebei, P.R.China, 050003E-mail:shiquan @***)

BDAR analysis is a kind of very complex analysis technology which can be used to determine the battle damage mode of equipment and relevant decision strategy. BDAR analysis is based on the information about FMEA/DMEA, MA(maintenance analysis), FTA(fault tree analysis) and vulnerability analysis. These information and analysis results are obtained on the basis of the domain expert's experience and knowledge. Upon the basis of the summary of BDARA methods, this paper provides applied knowledge database, puts forward BDARA's integrated thinking, implementing methods, and the key technology for IBDARA knowledge database's development.

关键词： BDAR IBDARA knowledge database knowledge database approach.

An overview for monitoring and prediction of pathogenic microorganisms in the atmosphere

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Fundamental Research 2024年第3期4卷 430-441页

作者： jianping Huang Danfeng wang Yongguan Zhu Zifeng Yang Maosheng Yao Xiaoming shi Taicheng An Qiang Zhang Cunrui Huang Xinhui Bi Jiang Li Zifa wang Yongqin Liu Guibing Zhu Siyu Chen Jian Hang Xinghua Qiu Weiwei Deng Huaiyu Tian Tengfei Zhang Tianmu Chen Sijin Liu Xinbo Lian Bin Chen Beidou Zhang Yingjie Zhao Rui wang Han Li Collaborative Innovation Center for Western Ecological Safety College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease(Guangzhou Medical University)Guangzhou 510230China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Vanke School of Public Health Tsinghua UniversityBeijing 100084China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 510640

Corona virus disease 2019(COVID-19)has exerted a profound adverse impact on human *** have demonstrated that aerosol transmission is one of the major transmission routes of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Pathogenic microorganisms such as SARS-CoV-2 can survive in the air and cause widespread infection among *** monitoring of pathogenic microorganism transmission in the atmosphere and accurate epidemic prediction are the frontier guarantee for preventing large-scale epidemic *** of pathogenic microorganisms in the air,especially in densely populated areas,may raise the possibility to detect viruses before people are widely infected and contain the epidemic at an earlier *** multi-scale coupled accurate epidemic prediction system can provide support for governments to analyze the epidemic situation,allocate health resources,and formulate epidemic response *** review first elaborates on the effects of the atmospheric environment on pathogenic microorganism transmission,which lays a theoretical foundation for the monitoring and prediction of epidemic ***,the monitoring technique development and the necessity of monitoring pathogenic microorganisms in the atmosphere are summarized and ***,this review introduces the major epidemic prediction methods and highlights the significance to realize a multi-scale coupled epidemic prediction system by strengthening the multidisciplinary cooperation of epidemiology,atmospheric sciences,environmental sciences,sociology,demography,*** summarizing the achievements and challenges in monitoring and prediction of pathogenic microorganism transmission in the atmosphere,this review proposes suggestions for epidemic response,namely,the establishment of an integrated monitoring and prediction platform for pathogenic microorganism transmission in the atmosphere.

关键词： Aerosol transmission Epidemic monitoring methods Epidemic prediction modelsEpidemic response Multidisciplinary cooperation

Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material

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Medicinal Plant Biology 2022年第1期1卷 24-30页

作者： Liang Cao Mei wang jianping Zhao Li-Hua Peng Jin-Le Cheng shi Qiu Ikhlas A.Khan Xing-Cong Li National Center for Natural Products Research School of PharmacyThe University of MississippiUniversityMississippi 38677USA Natural Products Utilization Research Unit Agricultural Research ServiceUnited States Department of AgricultureUniversityMississippi 38677USA Key Laboratory of Technologies and Applications of Ultrafine Granular Powder of Herbal Medicine State Administration of Traditional Chinese MedicineZhongshan Zhongzhi Pharmaceutical Group Co.Ltd.Zhongshan 528437P.R.China Hunan Provincial Key Laboratory of Dong Medicine Hunan University of MedicineHuaihua 41800P.R.China

Radix Astragali,one of the most popular herbs in traditional Chinese medicine(TCM),is used to strengthen the immune system,protect liver function,fight bacteria and viruses,and treat diabetes,heart failure and seasonal *** recent years,a new form of Radix Astragali material processed by cell wall disrupting technology,namely ultrafine granular powder(UGP)has been introduced into the *** order to determine chemical consistency and homogeneity of the UGP material prepared from sliced traditional materials(TM)of Radix Astragali,multiple batches of the UGP and TM samples derived from Astragalus membranaceus *** were analyzed by UHPLC/DAD-MS using isoflavones and triterpenoid glycosides as marker *** results demonstrated that the chemical profiles of UGP was identical or similar to that of TM,but UGP was highly homogeneous in terms of marker compound contents as assessed,e.g.,by the relative standard deviation values of the nine marker compounds in the range of 8.55%−43.80%for TM2 compared against 1.70%−8.38%for *** component preparation and 1H NMR analyses indicated that TM4 and its corresponding UGP4 produced similar polysaccharides,but the later had approximately two-fold dissolution rate of the polysaccharides when compared to the former(yield 7.22±0.35%vs 3.39±0.20%).This study confirms that UGP of Radix Astragali is chemically consistent and homogenous,supporting its use as a promising material in TCM prescriptions.

关键词： chemical deviation identical

Disaster Loss Evaluation and Characteristics of the Seismic Hazard of the Nilka-Gongliu Earthquake with M_S6. 0

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Earthquake Research in China 2014年第2期28卷 261-273页

作者： Tan Ming Tang Lihua Wu guodong Chang Xiangde Zhang Yong Song Lijun Li Yang Li Yigang wang Wei shi Guangling Li Zhihai Earthquake Administration of Xinjiang Uygur Autonomous Region China Earthquake Administration

The epicenter intensity of Nilka-Gongliu earthquake with MS6. 0 was Ⅶ degrees; no fatalities but many residential buildings and public facilities were moderately damaged during the earthquake. Traffic and water conservation facilities were damaged to a certain extent but after emergency repair,production and life in the disaster area were not influenced. According to a sample survey of the earthquake filed,this earthquake caused direct economic loss of approximately 678. 46 million yuan( RMB),and the reconstruction funds required will be about 1. 20349 billion yuan( RMB).

关键词： The Nilka-Gongliu earthquake Disaster loss evaluation Characteristic of seismic hazard

基于VirtuoZo的岩体结构面几何信息获取研究

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岩石力学与工程学报 2008年第1期27卷 169-175页

作者：王凤艳陈剑平付学慧石丙飞吉林大学地球探测科学与技术学院吉林长春130026 吉林大学建设工程学院吉林长春130026 吉林省测绘局地理信息工程院吉林长春130051 广东省物料实验检测中心广东广州510080

针对目前岩体结构面信息获取主要以人工现场接触测量为主,劳动强度大、效率低下的现状,进行基于数字摄影测量工作站——VirtuoZo获取岩体结构面几何信息的研究,以期为岩体结构面几何信息的快速获取开辟新的途径。以边坡为研究对象,以全... 详细信息

针对目前岩体结构面信息获取主要以人工现场接触测量为主,劳动强度大、效率低下的现状,进行基于数字摄影测量工作站——VirtuoZo获取岩体结构面几何信息的研究,以期为岩体结构面几何信息的快速获取开辟新的途径。以边坡为研究对象,以全站仪空间前方交会法进行控制测量,以普通数码相机为摄影工具,应用VirtuoZo进行像物关系模型的建立,获取立体影像并测取边坡岩体结构面特征点的空间坐标;再结合所研究的结构面迹线展示模型和基于空间坐标的产状计算模型,获取结构面的迹长和产状信息。与采用人工罗盘测得的产状信息进行比较,得到基于VirtuoZo的岩体结构面产状信息获取的精度。通过广州保利林语山庄边坡加固工程中岩体结构面几何信息获取和应用实践表明,该方法可行且有广阔的应用前景。

关键词：岩石力学数字摄影测量工作站结构面产状精度

Radiation-hardened property of single-walled carbon nanotube film-based field-effect transistors under low-energy proton irradiation

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Journal of Semiconductors 2021年第11期42卷 18-25页

作者： Xiaorui Zhang Huiping Zhu Song’ang Peng guodong Xiong Chaoyi Zhu Xinnan Huang Shurui Cao Junjun Zhang Yunpeng Yan Yao Yao Dayong Zhang Jingyuan shi Lei wang Bo Li Zhi Jin High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Science and Technology on Silicon Devices Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry City University of Hong KongHong Kong 999077China

Strong C-C bonds,nanoscale cross-section and low atomic number make single-walled carbon nanotubes(SWCNTs)a potential candidate material for integrated circuits(ICs)applied in outer ***,very little work combines the simulation calculations with the electrical measurements of SWCNT field-effect transistors(FETs),which limits further understanding on the mechanisms of radiation ***,SWCNT film-based FETs were fabricated to explore the total ionizing dose(TID)and displacement damage effect on the electrical performance under low-energy proton irradiation with different fluences up to 1×1015 p/*** negative shift of the threshold voltage and obvious decrease of the on-state current verified the TID effect caused in the oxide *** stability of the subthreshold swing and the off-state current reveals that the displacement damage caused in the CNT layer is not serious,which proves that the CNT film is ***,according to the simulation,we found the displacement damage caused by protons is different in the source/drain contact area and channel area,leading to varying degrees of change for the contact resistance and sheet *** analyzed the simulation results and electrical measurements,we explained the low-energy proton irradiation mechanism of the CNT FETs,which is essential for the construction of radiation-hardened CNT film-based ICs for aircrafts.

关键词： SWCNT FETs low-energy proton irradiation radiation effects electrical performance TID effect displacement damage effect simulation