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Impairment of recovery of muscle function by residual rocuronium after re-transfusion of intraoperative salvaged blood

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Chinese Medical Journal 2014年第5期127卷 821-824页

作者： wang geng wang jia zhou haibin zhao xia wu xinmin Department of Anesthesiology Beijing Jishuitan Hospital Beijing 100035 China

Background Recurarization has previously been described in the context of acute normovolemic *** aim of this study was to investigate the impairment of recovery of neuromuscular function after re-transfusion of intraoperative salvaged blood in patients treated with *** We enrolled 50 patients undergoing general anesthesia for lumbar *** blood salvage （IBS） was used in 30 patients （group Ⅰ）; the remaining 20 comprised a control group （group C）.Anesthesia was induced with fentanyl,midazolam,propofol and *** was infused to maintain neuromuscular blockade during *** was collected from the operative field and re-transfused in the post-anesthesia care unit （PACU）.Neuromuscular function was monitored using the train-of-four ratio （TOFr）.Once the train-of-four ratio exceeded 90 in the PACU,neuromuscular function was evaluated every 5 minutes for 30 *** TOFr and incremental recovery of TOFr from baseline were *** blood was re-transfused at the beginning of the evaluation for patients in group Ⅰ,and afterwards for patients in group *** gas analysis was assessed before anesthesia and in the *** Incremental recovery of TOFr from baseline was significantly less in group Ⅰ than controls at 25 minutes （6.1±3.2vs.9.1±3.2,respectively; P=0.001） and 30 minutes （7.1±3.2 vs.10.0±2.2,respectively; P=-0.001）.There were no significant differences in gas exchange between the *** In patients who had received a rocuronium infusion during anesthesia,re-transfusion of salvaged blood significantly impaired recovery of neuromuscular function recovery in the PACU,but without significant impairment of respiratory function.

关键词： intraoperative blood salvage neuromuscular blocking agents rocuronium recurarization

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