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Changes in serum cellular adhesion molecule and matrix metalloproteinase-9 levels in patients with cerebral infarction following hyperbaric oxygen therapy A case and intergroup control study

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Neural Regeneration Research 2008年第11期3卷 1245-1248页

作者： Renliang Zhao chunxia wang Yongjun wang Department of Neurology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China Department of Neurology Beijing Tiantan Hospital Capital University of Medical Sciences Beijing 100050 China Qingdao Mental Health Center Qingdao 266034 Shandong Province China

BACKGROUND： Animal studies have confirmed that hyperbaric oxygen （HBO） therapy can reduce matrix metalloproteinase activity and blood brain barrier permeability, thereby exhibiting neuroprotective effects. However, at present, consensus does not exist in terms of its clinical efficacy. OBJECTIVE： To validate the significance of changes in serum cellular adhesion molecule and MMP-9 levels in patients with cerebral infarction following HBO therapy. DESIGN, TIME AND SETTING： This randomized, controlled, neurobiochemical study was performed at the Department of Neurology, Affiliated Hospital of Qingdao University Medical College between December 2002 and March 2006. PARTICIPANTS： A total of 112 patients with acute cerebral infarction of internal carotid artery, comprising 64 males and 48 females, averaging （67 ±11） years, were recruited and randomized to a HBO group （n = 50） and a routine treatment group （n = 62）. An additional 30 gender- and age-matched normal subjects, consisting of 17 males and 13 females, averaging （63 ± 9） years, were enrolled as control subjects. METHODS： The routine treatment group received routine drug treatment and rehabilitation exercise. HBO treatment was additionally performed in the HBO group, once a day, for a total of 10 days. MAIN OUTCOME MEASURES： Serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were detected by enzyme linked immunosorbent assay. RESULTS： Upon admission, serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were significantly increased in patients with cerebral infarction, compared with control subjects （P 〈 0.01）. Following HBO and routine treatments, serum levels of the above-mentioned indices were significantly reduced in the HBO and routine treatment groups （P 〈 0.01）. Moreover, greater efficacy was observed in the HBO group

关键词： cerebral infarction E-selectin hyperbaric oxygen intercellular adhesion molecule matrix metalloproteinase-9 vascular cell adhesion molecule

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Rapid growth of environmental research in China

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Journal of Environmental Sciences 2016年第1期28卷 1-3页

作者： Guibin Jiang chunxia wang X.Chris Le State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Division of Environmental Chemistry Department of Chemical Sciences National Natural Science Foundation of China Beijing 100085 China Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology Faculty of Medicine and Dentistry University of Alberta Edmonton AB T6G 2G3 Canada

Environmental research in China has grown tremendously over the last thirty *** rapid and sustained growth has been supported by the remarkable increases in research funding,the number of graduate students,the degree-offering programs in environmental sciences and engineering,the state-of-the-art facilities,and international collaboration.

关键词： Rapid growth of environmental research in China

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Effects of Al and Co doping on the structural stability and high temperature cycling performance of LiNi_(0.5)Mn_(1.5)O_(4) spinel cathode materials

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Chinese Journal of Chemical Engineering 2023年第9期61卷 201-209页

作者： Jianfeng Cheng Meixuan Li Yutong wang Jiexiang Li Jiawei Wen chunxia wang Guoyong Huang College of New Energy and Materials China University of Petroleum(Beijing)Beijing 102249China State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of Petroleum(Beijing)Beijing 102249China

The poor structural stability and capacity retention of the high-voltage spinel-type LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)limits their further ***,Al and Co were doped in LNMO materials for a more stable structure and *** LNMO,LiNi_(0.45)Al_(0.05)Mn_(1.5)O_(4)(LNAMO)and LiNi_(0.45)Co_(0.05)Mn_(1.5)O_(4)(LNCMO)were synthesized by calcination at 900℃ for 8 h,which was called as solid-phase method and applied universally in ***,FT-IR and CV test results showed the synthesized samples have cation disordering Fd-3m space group ***,the incorporation of Al and Co increased the cation disordering of LNMO,thereby increasing the transfer rate of Li+.The SEM results showed that the doped samples performed more regular and *** EDS elemental analysis confirmed the uniform distribution of each metal element in the ***,the doped samples showed better electrochemical properties than undoped *** LNAMO and LNCMO samples were discharged with specific capacities of 116.3 mA·h·g^(-1)and 122.8 mA·h·g^(-1)at 1 C charge/discharge rate with good capacity retention of 95.8% and 94.8% after 200 cycles at room temperature,*** capacity fading phenomenon of the doped samples at 50℃ and 1 C rate was significantly ***,cations doping also enhanced the rate performance,especially for the LNCMO,the discharge specific capacity of 117.9 mA·h·g^(-1)can be obtained at a rate of 5 C.

关键词： High voltage spinel Al/Co doping High temperature cycling stability

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Studies and Properties of Ceramics with High Thermal Conductivity

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Journal of Rare Earths 2006年第Z1期24卷 189-192页

作者： Chen Guangle Fan Shigang Zhao chunxia wang Kun Xia Shuqin Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China

The sintering technology of the AlN ceramics power were discussed. It is discussed that the compound sintering aids is consistent with the enhancement of the the thermal conductivity of AlN ceramics, and sintering technics is helped to the improvement of density. It is analyzed how to sinter machinable AlN ceramics with high thermal conductivity. And the microstructure of compound ceramics based on AlN was studied.

关键词： sintering aids hot-pressed high thermal conductivity machinable composite ceramics

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Effects of autumn plowing on the movement and correlation of moisture,heat and nitrate nitrogen in seasonal freeze-thaw soil

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International Journal of Agricultural and Biological Engineering 2022年第6期15卷 143-152页

作者： Kai Sun chunxia wang Hongguang Liu Fei Liang Yaqin wang College of Water Conservancy&Architectural Engineering ShiheziUniversityShihezi 832000XinjiangChina Key Laboratory of Modern Water-saving Irrigation of Xinjiang Production&Construction Group Shihezi UniversityShihezi 832000XinjiangChina Xinjiang Academy of Agricultural Reclamation Shihezi 832000XinjiangChina

A two-year experiment was established in northern Xinjiang to investigate the effects of autumn plowing methods on nitrate nitrogen accumulation,spring-sown soil conditions and cotton emergence rate,and to explore the response relationship between soil water,heat and nitrate *** experiment included five autumn plowing treatments,namely,plough tillage(FG),no-tillage(MG),ridge and furrow alternation(LG),plough tillage with straw mulch(FJ)and plough tillage with activated charcoal mulch(FH).The results showed that both FH and FJ treatments were beneficial to promote the nitrate-nitrogen accumulation in topsoil,while FG,MG and LG treatments aggravated the nitrate nitrogen leaching in *** the freezing period,FH and FJ treatments were beneficial to reduce soil heat loss and facilitate the coordinated upward migration of soil water and nitrate *** the thawing period,FH and FJ treatments favored suppressing the synergistic downward transport of soil water and nitrate-nitrogen and motivated the synergistic upward migration of heat and nitrate nitrogen in deep *** regression analysis suggested that the interaction between water,heat and nitrate nitrogen under FH and FJ treatments showed a highly significant *** and FJ treatments showed obvious advantages in regulating soil conditions and optimizing soil water,heat and nitrate nitrogen co-transport *** the spring sowing period,the FH and FJ treatments increased the average soil temperature by 0.99℃and 1.29℃,and the average soil moisture content by 6.01%and 8.70%,and the average soil nitrate content by 10.20 mg/kg and 10.47 mg/kg,in the 0-25 cm soil layer,*** and FJ treatments significantly grew the emergence rate of cotton,which can be used as the main autumn tillage strategies in arid areas of northern Xinjiang.

关键词： autumn plowing seasonal freeze-thaw nitrate nitrogen accumulation water-heat-nitrogen interaction Xinjiang

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Brain structural changes and their correlation with vascular disease in type 2 diabetes mellitus patients: a voxel-based morphometric study

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Neural Regeneration Research 2014年第16期9卷 1548-1556页

作者： chunxia wang Kailiang Fu Huaijun Liu Fei Xing Songyun Zhang Department of Medical Imaging the Second Hospital of Hebei Medical University Department of Endocrinology the Second Hospital of Hebei Medical University

Voxel-based morphometry has been used in the study of alterations in brain structure in type 1 diabetes mellitus patients. These changes are associated with clinical indices. The age at onset, pathogenesis, and treatment of type 1 diabetes mellitus are different from those for type 2 diabetes mellitus. Thus, type 1 and type 2 diabetes mellitus may have different impacts on brain structure. Only a few studies of the alterations in brain structure in type 2 diabetes mellitus patients using voxel-based morphometry have been conducted, with inconsistent results. We detected subtle changes in the brain structure of 23 cases of type 2 diabetes mellitus, and demonstrated that there was no significant difference between the total volume of gray and white matter of the brain of type 2 diabetes mellitus patients and that in controls. Regional atrophy of gray matter mainly occurred in the right temporal and left occipital cortex, while regional atrophy of white matter involved the right temporal lobe and the right cerebellar hemisphere. The ankle-brachial index in patients with type 2 diabetes mellitus strongly correlated with the volume of brain regions in the default mode network. The ankle-brachial index, followed by the level of glycosylated hemoglobin, most strongly correlated with the volume of gray matter in the right temporal lobe. These data suggest that voxel-based morphometry could detect small structural changes in patients with type 2 diabetes mellitus. Early macrovascular atherosclerosis may play a crucial role in subtle brain atro- phy in type 2 diabetes mellitus patients, with chronic hyperglycemia playing a lesser role.

关键词： nerve regeneration diabetes mellitus ankle-brachial index albuminuria neuralregeneration

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Reduced graphene oxide supported Pd-Cu-Co trimetallic catalyst:synthesis,characterization and methanol electrooxidation properties

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Journal of Energy Chemistry 2019年第2期28卷 72-78页

作者： Fan Yang Bing Zhang Sen Dong chunxia wang Andong Feng Xiaoxu Fan Yongfeng Li State Key Laboratory of Heavy oil Processing China University of Petroleum

Trimetallic palladium-copper-cobalt nanoparticles supported on reduced graphene oxide(PdCuCo/RGO)with different molar ratios of Pd,Cu and Co can be synthesized by facile chemical reduction with NaBH_4 as reductant and cetrimonium bromide as *** morphology,structure and composition of the as-synthesized catalysts are characterized by transmission electron microscopy,X-ray diffraction and Xray photoelectron *** cyclic voltammetry and chronoamperometry are utilized to investigate the electrochemical activities and stabilities of the as-obtained *** results demonstrate that the PdCuCo/RGO catalyst shows superior catalytic activity and stability for methanol electrooxidation in alkaline media compared with PdCu/RGO,PdCo/RGO,and Pd/RGO *** findings suggest that the PdCuCo/RGO catalyst possesses a great potential as a promising anode catalyst for direct methanol fuel cells.

关键词： Trimetallic nanoparticles Reduced graphene oxide Methanol oxidation

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Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp^3)—H activation and cyclization of aliphatic amides with gem-dibromoolefins:A rapid access to γ-lactams

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Chinese Chemical Letters 2018年第1期29卷 191-193页

作者： Danni Zhou chunxia wang Mingliang Li Zheng Long Jingbo Lan Key Laboratory of Green Chemistry and Technology of Ministry of Education College of ChemistrySichuan University

The direct Pd-catalyzed β-C（sp3）--H activation and cyclization of aliphatic amides bearing a removable 2-pyridylmethyl directing group with gem-dibromoolefins is described for the first time to construct a variety of γ-lactams, The resulting products with Z- and E-configurations can be easily separated and purified after the reaction, demonstrating the effectiveness and applicability of the method herein developed.

关键词： C(spS)-H activationPalladium-catalyzedgem-DibromoolefinsRemovable directing groupγ-Lactams

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一类具有疫苗接种和垂直传播的SEIV传染病模型的动力学分析

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北华大学学报（自然科学版） 2025年第1期26卷 10-16页

作者：王春霞王晓东热木孜亚·热布哈提王凯新疆医科大学医学工程技术学院新疆乌鲁木齐830017

利用动力学方法建立了一类具有疫苗接种,并同时考虑垂直传播的SEIV传染病模型,利用下一代矩阵算法给出了决定疾病是否流行的阈值R_(0)。当R_(0)1时,模型存在唯一的地方病平衡点,并证明了它是一致持久的。最后,通过数值模拟,验证了以上... 详细信息

利用动力学方法建立了一类具有疫苗接种,并同时考虑垂直传播的SEIV传染病模型,利用下一代矩阵算法给出了决定疾病是否流行的阈值R_(0)。当R_(0)1时,模型存在唯一的地方病平衡点,并证明了它是一致持久的。最后,通过数值模拟,验证了以上结论。此外,为了更好地控制和预防疾病,模拟研究了几个关键参数对疾病传播的影响。

关键词：疫苗接种垂直传播基本再生数平衡点稳定性

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The RING-H2 gene LdXERICO plays a negative role in dormancy release regulated by low temperature in Lilium davidii var. unicolor

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Horticulture Research 2023年第4期10卷 135-146页

作者： Xinyue Fan Xiaoman Zou Linlan Fu Yue Yang Min Li chunxia wang Hongmei Sun Key Laboratory of Protected Horticulture of Education Ministry College of HorticultureShenyang Agricultural UniversityShenyang 110866China National and Local Joint Engineering Research Center of Northern Horticultural Facilities Design and Application Technology Shenyang 110866China

Dormancy regulation is the basis of the sustainable development of the lily ***,basic research on lily dormancy is crucial for innovation in lily cultivation and *** studies revealed that dormancy release largely depends on abscisic acid(ABA)***,the key genes and potential regulatory network remain *** used exogenous ABA and ABA inhibitors to elucidate the effect of ABA on lily *** on the results of weighted gene coexpression network analysis(WGCNA),the hub gene LdXERICO was identified in modules highly related to endogenous ABA,and a large number of coexpressed genes were *** was induced by exogenous ABA and expressed at higher levels in tissues with vigorous physiological *** LdXERICO increased the low-temperature sensitivity of bulblets and accelerated bulblet *** rescued the ABA insensitivity of xerico mutants during seed germination in Arabidopsis,suggesting that it promotes seed dormancy and supporting overexpression studies on lily *** significant increase in ABA levels in transgenic Arabidopsis expressing LdXERICO indicated that LdXERICO played a role by promoting ABA *** generated three transgenic lines by overexpressing LdICE1 in Arabidopsis thaliana and showed that,in contrast to LdXERICO,LdICE1 positively regulated dormancy ***,qRT-PCR confirmed that LdXERICO was epistatic to LdICE1 for dormancy *** propose that LdXERICO,an essential gene in dormancy regulation through the ABA-related pathway,has a complex regulatory network involving temperature *** study provides a theoretical basis for further exploring the mechanism of bulb dormancy release.

关键词： release Arabidopsis network

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