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The modulating effect of n coordination on single-atom catalysts researched by Pt-n_(x)-C model through both experimental study and DFT simulation

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Journal of Materials science & Technology 2021年第32期91卷 160-167页

作者： Mengmeng Fan Jiewu Cui Junjie Zhang Jingjie Wu shuangming Chen li song Zixing wang Ao wang Robert vajtai Yucheng Wu Pulickel MAjayan Jianchun Jiang Dongping sun nanjing Forestry University Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest ResourcesCollege of Chemical EngineeringNanjing 210037China Rice University Department of Materials Science and NanoEngineeringHoustonTX 77005USA Hefei University of Technology School of Materials Science and EngineeringHefei 230009China University of Cincinnati Department of Chemical and Environmental EngineeringCincinnatiOH 45221USA University of science and Technology of China National Synchrotron Radiation LaboratoryCAS Center for Excellence in NanoscienceHefei 230026China nanjing University of science and Technology Chemicobiology and Functional Materials InstituteNanjing 210094China Key lab of Biomass Energy and Material Jiangsu ProvinceJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesInstitute of Chemical Industry of Forest ProductsChinese Academy of ForestryNanjing 210042China

n-doped carbon-based single-atom catalysts(nC-sACs) are widely researched in various electrochemical reactions due to high metal atom utilization and catalytic *** catalytic activity of nC-sACs originates from the coordinating structure between single metal site(M) and the doped nitrogen(n) in carbon matrix by forming M-n_(x)-C structure(1≤x≤4).The M-n4-C structure is widely considered to be the most stable and effective catalytic ***,there is no in-depth research for the "x" modulation in Pt-nx-C structure and the corresponding catalytic ***,atomically dispersed Pt on n-doped carbon(Pt-nC) with Pt-nx-C structure(1≤x≤4),as a research model,is fabricated by a ZIF-8 template and applied to catalytic oxygen *** carbonization temperatures are used to control n loss,and then modulate the n coordination of Pt-nx-C *** Pt-nC has the predictable low half-wave potential(E_(1/2)) of 0.72 v vs RHE compared to the Pt/C 20% of 0.81 v due to low Pt ***,the Pt-nC shows a high onset potential(1.10 v vs RHE,determined for j=-0.1 mA cm^(2)) and a high current density of 5.2 mA cm^(-2),more positive and higher than that of Pt/C 20%(0.96 v) and 4.9 mA cm^(-2),*** the structural characterization and DFT simulation confirmed,the reducing Ptn coordination number induces low valence of Pt atoms and low free energy of oxygen reduction,which is responsible for the improved catalytic ***,the Pt-nC shows high mass activity(172 times higher than that of Pt/C 20%),better stability and methanol crossover resistance.

关键词： Modulating effect n coordination single-atom catalysts Pt-n_(x)-C model DFT simulation

基于数据挖掘法探讨专利中药复方治疗强直性脊柱炎的组方规律

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中国医药导报 2024年第24期21卷 16-20,44页

作者：吉富涛张凯罗俊普王留辉霍帅王彪彪顾海潮尹本敬郑州四六〇医院骨科中心河南郑州450007 云南省中医医院骨四科云南昆明650100

目的基于国家专利中药复方,探究中医药治疗强直性脊柱炎(As)的用药及组方规律。方法收集建库至2024年5月中国专利公布公告网站上公开发布的关于中药复方治疗As的专利,采用Excel 2010软件及中医传承辅助系统(v 2.5)对中药频次、性味归经... 详细信息

目的基于国家专利中药复方,探究中医药治疗强直性脊柱炎(As)的用药及组方规律。方法收集建库至2024年5月中国专利公布公告网站上公开发布的关于中药复方治疗As的专利,采用Excel 2010软件及中医传承辅助系统(v 2.5)对中药频次、性味归经进行统计,采用关联规则、复杂系统熵聚类进行分析及可视化处理,并对结果进行新方组合。结果共纳入符合专利复方194项,包含内外共用专利复方5项,排除中药复方中含有相同药物的处方后,获得有效中药复方149首,涉及中药531味。其中排名前20位的主要是当归、狗脊、甘草、杜仲、鸡血藤、怀牛膝、独活、白芍、威灵仙、桑寄生、熟地黄、续断、川芎、桂枝、黄芪、红花、羌活、土鳖虫、防风、丹参。药性多为温、寒、平性药,药味多为甘、苦、辛味药,归经多为肝、肾、脾经;应用关联规则分析,将支持度设置为20,置信度为0.6,共得到12组高频药物组合,包含中药10味(频次≥20),采用降序排列依次为“杜仲-狗脊、白芍-狗脊、杜仲-当归”等;并得到6个关系密切药物组合,降序依次排列为“白芍-狗脊”“续断-狗脊”“熟地黄-当归”等;采用无监督熵层次聚类算法分析,得到14组新方核心组合,在此基础上,共获得新方7个。结论专利中药复方治疗As以补益肝肾、健脾祛湿、活血化瘀止痛为主,本研究分析了中药复方专利治疗As的组方规律,对临床中治疗As的遣方用药和新药开发提供一定参考。

关键词：强直性脊柱炎数据挖掘中医传承辅助系统中药复方专利

study on the microwave-assisted extraction of polyphenols from tea

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Frontiers of Chemical science and Engineering 2010年第3期4卷 307-313页

作者： liyun wang Peiyong QIn Yan HU laboratory of Bioprocess of Beijing Beijing University of Chemical TechnologyBeijing 100029China

This study demonstrated a promising method for quickly extracting tea polyphenol(TP)by microwaveassisted extraction(MAE)*** influential parameters,including MAE temperature,microwave power,concentration of extraction solvent,MAE time and the solid/liquid ratio,were *** optimum condition of MAE was obtained by dual extraction with 60%ethanol(v/v)and the solid/liquid ratio 1:12 g/ml at 80℃ for 10 minutes under the microwave power *** yield of TP was 96.5%under the described *** with traditional methods,including hot reflux extraction(HRE),ultrasound-assisted extraction(UAE)and supercritical fluid extraction(sFE),the extraction time was saved 8 times than that of HRE,and the yield was increased by 17.5%.The extraction time at comparable levels of production was saved 2 times,and the energy consumption was one fourth that of *** extraction time was saved 5 times than that of sFE,and the yield of TP was increased by 40%.Moreover,compared with MAE of TP studied by others,it decreased the solid/liquid ratio from 1∶20 to 1∶12 g/ml without 90-min pre-leaching time,and the yield of TP was increased by 6%-40%.

关键词： microwave-assisted extraction tea polyphenols

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1135-1152页

作者： Jia-Jia Zhang Chang-Geng song Miao wang Gai-Qin Zhang Bin wang Xi Chen Peng lin Yu-Meng Zhu Zhi-Chuan sun Ya-Zhou wang Jian-li Jiang ling li Xiang-Min Yang Zhi-nan Chen national Translational science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi'an710032China Department of neurology Xijing HospitalFourth Military Medical UniversityXi'an710032China Key laboratory of synthetic and natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an710032China Department of neurosurgery Xi'an Daxing HospitalXi'an710032China Department of neurobiology and Institute of neurosciences Collaborative Innovation Center for Brain ScienceSchool of Basic MedicineFourth Military Medical UniversityXi'an710032China

Morphine is a frequently used analgesic that activates the mu-opioid receptor(MOR),which has prominent side effects of *** the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance,currently,there is no effective therapy to treat morphine *** the current study,we aimed to develop a monoclonal antibody(mAb)precisely targeting MOR and to determine its therapeutic efficacy on morphine tolerance and the underlying molecular *** successfully prepared a mAb targeting MOR,named 3A5C7,by hybridoma technique using a strategy of deoxyribonucleic acid immunization combined with cell immunization,and identified it as an immunoglobulin G mAb with high specificity and affinity for MOR and binding ability to antigens with spatial *** of two cell lines,HEK293T and sH-sY5Y,with 3A5C7 enhanced morphine-induced MOR endocytosis via a G protein-coupled receptor kinase 2(GRK2)/b-arrestin2-dependent mechanism,as demonstrated by immunofluorescence staining,flow cytometry,Western blotting,coimmunoprecipitation,and small interfering ribonucleic acid(siRnA)-based *** mAb also allowed MOR recycling from cytoplasm to plasma membrane and attenuated morphine-induced phosphorylation of *** established an in vitro morphine tolerance model using differentiated sH-sY5Y cells induced by retinoic *** blot,enzyme-linked immunosorbent assays,and siRnA-based knockdown revealed that 3A5C7 mAb diminished hyperactivation of adenylate cyclase,the in vitro biomarker of morphine tolerance,via the GRK2/b-arrestin2 ***,in vivo hotplate test demonstrated that chronic intrathecal administration of 3A5C7 significantly alleviated morphine tolerance in mice,and withdrawal jumping test revealed that both chronic and acute 3A5C7 intrathecal administration attenuated morphine ***,intrathecal electroporation of silencing short hairpin RnA illustrated that the in v

关键词： Morphine tolerance Mu-opioid receptor Endocytosis Monoclonal antibody Physical dependence

High-Performance li-ion Batteries and super-capacitors Based on Prospective 1-D nanomaterials

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nano-Micro letters 2011年第1期3卷 62-71页

作者： Dandan Zhao Ying wang Yafei Zhang Key laboratory for Thin Film and Microfabrication Technology of the Ministry of Education Research Institute of Micro/Nanometer Science and Technology Shanghai Jiao Tong University Key laboratory of nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University

One-dimensional（1-D） nanomaterials with superior specific capacity, higher rate capability, better cycling peroperties have demonstrated significant advantages for high-performance li-ion batteries and supercapacitors. This review describes some recent developments on the rechargeable electrodes by using 1-D nanomaterials（such as li Mn2O4 nanowires, carbon nanofibers, ni Mo O4 · n H2O nanorods, v2O5 nanoribbons,carbon nanotubes, etc.）. new preparation methods and superior electrochemical properties of the 1-D nanomaterials including carbon nanotube（CnT）, some oxides, transition metal compounds and polymers, and their composites are emphatically introduced. The vGCF/li Fe PO4/C triaxial nanowire cathodes for li-ion battery present a positive cycling performance without any degradation in almost theoretical capacity（160 m Ah/g）.The si nanowire anodes for li-ion battery show the highest known theoretical charge capacity（4277 m Ah/g）,that is about 11 times lager than that of the commercial graphite（372 m Ah/g）. The sWCnT/ni foam electrodes for supercapacitor display small equivalent series resistance（EsR, 52 m?） and impressive high power density（20 k W/kg）. The advantages and challenges associated with the application of these materials for energy conversion and storage devices are highlighted.

关键词： One-dimensional nanomaterials li-ion battery supercapacitor Electrochemical property

Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. Hs-13-94

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Acta Pharmaceutica sinica B 2015年第1期5卷 62-66页

作者： Zhenfang Zhou Xin wang Hui Zhang Jingya sun linghui Zheng Hongchun liu Jidong wang Aijun shen Meiyu Geng Yuewei Guo state Key laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhejiang Hisun Pharmaceutical Co. Ltd.

A bicyclic depsipeptide, chromopeptide A(1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. Hs-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K_α radiation(λ ? 0.71073 ?) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of Hl-60, K-562, and Ramos cells with average IC_(50) values of 7.7, 7.0, and 16.5 nmol/l, respectively.

关键词： Chromopeptide A Bacterium Depsipeptide Absolute configuration Marine-derived sediments Cytotoxicity Chromobacterium sp.

large-scale doping-engineering enables boron/nitrogen dual-doped porous carbon for high-performance zinc ion capacitors

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Rare Metals 2022年第7期41卷 2505-2516页

作者： Chun-liu Zhu Huan-lei wang Wen-Jie Fan sheng-li Zhai Xing-Jie wang Jing shi Ming-Hua Huang shuai liu Zhi li Jing-Wei Chen school of Materials science and Engineering Ocean University of ChinaQingdao 266100China Department of Chemical and Materials Engineering University of AlbertaEdmonton AB T6G 2V4Canada

Zinc ion capacitors(ZICs)have drawn increas-ing interest in energy storage devices because of their economic benefits,high safety,and long cycling ***,the lack of high-performance cathodes for ZICs remains a key ***,we fabricated B,n co-doped porous carbon(Bn-C)via a salt template *** aqueous ZICs assembled from Bn-C cathode delivered a high capacity of 190.2 mAh·g^(-1)and a remarkable energy density of 105.1 Wh·kg^(-1).Moreover,systematic charac-terization verifies that B/n dual-doping promotes the physical adsorption/desorption kinetics of anion and the chemical absorption/desorption kinetics of Zn^(2+),thus improving the electrochemical performance of *** addition,the quasi-solid-state pouch-type battery exhibited excellent electrochemical durability and mechanical flexi-bility,demonstrating its vast application potential as a flexible power ***,this research not only pre-sents a reasonable approach to the large-scale production of carbon cathode materials with excellent electrochemical performance but also strengthens the essential recognition of the charge storage mechanism of heteroatoms-doped carbon materials.

关键词： Heteroatom doping Porous carbon Zinc ion capacitor High energy density Charge storage mechanism

基于数据挖掘和网络药理学探讨活血祛瘀法治疗代谢相关脂肪性肝病用药规律及作用机制

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中国中医药图书情报杂志 2024年第5期48卷 69-75页

作者：罗维军吴驻林张维晴赖铭波陈舒影王婷婷王忠武南方医科大学附属龙华人民医院(深圳市龙华区人民医院) 广东深圳518109

目的基于数据挖掘和网络药理学探讨活血祛瘀法治疗代谢相关脂肪性肝病(MAFlD)的用药规律及代表药物的作用机制。方法检索中国知识资源总库(CnKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(vIP)、中国生物医学文献数据库(CBM... 详细信息

目的基于数据挖掘和网络药理学探讨活血祛瘀法治疗代谢相关脂肪性肝病(MAFlD)的用药规律及代表药物的作用机制。方法检索中国知识资源总库(CnKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(vIP)、中国生物医学文献数据库(CBM)建库至2023年6月1日活血祛瘀法治疗MAFlD的随机对照试验,利用古今医案云平台v2.3.7进行中药频次、关联规则及聚类分析。选取核心中药丹参进行网络药理学分析,基于TCMsP数据库筛选活性成分与靶点,检索GeneCards、OMIM等数据库获取疾病靶点,预测丹参治疗疾病的潜在作用基因,采用R语言4.0.3、Cytoscape3.7.1与sTRInG数据库进行通路分析、构建网络图,采用AutoDuck vina 1.1.2和PyMOl2.3.0软件进行分子对接验证。结果共纳入处方126首,涉及中药182味,丹参为使用频次最高的中药;用药药性以温、微寒、寒、平、微温为主,药味以辛、甘、苦为主,归经以肝经、脾经、肺经、胃经为主;活血祛瘀法核心配伍药物为丹参、山楂、泽泻、柴胡等,聚类分析得到4个聚类方。选取丹参作为代表药进行网络药理学分析。丹参存在65个活性成分,并可能通过RElA、EGFR、vEGFA等关键靶点及脂质与动脉粥样硬化、PI3K-Akt等通路发挥治疗MAFlD的作用。预测成分与对应靶点蛋白结合性好。结论本研究总结了活血祛瘀方药治疗MAFlD的配伍规律,其代表药丹参可通过多靶点、多通路治疗MAFlD。

关键词：活血祛瘀丹参脂肪肝数据挖掘网络药理学

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h-Bn中子探测器制备及中子响应

机电工程技术 2024年第8期53卷 28-31,46页

作者：焦伟勇黄河刘吉珍朱志甫王旭王玮邹继军龙炳旭东华理工大学机械与电子工程学院南昌330013 中国核动力研究设计院成都610005

h-Bn具有高的反应截面和高效率直接探测中子的优势,在中子探测技术领域具有潜在的应用场景。分析了三步脱氢法生长h-Bn的低气压化学沉积机理,对于生长高质量的h-Bn晶体,氨硼烷前驱体的升华温度是一个重要的参数。通过优化氨硼烷前驱体... 详细信息

h-Bn具有高的反应截面和高效率直接探测中子的优势,在中子探测技术领域具有潜在的应用场景。分析了三步脱氢法生长h-Bn的低气压化学沉积机理,对于生长高质量的h-Bn晶体,氨硼烷前驱体的升华温度是一个重要的参数。通过优化氨硼烷前驱体的升华温度,利用lPCvD外延生长技术在蓝宝石衬底上外延生长了高质量的h-Bn。XRD表征技术表明,优化氨硼烷前驱体的升华温度能够显著改善h-Bn晶体质量。利用半导体制备工艺在h-Bn上完成了中子探测器的制备,在中子源照射下,在不同的氨硼烷升华温度下,获得了单个中子的电信号。中子响应测试结果表明,当设定温度分别为165℃和170℃时,获得了2.088 v和2.16 v的电压信号,电荷收集效率分别达到了87%和90%,实验中所测量的电压值与理论预期值呈现出良好的一致性。本实验结果对未来晶圆级和高质量h-Bn晶体生长提供了实验数据,并为h-Bn中子探测器大规模商业化应用提供关键的技术支撑。

关键词： h-Bn 中子探测器氨硼烷升华温度