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Journal of Materials Science & Technology 2000年第1期16卷 19-22页

作者： wang, WL Liao, KJ wang, bb Chongqing Univ Dept Appl Phys Chongqing 400044 Peoples R China

Oriented textured diamond films were obtained on Si(100) substrate via electron emission in hot filament chemical vapor deposition (HFCVD). A de bias voltage relative to the filament was applied to the tungsten electrode between the substrate and the filament. The nucleation and subsequent growth of diamond films were characterized by scanning electron microscopy and Raman spectroscopy. The experimental results showed that the electron emission from the diamond coating on the electrode played a critical role during the nucleation. The maximum value of nucleation density was up to 10(11) cm(-2) on pristine Si surface at emission current of 250 mA. The effect of the electron emission on the reactive gas composition was analyzed by in situ infrared absorption, indicating that the concentration of CH3 and C2H2 near the substrate surface was extremely increased. This may be responsible for the enhanced nucleation by electron emission.

关键词： Diamond films

Uterus movement and cervical tumor regression during external beam radiotherapy for cervical cancer accessed by online cone beam computed tomography

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Uterus movement and cervical tumor regression during externa...

An association study of HFE gene mutation with idiopathic male infertility in Chinese Han population

首届浙赣两省肿瘤研究交流会

作者： Zhang X Liu JP wang bb Yu H Fang J Yin ZM Zhang YL Xiong M Department of Gynecologic Oncology and Medical Radiation Physics Zhejiang Cancer Hospital

Purpose To evaluate coverage of clinical target volume(CTV) influenced by interfraction uterus movement and cervical tumor regression and determine suitable planning margin for intact cervical cancer. Methods and Materials 5 patients undergoing external beam radiotherapy(EBRT) were asked to fill their bladders and empty rectums before computed tomography(CT) simulation and every fraction of *** target volume(PTV) margin was *** beam computed tomography(CBCT) was performed and images were registered

关键词： Image-guided radiation therapy CBCT Intensity-modulated radiation therapy uterus movement tumor regression intact cervical cancer

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An association study of HFE gene mutation with idiopathic ma...

Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer

中华医学会第六次全国生殖医学学术会议

作者： Yu XY wang bb Xin ZC Liu T Ma K Jiang J Fang X Yu LH Peng YF Ma X Institute of Reproductive Medicine Yijishan HospitalWannan Medical College National Research Institute for Family Planning Peking Union Medical College Andrology Center Peking University First Hospital World Health Organization Collaborating Centre for Research in Human Reproduction

Hemochromatosis(HFE) mutations influence the iron status of the general population in Northern Europe,and excess iron is related with impairment of *** aim of this study is to investigate the association between three...

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Decrease in phosphorylated ERK indicates the therapeutic eff...

Highly selective photocatalytic reduction of CO_(2) to CH_(4) on electron-rich Fe species cocatalyst under visible light irradiation

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Liu XL Xu YC wang YX Chen Y wang bb wang Y Chen YH Tan C Hu LD Ma QY Zhang YC Sun YM Gao YL Yang CH Ding J Meng LH University of Chinese Academy of Sciences Division of Anti-tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of Sciences Department of Medicinal Chemistry State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaUniversity of Chinese Academy of Sciences The Key Laboratory of Stem Cell Biology Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of Sciences

PI3 Ks are frequently hyper-activated in breast cancer and targeting PI3 Ka has exhibited promising but variable response in preclinical and clinical ***33 is a novel PI3 Kα-selective inhibitor in phase I clinical *** investigated the efficacy of CYH33 against breast cancer and explored potential predictive ***33 potently restrained tumor growth in mice bearing human breast cancer cell xenografts and in R26-Pik3 ca;MMTV-Cre transgenic ***33 significantly inhibited proliferation of a panel of human breast cancer cells,while diversity in sensitivity has been *** harboring activating PIK3 CA mutation,amplified HER2 were more responsive to CYH33 than their ***,cells in HER2-enriched or luminal subtype were more sensitive to CYH33 than basal-like breast *** to CYH33 has been further revealed to be associated with induction of G1 phase arrest and simultaneous inhibition of Akt and *** of patient-derived xenograft to CYH33 was also positively correlated with decrease in phosphorylated *** together,CYH33 is a promising PI3 Ka inhibitor for breast cancer treatment and decrease in ERK phosphorylation may indicate its efficacy,which provides useful clues for rational design of the ongoing clinical trials.

关键词： Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3K selective inhibitor CYH33 in breast cancer ERK

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Carbon Energy 2024年第1期6卷 255-266页

作者： Qianying Lin Jiwu Zhao Pu Zhang Shuo wang Ying wang Zizhong Zhang Na Wen Zhengxin Ding Rusheng Yuan Xuxu wang Jinlin Long State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhouChina

Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great ***,we demonstrate unprecedented hybrid SiC photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic *** exhibits a superior photocatalytic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record CH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatalytic performance and ***,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the CO_(2)→CH_(4) *** study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts.

关键词： artificial synthesis of CH_(4) electronic structure optimization Fe species cocatalyst photocatalytic CO_(2) reduction SiC

Polyoxometalates-derived nanostructures for electrocatalysis application

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Rare Metals 2024年第5期43卷 1845-1866页

作者： Chao-Yue Sun Wen Li Kai wang Wei-Jia Zhou Hai-Qing wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China Shandong Electrical Engineering and Equipment Group Intelligent Electric Co. Ltd.Jinan 250022China

The conversion of intermittent renewable electrical energy to chemical energy is of great importance which can not only mitigate current energy and environmental crisis but also contribute to the ongoing carbon neutrality national *** is serving as a low-carbon conversion technology that enables green and efficient energy conversion mainly through hydrogen evolution reaction(HER),carbon dioxide reduction reaction(CO_(2)RR),and nitrogen reduction reaction(NRR).The core of electrocatalysis is the design and construction of low-cost high-activity and high-stability electrocatalyst to drive reaction thermodynamics and *** employment of polyoxometalates(POMs)as platforms or precursors to construct different types of electrocatalysts has been widely ***,we systematically summarized the recent advances in POM-derived nanostructures for electrocatalysis *** strategies for precursor design and electrocatalyst synthesis were briefly *** morphology control,phase control,composite modulation,and heterostructure engineering in POM-derived nanostructures were presented in *** structure–activity relationship of POM-derived nanostructures is fully discussed for HER CO_(2)RR,and NRR ***,the current challenges and future outlooks of POM-derived nanostructures are summarized to provide insights toward high-efficiency electrocatalysts for energy conversion technologies.

关键词： Microforming Cylindrical compression Size effects Grain orientation Inhomogeneous deformation

Digital Twins for Wastewater Treatment:A Technical Review

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Engineering 2024年第5期36卷 21-35页

作者： Ai-Jie wang Hewen Li Zhejun He Yu Tao Hongcheng wang Min Yang Dragan Savic Glen TDaigger Nanqi Ren School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental Engineering Cornell UniversityIthacaNY 14850USA BIOMATH Department of Data Analysis and Mathematical ModellingGhent UniversityGhent 9000Belgium KWR Water Research Institute Nieuwegein 3430 BBNetherlands Centre for Water Systems University of ExeterExeter EX44QFUK Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109USA

The digital twins concept enhances modeling and simulation through the integration of real-time data and *** review elucidates the foundational elements of digital twins,covering their concept,entities,domains,and key *** specifically,we investigate the transformative potential of digital twins for the wastewater treatment engineering *** discussion highlights the application of digital twins to wastewater treatment plants(WWTPs)and sewage networks,hardware(i.e.,facilities and pipes,sensors for water quality and activated sludge,hydrodynamics,and power consumption),and software(i.e.,knowledge-based and data-driven models,mechanistic models,hybrid twins,control methods,and the Internet of Things).Furthermore,two cases are provided,followed by an assessment of current challenges in and perspectives on the application of digital twins in *** review serves as an essential primer for wastewater engineers navigating the digital paradigm shift.

关键词： Digital twins Urban water systems Wastewater treatment

Tal6b/AvrXa27A,a hidden TALE targeting the susceptibility gene OsSWEET11a and the resistance gene Xa27 in rice

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Plant Communications 2024年第2期5卷 122-134页

作者： Zhengyin Xu Xiameng Xu Ying Li Linlin Liu Qi wang Yijie wang Yong wang Jiali Yan Guanyun Cheng Lifang Zou Bo Zhu Gongyou Chen Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240China

Xanthomonas oryzae ***(Xoo)secretes transcription activator-like effectors(TALEs)to activate rice susceptibility(S)genes,causing bacterial blight(bb),as well as resistance(R)genes,leading to de-fense against *** activation follows a gene-for-gene paradigm that results in an arms race between the TALE of the pathogen and effector-binding elements(EBEs)in the promoters of host *** this study,we characterized a novel TALE,designated Tal6b/AvrXa27A,that activates the rice S gene OsSWEET11a and the rice R gene ***6b/AvrXa27A is a member of the AvrXa27/TalAO class and contains 16 repeat variable diresidues(RVDs);one RVD is altered and one is deleted in Tal6b/AvrXa27A compared with AvrXa27,a known avirulence(avr)effector of ***6b/AvrXa27A can transcriptionally activate the expression of Xa27 and OsSWEET11a via EBEs in their corresponding promoters,leading to effector-triggered immunity and susceptibility,*** 16 RVDs in Tal6b/AvrXa27A have no obvious similarity to the 24 RVDs in the effector PthXo1,but EBETal6b and EBEPthXo1 are overlapped in the OsSWEET11a ***6b/AvrXa27A is prevalent among Asian Xoo isolates,but PthXo1 has only been reported in the Philippine strain *** editing of EBETal6b in the OsSWEET11a pro-moter further confirmed the requirement for OsSWEET11a expression in Tal6b/AvrXa27A-dependent susceptibility to ***,Tal6b/AvrXa27A resulted in higher transcription of Xa27 than of OsSWEET11a,which led to a strong,rapid resistance response that blocked disease *** suggest that Tal6b/AvrXa27A has a dual function:triggering resistance by activating Xa27 gene expression as an avirulence factor and inducing transcription of the S gene OsSWEET11a,resulting in ***,Tal6b/AvrXa27A,but not AvrXa27,can bind to the promoter of *** underlying recognition mechanism for this binding remains unclear but appears to deviate from the currently accepted TALE code.

关键词： Xanthomonas oryzae pv.oryzae TALE AvrXa27 tal6b Xa27 OsSWEET11a

Influence of meteorological factors on open biomass burning at a background site in Northeast China

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Journal of Environmental Sciences 2024年第4期138卷 1-9页

作者： Yulong wang Linlin Liang Wanyun Xu Chang Liu Hongbing Cheng Yusi Liu Gen Zhang Xiaobin Xu Dajiang Yu Peng wang Qingli Song Jiumeng Liu Yuan Cheng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological SciencesBeijing 100081China Longfengshan Regional Background Station China Meteorological AdministrationHeilongjiang 150200China Heilongjiang Climate Center Heilongjiang 150030China

Biomass burning(bb)is a very important emission source that significantly adversely impacts regional air *** produces a large number of primary organic aerosol(POA)and black carbon(BC).Besides,bb also provides many precursors for secondary organic aerosol(SOA)*** this work,the ratio of levoglucosan(LG)to organic carbon(OC)and the fire hotspots map was used to identify the open biomass burning(Obb)events,which occurred in two representative episodes,October 13 to November 30,2020,and April1 to April 30,*** ratio of organic aerosol(OA)to reconstructed PM_(2.5)concentration(PM_(2.5)^(*))increased with the increase of LG/*** LG/OC ratio is higher than 0.03,the highest OA/PM_(2.5)^(*)ratio can reach 80%,which means the contribution of Obb to OA is *** to the ratio of LG to K^(+),LG to mannosan(MN)and the regional characteristics of Longfengshan,it can be determined that the crop residuals are the main *** occurrence of Obb coincides with farmers’preferred choices,i.e.,burning biomass in“bright weather”.The“bright weather”refers to the meteorological conditions with high temperature,low humidity,and without *** factors indirectly affect regional biomass combustion pollution by influencing farmers’active choices.

关键词： Air pollution Biomass burning Meteorological factors Organic trace Agricultural fires

Polybrominated biphenyl exposure and thyroid function tests in electronic waste dismantling and general population of Chinese adults

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Emerging Contaminants 2024年第1期10卷 72-79页

作者： Shijie wang Jingxi Jin Zhitong Zhang Chen Guo Zhigang Li Jicheng Hu Ying wang Yongjie Wei Jun Jin College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijing 100191China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Engineering Research Center of Food Environment and Public Health Beijing 100081China Center for Global Health School of Public HealthNanjing Medical UniversityChina

This study aimed to determine the concentration of 35 Pbb(polybrominated biphenyls)congeners in the human serum of residents from an electronic waste(e-waste)dismantling area compared to a control area in ***,four thyroid hormones,namely FT3,FT4,TSH,and TRH,were also *** findings revealed that the total Pbb concentrations(sum of the 35 Pbb congeners)ranged from 47.1 to 1360 ng/g lipid in the e-waste area and 105–1980 ng/g lipid in the control ***-1 and bb-10 were the dominant congeners in both study areas,followed by *** to the e-waste dismantling area,the control area samples had a significantly higher concentration of less-brominated(Br1–3)Pbbs,including the concentrations of less-brominated congeners such as bb-1,bb-4,bb-9,and bb-10,which were significantly higher than those in the e-waste dismantling ***,more-brominated hexabromobiphenyl congeners bb-153,bb-154 and bb-155 were found in samples from the e-waste dismantling area at significantly higher concentrations than in the control area.E-waste dismantling areas have released historically produced commercial Pbb products,but equally not negligible is the exposure of the general population to newly produced Pbb *** concentrations in the e-waste dismantling area samples decreased with increasing age,while they increased with increasing age in the control area ***,stepwise multiple regression analysis showed a significant association between bb-103 concentrations and thyroid hormone *** addition,bb-103 has the potential to interfere with the binding of T3 and thyroid hormone receptors(TR).Given these findings,the research on human exposure of Pbb and the relationships between the Pbb and thyroid hormones should be studied further.

关键词： Polybrominated biphenyls Human serum E-waste Thyroid hormone Human exposure