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Biomarkers in fluid inclusions of polymetallic deposit of Qixiashan, Nanjing

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Chinese Science Bulletin 1997年第14期42卷 1206-1209页

作者： Xie, SC Yin, HF wang, hm Zhou, XG Fu, JM Sheng, GY Zhang, HZ School of Geosciences China University of Geosciences Wuhan China Institute of Geochemistry Chinese Academy of Sciences Guangzhou China

MOST previous studies of organic geochemistry in an ore deposit focus on the bitumen and kero-gen associated with ores and host rocks, not on that of fluid inclusions. However, organicmatter only in ore-forming fluids is directly involved in metallogenesis. In this note, a series ofbiomarkers in hydrocarbon inclusions were identified through gas chromatography-mass spec-trometry (GC-MS). Comparison and contrast on extractable organic matter (EOM) was madeamong inclusions, ores and host rocks. Metallogenesis related to EOM was also discussed.

关键词： ore deposit hydrocarbon inclusion biomarker metallogenesis.

Regulation of embryo implantation by nitric oxide in mouse

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Chinese Science Bulletin 2002年第17期47卷 1461-1465页

作者： Zhang, X wang, hm Lin, HY Li, QL Liu, DL Qian, D Liu, GY Zhu, C Chinese Acad Sci State Key Lab Reprod Biol Inst Zool Beijing 100080 Peoples R China

Intrauterine injection and zymography were used to investigate the effect of nitric oxide (NO) on embryo implantation in mice. On day 3, one uterine horn of female pregnant mice was injected intraluminally with various doses of nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine methyl ester (L-NAME), while the contralateral horn served as control. Animals were sacrificed by cervical dislocation on day 7 of gestation, and the number of implanted embryos in each horn was calculated. The results showed that lower doses (0.05mg L-NAME) did not inhibit implantation significantly (P > 0.05), but high doses (0.2 mg L- NAME) resulted in a significant reduction in the number of implanted embryos (P < 0.05). Co-administration of SNP, a generator of NO, with L-NAME would reverse the anti-implantation effect of L-NAME. To further understand the precise mechanism of NO in implantation, matrix metallo-proteinase (MMPs) activities were detected by gelatin zymography. The reduction in the number of implanted

关键词： mouse nitric oxide nitric oxide synthase embryo im-plantation matrix metalloproteinases.

Experimental study of gold distribution in the algae-organic matter-fluid system

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Chinese Science Bulletin 1997年第19期42卷 1640-1642页

作者： Xie, SC Yin, HF wang, hm Zhou, XG Fu, JM Sheng, GY Zhang, HZ Lu, JL School of Geosciences China University of Geosciences Wuhan China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China

THE previous simulating experiments show that many algae can greatly accumulate goldfrom solution under some conditions. Some other experiments further indicate that organ-ic matter and crude oil can also play an important role in gold geochemistry processes such asleaching, migration, reduction and precipitation. However, these biometallogeneses are

关键词： gold algae organic matter fluid metallogenesis.

Significant Carnian Halobia Fauna found in the Zagunao Formation in the Songpan area, Sichuan, China

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Chinese Science Bulletin 1997年第12期42卷 1056-1056页

作者： wang, hm Yang, FQ Xie, SC Jin, GB Geology Faculty China University of Ceosciences Wuhan China The Sixth Geology Survey Institute of Jilin Province Yanji China

NORTHWEST Sichuan, a hotspot for geologic study, recently has yielded a series of large-medi-um scale gold deposits in the Upper Triassic. It is of great importance to determination andsubdivision of the Triassic System and eventually to exact locating of the gold *** Triassic Zagunao Formation in northwestern Sichuan has greatly changed in sensesince it was named in 1961. Now the Zagunao Formation only includes the metamorphic sand-stone with interlayers of slate lying between the Zhuwo Formation （T3） and the Zagashan For-

关键词： Significant Carnian Halobia Fauna found in the Zagunao Formation in the Songpan area China Sichuan

The lipoxin receptor agonist BML-111 protects against LPS/D-GalN-induced acute liver injury in rats

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The lipoxin receptor agonist BML-111 protects against LPS/D-...

BML-111 protected carbon tetrachloride-induced hepatic fibrosis in rats and the possible mechanisms

第九届全国免疫学学术大会

作者： Zhou XY Yan D Yu ZJ wang hm Xu FY Huang YH Min WP Medical College of Nanchang University Institute of Immunotherapy Nanchang University Jiangxi Academy of Medical sciences

Objective:Lipoxins(LXs),a class of arachidonic acid metabolites,display unique anti-inflammatory and pro-resolving actions in a variety of inflammatory *** present study was undertaken to investigate the effects of BML-111(the lipoxin A receptor agonist)in a model of acute liver injury,and to explore the ***:Acute liver injury was induced by intraperitoneal injection of LPS and D-Galactosamine(D-GalN).Forty SD rats were randomly divided into three groups,namely control group,model group and prevention *** carried out histopathological analysis to quantify hepatic neutrophil *** antioxidant capacity of BML-111 was analyzed using biochemical *** levels of TNF-αand IL-1βwere measured using ELISA,and the hepatic expression levels of TGF-β1 and AngII were examined using ***:The data demonstrated:(1)Administration of LPS and D-GalN caused severe damage in liver,the model of acute liver injury in rat was well.(2)Histopathologal examination demonstrated that the rats treated with LPS and D-GalN had marked necrosis,neutrophil infiltration and hyperemia.(3)LPS/D-GalN decreased the hepatic levels of CAT(43.6%,P<0.05),SOD(51.8%,P<0.05),T-AOC(28.1%,P<0.05)and hydroxyl radical-scavenging potential(30.1%,P<0.05),accompanied by a significant increase of MDA content in liver(88.5%,P<0.01).(4)LPS/D-GalN increased the expression levels of TNF-α(about five times,P<0.01)and Angll(65.8%,P<0.01),while inhibiting the expression of hepatic TGF-β1(75.5%,P<0.01).(5)As to the model,BML-111 prevented LPS/D-GalN-induced pathological changes.(6)As to the model,BML-111 increased the activities of SOD(149.9%,P<0.01),CAT(120%,P<0.01),TAOC(173.4%,P<0.01),stimulated hydroxyl radical-scavenging potential(89.3%,P<0.01),and decreased MDA levels(58.2%,P<0.05).(7)As to the model,BML-111 reduced TNF-a level(67.3%,P<0.01)and Angll expression(65.9%,P<0.05),and increased the expression of TGF-01(about 12.3 times,P<0.01).Conclusion:BML-11

关键词： Lipoxins liver injury antioxdation inflammation

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BML-111 protected carbon tetrachloride-induced hepatic fibro...

浙江省4个地区60岁以上老人生活满意度的调查

第九届全国免疫学学术大会

作者： Zhou XY Yu ZJ Yan D wang hm Xu FY Huang YH Min WP Medical College of Nanchang University Institute of Immunotherapy Nanchang University Jiangxi Academy of Medical sciences

Objective:LXs are a class of newly found arachidonic acid metabolites,possess potent anti-inflammatory and proresolution *** had previously confirmed the LXs agonists BML-111 had possessed the protection effects for ***,this study we investigated the protection effects of BML-111 on hepatic fibrosis and the possible ***:Forty Sprague-Dawley(SD)rats were used,CCL,was subcutaneous injected to build experimental hepatic fibrosis,and BML-111(1mg/kg)was injected to prevent or treat *** degree of liver injury and inflammatory cell infiltration were observed by HE *** and ALT activity in serum were tested to evaluate the liver *** level of hepatic fibrosis was conjunctively confirmed through general feature of liver,VG stain and Masson stain of liver biopsy,and content of hydroxyproline(Hyp).Western-blot and immunohistochemistry were used to examine the expressions of *** expression levels of TGF-β1 and PDGF were detected by ELISA and ***-blot was used to observe the expression levels of MMP-2,MMP-3,MMP-7,MMP-9,and *** content of MDA,the activity of SOD,GSH-Px and CAT,and the T-AOC were detected by reagent *** NF-κBp65 nuclear translocation was observed by ***:The data suggested:(1)Histopathologal examination via VG and Masson staining demonstrated the model of hepatic fibrosis in rat was well.(2)BML-111 inhibited liver injury and inflammatory cell infiltration in prevention group and treatment group.(3)The results of histopathologal and Hyp examination suggested BML-111 improved the degree of hepatic fibrosis.(4)Relative to the CCL,group,BML-111 repressed the expression ofα-SMA(P<0.01in prevention group,and P<0.05 in treatment group,n=6),the mark of hepatic stellate cell activation.(5)Compare to the model,BML-111 reduced the expression levels of TGF-pi(P<0.01 in prevention group,and P<0.05 in treatment group,n=4)and PDGF(P<0.01 in prevention group,and P<0.0

关键词： Lipoxins hepatic fibrosis Hepatic stellate cell inflammation

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中国组织工程研究与临床康复 2007年第17期11卷 3219-3221页

作者：陈玲娜汪红明王毓璈杭州师范学院临床医学院浙江省杭州市310018 杭州师范学院临床医学院全科医学教研室浙江省杭州市310018

目的:了解浙江省农村老年人生活满意度的现状及其有关影响因素。方法:于2005-07/10随机抽取浙江省乐清市北白象镇、白石镇、大荆镇,建德市的莲花镇及杭州下沙区和余杭区内能回答调查问卷的各项内容,同意参与该项调查的60岁以上老年人43... 详细信息

目的:了解浙江省农村老年人生活满意度的现状及其有关影响因素。方法:于2005-07/10随机抽取浙江省乐清市北白象镇、白石镇、大荆镇,建德市的莲花镇及杭州下沙区和余杭区内能回答调查问卷的各项内容,同意参与该项调查的60岁以上老年人430名为调查对象。应用WHO推荐的生活满意度指数A量表,一般状况调查表,最满意和最不满意的事情调查表进行入户问卷调查。生活满意度指数A量表,包括20个项目,其中12个条目反映正性情感,8个条目反映负性情感。每项最高分为2分,总分最高分为40分。评分越高,生活质量越佳。一般状况调查表包括姓名、年龄、性别、职业、文化程度、婚姻、健康状况、医疗费用来源、住址和联系电话。结果:共发放问卷430份,收回有效问卷389份。①389名老年人生活满意度评分为25.8±7.2,与正常值(12.4±4.4)比较,差异有显著性意义(P0.05),而在年龄、婚姻、文化程度、健康状况、职业、医疗费用来源和所在地区维度差异有显著性(P≤0.05)。③313人对“最满意和最不满意的事情”项目进行了回答,老年人最满意的事是“生活条件改善”和“家庭关系和睦”,有195人,占62.3%,最不满意的事主要是“家庭不和睦”(17.4%)、“社会发展不佳”(14.8%)、“身体状况差”(14.2%)、“生活条件差”(10.3%)。结论:浙江省农村老年人生活满意度较高,年龄、婚姻、文化程度、健康状况、职业、医疗费用来源、地区差异对老年人生活满意度有重要影响。

关键词：老年人生活质量因素分析统计学

Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach

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World Journal of Gastroenterology 2012年第38期18卷 5470-5475页

作者： Hong-Mei wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: wang hm and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. Department of Gastric Surgery Affiliated Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China.

AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SS

关键词： Gastric carcinoma Prognosis Receiver operating characteristic curve The lower third of stomach Tumor size

Screening for bacteria degrading oxalic acid and potential for biocontrol of sclerotinia diseases

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Screening for bacteria degrading oxalic acid and potential f...