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Mechanism of apoptosis of human osteosarcoma M-G63 induced by arsenic trioxide

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Journal of Central South University of Technology 2005年第z1期12卷 317-321页

作者： XIAO Tao LI Kang-hua FANG Jian-zhen wang Wan-chun LI Gui-yuan Cancer Research Institute Xiangya School of MedicineCentral South University Changsha 410078 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics Xiangya Hospital Central South University Changsha 410008 China Department of Central Laboratory the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Cancer Research InstituteXiangya School of MedicineCentral South University Changsha 410078 China

Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investigate the inducing apoptosis and inhibitative of As2O3 on osteosarcoma MG-63 cells. In order to study mechanism of apoptosis in MG-63 cells treated with As2 O3, microarray was performed. The down-regulated gene was confirmed by RT-PCR, Northern-blotting. Results After treated with As2O3, hypodiploid peak before G0/G1 phase was observed in MG-63 cells through FCM analysis. Loss of microvilli, condensation and fragmentation of nuclear chromatin, condensation of cytoplasmic organelles, dilatation of the endoplasmic reticulum shrinkage of cells and alterations in cell membranes and apoptosis bodies which were observed in MG-63 cells treated with As2O3 by transmission electronmicroscope. The results of microarray show that As2 O3 induced MG-63 cell apoptosis involves down-regulation of IEX-1 and the down-regulated gene is confirmed by RT-PCR and *** The results show that As2 O3 selectively inhibits growth of the solid tumor MG-63 cells by triggering apoptosis and indicates MG-63 induced by As2O3 cell apoptosis may through the IEX-1 pathway.

关键词： arsenic trioxide osteosarcorna MG-63 apoptosis IEX-1

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基于B探针的膛内电枢速度测量系统研究

兵工学报 2014年第6期35卷 762-768页

作者：刘福才李欢王大正王振春何锁纯燕山大学工业计算机控制工程河北省重点实验室河北秦皇岛066004 北京航天计量测试技术研究所北京100076

弹丸速度和位移的测量是电磁炮重要的测试项目之一。针对以往分布式探针测速需要多路高速采集通道的问题,提出采用探针串联和波形叠加进行增强型电磁轨道炮膛内电枢速度测量的两种新方法。通过仿真给出采用驱动电流信号和拟合速度变化... 详细信息

弹丸速度和位移的测量是电磁炮重要的测试项目之一。针对以往分布式探针测速需要多路高速采集通道的问题,提出采用探针串联和波形叠加进行增强型电磁轨道炮膛内电枢速度测量的两种新方法。通过仿真给出采用驱动电流信号和拟合速度变化曲线计算增强型电磁轨道炮磁探针感应电压的方法;通过实验分别采用探针串联和波形合并两种新方法对膛内电枢速度进行测量,并与分布式测量方法进行比较。仿真和实验结果表明:仿真所得探针波形与实验测得的波形基本一致,提出的两种新方法与分布式测量方法相比只需要一路高速采集端口,具有成本低、可靠性高等特点,为轨道电磁炮膛内电枢速度的测量提供了一条新途径。

关键词：电磁学增强型电磁轨道炮膛内速度 B探针固体电枢

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电磁发射测量系统的设计与实现

兵工学报 2008年第10期29卷 1256-1261页

作者：刘福才王世国王振春刘阳燕山大学工业计算机控制工程河北省重点实验室河北秦皇岛066004

设计了一种基于Rogowski线圈、B-dot探针、光幕靶及插入式数据采集卡(PC-DAQ)的电磁发射测量系统,开发出以动态链接库(DLL)为形式的数据处理模块,为系统的扩展和二次开发提供统一的接口,设计了具有Windows操作功能的人机交互界面,并成... 详细信息

设计了一种基于Rogowski线圈、B-dot探针、光幕靶及插入式数据采集卡(PC-DAQ)的电磁发射测量系统,开发出以动态链接库(DLL)为形式的数据处理模块,为系统的扩展和二次开发提供统一的接口,设计了具有Windows操作功能的人机交互界面,并成功地应用到实际研究中,为电磁发射系统的性能研究及技术匹配提供了数据依据。根据实验数据得出了触发放电和轨道拉弧时,整个测量系统受到了大的脉冲干扰;通过计算,可以得到本系统测量速度为1 km/s时的相对误差为0.7%.

关键词：电子技术电磁发射器高速数据采集光幕靶 B-dot探针 Rogowski线圈

重金属铊胁迫羽衣甘蓝的in situ-ATR-FTIR表征

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光谱学与光谱分析 2009年第1期29卷 119-121页

作者：姚焱张平汪珍春陈永亨广州大学生命科学学院广东广州510006 广州大学环境科学与工程学院广州市污染控制与同位素应用技术重点实验室广东广州510006

通过植物叶片光合作用消耗二氧化碳实验,实现了羽衣甘蓝光合作用的原位衰减全反射红外光谱表征。结果表明,羽衣甘蓝无论是否受到铊胁迫,其吸收峰的位置均无明显改变,其中3380 cm-1处的强吸收峰表征叶片中的水分,碳水化合物,蛋白质和酰... 详细信息

通过植物叶片光合作用消耗二氧化碳实验,实现了羽衣甘蓝光合作用的原位衰减全反射红外光谱表征。结果表明,羽衣甘蓝无论是否受到铊胁迫,其吸收峰的位置均无明显改变,其中3380 cm-1处的强吸收峰表征叶片中的水分,碳水化合物,蛋白质和酰胺化合物等;2916,2850 cm-1处的强峰以及2960 cm-1处的肩峰表征碳水化合物和脂肪族化合物等;1640 cm-1处的吸收峰表征水分。然而,通过对羽衣甘蓝叶片进行原位表征,发现表征CO2的2360和2340 cm-1双吸收峰("负峰")均从无到有,逐渐增强,说明羽衣甘蓝在进行光合作用。并且,铊胁迫组叶片二氧化碳的消耗速率明显高于空白样,即一定浓度铊胁迫会提高羽衣甘蓝的光合速率,表明羽衣甘蓝对重金属铊具有耐受的特性;结果也表明成年叶光合作用强度大于幼叶,这符合植物叶片光合作用的一般规律。

关键词：铊胁迫羽衣甘蓝光合作用原位衰减全反射红外光谱

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng Yan zhen wang Guansheng Ma Dechang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu wang chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He zhen wang Yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Mechanical Properties of Railway High-strength Manufactured Sand Concrete: Typical Lithology, Stone Powder Content and Strength Grade

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 194-203页

作者： wang zhen LI Huajian HUANG Fali YANG Zhiqiang WEN Jiaxin SHI Henan Railway Engineering Research Institute China Academy of Railway Science Corporation LimitedBeijing 100081China State Key Laboratory for Track Technology of High-Speed Railway Beijing 100081China

In order to achieve the large-scale application of manufactured sand in railway high-strength concrete structure,a series of high-strength manufactured sand concrete(HMC)are prepared by taking the manufactured sand lithology(tuff,limestone,basalt,granite),stone powder content(0,5%,10%,15%)and concrete strength grade(C60,C80,C100)as *** evolution of mechanical properties of HMC and the correlation between cubic compressive strength and other mechanical properties are *** to river sand,manufactured sand enhances the cubic compressive strength,axial compressive strength and elastic modulus of concrete,while its potential microcracks weaken the flexural strength and splitting tensile strength of *** powder content displays both positive and negative effects on mechanical properties of HMC,and the stone powder content is suggested to be less than 10%.The empirical formulas between cubic compressive strength and other mechanical properties are proposed.

关键词： manufactured sand concrete railway mechanical property lithology stone powder content

Dual modulation of homogeneous nanomaterialization and electrochemical activation enhancing zinc ion storage

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Science China Chemistry 2025年第01期 385-393页

作者： Jianwei wang Huan wang Kangning wang Wenhui wang Wenlin Zhang Yanzhong zhen School of Chemistry & Chemical Engineering Yan'an University

Vanadium-based electrode materials are widely investigated,but the low specific capacity and slow electrochemical kinetics in aqueous zinc-ion batteries still limit their commercial ***,the VS2/Ca V4O9material with the morphology of nanoflower was synthesized by a one-step hydrothermal *** to the blocky structure of pure VS2material,the VS2/Ca V4O9material is composed of thinner homogeneous *** open structures could provide abundant electrochemical active sites and ion transport channels,and then promote the electrochemical reaction *** addition,they can also buffer the bulk strain during the reaction *** improve the utilization of vanadium elements,an in-situ electrochemical activation strategy is used to explore the storage performance of the VS2/Ca V4O9material,the different activation voltage range of 0.4–1.6 and 0.4–1.4 V are selected,*** with the longer activation plateau of activated-VS2,the VS2/Ca V4O9cathode could quickly reach the activation state in the range of 1.4–1.6 V and cause the release of additional Zn storage sites *** VS2/Ca V4O9cathode delivers a higher power density of 37,000 W kg-1and a significant energy density of 423 Wh *** the high current density of 15 A g-1,the VS2/Ca V4O9cathode still has a discharge capacity of 183.9m Ah g-1after 5,000 cycles,and the capacity decay rate per cycle is only 0.0042%.Continuous cyclic voltammetry （CV） curves,electrochemical impedance spectroscopy （EIS） measurements,density functional theory （DFT） calculation and galvanostatic intermittent titration technique （GITT） measurements demonstrate that the VS2/Ca V4O9cathode has a faster ion diffusion/charge transfer ***,the assembled flexible device has an excellent mechanical stability.

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