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A New Triterpenoid Glycoside from Decaisnea Fargesii

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Chinese Chemical Letters 1999年第5期10卷 397-400页

作者： Kong, J Lu, RH Gao, HX wang, M wang, yp wang, HQ Chinese Acad Sci Lanzhou Inst Chem Phys Lanzhou 730010 Peoples R China NW Normal Univ Dept Chem Lanzhou 730070 Gansu Peoples R China

A new triterpenoid glycoside, named decaisoside F. has been isolated from Decaisnea faresii. Its structure was determined on basis of chi mical method, FAB-MS. homonuclear and heteronuclear correlation esperiments. including H-1--(HCOSY)-H-1. H-1--C-13 COSY, TOSCY, HMBC and NOESY techniques to be 3-O-beta-D- xylopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->2)-alpha-Larabinopyranosyl) hederagenin 28-O-beta-D-xylopyranosyl (1-->4)-beta-D-glucopyrancrsyl (1-->6)-beta-D-glucopyranoside.

关键词： Decaisnea fargesii triterpenoid glycoside decaisoside F 2D-NMR

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer brain and the possible mechanism

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中国病理生理杂志 2001年第8期 88-89页

作者： wang JZ Tung YC wang yp Li XT Iqbal K GRUNDKE-IQBAL I Department of Pathophysiology Tongji Medical College HUST 13 HongKang RoadHubei Wuhan 430030 China Chemical Neuropathology Department NYS Institute for Basic Research1050 Forest Hill Road Staten Island New York NY10314 USA

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高密度条形码在邮政上的应用

图象识别与自动化 1993年第2期 52-55,67页

作者： wang,yp 施柳

高频刺激人类丘脑前核去同步化癫痫网络的研究

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癫痫杂志 2018年第5期4卷 467-468页

作者：遇涛任连坤王玉平 wang X Li Y 首都医科大学宣武医院功能神经外科北京100053 首都医科大学宣武医院神经内科北京100053

背景癫痫是神经系统最常见的疾病之一,患病率约为0.7%-1%。尽管越来越多的抗癫痫药物（AEDs）上市,仍有约30%的患者对多种药物耐药。长期反复的癫痫发作,严重危害了患者的躯体和心理健康,同时也给家庭和社会带来严重的影响。针对药物难... 详细信息

背景癫痫是神经系统最常见的疾病之一,患病率约为0.7%-1%。尽管越来越多的抗癫痫药物（AEDs）上市,仍有约30%的患者对多种药物耐药。长期反复的癫痫发作,严重危害了患者的躯体和心理健康,同时也给家庭和社会带来严重的影响。针对药物难治性癫痫,特别是对最常见的难治性局灶性癫痫,在目前多种手段定位癫痫灶的情况下,癫痫灶切除手术是有力的治疗手段。

关键词：抗癫痫药物去同步化丘脑前核高频刺激药物难治性癫痫癫痫灶切除手术网络人类

Study on Alzheimer’s disease model

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中国病理生理杂志 2001年第8期 91-91页

作者： wang JZ wang QB Li XT wang yp WEI ZL XIAO RH wang Q HAO TL wang XC LIU R Department of Pathophysiology Tongji Medical University Wuhan 430030 China

It is well known that the main brain lesion in Alzheimer's disease (AD) brain is neurofibrillary tangles (NFT) and senile plaques (SP). The amount of NFT is positively correlated with clinical degree of dementia in AD. It is also well studied that the major component of NFT is abnormally hyperphosphorylated microtubule associated protein tau that is caused by an imbalance of protein kinase and protein phosphatase (PP). To reconstitute a specific AD model based on the above hypothesis, we have injected separately calcium calmodulin dependent protein kinase (CaMKKII) activator, bradykinin and PP-2B inhibitor, cyclosporin A into rat hippocampus in the present study. The results showed that the injection of bradykinin caused learning and memory deficient in rats as well as Alzheimer-like tau phosphorylation, including Ser-262/356, Thr-231/235 and Ser-396/404. On the other hand, the injection of cyclosporin A induced the same phosphorylation sites as above except Ser-262/356, however, it did not mimic rat behavior abnormality as bradykinin injection did. The data suggested that activating of CaMKII and the phosphorylation of Ser-262/356 at tau might responsible for the lesion of learning and memory in our model rats. We also incubated PP-2A and PP-1 inhibitor, okadaic acid with human neuroblastoma cell line (SH-SY5Y), and found that (1) inhibition of above PPs induced Alzheimer-like phosphorylation and accumulation of neurofilaments, and Alzheimer-like microtubule disruption, (2) melatonin showed certain protection of the cell from okadaic acid toxicity. The data obtained from this study is significant in AD specific model study.

关键词： Study on Alzheimer s disease model

Synthesis and Properties of Thermoresponsive Silicon/Poly(etheramine)hybrid nanoparticles

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Synthesis and Properties of Thermoresponsive Silicon/Poly(et...

The reformation of catalyst:From a trial-and-error synthesis to rational design

河南省化学会2016年学术年会

作者： YG DOU YR REN MD XU T DING XM FANG YQ XU H XU WK ZHANG BY LIU yp wang College of Chemistry and Chemical Engineering Henan University

Organic/inorganic nanocomposites combine the advantages of organic polymer(***,insulativity,ductility,and processability)and inorganic material(*** and thermal stability).There has been a rapid growth in the applicati...

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Nano Research 2024年第4期17卷 3261-3301页

作者： Ligang wang Jiabin Wu Shunwu wang Huan Liu Yao wang Dingsheng wang Department of Chemistry Tsinghua UniversityBeijing 100084China

The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules,which is of great importance in the study of chemistry,chemical industry,energy,materials and environmental ***,efficient,environmentally friendly,and easy to operate synthesis methods have been used to prepare various types of *** previous studies have reported the synthesis and characterization of the aforementioned catalysts,more still remain in trial and error methods,without in-depth consideration and improvement of traditional synthesis ***,we comprehensively summarize and compare the preparation methods of the trial-and-error synthesis strategy,structure–activity relationships and density functional theory(DFT)guided catalysts rational design for nanomaterials and atomically dispersed *** also discuss in detail the utilization of the nanomaterials and single atom catalysts for converting small molecules(H_(2)O,O_(2),CO_(2),N_(2),etc.)into value-added products driven by electrocatalysis,photocatalysis,and ***,the challenges and outlooks of mass preparation and production of efficient and green catalysts through conventional trial and error synthesis and DFT theory are featured in accordance with its current development.

关键词： trial-and-error synthesis structure–activity relationships density functional theory(DFT)guidance nanomaterials atomically dispersed catalysts

Numerical Analysis of PRISM-PY Calculations for Hard-and Soft-Core Generic Polymer Models

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Chinese Journal of Polymer Science 2024年第4期42卷 532-543页

作者： Qiang wang Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Generic polymer models capturing the chain connectivity and excluded-volume interactions between polymer segments can be classified, according to whether or not the 3D integral of the latter diverges, into hard- and soft-core models. Taking homogeneous systems of compressible homopolymer melts (or equivalently homopolymer solutions in an implicit, good solvent) in the continuum as an example, we recently compared the correlation effects on the structural and thermodynamic properties of the hard- and soft-core models given by the polymer reference interaction site model (PRISM) theory with the Percus-Yevick (PY) closure (Polymers 2023, 15, 1180). Here we analyzed in detail the numerical errors and behavior of the interchain pair correlation functions (PCFs) given by the PRISM-PY calculations of these models using an efficient numerical approach that we proposed. Our numerical approach has the least number of independent variables to be iteratively solved, analytically treats the discontinuities caused by the non-bonded pair potential (such as that of the hard spheres) and takes only the inverse Fourier transform of the interchain indirect PCF between polymer segments (which is continuous and decays towards 0 with increasing wavenumber much faster than both the interchain direct and total PCFs), and is essential for us to accurately solve the PRISM-PY theory for chain length N as large as 106. To capture the correlation-hole effect, the real-space cut-off in the PRISM calculations should be proportional to the square root of N.

关键词： Generic polymer models Soft potentials Polymer reference interaction site model theory

Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

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Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： wang Yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality