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Interannual variability of dimethylsulfide in the Yellow Sea

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Journal of Oceanology and Limnology 2022年第2期40卷 551-562页

作者： sijia wang Qun SUN Siyu LI Jiawei SHEN Qian LIU Liang ZHAO College of Marine and Environmental Sciences Tianjin University of Science and TechnologyTEDATianjin 300222China School of Marine Science and Technology Tianjin UniversityTianjin 300072China

The 22-year(1998-2019)surface seawater dimethylsulfi de(DMS)concentrations in the Yellow Sea(YS)were hindcasted based on satellite sea surface temperature(SST)and chlorophyll-a(Chl-a)data using a generalized additive mixed model(GAMM).A continuous monthly dataset of DMS concentration in the YS was obtained after using the data interpolation empirical orthogonal function(DINEOF)to reconstruct missing information in the ***,the interannual DMS variability in the YS was *** results indicated that the monthly climatological DMS concentration in the YS was 3.61 nmol/*** concentrations in the spring and summer were signifi cantly higher than those in the autumn and *** concentrations were highest in coastal YS waters and lowest primarily in off shore YS *** DMS variability between 1998 and 2019 was subdivided into two inverse phases:with the exception of the central YS,DMS increased before the turning point and decreased *** turning point in interannual DMS variation was earlier in the inshore YS as compared to the central *** analysis identifi ed some signifi cant patterns of interannual variation in the DMS anomaly in the *** a appeared to be the main factor infl uencing interannual trends in DMS in the *** DMS variability was under the joint control of Chl a and ***,short-term interannual DMS variation(2-3 years)was primarily related to SST,while longer term interannual DMS variation(6-8 years)was signifi cantly correlated with Chl a and SST.

关键词： interannual variability dimethylsulfi de hindcasting generalized additive mixed modelling Yellow Sea

神经免疫炎症交互作用在中医药治疗抑郁症中的研究进展

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中国比较医学杂志 2024年第8期34卷 167-177页

作者：郭冬静潘文超王思嘉毛前程张洪秀马柯山东中医药大学中医学院济南250355 济南市疾病预防与控制中心济南250021 山东中医药大学第一临床医学院济南250014 北京中医药大学第三附属医院北京100029

抑郁症作为常见的心境障碍,发病机制复杂,近年来随着人们生活节奏的加快,患病率逐年攀升,引起人们的广泛关注。外界应激和炎症共同损害血管和脑区功能,诱发免疫失调,引起小胶质细胞活化和促炎性细胞因子及其受体表达增加,炎症反应持续发... 详细信息

抑郁症作为常见的心境障碍,发病机制复杂,近年来随着人们生活节奏的加快,患病率逐年攀升,引起人们的广泛关注。外界应激和炎症共同损害血管和脑区功能,诱发免疫失调,引起小胶质细胞活化和促炎性细胞因子及其受体表达增加,炎症反应持续发生,影响神经递质系统的正常代谢和分子通路的正常运行,导致脑细胞和神经异变,进一步形成的免疫-炎症-神经循环路径成为抑郁症发生发展的重要机制。大量研究表明中医药治疗可以通过恢复神经免疫炎症稳态改善抑郁症状,本文从神经免疫炎症角度出发,阐述其与抑郁症及其发病机制的密切联系,并对多种中医疗法通过调节神经免疫炎症改善和治疗抑郁症的作用进行综述,以期为抑郁症的精准治疗以及中医药免疫靶向药物研发提供新视角。

关键词：抑郁症神经免疫炎症中医药交互作用

Human umbilical cord blood mesenchymal stem cells conditioned media inhibits hypoxia-induced apoptosis in H9c2 cells by activation of the survival protein Akt

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BIOCELL 2020年第3期44卷 329-336页

作者： XUHE GONG GUANGPU FAN HUI LIU sijia wang RONGCHONG HUANG Department of Cardiology Beijing Friendship Hospital Affiliated to Capital Medical UniversityBeijing100190China Department of Cardiac Surgery Peking University People’s HospitalBeijing100190China Emergency Department Beijing Friendship Hospital Affiliated to Capital Medical UniversityBeijing100190China

This work aimed to study the beneficial role of human umbilical cord blood-derived mesenchymal stem cellconditioned medium(MSC-CM)in hypoxia-induced apoptosis in H9c2 cardiomyoblasts,in which the serine/heroine kinases(Akt)pathway would be *** this,CM was collected by culturing MSCs in serum-free DMEM medium for 24 h,and paracrine factors were analyzed by protein chip.H9c2 cells were divided into the following groups:control group,hypoxia group,MSC-CM intervention group(CM group),MSC-CM+Akt phosphorylation inhibitor(LY294002)group(LY group).Apoptosis of the H9c2 cells was tested with chromatin dye Hoechst 33342 and FITC-conjugated Annexin V apoptosis detection kit by flow cytometer after a hypoxia/serum deprivation(H/SD)for 24 *** apoptosis-related proteins were evaluated by Western ***-CM displayed significantly elevated levels of growth factors,anti-inflammatory,and anti-apoptosis *** Hoechst 33342 apoptosis staining,the H9c2 cell morphology displayed a lower proportion of apoptosis in the CM group than those in the hypoxia group,while apoptosis was increased in LY *** cytometer analysis revealed the apoptosis ratio in the CM group was lower than the hypoxia group(12.34±2.00%vs.21.73±2.58%,p<0.05),while the LY group was significantly higher(22.54±3.89%).Active caspase-3 expression was increased in hypoxia group than control group(p<0.05),but decreased in CM group(p<0.01).Umbilical cord blood-derived mesenchymal stem cell-conditioned media secrete multiple paracrine factors that are able to inhibit hypoxia-induced H9c2 cardiomyoblasts apoptosis,and in which the activation of Akt phosphorylation is involved to achieve the protective effect.

关键词： Umbilical cord blood mesenchymal stem cells paracrine actions H9c2 cells anti-apoptosis caspase-3 Akt

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基于7~10岁儿童防护口罩设计的面部特征

西安工程大学学报 2024年第3期38卷 24-31页

作者：周捷万晴吴瑕玉王思佳西安工程大学服装与艺术设计学院陕西西安710048

为设计研发更贴合儿童面部的防护口罩,运用三维扫描技术采集130名7~10岁儿童的面部数据,获取了包括面宽、形态面长、耳屏颌下弧长等10项面部指标,探索儿童面部发展规律及脸型分类。运用Pearson相关性分析挖掘各面部指标的发育相关程度,... 详细信息

为设计研发更贴合儿童面部的防护口罩,运用三维扫描技术采集130名7~10岁儿童的面部数据,获取了包括面宽、形态面长、耳屏颌下弧长等10项面部指标,探索儿童面部发展规律及脸型分类。运用Pearson相关性分析挖掘各面部指标的发育相关程度,通过独立样本t检验分析面部指标在性别上的差异,使用主成分因子分析提取能反映面部数据的3个主要因子;基于主成分分析结果,结合K-means聚类将儿童脸型分为狭面型(44.9%)、中面型(32.2%)和阔面型(22.9%),提出按脸型分类进行儿童防护口罩设计的理念。

关键词：儿童面部特征儿童口罩三维扫描性别差异相关性分析脸型分类

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产品服务系统设计思维下的校园快递包装可持续系统设计研究

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设计 2024年第9期37卷 128-131页

作者：王思佳黄黎清李明珠江苏大学艺术学院

基于产品服务系统设计思维研究校园快递包装回收系统创新思路,以解决快递业务量增大与快递包装回收体系不健全之间的矛盾。使用全生命周期分析、AEIOU观察法找到系统的设计介入点;使用“由内向外”分析法挖掘利益相关人;使用用户访谈语... 详细信息

基于产品服务系统设计思维研究校园快递包装回收系统创新思路,以解决快递业务量增大与快递包装回收体系不健全之间的矛盾。使用全生命周期分析、AEIOU观察法找到系统的设计介入点;使用“由内向外”分析法挖掘利益相关人;使用用户访谈语言材料分析方法进行用户访谈定性研究。提出一套校园智能快递运输及包装回收一体化系统,通过快递取件和包装回收场景的整合,设计出集取件与包装回收于一体的智能车及配套小程序。整合校园内智能快递运输资源,简化了快递包装回收流程,促进低碳物流发展。

关键词：产品服务系统设计可持续设计快递包装回收智能快递车小程序设计

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ProNet Adaptive Retinal Vessel Segmentation Algorithm Based on Improved UperNet Network

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Computers, Materials & Continua 2024年第1期78卷 283-302页

作者： sijia Zhu Pinxiu wang Ke Shen CW Chu College Jiangsu Normal UniversityXuzhou221000China Biomedical Engineering College Southern Medical UniversityGuangzhou510080China

This paper proposes a new network structure,namely the ProNet *** medical image segmentation can help clinical diagnosis of related eye diseases and is essential for subsequent rational *** baseline model of the ProNet network is UperNet(Unified perceptual parsing Network),and the backbone network is ConvNext(Convolutional Network).A network structure based on depth-separable convolution and 1×1 convolution is used,which has good performance and *** further optimise ProNet mainly in two *** is data enhancement using increased noise and slight angle rotation,which can significantly increase the diversity of data and help the model better learn the patterns and features of the data and improve the model’s ***,it can effectively expand the training data set,reduce the influence of noise and abnormal data in the data set on the model,and improve the accuracy and reliability of the *** is the loss function aspect,and we finally use the focal loss *** focal loss function is well suited for complex tasks such as object *** function will penalise the loss carried by samples that the model misclassifies,thus enabling better training of the model to avoid these errors while solving the category imbalance problem as a way to improve image segmentation density and segmentation *** the experimental results,the evaluation metrics mIoU(mean Intersection over Union)enhanced by 4.47%,and mDice enhanced by 2.92% compared to the baseline *** generalization effects and more accurate image segmentation are achieved.

关键词： Retinal segmentation multifaceted optimization cross-fusion data enhancement focal loss

2011-2021年宁波市儿童青少年糖尿病发病趋势

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预防医学 2024年第9期36卷 750-754页

作者：薛喆王思嘉卢兰兰王永龚清海沈鹏宁波市鄞州区疾病预防控制中心健康教育与慢性病防制科浙江宁波315100 宁波市疾病预防控制中心浙江宁波315010 宁波市鄞州区下应街道社区卫生服务中心浙江宁波315100

目的分析2011—2021年浙江省宁波市儿童青少年糖尿病发病趋势,为儿童青少年糖尿病防制提供依据。方法通过宁波市慢性病协同管理系统糖尿病监测平台收集2011—2021年宁波市0~18岁儿童青少年糖尿病发病资料,计算粗发病率并采用2010年第六... 详细信息

目的分析2011—2021年浙江省宁波市儿童青少年糖尿病发病趋势,为儿童青少年糖尿病防制提供依据。方法通过宁波市慢性病协同管理系统糖尿病监测平台收集2011—2021年宁波市0~18岁儿童青少年糖尿病发病资料,计算粗发病率并采用2010年第六次全国人口普查数据标化;采用平均年度变化百分比(AAPC)分析发病趋势。结果2011—2021年宁波市报告儿童青少年糖尿病701例,粗发病率和标化发病率分别为6.86/10万和7.27/10万,呈上升趋势(AAPC=5.886%、7.147%,均P0.05);10~<15岁组粗发病率为4.56/10万,高于其他年龄组;女性标化发病率为3.49/10万,高于男性的3.04/10万;城市标化发病率为3.60/10万,高于农村的3.15/10万(均P<0.05)。2型糖尿病粗发病率和标化发病率分别为3.43/10万和3.87/10万,呈上升趋势(AAPC=4.904%、7.579%,均P<0.05);15~18岁组粗发病率为10.53/10万,高于其他年龄组(均P<0.05),10~<15岁和15~18岁组粗发病率呈上升趋势(AAPC=15.030%、6.637%,均P<0.05);男性标化发病率为4.01/10万,高于女性的3.57/10万(P<0.05);城市标化发病率为4.57/10万,高于农村的3.34/10万(P<0.05)。结论2011—2021年宁波市儿童青少年2型糖尿病发病率呈上升趋势,病例以15~18岁、男性和城市儿童青少年为主;1型糖尿病未见变化趋势,病例以10~<15岁、女性和城市儿童青少年为主。

关键词：糖尿病发病率儿童青少年

Red Blood Cell-Mimic Nanocatalyst Triggering Radical Storm to Augment Cancer Immunotherapy

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Nano-Micro Letters 2022年第4期14卷 15-28页

作者： Jiong Li sijia wang Xinyi Lin Yanbing Cao Zhixiong Cai Jing wang Zhenxi Zhang Xiaolong Liu Ming Wu Cuiping Yao Key Laboratory of Biomedical Information Engineering of Ministry of Education Institute of Biomedical Photonics and SensingSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350025People’s Republic of China Mengchao Med‑X Center Fuzhou UniversityFuzhou 350116People’s Republic of China

Red blood cells(RBCs)have recently emerged as promosing candidates for cancer treatment in terms of relieving tumor hypoxia and inducing oxidative damage against cancer cells,but they are still far from satisfactory due to their limited oxygen transport and reactive oxygen species generation rate in tumor ***,artificial RBCs(designated FTP@RBCM)with radical storm production ability were developed for oncotherapy through multidimensional reactivity pathways of Fe-protoporphyrin-based hybrid metal-organic frameworks(FTPs,as the core),including photodynamic/chemodynamic-like,catalase-like and glutathione peroxidase-like ***,owing to the advantages of long circulation abilities of RBCs provided by their cell membranes(RBCMs),FTP with a surface coated with RBCMs(FTP@RBCM)could enormously accumulate at tumor site to achieve remarkably enhanced therapeutic ***,this ROS-mediated dynamic therapy was demonstrated to induce acute local inflammation and high immunogenic cancer death,which evoked a systemic antitumor immune response when combined with the newly identified T cell immunoglobulin and mucin-containing molecule 3(Tim-3)checkpoint blockade,leading to not only effective elimination of primary tumors but also an abscopal effect of growth suppression of distant ***,such RBC-mimic nanocatalysts with multidimensional catalytic capacities might provide a promising new insight into synergistic cancer treatment.

关键词： Red blood cell mimic Metal-organic framework Nanocatalyst Radical storm Cancer immunotherapy

A gel polymer electrolyte with IL@UiO-66-NH_(2) as fillers for high-performance all-solid-state lithium metal batteries

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矿物冶金与材料学报:英文版 2023年第10期30卷 1897-1905页

作者： Tao Wei Qi Zhang sijia wang Mengting wang Ye Liu Cheng Sun Yanyan Zhou Qing Huang Xiangyun Qiu Fang Tian School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China Power&Energy Storage System Research Center School of Mechanical and Electrical EngineeringQingdao UniversityQingdao 266071China College of chemical Engineering and Materials Handan CollegeHandan 056005China

All solid-state electrolytes have the advantages of good mechanical and thermal properties for safer energy storage,but their energy density has been limited by low ionic conductivity and large interfacial resistance caused by the poor Li~+transport kinetics due to the solid-solid contacts between the electrodes and the solid-state ***,a novel gel polymer electrolyte(UPP-5)composed of ionic liquid incorporated metal-organic frameworks nanoparticles(IL@MOFs)is designed,it exhibits satisfying electrochemical performances,consisting of an excellent electrochemical stability window(5.5 V)and an improved Li^(+)transference number of ***,the Li/UPP-5/LiFePO_(4) full cells present an ultra-stable cycling performance at 0.2C for over 100 cycles almost without any decay in *** study might provide new insight to create an effective Li^(+)conductive network for the development of all-solid-state lithium-ion batteries.

关键词： all solid-state lithium-ion batteries metal-organic frameworks gel polymer electrolytes ionic liquid solid electrolyte interphase