检索结果-南通市图书馆

Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosafety and Health 2024年第1期6卷 12-20页

作者： Shuang Zhao Amelia Siqi Huang Weibo Zhang Lili Ren hexiang wang Jianbin wang Xinyang Shao Guanbo wang Institute of Agri-Food Processing and Nutrition Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBejing 100097China Bejing Key Laboratory of Fruits and Vegetable Storage and Processing Key Laboratory of Vegetable Postharvest ProcessingMinistry of AgricultureBejing 100097China Dalton Academy The Affliated High School of Peking UniversityBeijing 100190China NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory National Institute of Pathogen BiologyBejing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China College of Biological Sciences China Agricultural UniversityBejing 100193China School of Life Sciences Tsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 518132China

The coronavirus disease of 2019(COVID‐19),a global pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),can result in severe health *** addition to physical preventative measures,pharmaceutical intervention is also *** natural products from medicinal fungi have shown promise as potential antiviral drugs and may serve as a source of effective components with antiviral activity against SARS‐CoV‐2 and other *** this study,we developed a workflow that integrates viral infection inhibition assays at both cellular and molecular levels,as well as molecular separation and characterization,to screen and identify natural products with antiviral *** this workflow,we screened 167 extracts extracted from 36 medicinal fungi using optimized extraction *** assessed the antiviral effects of these extracts by measuring their ability to inhibit SARS‐CoV‐2 infection and receptor binding domain‐human angiotensin‐converting enzyme 2(RBD‐hACE2)binding in *** charge‐and size‐based characterization of the active compounds through filtration and chromatographic fractionation,mass spectrometry characterization of the fractionated compounds revealed that the active components are polysaccharides and determined their monosaccharide residue *** findings provide new insights into the antiviral potential of natural products and their screening strategies and may contribute to the development of effective antiviral therapeutics against COVID‐19 and other diseases.

关键词： Medicinal fungi Natural products Antiviral activity COVID‐19 Polysaccharides

Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第08期 19-25页

作者： Yao Pei Ran wang Xiang Rong Xiang Xia hexiang wang Zongwei Zhang Tian Qiu Saran Long Jianjun Du Jiangli Fan Wen Sun Xiaojun Peng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology Ningbo Institute of Dalian University of Technology

The key factor in photothermal therapy lies in the selection of photothermal agents. Traditional photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficiency. Herein, we have designed and synthesized an isoindigo(IID) dye. We used isoindigo as the molecular center and introduced common triphenylamine and methoxy groups as rotors. In order to improve the photothermal stability and tumor targeting ability, we encapsulated IID into nanoparticles. As a result, the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency(67%) upon 635 nm laser irradiation. Thus, the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.

关键词：

五味子提取物对仔猪生长性能、肠道形态和免疫功能的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国饲料 2024年第12期 53-56页

作者：王荷香王申锋王东方河南农业职业学院河南郑州451450 河南省动物疫病预防控制中心河南郑州450008

文章旨在探究五味子提取物对仔猪生长性能、肠道形态和免疫功能的影响。试验将400头28日龄健康、体况良好的三元杂交猪随机分为4组,每处理10个重复,每重复10头。试验日粮分别向基础日粮中添加0、200、400和800 mg/kg的五味子提取物,预饲... 详细信息

文章旨在探究五味子提取物对仔猪生长性能、肠道形态和免疫功能的影响。试验将400头28日龄健康、体况良好的三元杂交猪随机分为4组,每处理10个重复,每重复10头。试验日粮分别向基础日粮中添加0、200、400和800 mg/kg的五味子提取物,预饲期3 d,正试期28 d。结果表明:补充400和800 mg/kg五味子提取物可显著提高仔猪6.25%和4.61%的终末体重(P0.05);显著降低仔猪10.41%和9.09%的料重比(P0.05)。800 mg/kg的五味子提取物可显著提高仔猪血清IgM含量(P0.05)。400和800 mg/kg五味子提取物组仔猪空肠绒毛高度显著提高(P0.05)。在本试验条件下,五味子提取物最适添加量为400 mg/kg。

关键词：五味子提取物仔猪生长性能免疫功能

中西医结合治疗脑卒中合并睡眠呼吸暂停综合征临床效果观察

在线全文

学校读者我要写书评

暂无评论

世界睡眠医学杂志 2024年第4期11卷 932-935页

作者：王鹤翔宝清县中医院急诊科宝清155600

目的:探讨中西医结合治疗脑卒中合并睡眠呼吸暂停综合征患者的临床效果及对睡眠质量的改善作用。方法:选取2021年12月至2023年12月宝清县中医院收治的脑卒中合并睡眠呼吸暂停综合征患者68例作为研究对象,按照随机数字表法分为对照组和... 详细信息

目的:探讨中西医结合治疗脑卒中合并睡眠呼吸暂停综合征患者的临床效果及对睡眠质量的改善作用。方法:选取2021年12月至2023年12月宝清县中医院收治的脑卒中合并睡眠呼吸暂停综合征患者68例作为研究对象,按照随机数字表法分为对照组和观察组,每组34例。对照组行持续气道正压通气治疗,观察组行持续气道正压通气+针刺+耳穴压豆治疗,比较2组睡眠呼吸参数、中医证候积分及疲乏、嗜睡、睡眠和生命质量评分。结果:治疗后,观察组睡眠呼吸参数优于对照组,差异有统计学意义(P<0.05);中医证候积分低于对照组,差异有统计学意义(P<0.05);疲劳严重度量表、Epworth嗜睡量表、匹兹堡睡眠质量指数评分均低于对照组,Calgary睡眠呼吸暂停生命质量指数评分高于对照组,差异有统计学意义(P<0.05);治疗总有效率比对照组高,差异有统计学意义(P<0.05)。结论:中西医结合治疗脑卒中合并睡眠呼吸暂停综合征的疗效确切,值得推广。

关键词：脑卒中睡眠呼吸暂停综合征中西医结合治疗效果睡眠质量

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

直升机核生化防护体系集成设计与仿真

空军工程大学学报 2024年第1期25卷 17-24页

作者：毛晓东张策王鹤翔李洋王伟华沈阳航空航天大学航空发动机学院沈阳110136

直升机作为国家战略层次的飞行器,其快速进出战场的能力必将在核生化威胁中起到关键作用。为了保障舱内人员的安全,必须对直升机的核生化防护系统进行研究。从系统顶层架构设计出发,基于系统集成手段,设计了一种直升机核生化防护体系。... 详细信息

直升机作为国家战略层次的飞行器,其快速进出战场的能力必将在核生化威胁中起到关键作用。为了保障舱内人员的安全,必须对直升机的核生化防护系统进行研究。从系统顶层架构设计出发,基于系统集成手段,设计了一种直升机核生化防护体系。针对各子系统开展了详细构型设计,包括:基于小型高转速电动压气机的气源增压子系统;基于变压吸附原理,可实现机载实时再生的滤毒通风子系统;基于热泵型蒸发制冷循环,利用滑油废热及双蒸发器并联驱动的温度控制子系统;综合座舱超压防护及增压需求的压力调节子系统。基于系统构型,建立了仿真模型,对系统动态性能开展了仿真验证研究。仿真结果表明:在各种极端条件下,舱内压力、温度均满足设计要求。当进入核生化威胁区域时,滤毒通风子系统能够有效吸附有毒物质,吸附床通过机载实时再生,延长了在核生化威胁区域的作业时间,为直升机核生化防护系统设计提供了新的思路。

关键词：核生化防护直升机座舱变压吸附蒸发制冷循环飞行动态特性

在线全文

学校读者我要写书评

暂无评论

无人机倾斜摄影三维建模软件对比分析

测绘与空间地理信息 2024年第5期47卷 176-179页

作者：贾蕾王承安王贺祥内蒙古师范大学地理科学学院内蒙古呼和浩特010022 广州南方测绘科技股份有限公司呼和浩特分公司内蒙古呼和浩特010020

倾斜摄影测量是一种能够在短时间内实现对大型真实场景进行三维建模的有效方法。本文通过五镜头旋翼无人机倾斜摄影获得立体影像数据,将其分别导入Context Capture和重建大师两个软件中,空三创建研究区高精度三维模型,通过建模及对模型... 详细信息

倾斜摄影测量是一种能够在短时间内实现对大型真实场景进行三维建模的有效方法。本文通过五镜头旋翼无人机倾斜摄影获得立体影像数据,将其分别导入Context Capture和重建大师两个软件中,空三创建研究区高精度三维模型,通过建模及对模型成果分析,对比出两个软件的优缺点和差异。研究发现重建大师的建模效果和建模速度优于Context Capture,但后者的模型精度优于前者。

关键词：无人机倾斜摄影三维建模软件对比重建大师

Professor Tafu Yu: an eminent agricultural scientist and outstanding educator of our nation

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2019年第8期10卷 545-549页

作者： Shuang Zhao Tiantian Xu hexiang wang Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry Sciences Beijing Engineering Research Center for Edible Mushroom Beijing 100097 China State Key Laboratory of Agrobiotech no logy and College of Biological Sciences China Agricultural Un iversity Beijing 100193 China

Prof. Tafu Yu (1901-1993)(Fig. 1) is a pioneering scientist of phytopathology and agricultural microbiology in China. Like most of the scientists of his generation, Prof. Yu gave up the attractive conditions abroad and went back to China with the determination to rescue the nation with his knowledge. He has devoted his entire life to the development of phytopathology in China since 1924. Prof. Yu is also a distinguished educator who has instructed and in spired several generations of talent students for the country and has made outstanding contributions to the development of the agricultural scienee and education in China.

关键词： Professor Tafu Yu eminent agricultural scientist nation

基于MRI影像及数字病理图像的组学列线图预测软组织肉瘤术后复发风险的研究

在线全文

学校读者我要写书评

暂无评论

中华放射学杂志 2024年第2期58卷 216-224页

作者：王童语王鹤翔赵心迪侯峰杨江飞侯明妤万光耀岳斌郝大鹏青岛大学附属医院放射科青岛266003 青岛大学附属医院病理科青岛266003 山东第一医科大学附属省立医院医学影像科济南250021 青岛大学附属妇女儿童医院病理科青岛266034 青岛大学附属医院骨肿瘤科青岛266003

目的探讨基于MRI影像及数字病理图像的组学列线图预测软组织肉瘤(STS)术后复发风险的价值。方法本研究为回顾性队列研究, 回顾性收集2016年1月至2021年3月青岛大学附属医院经手术病理证实的192例STS患者, 其中于崂山院区就诊的患者作为... 详细信息

目的探讨基于MRI影像及数字病理图像的组学列线图预测软组织肉瘤(STS)术后复发风险的价值。方法本研究为回顾性队列研究, 回顾性收集2016年1月至2021年3月青岛大学附属医院经手术病理证实的192例STS患者, 其中于崂山院区就诊的患者作为训练集(112例), 市南院区就诊的患者作为验证集(80例)。对患者进行随访, 分为复发组(87例)和未复发组(105例)。收集患者的临床和影像学特征, 提取病灶脂肪抑制T2WI图像的影像组学和数字病理图像的病理组学特征, 采用多因素Cox回归建立临床模型、影像组学模型、病理组学模型和联合组学模型, 并结合最优组学模型和临床模型, 构建组学列线图。采用一致性指数(C index)和时间依赖受试者操作特征曲线下面积(t-AUC)评价各模型预测STS术后复发风险的效能, 采用DeLong检验比较t-AUC间的差异。采用X-tile软件确定组学列线图的截断值, 将患者分为低风险(106例)、中风险(64例)及高风险(22例)组, 采用Kaplan-Meier生存曲线和log-rank检验计算并比较3个复发风险组的累积无复发生存(RFS)率。结果联合组学模型的性能优于单一影像组学或病理组学模型, 在验证集中的C index为0.727(95%CI 0.632~0.823)、中位t-AUC为0.737(95%CI0.584~0.891)。结合临床模型和联合组学模型构建组学列线图, 在验证集中的C index为0.763(95%CI 0.685~0.842), 中位t-AUC为0.783(95%CI0.639~0.927)。在验证集中, 组学列线图的t-AUC值高于临床模型、TNM模型、影像组学模型及病理组学模型, 差异有统计学意义(Z=3.33、2.18、2.08、2.72, P=0.001、0.029、0.037、0.007);组学列线图与联合组学模型的t-AUC值差异无统计学意义(Z=0.70, P=0.487)。在验证集中, 低、中、高复发风险组STS患者术后1年RFS率为92.0%(95%CI 81.5%~100%)、55.9%(95%CI 40.8%~76.6%)、37.5%(95%CI 15.3%~91.7%)。在训练集和验证集中, 低、中、高复发风险组STS患者的术后累积RFS率差异有统计学意义(训练集χ^(2)=73.90, P<0.001;验证集χ^(2)=18.70, P<0.001)。结论基于MRI影像和数字病理图像的组学列线图对STS术后复发风险具有较好的预测性能。

关键词：软组织肿瘤肉瘤磁共振成像影像组学病理组学

Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 2451-2461页

作者： Zhichao Yu Ruijin Zeng hexiang Gong Yuan Gao Shuyun Chen Yunsen wang Dianping Tang Key Laboratory for Analytical Science of Food Safety and Biology(MOE&Fujian Province) Department of ChemistryFuzhou UniversityFuzhou 350108China

Highly evolved multi-enzyme cascade catalytic reactions in organisms facilitate rapid transfer of substrates and efficient conversion of intermediates in the catalytic unit,thus rationalizing their efficient *** this study,pore-ordered mesoporous single-atom(Fe)nitrogen-doped carbon nanoreactors(Mp-Fe-CN)were designed,in which a reasonable pore size was designed as a natural enzyme trap coupled to a simulated enzyme center.A polarity-mediated strategy was developed to obtain atomically dispersed nanoporous substrates,with the finding that polarity-guided engineering of the nitrogen-ligand environment and vacancy cluster defects clearly affects nanoporous activity,accompanied by appreciable mesoporous pore size *** active center and distal N atom coordination of Fe-N_(4) affect the catalytic process of the nanozyme exposed by density functional theory(DFT),determining the contribution of hybridized orbitals to electron transfer and the decisive step.A cascade nanoreactor-based domain-limited sarcosine oxidase developed for non-invasive monitoring of sarcosine levels in urine for evaluation of potential prostate carcinogenesis as a proof of *** on the design of surface mesoporous channels of nanocatalytic units,a bridge was built for the interaction between nanozymes and natural enzymes to achieve cascade nanocatalysis of natural enzymatic products.

关键词： nanozyme single-atom catalyst bioreactor cascade catalysis non-Invasive sensing